UNLABELLED:Empirical choice of antihypertensive therapy (AGT) for patients with complicated hypertensive disease (HD) encounters difficulties due to high variability of arterial pressure (AP) and inadequate response to intake of medicines. The objective methods for the choice of AGT methods are absent.AIM:To evaluate effectiveness ofthe choice of AGT taking account of AP profile calculated based on the analysis of results of 3 day AP monitoring in patients with complicated HDfor whom the empirical prescription of medicines does not give the desirable result.MATERIALS AND METHODS:The study included 51 patients aged 56 +/- 19 yr with HD 18 +/- 13 yr in duration without adequate control of AP despite combined AGT AD was measured (BPLab, Nizhni Novgorod) every 30 min for 3 days, the AP profile was calculated by special FORM-based algorithm. Peak time and magnitude were calculated, the first and second derivatives of the process were determined, AGT was prescribed at the computed AD maximum points.RESULTS:Systolic and diastolic AP decreased within 2 weeks after AGT The number of patients with enhancedAP in the daytime and at night and those with highly variable AP decreased from 33 to 11% (chi2 = 8.4, p < 0.005), from 61 to 33% (chi2 = 10.1, p < 0.005), from 51 to 26% (chi2 = 8.2, p<0.005) respectively. The number ofpatients with inadequate lowering of night-time AP and those with abnormally high fluctuations of AP decreased from 53 to 24% (chi2 = 9.3, p < 0.005) and from 31 to 15%, (p < 0.005) respectively. The frequency of intake of AGT drugs did not change.CONCLUSION:Approximation of real AP circadian profile fluctuations based on results of 3 day monitoring is a sensitive diagnostic tool facilitating the choice of rational AGT for patients with markedly altered circadian rhythms when empirical prescription of AGT does not ensure desired control ofAP

Here we introduce an algorithmic tool to extract significant information out of the long-term physiological monitoring data following an originally designed methodology that is implemented as an integrative software solution. The algorithm consists of several consecutive steps including elimination of outlier measurements, filtering out high-frequency noise, detection of the long-term trend and an enhanced elicitation and analysis procedure of the rhythms based on the spectral analysis of the fluctuations around the detected trend. The designed solutions are especially suited to operate with non-equidistant data series that are common in ambulatory monitoring data due to the limited control over the measurement procedures and elimination of unreliable measurements. The potential application area includes not only the analysis of biological data series but also extends to astronomical, climatological, hydrological, meteorological and other data series. The integrated solution providing the universal analysis algorithm for data sets from different sources is especially interesting for elicitation of various cross-modulation effects like governing of physiological rhythms by astronomic cycles.

In the present research the visualization of amplitude-phase relationships in entrainment processes is based on the expression serial time sections [3] allow tracing the behavior of different parameters of any rhythmical component of spectrum during a time which includes spans before, during and after any synchronizing (desynchronizing) event. There is a simple and noninvasive method for acquiring information on the visualization of amplitude-phase relationships. The method used the mathematical and graphic analysis simultaneously visualization the dynamics of amplitude, its statistical significance and acrophase in entrainment processes, the three modifications of serial sections was elaborated: procedure of adding logarithms of P-values-matrices, plotting 2D image and 3D image. As examples for illustration serial section method, automatic measurements of blood pressure (BP), both systolic (S) and diastolic (D), and heart rate (HR) were used. Five flights from Minneapolis (USA) to Saint-Petersburg (Russia) crossing 9 time zones and 4 flights in the opposite direction were performed during that time (during the second return flight, no measurements were taken). The simultaneous drop in amplitude and the rapid shift in acrophase associated with West-to-East flights, and more gradual changes for East-to-the-West flights led to the hypothesis that the rapid entrainment is performed by collapse of the rhythm at a singularity time point. Application of the present method has allowed the authors to carry out visualised dynamic chronobiological the control parameters of cardiovascular system. The method has higher diagnostic value in comparison with well-known procedures of an estimation of chronomedicine.

Heart rhythm (HR), and blood pressure (SBP, DBP) was registered at a group of practically healthy workers with a normal operating mode (51 persons) and machinists of locomotive brigades with replaceable operating mode (200), and also at oncological patients (23). The statistical importance of primary factors of regress and correlation between the investigated functions in all examined groups, as a mutual coordination in orientation of these changes (their conjugacy) was estimated. Desinchronosis of blood circulation have been found both in oncological patients and in machinists of locomotive brigades.

Countering the trend in specialization, we advocate the trans-disciplinary monitoring of blood pressure and heart rate for signatures of environmental cyclic and other variabilities in space as well as terrestrial weather on the one hand, and for surveillance of personal and societal health on the other hand. New rules (if confirmed novel laws) emerge as we recognize our inheritance from the cosmos of cycles that constitute and characterize life and align them with inheritance from parents. In so doing, we happen to follow the endeavors of Gregor Mendel, who recognized the segregation and independent assortment of what became known as genes. Circadians, rhythms with periods, τ, between 20 and 28 hours, and cycles with frequencies that are higher (ultradian) or lower (infradian) than circadian, are genetically anchored. An accumulating long list of very important but aeolian (nonstationary) infradian cycles, characterizing the incidence patterns of sudden cardiac death, suicide and terrorism, with drastically different τs, constitutes the nonphotic (corpuscular emission from the sun, heliogeomagnetics, ultraviolet flux, gravitation) Cornélissen-series.

Patient N presented with a well-apparent abnormality of chronological structure of heart beat biorhythms despite the absence of subjective complaints throughout the six-month long observation period. It was shown that AP peaks were associated with a significant decrease of circadian index (CI), i.e. the development of a rigid daily heart contraction rhythm. The reduction of CI as a specific indicator of stability of the daily cardiac contraction rhythm gave evidence of altered vegetative regulation of cardiac function during hypertension. Rigidity of the daily heart contraction rhythm increased with increasing severity of the disease. Smoothing of the circadian rhythm profile suggests depletion of adaptive reserve and the development of the "denervated" heart phenomenon. Cardioversion created a tendency towards normalization of circadian index.