Introduction. Medical clays are polymineral sorbents with a predominance of the underlying clay mineral, the concentration of which determines the quality of mineral raw materials and its adsorption activity. One of the methods of improving the quality of mineral raw materials is its activation by means of ultrasonic treatment.Aim. To study the effect of ultrasound on the activation and adsorption activity of mineral sorbents.Materials and methods. Clinoptilolite mineral raw materials of the Kholinsky deposit, montmorillonite mineral raw materials of the Belgorod deposit and kaolinite mineral raw materials of the Eleninsky deposit were used as objects of research. A high-frequency UZDN-1 unit was used for ultrasonic treatment. Determination of adsorption activity was carried out by methylene blue.Results and discussion. The effect of ultrasound on the activation of mineral sorbents at an ultrasonic wave frequency of 40 kHz for five minutes has been studied. It was found that the average content of Clinoptilolite, taking into account all fractions in the clay of the Kholinsky deposit, increases by 20 %, the average content of Montmorillonite, taking into account all fractions in the clay of the Belgorod deposit, increases by 14 %, the average content of Kaolinite, taking into account all fractions in the clay of the Eleninsky deposit, increases by 18 %. The effect of ultrasound on the adsorption activity of mineral sorbents has been investigated. The use of ultrasonic treatment increases the adsorption activity of mineral sorbents by 12–19 %.Conclusion. The developed method of activation of mineral sorbents by ultrasonic treatment can be used to activate mineral sorbents by increasing the concentration of the underlying mineral (Clinoptilolite, Montmorillonite, Kaolinite), as well as increasing their adsorption activity.

Introduction. In the Russian Federation, the latest version of the State Pharmacopoeia, XV edition, has been developed and is actively used. (entered into force on September 1, 2023). However, when developing and introducing various medicines into production, pharmaceutical services are forced to turn to GMP and GLP standards to bring the requirements into compliance with European standards. In this connection, it is relevant to conduct a comparative analysis of the regulatory requirements imposed, in particular, on soft dosage forms, in order to identify their similarities and differences. The established differential features specified in the General Pharmacopoeial Article «Soft Dosage Forms» (GF XV ed., OFS.1.4.1.0008) and foreign pharmacopoeial articles will allow pharmaceutical specialists to harmonize the requirements and use them in the pharmaceutical development and standardization of dosage forms in the form of gels , creams, liniments, ointments, pastes. Objective: comparative analysis of Russian and international pharmacopoeial requirements for soft dosage forms to identify differential features and develop proposals for harmonizing quality indicators in accordance with modern standards. Material and methods. The main materials for carrying out the information and analytical research method were the requirements reflected in domestic and foreign regulatory documentation that controls the quality of soft dosage forms. To solve the problems, we used materials from monographs of six leading pharmacopoeias, including foreign ones – State Pharmacopoeia of the Russian Federation XV ed. (SF RF), State Pharmacopoeia of the Republic of Belarus (SP RB), Pharmacopoeia of the Eurasian Economic Union (Ph. Eur.), British Pharmacopoeia (Ph. Br.), Chinese Pharmacopoeia (Ch. Ph.), Indian Pharmacopoeia (Ind. Ph.) and Ayurvedic Pharmacopoeia 2010 (Ayur. Ph.). Results. A comparative study of pharmacopoeial requirements for the characteristics and quality indicators of soft dosage forms presented in the State Pharmacopoeia of the Russian Federation XV (2023), State Pharmacopoeia of the Republic of Belarus (2013, 2016), Pharmacopoeia of the Eurasian Economic Union (2020) was carried out, Ph. Br. (2020), Chinese Pharmacopoeia (2020), Indian Pharmacopoeia (2022) and Ayurvedic Pharmacopoeia (2010). The analysis showed differences in approaches to standardization and quality control of soft dosage forms in leading pharmacopoeias. The results of the study can be used in the pharmaceutical development and standardization of soft dosage forms, as well as in adjusting the General Pharmacopoeia Monograph “Soft dosage forms”. Differences in pharmacopoeial requirements, reflected in Pharmacopoeial monographs, have been identified in the development and quality control of soft dosage forms. Conclusion. The fundamental differential features of regulatory requirements have been identified, making it possible to formulate changes and additions to the General Pharmacopoeia Monograph «Soft dosage forms» during their pharmaceutical development and standardization.

Introduction. Lactoferrin is a biologically active substance, a natural glycoprotein from the group of iron-containing proteins, transferrin. This article is devoted to a review of the literature data on the properties and prospects for the use of lactoferrin in medicine and veterinary medicine.Text. The problem of widespread use of lactoferrin is the need to use a large volume of raw materials, the difficulty of extracting it from agricultural raw materials and subsequent purification. In this view, at present, it is very promising to use transgenic animals to obtain such a valuable compound in the required volume. Discovered in 1939 in cow's milk, lactoferrin exhibits a wide spectrum of biological activity, new properties of this protein are constantly being established. The most studied are the immunomodulatory effects, anti-inflammatory, antimicrobial, antiviral, antifungal activities of lactoferrin, and the search for the possibility of using this compound for the treatment and prevention of the new coronavirus infection SARS-CoV-2, as well as for the prevention of postCOVID complications, has begun. In recent years, the antitumor activity of lactoferrin has been actively studied, as well as the prospects for its use as a biomarker for early diagnosis of neurodegenerative diseases. Lactoferrin can play a special role in the delivery of drugs to target organs, as well as in the manufacture of functional food products and various drugs for both humans and animals.Conclusion. Thus, the performed theoretical study and the data obtained on a wide spectrum of biological activity of lactoferrin confirm the prospects and expediency of the development of formulations and technology of drugs, functional food products, veterinary drugs and animal products based on lactoferrin.

A dosage form as a bioresorptive polymer film is one of the innovations intended for application to mucous membranes and has a number of positive characteristics such as simplicity and usability, the predicted profile of the drug substance release, the dosing accuracy and local delivery of the pharmaceutical substance. Despite the increased interest in mucoadhesive systems, currently, there are no formal techniques to standardize biopolymer films, both during the pharmaceutical formulation and the final dosage form. During the development of mucoadhesive drug forms, one of the important issues is to measure the interaction of films containing polymers of different origin in a carrier matrix with mucous tissue. The article deals with possible scoring methods of mucoadhesive parameters of the dosage form characterizing the time of its exposure on the mucosa: time loss of strength, swelling index, adhesion time. In order to adapt to physiological experimental conditions, the mucosal tissue and the aqueous medium with a pH value necessary for its hydration are used in the proposed methods. The obtained data will allow establishing the dependence of mucoadhesive parameters on quantitative relations of polymers forming a depot matrix of medicated films.

The article presents data on the chemical study of herbs Boudreau hederacea representative of the family Labiatae, as a promising source of flavonoids. The chemical study of 70% alcoholic extract of the herb Boudreau hederacea by mass spectrometry and UV spectrophotometry were found luteolin-7-glucoside, apigenin, apigenin-7-glycoside, coffee-ACETIC ACID. By UV spectrophotometry conducted standardized grass Boudreau hederacea on the content of flavonoids. The results are processed statistically, the percentage of flaveo Noida, in terms of luteolin-7-glucoside was 1,83 ± 0,05%. Error of a single definition of confidence interval P, 95%, up 2.86%, which fits into the regulated rate of GF. Next, from the grass Boudreau made hederacea extract thick as a semi. Pro-vedena its standardization. According to data obtained in the course of the experiment it was found that the percentage of flavonoids in terms of luteolin-7-glucoside was 1,445 ± 0,059%. The results are processed statistically, the error of a single definition of confidence interval, P, 95% is 4.08%, which fits into the regulated rate of GF. On the basis of an extract of thick grass Boudreau hederacea developed dosage form in the form of granules.

Use of microbiological researches is an integral part of experimental researches during working out of structure, technology, an estimation of quality of new medicinal forms with antibacterial substances. Applied microbiological methods (in an agar and membrane filtrations) in the course of experimental researches have allowed to carry out a choice of the optimum polymeric basis, to prove concentration of metronida-zole, to study spectrum and force of antibacterial activity, to track microbiological cleanliness of the developed new structures of biosoluble films.