某三级综合医院以STEM评价指标为基础,通过制定切实有效的医院创新人才培养模式,提升医院创新人才培养的效果.文章通过对入选人才培养计划的医师在培养前后 3 年科研业绩进行对比分析,发现经过培养后的医学创新人才在科技产出方面业绩较为突出,差异具有统计学意义(P<0.05),成功助力医院登上中国医院科技量值百强榜.因此,该培养计划对医师科研水平的提升有一定的效果,有助于医院科研竞争力的进一步提升,助力医院高质量发展.

目的:探讨杰出青年医师的培养模式,以加快医师队伍建设步伐,为提升医院实力提供人才保障和智力支撑.方法:对某大学附属医院青年医师培养工程入选人才在培养前后三年获得的科研和诊疗技术成果数,以及人才在三年培养期与未入选人员获得的科研及诊疗技术成果数进行对比分析.结果:青年医师培养工程入选人才在经过培养后获得的高层次科研项目、高水平科研成果、技术奖项明显高于未入选人员.差异具有统计学意义(P＜0.05).结论:青年医师培养工程对医师科研和诊疗水平的提升有显著效果,有助于医院整体实力的提升.

在国家三级公立医院绩效考核、推动公立医院高质量发展及研究型医院建设背景下,从政策视角对医院科技成果转化工作进行剖析.以江苏省某公立三甲综合医院以例,通过SWOT分析法,深入探讨三级公立医院科技成果转化政策方面面临的优势与机遇、劣势与挑战,以期提出相应对策,提高医院科技成果转化政策及制度方面的决策水平.

Objective:To investigate the effects of poly adenosine diphosphate ribose polymerase-1(PARP-1) inhibitor fluzoparib on proliferation, apoptosis and migration of pancreatic cancer PANC1 cells.Methods:PANC1 cells cultured in conventional culture medium were used as control group, and PANC1 cells cultured in the medium containing fluzoparib were used as fluzoparib group. The effects of fluzoparib with different concentrations on the proliferation of PANC1 cells were detected by CCK8 method, and the half inhibitory concentration (IC 50) of fluzoparib on PANC1 cells was calculated. The effect of fluzoparib on apoptosis and cell cycle of PANC1 cells was detected by flow cytometry, and the migration ability of PANC1 cells was detected by cell scratch test and Transwell chamber. Results:Compared with control group, with the increase of fluzoparib concentration and the prolongation of the action time, the cell proliferation activity of PANC1 in fluzoparib group was significantly decreased, and the differences were statistically significant (all P values <0.05). IC 50 of fluzoparib on PANC1 cells cultured for 24 h was 0.03 mmol/L. After 24 h culture, the IC 50 apoptosis rate of fluzoparib group was (32.19±2.48)%, and the apoptosis rate of control group was (21.99±6.30)%. The former was greatly higher than the latter, and the difference was statistically significant ( P<0.05). The proportion of cells in G 2/M phase was (16.28±0.62)% in the fluzoparib group and (11.64±0.88)% in the control group, and the difference between the two groups was statistically significant ( P<0.05). The migration rates of PANC1 cells in IC 50 fluzoparib group in 12 h and 24 h culture were (2.59±1.46)% and (19.76±7.84)%; and those in control group were (27.08±2.17)% and (45.92±3.61)%, respectively. The number of transmembrane cells was (348±19) cells/10 visual field in the fluzoparib group and (587±14) cells/10 visual field in the control group. The migration ability of PANC1 cells in fluzoparib group was significantly lower than that in control group ( P<0.05). Conclusions:Fluzoparib can inhibit the proliferation and migration of PANC1 cells and promote the apoptosis of PANC1 in vitro, which may be an effective drug for the treatment of pancreatic cancer.

利用信息化的手段可以有效提升科研工作精细化管理的效果.文章根据国家推动公立医院高质量发展以及国务院优化科研管理的要求,结合某三级甲等综合医院第一代科研管理平台引进及推进过程中存在的问题以及问题产生的原因,进而对信息化建设助力科研工作精细化管理的路径进行研究.研究结果表明:该院自主研发的以用户导向、整体推进及持续改进为设计理念的第二代科研管理综合服务平台获得了临床一线用户、兄弟科室管理人员和院外审核专家的支持与配合,实现了高效、规范、精细的科研管理效果.

Objective:To explore a more efficient and standardized scientific research management mode, in order to enhance the best practice of conducting research, improve the agency and satisfaction of scientific research investigators, to improve the efficiency of scientific research management.Methods:According to the problems and deficiencies identified during the process of scientific research management, combined with the latest scientific research management policies and guidelines, the research and development concept of hospital scientific research management platform was formed, and tailored scientific research management information platform was developed by making good use of information technology.Results:After the application of the tailored scientific research management information platform, the efficiency of reimbursement and information access of scientific research personnel was significantly improved, with a significant difference.Conclusions:The construction of scientific research information platform based on the combination of education and management helps to achieve the goal of efficient, standardized and refined scientific research management.

目的 了解南通大学附属医院(以下简称"我院")医务人员专利的申请现状及专利知识的掌握情况,为今后我院专利管理的政策制订和调整等工作提供参考依据.方法 于2020年5月,采用便利抽样方法,在阅读和参考文献的基础上设计调查问卷,对我院医务人员申请专利现状及相关专利知识的掌握情况进行调查和分析.结果 本研究共发放问卷410份,回收有效问卷408份,有效回收率为99.5％.本调查中,仅125名医务人员申请过专利,占30.6％,没有申请的原因主要是没有项目要申请专利.其中105名获得授权,以实用新型专利为主,81项处于维持、4项失去保护专利权终止,仅有1项已转让.仅69名(16.9％)对专利基本知识和申请程序有一些了解,339名(83.1％)基本不了解.不同专业技术领域、职称医务人员备案比例比较,差异有统计学意义(P＜0.05).不同专业技术领域、学历、职称及既往是否申请专利的医务人员对专利基本知识和申请程序了解程度比例比较,差异有高度统计学意义(P＜0.01).多因素logistic回归结果显示,高级职称[OR(95％CI):5.19(2.36～11.42)]、了解申请专利[OR(95％CI):9.92(4.75～20.70)]、实用新型和外观设计专利权的保护期限回答正确[OR(95％CI):2.36(1.33～4.20)]的医务人员是申请专利的影响因素(P＜0.05).结论 我院医务人员专利申请率较低,且对专利知识掌握不足,医院应重视专利管理工作,挖掘培育高价值专利,加强专利知识培训与普及,改善激励机制,调动专利创造与运用的积极性,运用全面质量管理理念,提高专利申请质量和转化率.

目的 探讨适应社会发展需求的医学专业学位与学术学位研究生培养模式,推动卫生医疗行业的健康发展,提高国民的健康水平与生活质量.方法 通过分析我国医学研究生培养模式的现状,针对存在问题,课题组随机挑选了2016级20名研究生(5名学术学位研究生,15名专业学位研究生)采用临床与科研协同发展方式进行培养.结果 该模式培养下的研究生临床基础知识较为扎实、科研能力更强,有助于塑造出基础与临床相结合的复合型人才.同时,能够充分调动研究生导师的积极性,实现教学资源共享,培养出一批优秀的研究生导师.结论 医学专业学位与学术学位研究生协同培养模式对提高研究生的创新能力和科研能力,丰富研究生导师带教经验具有实践意义.

随着全球新型冠状病毒性肺炎疫情暴发,限制人员流动聚集是最有效的防控措施之一,但是每年的2—5月是各类各级科研项目申报以及学术交流会议举办的高峰期,显然传统局部网络化科研管理模式不再适用于重大公共卫生事件突发时期.因此,需提高科研工作精细化网络管理服务意识,建立全流程科研活动网络化管理模式,以防范和应对公共卫生事件对科研活动的限制和影响.文章介绍了新型冠状病毒性肺炎疫情流行期间,某三甲定点救治医院充分利用办公系统、微信、邮箱、视频会议软件等网络化管理方式,通过探索实践提出医院科研活动网络化管理的新建议.

目的 医学科学技术发展日新月异,时代要求医务工作者了解最新学科发展动态.本文通过对医院职工参加学术交流活动现状调查,发现存在问题,提出整改建议.方法 以某三甲医院2017年度职工参加学术交流情况为例,统计分析现状.结果 学术交流管理制度执行力不够、活动中发言及论文投稿者甚少、国际性学术交流活动占比低、年轻职工参加学术交流活动的机会不多.结论 建议完善学术交流管理制度,支持鼓励优秀的年轻职工多参加高层次的学术交流活动,有利于医院医疗及科研水平的提高.

目的:探讨关节病型银屑病的各种护理要点。方法:对14例关节病型银屑病患者采取一系列的护理措施。结果:14例好转出院。结论:对关节病型银屑病患者给予对症护理,可提高患者生命质量,避免皮肤感染及并发症的发生。