Objective: To strengthen the management of haemodialysis machines on clinical engineering aspect, in order to enhance the safety and usage rate of haemodialysis machines, as well as to reduce clinical risk. Methods: Through 4 respects including clearing of engineer responsibility, establishing of regulations, reinforcing of maintenance, and emphasis on personnel training to figure out effective method of management. Results:Effectively reduce the failure rate of haemodialysis machine, avoid the safety loophole during clinical treatment, and improve the quality of treatments. Conclusion:Clinical engineering management on haemodialysis machines can effectively prolong the life of devices, improve the security, and have positive impact on treatment quality.

Objectives Mesenchymal stem cells (MSCs) represent a powerful tool in regenerative medicine because of their differentiation and migration capacities. Moreover, the immunomodulatory ability of MSCs may be used to develop therapies for the treatment of autoimmune diseases.Methods In this study, we isolated Flk-1(+)Sca-1(-) MSCs from bone marrow (bMSCs). Next, we studied their biological characteristics and immunologic functions. We also investigated their effects on graft-versus-host disease (GVHD) associated with allogeneic bone marrow transplantation in mice.Results Flk-1(+)Sca-1(-) bMSCs were able to differentiate into fat and cartilage cells, indicating that the isolated cells had stem cell properties. They could also suppress alloantigen-induced T cell proliferation in vitro in a dose-dependent manner. Infusion of bMSCs into allogeneic bone marrow-transplanted mice alleviated the lethal GVHD that occurred in control recipient mice. There was significantly lower mortality among the recipients of the Flk-1(+)Sca-1(-) bMSCs that also ameliorated the clinical symptoms and GVHD histopathology. Beneficial effects on GVHD by Flk-1(+)Sca-1(-) bMSCs were also observed when MSCs were engineered to express anti-inflammatory cytokines IL-4 and IL-10 and decrease expression of proinflammatory cytokines IFN-, TNF-, and IL-2.Conclusion Flk-1(+)Sca-1(-) bMSCs have stem cell properties and can efficiently ameliorate the GVHD associated with allogeneic bone marrow transplantation in mice.

Our aim was to evaluate the therapeutic effects of bone-marrow-derived mesenchymal stem cells (BMMSCs) on ConA-induced hepatitis and to elucidate the possible mechanism involved. MSCs were isolated from bone marrow and their characteristics and anti-apoptotic effects on the L02 cell line were analyzed. The effect of intravenous infusion of BMMSCs on liver damage was also tested. Furthermore, the recruitment of donor BMMSCs to the liver of recipient animals and their effects on the activity of intrahepatic natural killer T (NKT) cells were investigated. BMMSCs ameliorated liver damage in a time- and dose-dependent manner. Donor BMMSCs were detected in the livers of recipient animals, suggesting that tissue damage stimulated the migration of BMMSCs. Transplanted BMMSCs also suppressed the activity of intrahepatic NKT cells, not only in the liver but throughout the body. The general infusion of BMMSCS ameliorated immunoregulatory activities by the suppression of intrahepatic NKT cells.

Objective：d ionization chamber and X-ray beam plane on relevant deviation（RD）,on behalf of the accuracy of CTDIw measurement,while The influence of offset distance（OD）between the center of pencile conducting axial scanning with multi-detector CT.Method：A head phantom（in compliance with ICE standard） and penciled ionization chamber are utilized to measure the CTDIw at variant OD with Philip Brilliance iCT256 using axial scanning,meanwhile,impact factors on RD were analyzed.Result：when offset distance（OD）equal to ±1 cm,the relevant deviation（RD）within the range of±5%;when OD equal to±3 cm,RD within the range of -5%~15%,and when OD equal to±5 cm,RD within the range of 40%~70%.Conclusion：OD is considered as a main impact factor to RD,while the milliampere time second（mAs）and tube voltage have little relevance on RD. However,mAs and tube voltage might affect the value range of RD at a certain OD.More importantly,dose distribution along Z axial exhibits asymmetry.

Mesenchymal stem cells (MSCs) are multipotent cells that can be derived either from the bone marrow (bMSCs) or adipose tissue (aMSCs). We have compared the immune regulatory properties of cells derived from bone marrow and adipose tissue to provide a theoretical basis for the choice of stem cell source for transplantation. The phenotypes of bMSCs and aMSCs are similar, differing only in the expression of CD106. aMSCs proliferate faster than bMSCs, but aMSCs suppressed T-lymphocyte proliferation and activation more poorly than bMSCs. Thus cell origin and abundance are important factors in determining the suitability of MSCs for transplantation. Adipose tissue offers a more promising source of cells for such an application.

目的 介绍了一种用半导体电离室测量多排CT辐射剂量的原理和方法,为完善我国现有医疗CT检测规范提供技术信息.方法 通过介绍X射线辐射剂量计Barracuda的测量原理和多排CT辐射剂量测量的参数设置依据,并结合在Philip Brilliance iCT 256机器上的应用实例,阐述了用半导体电离室的探测器测量多排CT辐射剂量的关键技术.结果 基于CT扫描参数合理设置探测器参数后,多排CT辐射剂量空间分布情况得以较好展示.100 mm长杆空气电离室的测量范围远小于多排CT线束覆盖范围,需要对多排CT辐射剂量测量方法和技术进行更新.结论 新型探测器有利于揭示多排CT辐射剂量的特性规律.

Cancer stem cells (CSCs) are proposed to persist in tumors as a distinct population and cause relapse and metastasis by giving rise to new tumors. Development of specific therapies targeted at CSCs holds hope for the improvement of survival and quality of life of cancer patients, especially for sufferers of metastatic disease. This is particularly true in chronic myeloid leukemia (CML).