Objective:To investigate the efficacy and safety of transcranial alternating current stimulation (tACS) in treating migraine without aura.Methods:A prospective study was performed. From June 2021 to June 2022, 40 migraine without aura patients treated at Vertigo Center, Department of Neurology, Second Affiliated Hospital of Zhengzhou University were enrolled; they were randomly assigned to true group ( n=20) and pseudo group ( n=20); treatment was given for 4 consecutive weeks and follow-up was given for 4 weeks. Pseudo group did not receive current stimulation, while true group received stimulation by 77.5 Hz, 15 mA alternating current through electrodes placed on the forehead and bilateral mastoid (twice/d, 40 min each time, 5 d as a course, a total of 4 courses). Efficacies and adverse reactions were assessed before treatment, and at the end of treatment and follow-up, respectively. Results:Compared with pseudo group, the average monthly migraine days, visual analog scale (VAS) scores, Pittsburgh Sleep Quality Index (PSQI), Hamilton Anxiety Scale (HAMA) scores and Hamilton Depression Scale (HAMD) scores decreased statistically in true group ( P<0.05), and Migraine-specific Quality of Life Questionnaire (MSQ) scores increased statistically in true group ( P<0.05). In true group, compared with those before treatment, the average monthly migraine days, VAS scores, PSQI, HAMA scores and HAMD scores significantly decreased, and MSQ scores increased statistically at the end of treatment and follow-up ( P<0.05). During treatment, no adverse reactions such as seizures, hearing loss, scalp burns, dizziness, or tinnitus were noted in true group and pseudo group. Conclusion:Repeated tACS can obviously reduce frequency and degree of migraine, improve quality of life in migraine without aura patients; and good safety can be recorded.

目的 分析血管迷走神经性晕厥(VVS)患者的多导睡眠图特点.方法 收集2020-09—2022-06于郑州大学第二附属医院神经内科就诊的VVS患者40例和健康体检者45例(对照组),应用多导睡眠监测对2组睡眠结构进行分析.结果 与对照组相比,VVS患者睡眠质量降低,快速眼球运动睡眠期[分别为(17.97±0.96)％、(23.88±4.45)％,t=8.226,P<0.01]和慢波睡眠(N3期)[分别为(13.3±10.17)％、(21.76±6.42)％,t=4.638,P<0.05]比例降低,N1期[分别为(10.85±16.45)％、(4.95±5.34)％,t=2.379,P<0.05]和N2期[分别为(59.88±10.5)％、(49.41±6.5)％,t=5.593,P<0.01]睡眠比例增加,微觉醒指数[分别为9.3(7.05,12.5)、4.3(3.2,5.5),Z=—5.567,P<0.01]以及觉醒次数[分别为56(40,85.5)、25(19,34),Z=—5.4,P<0.01]升高.结论 VVS患者的睡眠质量差,夜间睡眠结构紊乱,表现为浅睡眠增多,深睡眠减少,觉醒次数增加,可能与VVS患者交感神经活性的增强、5-羟色胺递质的紊乱以及反复脑缺血等相关.

目的 观察本体感觉神经肌肉促进技术治疗重度周围性面瘫患者的疗效.方法 纳入重度周围性面瘫患者40例,随机分为实验组和对照组各20例.实验组采用本体感觉神经肌肉促进技术训练面部肌肉,同时采用与对照组相同的治疗手段:针灸、理疗、药物治疗等,总疗程4～6周.治疗结束后比较2组面神经功能分级House-Brackmann(H-B)量表评分、Portmann评分.结果 2组H-B量表评分比较:对照组治疗前(4.6±0.8)分,治疗后(2.6±0.7)分;实验组治疗前(4.9±0.7)分,治疗后(1.7±0.7)分.2组Portmann评分比较:对照组治疗前(4.4±2.7)分,治疗后(13.7±3.0)分,实验组治疗前(3.5±2.4)分,治疗后(17.9±2.3)分.治疗后2组H-B分级评分均降低、Portmann评分均提高,但对照组H-B分级评分高于实验组,Portmann评分低于实验组,差异有统计学意义(P<0.05),且2组治疗前后H-B分级评分及Portmann评分组内对比,差异有统计学意义(P<0.05).2组疗效比较:实验组治愈率为45％,对照组为10％,差异有统计学意义(P<0.05).结论 本体感觉神经肌肉促进技术治疗重度周围性面瘫患者,可诱导26块面部表情肌产生正确运动反应,促进面肌运动控制能力的提高,有效改善体征,提高治愈率,缩短疗程.

目的 探讨经颅入路联合神经内镜下经鼻蝶入路手术防治侧颅底脑膜瘤术后脑脊液漏的效果.方法 回顾性分析2016年1月至2020年8月经颅入路联合神经内镜下经鼻蝶入路手术治疗的20例侧颅底脑膜瘤的临床资料.结果 8例未延伸至海绵窦或眶上裂的肿瘤实现全切除;12例次全切除,为减少术后眼神经损伤的风险、有小块肿瘤残留在海绵窦或眶上裂.术后病理检查均为脑膜瘤(WHO分级Ⅰ级).术后随访12～41个月,平均24.4个月,无脑脊液漏;13例肿瘤复发或进展,其中11例接受立体定向放疗,2例术后12、15个月再次手术.结论 经颅入路联合神经内镜下经鼻蝶入路手术治疗侧颅底脑膜瘤,可有效预防术后脑脊液漏.当肿瘤切除导致经颅入路侧的带血管蒂皮瓣不可用、肿瘤延伸至副鼻窦时,建议优先考虑该种联合入路手术方式.

Objective:To analyze the abnormal vestibular function of Wernicke encephalopathy (WE) and to explore its diagnostic value.Methods:WE patients who visited the Vertigo Center of the Second Affiliated Hospital of Zhengzhou University from January 2018 to January 2021 were retrospectively collected. All patients were evaluated by clinical neurology. Before treatment, all patients completed video head impulse test (vHIT) and video nystagmusgraphy (VNG) in addition to cranial magnetic resonance and serum thiamine level examination.Results:All 12 patients had a history of eating defects, including 8 cases of alcoholism. All 12 patients had walking instability, 7 cases had dizziness and 8 cases had oscillopsia. Six cases had ophthalmoplegia. All 12 cases showed positive gaze nystagmus. The pathological saccades of bilateral horizontal semicircular canals were found in 12 patients by vHIT before treatment, but there was only 1 patient showing abnormality in vertical semicircular canals, the difference being statistically significant ( P<0.05). All patients could detect bilateral, horizontal, gaze-evoked nystagmus, including 3 cases with vertical nystagmus, 1 case with abnormal saccade test, 3 cases with abnormal smooth tracking test and 1 case with abnormal optokinetic test. There were abnormalities in the caloric test, including 6 cases of bilateral dysfunction and 2 cases of unilateral dysfunction. Conclusions:WE patients may have abnormal vHIT and bilateral, horizontal, gaze-evoked nystagmus, which is similar to the special abnormal signs of simultaneous damage of both peripheral and central vestibular dysfunction.Vestibular function test is valuable for diagnosis of WE, and it is suitable for patients with a history of nutritional disorders who have dizziness or walking instability and suspected WE.

Analyzing sleep quality and sleep structure in patients with patent foramen ovale (PFO) complicated with obstructive sleep apnea (OSA) and the interaction between OSA and PFO in sleep. We compared patients with PFO complicated with OSA, patients with simple PFO, and controls. Pittsburgh Sleep Quality Index was used to compare sleep quality and polysomnography was used to compare sleep structure of the three groups. Compared with the control group (n = 62), PFO with OSA (n = 48) and simple PFO (n = 61) groups had more frequent occurrence of poor sleep quality (χ2 = 89.901; p < 0.001). These two groups also showed decreased sleep efficiency (p < 0.010), lower percentages of REM sleep, and reduced N3 sleep (p < 0.050). The N2 sleep was prolonged (p < 0.010). The nocturnal lowest SpO2 was lower and the oxygen desaturation index was higher (p < 0.50). Compared with the simple PFO group, the poor sleep quality was more frequent in the PFO with OSA group; sleep latency (p < 0.001) was prolonged; wake after sleep onset (p < 0.001) and arousal times (p = 0.031) were increased; and sleep micro-arousal index (p = 0.037), periodic leg movement index (p = 0.024), and apnea hypopnea index (p < 0.001) were higher in the PFO with OSA group. Patients with PFO and OSA have poor sleep quality with changes in sleep stage and high occurrence rate of sleep disorders. OSA further deteriorates sleep quality and alters sleep structure in patients with PFO.

目的 探讨急性腰部神经痛的简便、快捷、效果显著的治疗方法 .方法 急性腰部神经痛主要治疗方法 包括静脉输液疗法、脐部针灸疗法、脐部艾灸疗法和牵引四联疗法.其中47例为急性腰椎间盘突出症患者,38例为慢性腰肌劳损急性发作,观察疗效并分析治疗方法 和效果.结果 中西医结合综合治疗85例患者,其中显著65例,有效20例,无效0例,复发10例,47例患者均一次治愈,10例半年后因劳累和久坐复发,总有效率100％.结论 四重综合治疗急性腰部神经痛患者效果明显,可有效改善临床情况,操作简单,费用低廉,治疗周期短,疗效快,值得推广.

目的 报道并分析3例更为晚发型(年龄>75岁)视神经脊髓炎谱系疾病(Neuromyelitis Optica Spectrum Disorders,NMOSDs)患者的临床特点、诊疗和预后,并复习既往相关文献,以提高更为晚发型NMOSDs患者诊治及预后的认识.方法 通过检索近10 y内国内外数据库,结合郑州大学第一附属医院神经内科病例,回顾性分析年龄在75岁以上NMOSDs患者临床资料,包括临床特点、实验室检查及治疗.结果 共纳入年龄>75岁以上的NMOSDs患者12例,女性7例,男性5例,平均发病年龄(82.67±4.42)岁.均以长节段脊髓炎(longitudinally ex-tensive transverse myelitis,LETM)起病,单相病程为主,AQP4抗体(Antiaquaporin-4 antibody,AQP4-Ab)检查均为阳性,MRI以胸髓损伤为主.12例均行激素治疗(Intravenous methylprednisolone,IVMP),3例联合血浆置换(plasma exchange,PLEX),4例应用免疫抑制剂,5例存在复发,治疗过程中见效者9例,显效者2例,恶化3例.治疗及随访过程中死亡3例.结论 更为晚发型NMOSDs患者以LETM多见,致残率较高,IVMP联合PLEX效果较好,免疫抑制剂可能有效.

目的 胱抑素C(Cystain C,Cys C)是半胱氨酸蛋白酶(cathepsins,Cat)的抑制剂,在生物体调节先天免疫细胞吞噬、主要组织相容性复合体-Ⅱ介导的抗原表达及凋亡等过程中扮演重要角色.本文旨在观察探讨急性期重症肌无力(myasthenia gravis,MG)患者血清Cys C的水平变化及其与临床特征的关系.方法 选择2018年6月至2019年8月就诊于我院的MG患者70例及健康对照组42例,收集各组患者临床资料,包括性别、年龄、空腹血清Cys C、肌酐、肾小球滤过率、MG组患者胸腺增强CT和血清乙酰胆碱受体(acetylcholine receptors,AChR)抗体滴度,采用Osserman分型方法为MG患者分型,采用定量重症肌无力(Quantitative myasthenia gravis,QMG)评分评价MG患者临床症状的严重程度.比较MG患者和对照组血清Cys C水平的差异和MG患者血清Cys C水平与QMG评分、Osserman分型、AChR抗体滴度之间的相关性.结果 3组间统计学结果有显著差异,未合并胸腺瘤MG组和合并胸腺瘤MG组血清Cys C水平均显著高于对照组[(0.900 ±0.238,0.998±0.235,0.776±0.123) mg/L,P=0.000].血清Cys C水平与临床QMG评分呈正相关关系(r=0.482,P＜0.0001),但与胸腺瘤、Osserman分型、AChR抗体滴度无明显相关(P＞0.05).结论 MG患者血清Cys C水平明显升高,Cys C可能参与MG疾病的发生发展.

目的:探讨小儿安全输液中外周固定板的临床应用效果.方法:选取输液患儿150例,按照随机数字表法分为对照组和观察组,各75例.对照组应用传统胶布进行固定,观察组应用输液固定板进行固定,比较两组单次穿刺固定完成时间、重复穿刺率和患儿家长满意度.结果:观察组单次穿刺固定完成时间短于对照组,重复穿刺率低于对照组,差异均具有统计学意义(P<0.05);观察组患儿家长满意度高于对照组,差异具有统计学意义(P<0.05).结论:外周固定板的应用可有效缩短小儿输液中的单次穿刺固定时间,降低重复穿刺率,提升患儿家长的满意度.

前庭阵发症(VP)是一种以短暂、频繁的发作性眩晕为主要表现,伴或不伴耳部症状的外周眩晕疾病.其发病机制尚不明确,缺乏特异性的检查方法,诊断主要依靠典型的临床表现及相关辅助检查.脑干听觉诱发电位(BAEP)是一项反映听神经传导通路上电位变化的电生理检查手段,I～Ⅲ波峰间期延长是VP在BAEP上最常见的异常表现.前庭诱发肌源性电位(VEMPs)是反映前庭-眼肌和前庭-颈肌反射通路的电生理测试手段,可准确发现VP损害部位,对前庭系统的微变化更敏感.眼震视图(VNG)是通过红外线摄像头直接记录眼球震颤,反映视动系统和前庭系统功能状态的检查方法,VP的眼震形式多样.本综述总结了VP的BAEP、VEMPs、VNG表现特点及三者在VP诊疗中的应用,以期提高临床医生的诊疗效率和水平,避免漏诊和误诊.

Objective To observe the extraction rate and parameters of vestibular evoked myogenic potentials (VEMPs) in patients with vestibular paroxysmia (VP) , and to explore the clinical diagnosis and application value of VEMPs. Methods 20 VP patients with neurovascular compression (NVCC) were selected as VP group, and 20 healthy subjects with similar age, sex distribution and no NVCC were used as control group. The ocular vestibular evoked potential (o VEMP) and the cervical vestibular evoked potential (c VEMP) were examined in all subjects. The extraction rate and parameters of VEMPs were compared between and within groups, and the characteristics of VP VEMPs were analyzed. Results (1) In VP group, 22 ears (55％) were induced by o VEMP, 16 ears (84. 21％) were induced by non-NVCC side (28. 57％) , 6 ears (28. 57％) of NVCC, the difference was statistically significant (P < 0. 05) , and 35 ears (87. 50％) in control group; In VP group, 26 ears (65％) were induced by c VEMP, 17 ears (89. 47％) were induced by non-NVCC side, which was significantly higher than 9 ears (42. 86％) by NVCC side (P < 0. 05) , and 35 ears (87. 50％) by control group.There were significant differences in the extraction rates of o VEMP、c VEMP between the NVCC side of VP group and the control group (P < 0. 05) . There was no significant difference between the non-NVCC side of VP group and the control group (P> 0. 05) . (2) In group VP, there was no significant difference in the extraction rate between c VEMP and o VEMP (χ2= 0. 83, P> 0. 05) . (3) In VP group, the latency of NVCC side was prolonged and the amplitude was decreased, VEMPs parameters were significant differencest between NVCC side and non-NVCC side (P < 0. 05) . There were significant differences between NVCC side of VP group and control group (P < 0. 05) . There was no significant difference between non-NVCC side of VP group and control group (P> 0. 05) . Conclusion Extraction rate of VEMPs on the NVCC side of VP patients were decreased, latency prolonged, amplitude decreased, NVCC is one of the pathogenesis of VP, VEMPs can help to distinguish the lesion side. In the patients with VP, the superior and subvestibular nerve conduction pathwaieys were abnormal on the side of NVCC.

目的 分析预见性护理预防早产儿颅内出血的应用效果.方法 对郑州大学第二附属医院NICU 2016年1月至2017年12月收治的101例早产儿的护理资料进行回顾性综合分析.结果 两组患儿头颅B超结果显示在实施预见性护理后,早产儿出生后24 h内颅内出血的发生率明显降低,并且72 h后Ⅰ度颅内出血发生率未明显增加,Ⅱ度颅内出血的发生率明显降低.预见性护理的有效率高于对照组.结论 对早产儿实施预见性护理,能够减少早产儿颅内出血的发生率,降低死亡率和伤残率,具有较高临床应用价值.

Objective To analyze the distribution of Virchow-Robin spaces (VRS) in migraine by MRI,and to study the effects of the duration of the disease,the attack frequency and the migraine with or without aura on the number of VRS in order to provide imaging support for migraine diagnosis.Methods Fifty migraine patients were enrolled as migraine group and 50 healthy people as control group during January 2013 to December 2016 from Department of Neurology,the Second Affiliated Hospital of Zhengzhou University.The number of VRS in the fronto-parietal subcortical white matter,semioval central,and basal ganglia areas was calculated and compared between groups and within the group by performing a MRI scan of the same sequence,and the impact of the history of migraine,the attack frequency and the migraine with or without aura on the number of VRS was investigated.Results The VRS were found in 48 cases in the migraine group,accounting for 96％,significantly higher than in the control group (41 cases,accounting for 82％),the difference being statistically significant (x2 =5.00,P ＜ 0.05).In the migraine group,the sum of the number of VRS (13.00 (6.75,20.00)) was significantly higher than that of the control group (8.00 (5.00,12.00);Z=3.33,P＜ 0.01).In the migraine group the VRS numbers in the fronto-parietal subcortical white matter,semioval central and basal ganglia areas were 6.00(4.00,12.00),2.00(0.00,4.00)and 4.00 (2.00,6.00) respectively,while the numbers of VRS in the same areas of the control group were 0.00 (0.00,2.00),2.00 (0.75,4.00) and 4.00 (3.50,6.00).The total number of VRS in different areas was significantly different within the two groups (migraine group x2 =39.86,P ＜ 0.01;control group x2 =40.15,P ＜0.01).In the migraine group,the VRS was mainly located in fronto-parietal subcortical white matter,whereas in the control group the VRS was mainly distributed in the basal ganglia.The total number of VRS in the migraine with aura group (20.00 (14.50,26.00)) was more than that in the migraine without aura group (11.00 (6.00,20.00);Z =2.52,P =0.02).The numbers of VRS in the fronto-parietal subcortical white matter,semioval central and basal ganglia areas of the migraine with aura group were 12.00(9.00,14.00),2.00(2.00,6.00) and 4.00(2.50,7.50) respectively;The numbers of VRS in the same areas of the migraine without aura group were 6.00(4.00,10.00),1.00(0.00,4.00) and 4.00 (2.00,6.00) respectively;The numbers of VRS in different areas within the two groups were significantly different (with aura group x2 =16.31,P ＜0.01;without aura group x2 =29.48,P ＜0.01).There were statistically significant differences in the number of VRS among migraine without aura patients with different duration and frequency of episodes.Conclusions The incidence rate of perivascular space in migraine is high.VRS is mainly distributed in the fronto-parietal subcortical white matter,which may provide an imaging assistant basis for the diagnosis of migraine.Migraine with aura is more prone to VRS than those without aura.The disease course and the attack frequency have a certain impact on occurrence of VRS.

偏头痛是一种原发性,以反复发作的伴自主神经功能障碍为主要临床特征的慢性神经血管功能障碍性疾病.其发病机制目前尚不清楚,临床上会导致多种并发症,尤其是神经精神系统疾病的发生.该病缺乏特异的影像学特征,其在磁共振上可表现为脑白质异常、血管周围间隙数目增多或扩大等影像学改变.其中血管周围间隙的改变属于脑小血管病,与神经系统疾病也有着一定的关联.目前,关于偏头痛、血管周围间隙的研究进展以及两者之间关系的相关报道日益增多,本综述总结了偏头痛、血管周围间隙扩大的发病机制;两者引起常见并发症的病理机制以及两者之间的相互关系,以期临床上对其有更多的关注、认识和研究.

Objective To investigate the effect of mirtazapine combined with zopiclone in the treatment of chronic insomnia in elderly patients.Methods 80 elderly cases with chronic insomnia were randomly divided into treatment group (n=40) and control group (n=40).The patients in the treatment group were treated by Mirtazapine combined with zopiclone,and patients in the control group just received zopiclone.Pittsburgh Sleep Index (PSQI) scores were observed in the two groups before treatment and at the second,fourth and eighth week after treatment.At the same time,the effective rate was also compared according to the rate of decreases in PSQI scores after treatment.Results The PSQI scores in the two groups were all declined after treatment at the different time points compared with those before treatment,but there was no significant difference between the two groups at the second week after treatment (P>0.05).At the fourth and eighth week after treatment,the PSQI scores were further reduced,and the difference between the two groups was significant (P<0.05).At the eighth week the effective rate in treatment group was 95%,obviously higher than 75% in the control group (P<0.05).Conclusion Zopiclone combined with mirtazapine can better improve intractable insomnia in elderly patients and can elevate the effective rate.

目的：探讨慢性鼻-鼻窦炎与血浆炎症指标和脑梗死发生的相关性。方法将入选的95例患者分为单纯脑梗死组（A组）、慢性鼻-鼻窦炎合并脑梗死组（ B组）及正常对照组（C组），分别检测各组中CRP、TNF-α和IL-6的血浆含量。结果 A组的CRP、TNF-α和IL-6分别为（18.72±0.13）mg／L、（93.23±40.89）ng／IL和（18.23±3.42）ng／IL ；B组分别为（28.76±0.89）mg／L、（126.32±34.64）ng／IL和（31.52±5.42）ng／IL ；A组和B组的CRP、TNF-α和IL-6的表达水平均明显高于C组（ P＜0.05），其中B组上述各炎症因子表达水平最高（ P＜0.05）。结论慢性鼻-鼻窦炎与血浆中炎症指标的表达水平增高均与脑梗死的发生存在相关性。

目的 探讨椎基底动脉压迫型前庭阵发症的磁共振影像学特征.方法 共收集前庭阵发症(vestibular paroxysmia,VP)患者64例,分为非椎基底动脉压迫型组(对照组)32例和椎基底动脉压迫型组(观察组)32例,应用三维时间飞跃法磁共振血管成像技术,判断64例患者的前庭蜗神经周围有无神经血管交互压迫(neurovas-cular cross-compression,NVCC)及其压迫类型,并对两组间NVCC压迫点至前庭蜗神经出脑干处的最短距离、基底动脉及双侧椎动脉血管直径、双侧椎动脉间血管直径变异度进行统计学分析.结果 在观察组NVCC压迫点距前庭蜗神经出脑干处距离为(6.26±2.02) mm明显小于对照组(8.17±1.98) mm(t=-3.872,P=0.000,P＜0.01);而观察组椎动脉血管直径(3.53 ±0.42) mm与对照组(3.44 ±0.31) mm无明显差异(t=0.962,P=0.340,P＞0.05);两组的基底动脉血管直径观察组(3.74±0.41) mm与对照组(3.65±0.29) mm间亦无统计学意义(t=0.992,P=0.326,P＞0.05);而观察组的双侧椎动脉血管直径变异度(1.09 ±0.31) mm明显高于对照组(0.82±0.35)mm(t =3.330,P=0.001,P＜0.05).结论 椎基底动脉压迫型VP患者NVCC压迫点距前庭蜗神经出脑干处距离较近且双侧椎动脉血管直径变异度较大.

目的：探讨慢性鼻-鼻窦炎（chronic rhinosinusitis ，CRS）合并脑梗死患者血清炎症因子、血脂水平与动脉粥样硬化的相关性。方法收集2013-07—2014-12在我院神经内科就诊的急性动脉粥样硬化性脑梗死（acute atherosclerotic cere‐bral infarction ，ATCI）患者50例、ATCI合并CRS患者50例及健康体检者30例，检测3组血清CRP、TNF-α、IL-1β、IL-6水平及VLDL-C、LDL-C、HDL-C、TC、TG水平，同时检测颈动脉内膜厚度、颈动脉斑块及其性质。结果 ATCI合并CRS组和ATCI组患者血清CRP、TNF-α、IL-1β、IL-6、VLDL-C、LDL-C、TC、TG水平均显著高于健康对照组（P＜0.05）；同时ATCI合并CRS组上述炎症因子水平又显著高于ATCI组（P＜0.05）。ATCI合并CRS组和ATCI组患者血清 HDL-C水平均低于健康对照组（均 P＜0.05），同时ATCI合并CRS组又低于ATCI组（P＜0.05）。ATCI合并CRS组及ATCI组患者IMT均较健康对照组增厚（P＜0.05），且ATCI合并CRS组患者IMT厚度又较ATCI组增加（P＜0.05）。3组间动脉粥样硬化斑块发生率及斑块性质构成比差异有统计学意义（P＜0.05）。结论 CRS可能通过升高全身炎症介质水平，进而对机体代谢及血脂水平产生影响，促进动脉粥样硬化的发生发展，进而参与动脉粥硬化性脑梗死的发病过程。

水痘带状疱疹病毒是一种噬神经病毒，呈散发性，人类发生率为10％～20％［1］。一般情况下，病毒沿周围神经下行引起相应皮节的疱疹样改变。少数情况下病毒可沿感觉神经逆行引起中枢神经系统感染，导致脑膜炎、脑炎、脊髓炎、脊神经根炎和多神经炎等［2］，而带状疱疹引起的骶丛神经或臂丛神经损伤临床鲜见。郑州大学第二附属医院神经内科近年收治2例特殊类型水痘‐带状疱疹病毒感染病例，现将其临床诊断与治疗报告如下，希望引起神经科同行的重视。