Chronic inflammation, atherosclerosis, tubulointerstitial fibrosis, and vascular damage play a crucial role in the progression of chronic kidney disease (CKD) in patients with type 2 diabetes mellitus (DM). However, specific biomarkers that can determine the progression of diabetic kidney disease, including patients with minimal albuminuria, remain undefined. The present study aimed to determine markers of chronic inflammation as indicators of CKD progression in patients with type 2 DM. Methods. 45 patients with type 2 DM and stage 1-3 CKD were involved in this cross-sectional observational study. Analysis of cellular mechanisms of CKD progression was performed on the concentrations of endothelin-1 (ET-1), fibronectin (FN), tumor necrosis factor-alpha (TNF-α), transforming growth factor beta-1 (TGF-β1), and monocyte chemoattractant protein (MCP) -1) in the serum. Results. In patients with type 2 DM, an increasing trend in the majority of endothelial and proinflammatory mediators was found according to the CKD stages despite normal albuminuria. Conclusions. Concentrations of TNF-α, ET, TGF-β1 and MCP-1 can be used to assess the progression of CKD in patients with type 2 DM with normal albuminuria. Further researches are needed to determine early indicators of diabetic kidney disease progression.

The aim of our study is the definition of diabetic nephropathy peculiarities and the relationship between albuminuria and indicators of lipid profile, genotype variants of СУР7А1 for patients with type 2 diabetes mellitus and the third stage of arterial hypertension. Patients are divided into 3 groups. The patients of the I group are defined with normoalbuminuria, microalbuminuria – in the ІІ, macroalbuminuria – in the III. The definition of albumin to creatinin ratio is the most precise, but a more expensive method. The SNP –204 А > С [rs 3808607] of СУР7А1 promotor section is defined. Homozygotes by major allele with AA genotype have the less level of albuminuria, aterogenic lipoproteids, general cholesterol, triglycerides and the biggest level of antiaterogenic lipoproteids in comparison with patients with AC and CC genotype. The genotype CC is the worst in the terms of prognosis because the level of albuminuria, aterogenic lipoproteids, general cholesterol, triglycerides and lipoproteids with low density is increased but the level of lipoproteids with high density is decreased.

Background: Hypertensive patients with type 2 diabetes mellitus are also at increased risk for diabetes mellitus–specific complications, including nephropathy. Even the smallest degree of albuminuria increases risk for cardiovascular diseases and all-cause death. The common conditions coexisting with type 2 diabetes (e.g., hypertension and dyslipidemia) are clear risk factors for cardiovascular diseases.Methods and materials: The first (I) group consists of 99 obtained patients with type 2 and AH, the second (II) includes 49 practically healthy people. We evaluated such markers of cardiovascular complications as glycated hemoglobin, lipid profile components by biochemical method and albumin excretion rate with the help of enzyme immunoassay.Result: The positive correlation between the level of albumin excretion rate and glycated hemoglobin (r = 0,23, p < 0,001) is confirmed that albuminuria is a main marker of diabetic nephropathy. The positive correlation between albuminuria and low density lipoproteins (r = 0,34, p < 0,001), triglycerides (r = 0,04, p < 0,001) is the definition of the important role of dyslipidemia in diabetic nephropathy.Conclusion: Determination of albumin excretion rate, glycated hemoglobin as markers of nephropathy, lipid profile components is necessary for patients with type 2 diabetes mellitus and arterial hypertension for prevention cardiovascular complications.Bangladesh Journal of Medical Science Vol.17(2) 2018 p.319-322

Проведено аналіз ефективності комплексу лікувально-оздоровчих заходів з метою покращання функціонального стану серцево-судинної системи у школярів, народжених недоношеними. Обстежено 21 дитину віком від 10 до 12 років, народжену в термін гестації 34–36 тиж і проліковану запропонованим комплексом. Встановлено підвищення рівня показників систолічної функції міокарда лівого шлуночка та діастолічної функції міокарда обох шлуночків.

The purpose of work was an assessment heart small anomalies prevalence at children that was born as late-pretrem. By echocardiography method the 93 children at the age of 10-12 years were investigated. Frequency of detection heart small anomalies was 59% and at children with disproportional development at the birth--77%. Prevailing anomalies of development were anomalies of the left side of the heart, the mainly left ventricle abnormally located chords.

У статті за допомогою ехокардіографії вивчали поширення малих аномалій розвитку серця (МАРС) у 45 здорових дітей та 93 дітей, народжених пізньонедоношеними, у віці 10–12 років. Частота виявлення МАРС становила 59 %, при диспропорційному розвитку при народженні до 77 %. Превалюючими МАРС були аномалії лівих відділів серця, переважно аномально розташовані хорди лівого шлуночка.