目的 探究六字诀联合火针治疗气滞血瘀型带状疱疹的效果.方法 选取2022年4月-2023年4月我院收治的76例带状疱疹患者作为研究对象,随机分为对比组与结合组,各38例.对比组予以常规治疗,结合组予以六字诀联合火针治疗,比较两组疼痛情况、临床疗效、不良反应发生率以及生活质量.结果 结合组VAS评分及PRI指数均低于对比组,差异有统计学意义(P<0.05);结合组治疗总有效率高于对比组,差异有统计学意义(P<0.05);结合组不良反应发生率低于对比组,但差异无统计学意义(P>0.05);结合组生活质量各项评

Objective To study the therapeutic effect of carbon dioxide fractional laser combined with psychological intervention on patients with rosacea. Methods A total of 80 patients with rosacea who were admitted to our hospital from April 2020 to May 2021 were selected as subjects. They were divided into an observation group and a control group according to the random number table method, with 40 cases in each group. The control group was treated with carbon dioxide lattice laser alone, and the observation group was given carbon dioxide lattice laser combined with psychological intervention. The treatment compliance, clinical efficacy and VISIA red zone test results of the two groups were compared. Results The treatment compliance of the observation group was higher than that of the control group (P ＜0.05). The total effective rate of the observation group was higher than that of the control group (P ＜0.05). After treatment, the VISA red zone detection values of the two groups were higher than those before treatment and the observation group was higher than the control group (P ＜0.05). Conclusion The treatment plan of carbon dioxide lattice laser combined with psychological intervention can improve the treatment compliance of patients and enhance their clinical efficacy, which is worthy of clinical application.

目的 探讨对带状疱疹后遗神经痛患者采用威伐光+普瑞巴林+火针完成治疗后获得临床效果.方法 方便选取2018年1月-2020年12月收治的68例带状疱疹后遗神经痛患者进行治疗研究,随机分为常规组(采用普瑞巴林药物完成疾病治疗)和研究组(采用威伐光+普瑞巴林+火针完成疾病治疗),各34例.比较两组患者治疗总有效率、治疗不良反应(头晕、嗜睡)总发生率、不同时间段视觉模拟评分法(VAS)评分.结果 研究组治疗总有效率(94.12％)高于常规组(70.59％),差异有统计学意义(x2=6.476,P＜0.05);研究组治疗不良反应(头晕、嗜睡)总发生率(5.88％)同常规组(2.94％)比较,差异无统计学意义(x2=0.000,P＞0.05);治疗前,研究组VAS评分(6.85±1.15)分同常规组(6.89±1.17)分比较,差异无统计学意义(t=0.142,P＞0.05);研究组治疗后4周VAS评分(3.69±1.05)分、治疗后8周VAS评分(1.71±1.13)分、治疗后16周VAS评分(0.37±0.05)分均低于常规组的(5.57±1.07)分、(3.95±0.99)分、(2.21±0.15)分,差异有统计学意义(t=7.312、8.694、67.855,P＜0.05).结论 威伐光+普瑞巴林药物+火针联合应用后,可将带状疱疹后遗神经痛患者治疗效果显著增强,并确保其疼痛程度获得显著改善,促进其预后水平提升.

医疗美容指使用药物或医疗器械、采用手术或其他具有不可逆性的医学技术手段和方法,对人类容貌、体型等身体部位的形态进行修复、修整与重塑,使其更加符合美学准则和自身心理的需求的医疗技术.随着社会物质生活水平的提高,广大人民群众对容貌,形体美观和健康需求急剧增加,医学美容这个近年来兴起的行业也得到了突飞猛进的发展.本文通过回顾常见的医疗美容心理认知误区类型,有针对性的分析总结了对不同类型就医者心理疏导的有效方法,促使求美就医者对医疗美容有全面正确的理解和认识,以正常的心理认知选取医疗美容项目,从而取得比较满意的医疗美容效果,减少医疗纠纷的发生,促进医疗美容事业的发展.

基底细胞癌(BCC)是最常见的皮肤恶性癌症类型之一,其发病率每年都在增加.然而,关于SLC25A43在基底细胞癌中的作用尚不清楚.本研究采用定量聚合酶链反应和免疫组织化学方法对40例基底细胞癌和癌旁正常皮肤标本进行研究,对SLC25A43基因从mRNA水平以及蛋白表达水平进行分析.结果表明SLC25A43的mRNA和蛋白质表达量在基底细胞癌组织标本中高表达,此外,在这40对样本中用免疫组化检测了SLC25A43的表达情况,统计结果显示SLC25A43在肿瘤组织中表达量明显高于癌旁组织(P<0.05),结果具有统计学意义;年龄、性别、组织学、肿瘤位置在SLC25A43低表达组和高表达组之间无统计学差异,P>0.05.BCC的生物学特征是人们研究的热点和重点,SLC25A43基因与BCC的发生、发展、生物学特征的相关性研究尚未见报道.

目的 探讨表皮移植联合308 nm准分子光治疗稳定期白癜风的临床疗效.方法 选取2018年11月～2019年6月在黑龙江省齐齐哈尔市第一医院皮肤科就诊的白癜风稳定期患者120例,根据患者治疗方案不同分为三组,其中A组患者接受表皮移植治疗,B组患者接受308nm准分子光治疗,C组接受两种方式联合治疗,分析三组患者临床疗效、不同白癜风类型临床疗效、患者不良反应发生情况及治疗满意度.结果 C组总有效率高于A组、B组(P<0.05),A组与B组相比,总有效率无明显差异(P>0.05);A组、B组、C组患者局限性、散发型以及节段型白癜风临床疗效均高于泛发型白癜风患者(P<0.05);三组患者不良反应发生情况比较,差异无统计学意义(P>0.05);C组有满意度高于A组、B组(P<0.05),A组与B组相比,满意度无明显差异(P>0.05).结论 对稳定期白癜风患者采用表皮移植联合308 nm准分子光治疗可以有效提高患者临床疗效,在泛发型白癜风治疗中同样具有较高疗效,不会增加患者不良反应发生率,患者具有较高的满意度,可以在临床中进行进一步推广应用.

目的 分析观察在成人慢性湿疹的治疗中采用多磺酸黏多糖乳膏联合曲安奈德益康唑乳膏的临床治疗效果.方法 选取2017年10月至2018年10月在我院接受成人慢性湿疹治疗的病患68例,将病患随机分为两组,即观察组和对照组,两组各34例,给予对照组病患曲安奈德益康唑乳膏,给予观察组病患多磺酸黏多糖乳膏联合曲安奈德益康唑乳膏进行治疗,对两组病患的临床治疗效果进行对比分析.结果 两组病患在经治疗后,观察组病患的总体治疗有效率明显高于对照组(P<0.05);观察组病患的瘙痒、弹性、厚度以及颜色评分显著优于对照组(P<0.05).结论 在成人慢性湿疹的治疗中采用曲安奈德益康唑乳膏联合多磺酸粘多糖乳膏,可有效改善病患的临床症状,值得在临床上大力的推广.

目的:研究火针联合生物活性光对聚合性痤疮的临床疗效.方法:将符合标准的200 例患者,随机分为2组,每组100人,治疗组给予火针联合生物活性光即红、蓝光治疗;对照组给予西药治疗,疗程4周.结果:治疗组与对照组的有效率分别为98.00％和 90％(P<0.05),比较两组差异有统计学意义.结论:火针联合生物活性光治疗聚合性痤疮,疗效确切而且不良反应少.

目的：：探析黄金微针射频结合表皮生长因子在面部皮肤年轻化治疗中的应用效果.方法：选取2015年5月到2016年3月我院收治的面部皮肤老化30例作为对照组，给予光子嫩肤治疗；选取同期同类型30例作为研究组，给予黄金微针射频结合表皮生长因子治疗.对两组患者的临床治疗效果进行分析和对比.结果：给予两种不同的治疗方法后，研究组治疗总体有效率以及总体满意率均高于对照组(P＜0．05)．讨论：黄金微针射频结合表皮生长因子在面部皮肤年轻化治疗中具有极高的应用价值，值得大力推广以及应用.

Objective To investigate Protopic ( tacrolimus) on the expression of vitiligo skin tissue fluid of patients with ET-1 and SCF, and lay the foundation for further clarify the mechanism of Protopic treatment of vitiligo.Methods 30 cases of vitiligo patients before and after treatment with Protopic white and non-white parts of the skin tissue fluid ET-1 and SCF levels by ELISA.Results White skin tissue fluid ET-1 and SCF levels were significantly higher than non-white parts, the difference was statistically significant.Conclusions Protopic can promote keratinocytes secrete ET-1 and SCF, thereby inducing the formation of melanocytes.

目的：观察干扰素-α联合窄谱中波紫外线治疗皮肤 T 细胞淋巴瘤的临床疗效。方法我院2012年1月至2013年12月期间所收治的皮肤 T 细胞淋巴瘤患者中选取20例作为此次研究对象，随机分为观察组和对照组，两组患者的年龄、性别等一般情况比较没有明显的差异，有可比性，P>0.05，具有统计学意义。结果观察组患者的治疗有效率为90.0%，对照组患者的治疗有效率为60.0%，观察组患者治疗有效率明显高于对照组患者，P<0.05，差异具有统计学意义。结论对于皮肤 T 细胞淋巴瘤患者，采用干扰素-α联合窄谱中波紫外线治疗，有助于提高患者治疗总有效率，安全性较高，具有一定的应用价值和治疗优势，值得大力推广使用。

ObjectiveTo observe the safety of methotrexate combined with glucocorticoid in the treatment of patients with dermatomyositis.MethodsTotal 100 patients with dermatomyositis, from January 2010 to December 2013, treated in our hospital, according to random number table, divided into observation group (n=50) and control group (n=50). The observation group toke methotrexate combined with glucocorticoid therapy, the control group was treated with glucocorticoid. The total course of treatment lasted for 6 months, then the curative effect was evaluated and the efficiency of two groups were compared, as well as muscle enzymes, muscle strength changes and adverse reactions.ResultsThe effective rate of observation group (70%) was signiifcantly higher than the control group (50%) (P<0.05); to be compared with before treatment, the serum muscle enzyme spectrum of the two groups both have signiifcant improvement (P<0.05); muscle enzyme spectrum of the two groups after treatment had signiifcant difference (P<0.05);the incidence of adverse reactions of the observation group (10%) was signiifcantly lower than that of the control group (40%) (P<0.05). ConclusionThe therapeutic effect of methotrexate combined with glucocorticoids in the treatment of dermatomyositis is remarkable, which can signiifcantly improve the muscle enzyme spectrum in patients and reduce a variety of adverse reactions caused by corticosteroids, as well as improve the symptoms of patients, so the combined treatment is worthy of application.

Objective:To analyse the clinical efficacy of surgery combined with 5-aminolevulinic acid-Photody-namic theraPy( ALA-PDT)treatment on basal cell carcinoma. Methods:Thirty basal cells cancer Patients were di-vided into observation grouP and control grouP,15 cases in each grouP. In observed grouP Patients before surgery were treated by ALA-PDT treatment once a week,a total of 3-7 times,then surgical treatment and control grouP Patients only take surgery,follow-uP for 16 to 25 months. Results:The total effective rate of the observation grouP was 100%(15/15),in the control grouP,the total effective rate was 86. 7%(13/15)(P>0. 05). Healing rates,adverse reac-tion rates were statistically significant different(P<0. 05),the observation grouP was better than the control grouP. Conclusion:Surgery combined with ALA-PDT treatment for basal cell carcinoma is effective and safe.

Objective To investigate the acitretin A can be induced in primary human skin keratinocytes apoptosis and acitretin A anti psoriasis.Methods Flow cytometry double labeling and transmission electron microscopy were used to observe the apoptosis of the cells before and after induction of drug interaction analysis, by enzyme linked immunosorbent assay. Results Acitretin A can be induced in primary human skin keratinocytes apoptosis, cell apoptosis degree in a concentration and time obvious dependence.Conclusions The citretin A can induce the apoptosis of the primary human keratinocytes, and the citretin A has curative effect on the clinical curative effect of acitretin.

Objective To study the expressions and relationship of COX-2 and Ki67 in Bowen’s disease. Methods Specimens from 27 Bowen's disease patients and 15 normal persons were assayed for COX-2 and Ki67 by immunohistochemistry. Results The expressions of COX-2 and Ki67 in normal skin was very low, but in Bowen's disease was signiifcantly increased. COX-2 was positive correlated with Ki67 in Bowen's disease(r=0.451, P<0.05). Conclusion The abnormal level of COX-2 and Ki67 plays a role in carcinogenesis and development of Bowen's disease, the over-expression of COX-2 may result in the proliferation of tumor cell.

<正>2009年6月至2012年12月,笔者应用光子嫩肤术治疗面部激素依赖性皮炎104例,取得满意疗效,现报道如下。资料与方法1.临床资料面部激素依赖性皮炎患者104例,男性8例,女性96例;年龄20~58岁,平均年龄32岁。病程3个月至8年,平均病程3.2年。本组病例发病前均有面部外用皮炎平、肤轻松、皮康王等激素性药膏1个月以上病史,面部发生明显红斑、丘疹、脱屑伴瘙痒、灼痛、光敏感,再用激素性药膏可缓

目的观察中药联合千白氢醌乳膏治疗黄褐斑、炎症后色素沉着斑的治疗的效果。方法 99例患者随机分组随即分为治疗组(52例)与对照组(47例),治疗组中用中药联合千白氢醌乳膏治疗黄褐斑、炎症后色素沉着斑的治疗,对照组单纯用千白氢醌乳膏。结果 1个疗程后两组有效率分别为80.77%、53.19%,治疗组有效率明显高于对照组两组比较差异有显著性(P<0.01)。两者用药过程中均无明显不良反应。结论中药联合千白氢醌乳膏治疗黄褐斑、炎症后色素沉着斑的治疗疗效肯定。

目的探讨窄谱中波紫外线(NB-UVB)照射治疗玫瑰糠疹的临床疗效。方法对50例玫瑰糠疹患者采用德国Waldmann公司的UV100L NB-UVB治疗仪进行照射,光疗期间配合口服复方甘草酸苷。结果本组治愈32例,显效15例,好转3例,总有效率94%;在UVB光疗过程中,有3例出现照射部位红斑、疼痛,1例水疱。分别采用暂停UVB照射治疗或减少照射剂量,待反应缓解后恢复治疗或渐增照射剂量等措施,水疱愈后无瘢痕。结论窄谱中波紫外线照射治疗玫瑰糠疹疗效确切,患者依从性好,不良反应少,光疗期间配合口服复方甘草酸苷疗效更好,值得临床推广应用。

目的探讨卡介菌多糖核酸联合复方甘草甜素注射液治疗慢性湿疹的临床疗效。方法将76例慢性湿疹患者随机分为观察组和对照组各38例,观察组采用卡介菌多糖核酸联合复方甘草甜素注射液,对照组给予西替利嗪10 mg口服。结果观察组有效率76.3%,对照组有效率44.7%。观察组的有效率高于对照组,差异有统计学意义(P<0.05)。两组患者经随访均无明显不良反应发生。结论卡介菌多糖核酸联合复方甘草甜素注射液治疗慢性湿疹无明显不良反应,疗效满意。

目的探讨慢性特发性荨麻疹的有效治疗方法。方法采用咪唑斯汀联合雷公藤多甙对75例慢性特发性荨麻疹患者进行治疗,治疗第14天、28天时分别判断疗效。结果治疗后第14天痊愈率和总有效率分别为58.7%、72.0%;治疗后第28天痊愈率和总有效率分别为64.0%、90.7%。经统计学处理,两个时间点的痊愈率比较无差异统计学意义(P>0.05),总有效率比较差异有统计学意义(P<0.05)。结论咪唑斯汀联合雷公藤多甙具有起效快、疗效好、不良反应少的特点,是慢性特发性荨麻疹的有效治疗方法。