Objective To investigate the effect of oxytocin on the expression of MKP-1 level in the hippocampus of post-traumatic stress disorder rats.Methods Eighteen SD rats were randomly divided into the control group,administration group and the experimental group with 6 rats in each group.The administration group and the experimental group were treated with internationally recognized single prolongation stress (SPS) method to stimulate the rats in order to establish PTSD models.The 14-day oxytocin intervention was given to rats of the administration group after the SPS stimulation within 8 hours.And the behavioral changes of rats were observed by open-field test and Morris water maze test.The changes of MKP-1 mRNA in the hippocampus of rats were detected by real-time quantitative PCR (qRT-PCR),and the levels of MKP-1 Protein in the hippocampus of rats were detected by Western Blot.Results (1) Compared with the model group (2.50± 1.05 and 22.16±7.14),the times of the standing and crossing grid section quantities in the open-field test in the administration group(5.16± 1.17and 32.83±5.71) and control group (6.67±2.16 and 39.83± 4.62) significantly decreased (P＜0.05).Morris water maze showed that the incubation of the model group was markedly prolonged (P＜0.05) compared with that of the administration group,while in spatial probe test,the incubation period of the rats in administration group was prolonged,and the number of wearing stage decreased (P＜0.05).(2) Compared with the administration group (1.30±0.03),the expression of MKP-1 mRNA in hippocampus of rats in model group (4.04±0.46) was notably up-regulated (P＜0.05).And the protein level of MKP-1 in model group(1.95±0.68) was also increased compared with that in administration group (1.46±0.27) (P＜0.05).Conclusions Oxytocin can protect the learning and memory ability and reduce the stress-related performance of rats via regulating the expression of MKP-1.

目的 探讨患者的人格特征及社会支持系统与患者脑卒中后出现PTSD的关系.方法 利用社会支持评定量表和艾森克人格问卷量表评价观察组脑卒中后PTSD患者与对照组脑卒中后未发生PTSD患者的人格特征和社会心理状态,并通过对比分析各量表评分结果从而探讨患者的人格及社会支持系统对脑卒中后PTSD发病的影响.结果 研究组脑卒中后PTSD患者SSRS量表评分显著低于对照组脑卒中后未发生PTSD患者(P＜0.05);研究组EPQ-RS量表中E量表、L量表评分情况与对照组对比无明显差异(P＞0.05);研究组EPQ量表中N量表、P量表评分与对照组对比,差异有统计学意义(P＜0.05).结论 人格特征和社会的支持对脑卒中后PTSD的发生有着明显的影响,临床医护人员应根据此项特点接诊后准确评估脑卒中患者社会心理状态,及早的对高危人群提供正确有效的干预措施,降低PTSD发生率,提高患者的社会功能、健康状况及生活质量.

目的 探讨MoCA量表在创伤后应激障碍(PTSD)患者认知功能损伤中的应用.方法 纳入PTSD患者28例、经历创伤事件未发生PTSD患者28例和心理健康测评者28例,共3组.均行PTSD自评量表(PCL-C)和认知功能评定量表(MoCA)评估.结果 PCL-C总分与再体验、回避麻木与警觉性增高分项得分PTSD组＞非PTSD组＞对照组(F=164.790,F=98.570,F=124.879,F=138.570,P＜0.05);PTSD组和对照组在MoCA总分和各个分项上的差异具有统计学意义(P＜0.05);除了语言表达能力(2组无统计学差异,F=7.572,P＞0.05),PTSD组和非PTSD组在MoCA总分和各个分项上的差异具有统计学意义(P＜0.05);非PTSD组和对照组在语言表达和注意力上的得分差异具有统计学意义(F=7.572,F=38.626,P＜ 0.05);在空间与执行能力、命名能力、抽象、延时回忆、定向力和MoCA总分的差异无统计学意义(P=0.074,P=0.256,P=0.316,P=0.274,P=0.063,P=0.052);行Spearman相关分析显示,PTSD组PCL-C总分及3个症状群均和MoCA总分和7个认知小分项呈显著负相关(P＜0.01);行多元线性回归分析显示,R2=0.968,F=240.135,表明再体验、麻木回避和警觉性增高联合起来对PTSD患者的认知功能损伤的影响是显著的,在对单个预测变量的回归系数B进行t检验时发现,只有预测变量警觉性增高的P=0.275＞0.05,说明警觉性增高对PTSD患者认知功能损伤的影响是不显著的,而再体验和麻木回避对PTSD患者认知功能损伤的影响是显著的.结论 PTSD患者存在认知功能损伤,且随着PTSD症状加重,认知功能的损伤越明显;其中再体验和麻木回避这两大症状群对认知功能的损伤有显著的影响.

目的 探讨音乐治疗配合吞咽功能训练对卒中后吞咽功能障碍患者的影响.方法 选取该院2015年8月至2016年1月收治的卒中后吞咽困难患者88例,分为观察组和对照组.对照组采用常规吞咽功能训练,观察组在对照组基础上加用音乐疗法.于治疗前、治疗后4周、治疗后3个月,采用标准吞咽功能评价量表(SSA)及汉密尔顿抑郁量表(HAMD)对所有患者进行测评并比较分析.结果 组内比较显示:治疗后4周,两组SSA评分均低于治疗前,高于治疗后3个月,差异均有统计学意义(P<0.05),且观察组HAMD评分低于治疗前,差异有统计学意义(P<0.05).组间比较显示:治疗后4周,观察组SSA及HAMD评分均低于对照组,差异有统计学意义(P<0.05);治疗后3个月随访时,观察组SSA评分仍低于对照组,差异有统计学意义(P<0.05),但两组HAMD评分比较差异无统计学意义(P>0.05).结论 对于卒中后吞咽困难患者,音乐治疗的积极开展能明显改善患者的吞咽功能,同时还能减轻患者的抑郁情绪,可作为卒中后患者吞咽功能训练的辅助治疗方式.

目的 探讨综合干预对脑卒中照护者及患者的影响.方法 以2014年1月—2015年9月间在石河子大学医学院第一附属医院住院的脑卒中主要照护者为研究对象,共84人,随机分为实验组(综合干预组)和对照组两组.对照组照护者在患者出院后给予常规指导;实验组照护者接受多专业团队提供的综合干预.干预前及干预后第2周用Bakas照护结局量表(BCOS)、世界卫生组织生存质量测定量表(WHOQOL-Bref)及汉密尔顿抑郁量表(HAMD)对所有照护者进行测评,用改良Barthel指数量表对脑卒中患者进行测评.结果 组内比较结果表明,实验组中,BCOS后测分数高于前测、HAMD后测分数低于前测,差异均有统计学意义(P=0.012;P=0.032);对照组中,HAMD后测分数高于前测,差异有统计学意义(P=0.012).组间比较结果表明,BCOS分数实验组高于对照组,差异有统计学意义(P=0.019)、HAMD评分实验组低于对照组,差异有统计学意义(P<0.001)、实验组患者能自理人数较对照组多,差异有统计学意义(P=0.046).结论 以健康教育与团体心理辅导为主要内容的综合干预能够有效减轻脑卒中照护者的照护负担及抑郁情绪,提高脑卒中患者的自理能力,值得推广应用.

Aim:To estimate memory changes in patients with post-traumatic stress disorder ( PTSD) by WMS.Meth-ods:Three groups of participants (20 cases with current PTSD , 20 cases with trauma but without current PTSD , and 20 normal controls) were assessed by WMS.Results:In the first measurement, PTSD individuals′appraised scores had sig-nificant difference in experience , picture memory,visual recognition,associative memory,tactile memory,intelligent memo-ry,and immediate memory compared with controls′(P<0.05).And, compared with non-PTSD individuals′, there were significant differences in tactile memory and immediate memory (P<0.05).In addition, when non-PTSD group compared with control group, there were significant differences in experience , associative memory,tactile memory,and intelligent memory,and immediate memory(P<0.05).However, when being evaluated again after 15 days, there were significant differences in picture memory ,visual regeneration , associative memory ,and intelligent memory between 2 time points ( P< 0.05).Conclusion:Memory function and re-learning ability of PTSD individuals exist certain damage .

Objective To investigate the advantages and disadvantages of eye movement desensitization and reprocessing( EMDR)and cognitive behavioral therapy( CBT)in the treatment of posttraumatic stress disorder( PTSD)due to bereavement. Methods We enrolled patients Who Were diagnosed With PTSD due to bereavement in the First Affiliated Hospital of Shihezi University from January to December in 2013 and randomly divided them into EMDR group and CBT group. The PTSD symptoms,anxiety and depression Were assessed before and after treatment. Results A total of 34 patients Were included( 17 patients each group). Before treatment,the tWo groups Were not significantly different(P>0. 05)in the total score of PCL-C, the scores of three syndromes,and scores of HAMA and HAMD. After treatment,EMDR group Was loWer(P<0. 05)than CBT group in the total score of PCL-C,the scores of flashback and hyperarousal and the score of HAMA. Conclusion EMDR and CBT are all effective in the treatment of PTSD,While EMDR is more effective in alleviating PTSD symptoms and anxiety.