The aim of the study is to assess the structure of use of hypotensive drugs and adherence to the antihypertensive therapy among pharmacy visitors in Grodno. Material and methods. We conducted questionnaire survey among 109 pharmacy visitors who bought antihypertensive drugs.Results. ACE inhibitors is the most widely used group of antihypertensive drugs among the pharmacy visitors in Grodno. 44% of them took one drug. The most of the pharmacy visitors used hypotensive drugs regularly; however, 19,3% respondents were non-adherent, mostly from the middle-aged group (45-59 years). Conclusion. The structure of use of antihypertensive drugs among the pharmacy visitors in Grodno complies to the international guidelines for the management of arterial hypertension. However, there are some disadvantages: 1) relatively large number of respondents use only one antihypertensive drug; 2) some respondents, especially among middle-aged persons, take antihypertensive drugs not regularly.

The aim of the study is to assess the structure of use of hypotensive drugs and adherence to the antihypertensive therapy among pharmacy visitors in Grodno. Material and methods. We conducted questionnaire survey among 109 pharmacy visitors who bought antihypertensive drugs.Results. ACE inhibitors is the most widely used group of antihypertensive drugs among the pharmacy visitors in Grodno. 44% of them took one drug. The most of the pharmacy visitors used hypotensive drugs regularly; however, 19,3% respondents were non-adherent, mostly from the middle-aged group (45-59 years). Conclusion. The structure of use of antihypertensive drugs among the pharmacy visitors in Grodno complies to the international guidelines for the management of arterial hypertension. However, there are some disadvantages: 1) relatively large number of respondents use only one antihypertensive drug; 2) some respondents, especially among middle-aged persons, take antihypertensive drugs not regularly.

Исследовали противосудорожную активность 10 производных декагидрохинолина на модели острой никотиновой интоксикации у мышей. Среди изученных 10 производных декагидрохинолина противосудорожной активностью обладают 3 соединения: ФАВ-66, ФАВ-69 и ФАВ-70. В дозе 1/4 LD50 они укорачивают продолжительность никотиновой интоксикации в среднем на 22,2 %, p < 0,005, увеличивают латентный период судорог в среднем на 48,9 %, p < 0,005, понижают стадию судорог, оцениваемую по 4-балльной шкале, в среднем на 60,7 %, p < 0,005, а также уменьшают продолжительность судорог в среднем на 42,4 % при p < 0,005. Эффекты ФАВ-66 более выражены и сохраняются в дозе вплоть до 1/8 LD50. Способность ФАВ-66 в эксперименте ослаблять токсическое действие никотина, вероятно, связана с блокадой н-холинорецепторов.

Установлены и изучены анальгетические свойства 10 производных декагидрохинолина (фармакологически активных веществ, ФАВ) в эксперименте in vivo, определена роль опиоидных рецепторов в механизме действия соединений. В ряду изученных производных декагидрохинолина выраженными анальгетическими свойствами в дозе 1/4 LD50 обладают 2 соединения: ФАВ-70 и ФАВ-71. ФАВ-66, ФАВ-69, ФАВ-74, ФАВ-76 оказывают небольшой и непродолжительный обезболивающий эффект. ФАВ-70 и ФАВ-71 проявляют анальгетическое действие и в дозе 1/8 LD50. Максимальный эффект ФАВ-70 и ФАВ-71 развивается через 20 – 60 мин после их введения и сохраняется на протяжении не менее 2 ч (ФАВ-70 в дозе 1/4 LD50, ФАВ-71 в дозах 1/4 и 1/8 LD50). Анальгетический эффект ФАВ-70 в дозе 1/4 LD50, а также ФАВ-71 в дозах 1/4 и 1/8 LD50 значительно превосходит таковой у метамизола (1/4 LD50) и кеторолака (1/4 LD50). Механизм обезболивающего действия ФАВ-70 и ФАВ-71 не связан с влиянием на опиоидные рецепторы.

The new method of the orbital cavity volume measurement was offered. The article deals with the linear and volume characteristics of the orbita. We described the specific features of the cranial asymmetry according to the example of the orbital sizes.

anesthesia. Material and Methods. Decahydroquinolinyl derivative under laboratory code PAS-68 synthesized in the A. B. Bekturov Institute of Chemical Sciences under the guidance of K. D. Praliev has been studied. Benzocaine, lido-caine and tetracaine were used as the comparison drugs. Male rabbits of 2,0-3,5 kg weight were used as experimental animals. A threshold of corneal sensitivity to tactile effects (Rainier index) was determined by the standard method. Computer prognosis of PAS-68 acute toxicity also was made. Results. The local anesthetic activity of 1 %, 0,5% and 0,25% solutions of PAS-68 were identified as higher than that for lidocaine and benzocaine in similar concentrations (p <0,05) but lower than that for tetracaine (p<0,05). PAS-68 has no local irritating action. The duration of anesthesia, 0,5% and 1 % PAS 68 exceeds that for benzocaine and lidocaine at equivalent concentrations (p<0,05). By this kind of activity PAS-68 is a second to the duration of anesthesia by tetracaine (p<0,05). The latent period of anesthesia induced by PAS-68 is shorter than the latent periods induced by benzocaine, lidocaine and tetracaine. On the base of predictive analysis it was concluded that PAS-68 is of low toxicity. Conclusion. PAS-68 exceeds benzocaine and lidocaine by the local anesthetic activity and duration of anesthesia and is second only to tetracaine. The latent period of anesthesia PAC-68 is shorter than the latent period of benzocaine, lidocaine and tetracaine respectively.