Objective To analysis the research status and development trend of traditional Chinese medicine in the treatment of endometrial cancer through bibliometrics. Methods The relevant literatures on the treatment of endometrial cancer by traditional Chinese medicine collected from CNKI, Wanfang Data, and VIP from inception to December 2021 were searched by computer. Cite Space 5.8 software was used to analyze the number of articles published, the cooperation between authors and institutions, the co-occurrence of keywords, clustering and emergence, and corresponding maps were drawn to explore the research hotspots and trends in this field. Results A total of 162 literatures were included, and the number of publications showed an increasing trend. A total of 303 authors were included in the collaborative network atlas, and the largest team was a multi-person team represented by Xue Xiaoou. A total of 156 institutions were included in the atlas of institutional cooperation network, and Dongzhimen Hospital, Beijing University of Chinese Medicine published the most papers. Key words cluster graph showed that the hot spots of traditional Chinese medicine in the treatment of endometrial cancer mainly focus on related disease research, traditional Chinese medicine pathogenesis and syndrome type, traditional Chinese medicine clinical experience, curative effect observation, and traditional Chinese medicine mechanism research.Conclusion Research on the treatment of endometrial cancer by traditional Chinese medicine has been on the rise, and the research hotspot tends to be traditional Chinese medicine, prescription and medicine, clinical observation, and mechanism research. It is suggested to strengthen institutional cooperation in the future, carry out high-quality clinical research, and mechanism research, and further explore the clinical application value of traditional Chinese medicine in the treatment of endometrial cancer.

目的:采用网络药理学的方法预测三棱-莪术药对治疗子宫内膜异位症(EMT)的主要活性成分、靶点及信号通路,探讨其作用机制.方法:通过中药系统药理学数据库与分析平台(TCMSP)检索三棱-莪术药对的中药化学成分,以口服生物利用度(OB)≥30％、类药性(DL)≥0.18为阈值筛选潜在的活性化合物;通过TCMSP查询活性化合物对应的靶标;运用GeneCards和人类孟德尔遗传数据库(OMIM)预测疾病靶点;利用韦恩图找到活性成分靶点和疾病靶点的交集靶点;使用Cytoscape 3.7.2软件构建疾病-药物-有效成分-靶点蛋白质-蛋白质相互作用(PPI)网络;采用String在线数据库和Cyto-scape软件绘制交集靶点PPI网络;最后借助R软件和Bioconductor生物信息软件包进行基因本体(GO)功能富集分析及京都基因和基因组百科全书(KEGG)通路富集分析,并使用Cytoscape软件绘制靶点-信号通路网络图.结果:筛选得到三棱-莪术活性成分8个,对应靶点77个,EMT相关靶点1600个,交集靶点34个.GO功能富集分析结果显示三棱-莪术药对可影响1054个生物学过程、22个细胞组分和65个分子功能.KEGG通路富集分析得到91条通路,三棱-莪术药对治疗EMT主要与雌激素信号通路、IL-17信号通路、AGE-RAGE信号通路、甲状腺激素信号通路、P53信号通路等有关.结论:三棱-莪术药对治疗EMs具有多靶点、多途径、多通路的特点.

目的 为优化医用耗材本市医疗保障信息业务编码贯标工作(无论医保内外均要对照核定国家医保编码),解决同一耗材医保编码、物价编码、耗材管理编码三码不统一问题.方法 我院以此次医用耗材贯标工作为契机,通过数据的分类对比、同类耗材关键词提取,收费价格及入库价格匹配,依托已有的耗材管理信息系统,使用一物三码合一的管理办法进行实践.结果 在不增加信息系统升级改造成本的前提下,完成现用的可单独收费医用耗材的国家医保编码贯标工作.结论 医用耗材种类多、用量大、对医保资金占用明显,在不增加信息系统升级成本的前提下,一物三码合一后,工作效率提高,没有附加人力成本投入,且更便于医院对医用耗材管控工作持续改进.增加医院收费环节的准确率,降低医保收费项目错收、漏收现象的发生,为医院有效节流.

目的 建立一套适合北京妇产医院特色的供应商评价体系,以规范供应商管理,提高医务人员的体验感,提升医工人员配合度,进而提升患者的就诊满意度.方法 本研究通过调查问卷、专家访谈、德尔菲法等形成评价体系指标,为我院遴选适用的医疗设备供应商提供科学客观的参考.结果 通过两轮专家咨询共筛选出4个一级指标,18个二级指标,45个三级指标.再将该体系指标细分为准入评价体系指标和准入后评价体系指标.结论 本研究不仅建立了供应商的评价体系指标,还对建立的体系指标进行了验证.后续计划将评价体系指标广泛应用,并根据实际情况对指标进行升级和完善,为构建普遍适用的供应商评价体系指标提供参考依据.

目的 通过挖掘脉搏波中蕴含的与血压相关的特性,分析高血压患者和正常人上下肢脉搏波的差异,以探索高血压的前兆信息.方法 分别选取20位特征明显的高血压患者和正常人作为受试者,采集其上下肢脉搏波信号.将脉搏波信号通过无限冲激响应(infinite impulse response,IIR)二阶低通滤波器去除高频干扰,采用单波判别算法进行基线漂移校正,并用三次样条插值法进行标准化归一化处理后,选取脉搏波时域特征参数(脉搏波特征参数K、收缩期特征参数K1、舒张期特征参数K2、主波宽度)、踝臂指数(ankle brachial index,ABI)和肱踝脉搏波传导速度(brachial ankle pulse wave velocity,baPWV)作为上下肢脉搏波特征参数.最后,用SPSS25.0软件对数据进行t检验、相关性分析和主成分分析.结果 高血压组与正常组的肱踝脉搏波特征参数差异具有统计学意义.特征参数的相关性分析结果表明,左侧和右侧的脉搏波特征具有较强的相关性,左侧和右侧的脉搏波测量可相互替代;而上肢和下肢的脉搏波特征相关性较弱,上肢和下肢的脉搏波测量不可相互替代.采用主成分分析法进行特征降维,分析最能表征高血压的特征成分,并筛选出高血压组与正常组的典型脉搏波波形图,验证了两组脉搏波具有明显特征差异.结论 脉搏波传导速度、踝臂指数及上下肢脉搏波特征参数K对血压水平估计具有重要意义,可为无创血压监测和预防高血压提供参考.

目的:建立医院一站式女性盆底功能障碍(PFD)诊治中心,简化患者就诊流程,实现对盆底疾病及生殖整形患者的系统化和规范化管理,提高医院诊疗效率.方法:对医院产科和妇科现有医疗设备进行资源整合,对各设备房间重新调整和功能重新定位,通过盆底诊治一站式信息化管理平台,实现对盆底问诊、评估、诊断、治疗及随访的全病程管理.结果:2020年6月一站式女性PFD诊治中心投入使用后,就诊患者整体满意度由2019年的82.20％提升至2020年的91.4％,设备使用率提高.采用盆底诊治一站式信息化管理平台实现了多学科协作(MDT)诊疗模式,为患者制定最优和最科学的治疗方案,利用大数据长期追踪管理患者治疗效果.结论:医院一站式女性PFD诊治中心能够减少患者诊治中间的转科环节,便于PFD患者治疗,有效提升医疗设备使用效率.

备孕是夫妻双方为了给新生命提供更好的孕育条件,而补充营养、调理身体的过程. 但有些女性在备孕前就有些肥胖,或是过度补充营养,导致备孕期间体重上涨.富足的营养虽然能为孕育新生命打下夯实的基础,但肥胖也会影响受孕的成功几率.

目的:探讨女性生殖相关激素依赖性与非激素依赖性恶性肿瘤的中医证候分布规律差异.方法:采用回顾性研究方法,收集208例女性生殖相关恶性肿瘤患者的信息,分析并比较二者的中医证候分布规律及在年龄、初潮年龄、绝经年龄、体重指数、合并症、恶性肿瘤家族史等方面的分布差异.结果:经统计,女性生殖相关激素依赖性恶性肿瘤患者121例,以痰湿凝聚证为主,非激素依赖性恶性肿瘤患者87例,以肝肾阴虚证为主,组间比较差异有统计学意义(P<0.05).激素依赖性恶性肿瘤患者平均年龄小于非激素依赖性患者,组间比较差异有统计学意义(P<0.05);激素依赖性恶性肿瘤患者超重及肥胖比例高于非激素依赖性患者,组间比较差异有统计学意义(P<0.05);激素依赖性恶性肿瘤患者初潮早于非激素依赖性患者,绝经晚于非激素依赖性患者,但组间比较不具有统计学意义(P>0.05);激素依赖性恶性肿瘤患者合并血脂异常、糖尿病高于非激素依赖性患者,组间比较差异有统计学意义(P<0.05).结论:女性生殖相关激素依赖性恶性肿瘤患者以痰湿凝聚证为主,非激素依赖性恶性肿瘤患者以肝肾阴虚证为主,二者在年龄、BMI、合并血脂异常、糖尿病等方面分布具有差异性,临床可以根据激素依赖与否进行辨证论治,为中医药更好地防治女性生殖相关恶性肿瘤提供新的切入点.

目的探讨Ⅰ型和Ⅱ型子宫内膜癌（EC）患者中医证候分布规律及其在年龄、子宫内膜厚度、体重指数（BMI）等方面的差异,以期为中医药防治EC提供理论依据。方法回顾性分析87例EC患者的临床病例资料,归纳并比较Ⅰ型和Ⅱ型EC患者中医证候分布、年龄、子宫内膜厚度、BMI等方面的分布差异。结果Ⅰ型EC患者67例,以脾肾阳虚证为主,Ⅱ型EC患者20例,以肝肾阴虚证为主,组间比较差异有统计学意义（P＜0.05）。Ⅰ型EC患者平均年龄小于Ⅱ型EC患者,可见于育龄期及非育龄期,Ⅱ型EC患者均为非育龄期,组间比较差异有统计学意义（P＜0.05）;Ⅰ型EC患者术前内膜厚度大于Ⅱ型EC患者,组间比较差异有统计学意义（P＜0.05）;Ⅰ型EC患者超重比例高于Ⅱ型EC患者,组间比较差异有统计学意义（P＜0.05）;Ⅰ型EC患者合并高血压、糖尿病、血脂异常人数多于Ⅱ型EC患者,但组间比较差异无统计学意义（P＞0.05）。结论Ⅰ型EC患者以脾肾阳虚证为主,Ⅱ型EC以肝肾阴虚证为主,二者在年龄、子宫内膜厚度、BMI等方面分布具有差异性。临床应根据EC患者具体情况辨证施治,以更好地发挥中医药在防治EC方面的优势。

目的 讨论不同类型子宫内膜病变中医证候、证素的分布特点.方法 采用流行病学调查方法,收集子宫内膜病变患者中医四诊信息,根据症状出现的频率,对筛选出的31个主要症状进行判定与统计分析.结果 经因子分析共提取14个公因子,累计贡献率为72.6％.增生不伴非典型(endometrial hyperplasia without atypia,EHWA)病位证素以肝、脾为主,病性证素以湿、气滞、气虚为主,证候以肝郁气滞证为主,其次为脾虚痰湿证;增生伴非典型(atypical endometrial hyperplasia,AEH)病位证素以脾、肝为主,病性证素以湿、痰、热、气滞为主;子宫内膜癌(endometrial carcinoma,EC)病位证素以脾、肝为主,病性证素以湿、痰、热为主;AEH和EC以脾虚痰湿证和脾虚湿热证为主.结论 利用因子分析方法在一定程度上揭示了不同类型子宫内膜病变证候、证素的分布特点,其恶变的关键阶段为AEH,发挥中医药优势,延缓、阻断甚至逆转该演变过程是防治子宫内膜病变由良性向恶性转化的有效途径.

目的研究高、低浓度金雀异黄素对雌激素受体（ER）阳性人子宫内膜癌Ishikawa细胞增殖、集落形成及ERα/ERβ蛋白表达比值影响的差异。方法以ER阳性人子宫内膜癌Ishikawa细胞为研究对象,正式实验前用Opti-MEM无酚红减血清培养基培养24 h,然后分为金雀异黄素低浓度组、高浓度组及溶剂对照组,依次加入由2%DCS-FBS的Opti-MEM无酚红减血清培养基配置所需浓度的金雀异黄素药液及含0. 5‰DMSO的培养液。应用CCK-8法检测高浓度（10、25、50μmoL/L）和低浓度（0. 001、0. 01、0. 1、1μmoL/L）的金雀异黄素干预Ishikawa细胞24、48、72 h对增殖的影响。平板集落形成实验检测高浓度（25、50μmoL/L）和低浓度（0. 01、0. 1μmoL/L）金雀异黄素干预1周对集落形成的影响。用Western blot法检测高浓度（25、50μmoL/L）和低浓度（0. 01、0. 1μmoL/L）金雀异黄素干预48 h后对ERα/ERβ蛋白表达比值的影响。结果低浓度（0. 001、0. 01、0. 1μmoL/L）范围内金雀异黄素促进Ishikawa细胞增殖,在干预48 h后最明显,0. 1μmoL/L浓度促增殖作用达到最强（P ＜0. 01）;高浓度时（10、25、50μmoL/L）抑制细胞增殖（P ＜0. 05）,且呈时间和浓度的依赖性,50μmoL/L浓度下干预72 h后抑制作用达到最强（P ＜0. 01）。低浓度金雀异黄素的集落形成率分别为14. 60%和15. 13%,和溶剂对照组（12. 20%）相比有统计学差异（P＜0. 05）;高浓度集落形成率分别为6. 07%、4. 27%,显著低于溶剂对照组（P ＜0. 01）。高浓度和低浓度下ERα蛋白表达均上调,且在0. 1μmoL/L时达到最高; ERβ蛋白表达均下降,在25、50μmoL/L时达到最低; ERα/ERβ蛋白比值均明显上调,在0. 1μmoL/L时达到最高。结论低浓度金雀异黄素具有促ER阳性Ishikawa细胞生长的作用,可能通过上调ERα/ERβ蛋白表达比值实现;高浓度金雀异黄素虽然也可以上调ERα/ERβ蛋白表达比值,但可能存在其他非ER依赖机制主导发挥抑制Ishikawa细胞生长的作用。

目的:通过临床随机对照研究及初步探讨“滋肾养肝法”中药治疗卵巢储备功能下降(DOR)的临床疗效.方法:收集2015年12月至2016年12月在北京中医药大学东直门医院就诊且符合纳入标准的患者60例,根据随机数字表法分为治疗组(滋肾养肝法)和对照组(雌孕激素序贯疗法),治疗3个月经周期比较治疗前后中医证候积分及基础性激素水平并观察不良反应.结果:组内比较,2组月经周期及经量、色、质、心烦易怒、腰酸症状和FSH值在治疗后均明显改善,治疗组FSH/LH亦有显著下降.组间比较,治疗组能显著改善同房次数和FSH/LH且无不良反应,对照组有7例不良反应.结论:“滋肾养肝法”中药可改善DOR患者月经周期、经量、心烦易怒和腰酸等症状,降低FSH和FSH/LH值且无明显副作用.

目的:探讨18F-脱氧葡萄糖(18FDG)正电子发射计算机断层显像(PET)/计算机断层显像(CT)在皮肌炎(DM)/多发性肌炎(PM)伴恶性肿瘤中的影像特点,为DM/PM的诊断提供依据.方法:收集2009-2015年北京协和医院收治的17例DM/PM并发肿瘤的患者和39例同期末并发肿瘤患者的临床资料和18FDGPET/CT影像资料,并进行分析.结果:56例DM/PM患者中并发肿瘤17例,包括淋巴瘤5例(其中3例为T细胞淋巴瘤),肺癌7例,甲状腺癌、乳腺癌、宫颈癌、肝脏神经内分泌肿瘤和胸腺瘤各1例,肿瘤病灶的18 FDG摄取较高,最大标准摄取值(SUVmax)为1.47～22.93 (7.67±6.60).全部患者中22例患者18FDGPET/CT显像示全身肌肉弥漫性摄取升高,肌肉的SUVmax为0.71～2.93 (1.43±0.68),其中9例患者(40.91％)伴有恶性病变;26例患者18FDG PET/CT显像示局部肌肉摄取升高,肌肉的SUVmax为1.06～8.74 (2.62±1.65),其中6例患者(23.08％)伴有恶性病变;8例患者的18 FDG PET/CT显像示全身肌肉18FDG未见摄取升高,其中3例患者(37.50％)伴有恶性病变.15例并发问质性肺炎,其中2例患者(13.33％)伴有恶性病变.结论:肿瘤相关性DM的18FDGPET/CT影像表现有一定特征性,其中全身肌肉弥漫性摄取升高者肿瘤发病率最高;对可疑DM/PM伴恶性肿瘤患者,18FDGPET/CT可以作为有效的辅助诊断方法.

Objective To study the effects of TNF-α and baicalin on the activity of HUVEC. To research the effects of baicalin on HUVEC apoptosis induced by TNF-α. Methods HUVEC were cultured with different concentrations of TNF-α and baicalin.After culturing for 24 h,the activity of HUVEC was examined by MTT assay. Flow cytometric analysis were used to determine the apoptotic cells. Results The activcty of the hepatocyte( A) in the groups of 10 ng·ml-1and 50ng·ml-1of TNF-α were significantly lower than black control group( P 0. 05). The activcty of the hepatocyte( A) in the different concentrations of baicalin groups were all higher than black control group. The activcty of the hepatocyte( A) in the groups of baicalin were significantly higher than those in apoptotic model group( P 0. 05). The flowcytometry showed that the apoptosis rates in the baicalin group were lower than that of the apoptotic model group. Conclusion TNF-αcan restrain HUVEC's proliferation. Baicaline can advance HUVEC's growth. Baicaline can restrain HUVEC apoptosis induced by TNF-α.

Objective To verify the reported CTDIvol value and explore dose safety managementprotocol of Philips Brilliance iCT 256 under axial scan mode with head protocolMethods A pencil dosimeter,Solidose 400 from Sweden RTI Electronics,is utilized to detect radiation dose index of phantom T6M1 64 (incompliance with IEC standard 61 223-2-6,provided by National Institute of Metrology of China)when scannedby iCT 256 under head axial protocolResults (1)Relative deviation of CTDI1 00 in the center point is about 2%and those in the peripheral 4 points are about 20% (2)Tested CTDIvol value is 5% ~1 6% greater thanreported value(3) Effective absorbing dose during one head axial scanning is about 086 mGy to 363mGyConclusions Accuracy of CTDI1 00 measurement in the center point is better than the peripheral fourpointsTested CTDIvol value might be greater than reported CTDIvol in certain conditions and supervision onaccumulated radiation dose of patient should be recommended.

目的:观察金凤丸治疗月经过少的临床疗效。方法:将81例月经过少患者予以口服金凤丸,并进行自身治疗前后月经量、月经持续时间、临床证候评分、子宫内膜厚度变化的比较。结果:经治疗后月经量、月经持续时间、临床证候评分、子宫内膜厚度与治疗前比较,差异均有统计学意义(P<0.05)。结论:金凤丸治疗肾虚型月经过少疗效确切。

Objective：d ionization chamber and X-ray beam plane on relevant deviation（RD）,on behalf of the accuracy of CTDIw measurement,while The influence of offset distance（OD）between the center of pencile conducting axial scanning with multi-detector CT.Method：A head phantom（in compliance with ICE standard） and penciled ionization chamber are utilized to measure the CTDIw at variant OD with Philip Brilliance iCT256 using axial scanning,meanwhile,impact factors on RD were analyzed.Result：when offset distance（OD）equal to ±1 cm,the relevant deviation（RD）within the range of±5%;when OD equal to±3 cm,RD within the range of -5%~15%,and when OD equal to±5 cm,RD within the range of 40%~70%.Conclusion：OD is considered as a main impact factor to RD,while the milliampere time second（mAs）and tube voltage have little relevance on RD. However,mAs and tube voltage might affect the value range of RD at a certain OD.More importantly,dose distribution along Z axial exhibits asymmetry.

目的:探讨子宫内膜病变患者中医证候特点及规律。方法:回顾性分析113例子宫内膜病变患者的中医证型和合并疾病,并比较不同程度的子宫内膜病变患者中医证型的变化。结果:随着子宫内膜病变的进展及恶变,中医证型中肝郁化火、湿热蕴结、阴虚火旺等具有火热之邪的证型逐渐增多。结论:火热之邪是促进子宫内膜恶变的病因之一。

Objective To study the effect of berberine on human endometrial carcinoma cell line Ishikawa co-cultured with tumor-associated macrophages(TAM),and its influences on the expressions of interleukin-8(IL-8) and nuclear factor кBp65(NF-кBp65).Methods The effective concentration and time of berberine for inhibiting the proliferation of Ishikawa,and inhibitory rate of berberine on Ishikawa co-cultured with TAM were detected by using MTT.The changes of IL-8 concentration in the supernatant were detected by using ELISA.The changes of p65 of the signal pathway of NF-кB were detected by using Western blot method 48 hours after the intervention of berberine.Results Berberine inhibited significantly the growth of Ishikawa showing a time-dose dependency,and it(40 mg/L) also inhibited the proliferation of Ishikawa co-cultured with TAM.The concentration of IL-8 in the supernatant decreased with the time of intervention(P0.01).The expression of NF-кBp65 decreased significantly 48 hours after berberine intervention(P0.01).Conclusion Berberine can inhibit the proliferation of Ishikawa co-cultured with TAM and production of IL-8,and block NF-кB signal pathway to restrain the metastasis of endometrial carcinoma.

Objective To investigate the influence and its receptor mechanism of genistein on the proliferation of negative cell line of estrogen receptor and progesterone receptor of endometrial carcinoma,HEC-1B and provide the theoretical base for the application of genistein in clinic.Methods HEC-1B were cultured in vitro,and than divided into the blank group,genistein group 1(10×10-6 mol/L),genistein group 2(20×10-6 mol/L),genistein group 3(40×10-6 mol/L),genistein group 4(80×10-6 mol/L) and genistein group 5(160×10-6 mol/L) with different action time(24 hours,48 hours,72 hours and 96 hours).The influence of genistein on the proliferation of HEC-1B was detected by using MTT method.The influences of genistein in different doses on the expressions of estrogen receptor-α(ER-α) and estrogen receptor-β(ER-β) regulated by estrogen response element(ERE) by applying the method of luciferase reporter gene.The difference between genistein effects on ER-α and ER-β were compared.Results The proliferation of HEC-1B in vitro was inhibited significantly by genistein with statistical difference(P0.05).The inhibitory effect of genistein increased along with the increase of its concentration(10×10-6 mol/L-160×10-6 mol/L) and action time(24-72 hours) showing a dose-time dependency.The expressions of reporter genes were much higher in the genistein group 2 and 3 than those in the blank group(P0.05) showing a dose dependency.The increase of the expression of reporter gene mediated by ER-β was more significant that that by ER-α(P0.01).Conclusion Genistein can inhibit the proliferation of endometrial carcinoma through regulating the expressions of ER-α and ER-β,and proportion of ER-β to ER-α.