目的：观察干扰素-α联合窄谱中波紫外线治疗皮肤 T 细胞淋巴瘤的临床疗效。方法我院2012年1月至2013年12月期间所收治的皮肤 T 细胞淋巴瘤患者中选取20例作为此次研究对象，随机分为观察组和对照组，两组患者的年龄、性别等一般情况比较没有明显的差异，有可比性，P>0.05，具有统计学意义。结果观察组患者的治疗有效率为90.0%，对照组患者的治疗有效率为60.0%，观察组患者治疗有效率明显高于对照组患者，P<0.05，差异具有统计学意义。结论对于皮肤 T 细胞淋巴瘤患者，采用干扰素-α联合窄谱中波紫外线治疗，有助于提高患者治疗总有效率，安全性较高，具有一定的应用价值和治疗优势，值得大力推广使用。

ObjectiveTo observe the safety of methotrexate combined with glucocorticoid in the treatment of patients with dermatomyositis.MethodsTotal 100 patients with dermatomyositis, from January 2010 to December 2013, treated in our hospital, according to random number table, divided into observation group (n=50) and control group (n=50). The observation group toke methotrexate combined with glucocorticoid therapy, the control group was treated with glucocorticoid. The total course of treatment lasted for 6 months, then the curative effect was evaluated and the efficiency of two groups were compared, as well as muscle enzymes, muscle strength changes and adverse reactions.ResultsThe effective rate of observation group (70%) was signiifcantly higher than the control group (50%) (P<0.05); to be compared with before treatment, the serum muscle enzyme spectrum of the two groups both have signiifcant improvement (P<0.05); muscle enzyme spectrum of the two groups after treatment had signiifcant difference (P<0.05);the incidence of adverse reactions of the observation group (10%) was signiifcantly lower than that of the control group (40%) (P<0.05). ConclusionThe therapeutic effect of methotrexate combined with glucocorticoids in the treatment of dermatomyositis is remarkable, which can signiifcantly improve the muscle enzyme spectrum in patients and reduce a variety of adverse reactions caused by corticosteroids, as well as improve the symptoms of patients, so the combined treatment is worthy of application.

Objective:To analyse the clinical efficacy of surgery combined with 5-aminolevulinic acid-Photody-namic theraPy( ALA-PDT)treatment on basal cell carcinoma. Methods:Thirty basal cells cancer Patients were di-vided into observation grouP and control grouP,15 cases in each grouP. In observed grouP Patients before surgery were treated by ALA-PDT treatment once a week,a total of 3-7 times,then surgical treatment and control grouP Patients only take surgery,follow-uP for 16 to 25 months. Results:The total effective rate of the observation grouP was 100%(15/15),in the control grouP,the total effective rate was 86. 7%(13/15)(P>0. 05). Healing rates,adverse reac-tion rates were statistically significant different(P<0. 05),the observation grouP was better than the control grouP. Conclusion:Surgery combined with ALA-PDT treatment for basal cell carcinoma is effective and safe.

Objective To investigate the acitretin A can be induced in primary human skin keratinocytes apoptosis and acitretin A anti psoriasis.Methods Flow cytometry double labeling and transmission electron microscopy were used to observe the apoptosis of the cells before and after induction of drug interaction analysis, by enzyme linked immunosorbent assay. Results Acitretin A can be induced in primary human skin keratinocytes apoptosis, cell apoptosis degree in a concentration and time obvious dependence.Conclusions The citretin A can induce the apoptosis of the primary human keratinocytes, and the citretin A has curative effect on the clinical curative effect of acitretin.

<正>近年来,我国梅毒发病率及先天梅毒的发病率均呈上升趋势,先天梅毒已是威胁新生儿生命的重要疾病之一。现将1例早期先天梅毒病例报道如下:1临床资料患儿,女,54天,第一胎,足月剖腹产,在当地乡

临床资料 患者男,52岁,农民.患者8岁时因烧伤致右侧肢体多部位形成瘢痕,患者常因瘙痒而搔抓.1年前患者右上臂瘢痕被铁犁误伤后破溃,先后口服及外用消炎药,破损处不见好转,且逐渐增大至成人手掌大,质脆,易出血,呈菜花样改变,伴臭味,始终未系统诊治,菜花样皮损渐扩展至肘部全部瘢痕处(约20cm×12 cm).