Background. There was a remarkable downgrade in China’s COVID-19 response strategies in January 2023. The COVID-19 infection rate grew rapidly in the early stages following the management policy shift. This study attempted to explore the associations between SARS-CoV-2 infection and mental or physical health status in pregnant and postpartum women and the role of perceived health risks and family members’ SARS-CoV-2 infection status on these associations by capturing the impact of policy shifts in a short period of time. Methods. This cross-sectional study with a random sample from a convenience sample of hospitals was conducted in pregnant and postpartum women in January 2023. Standardized assessment tools were employed to assess anxiety, depressive and physical symptoms, and feelings of hopelessness. Hierarchical multiple logistic regressions were conducted to examine the mechanisms of associations of interests by including a range of sociodemographic factors, self-perceived health, SARS-CoV-2 infection status, and perceived health risks as covariates. Results. Of the 1,013 pregnant and postpartum women aged 32.0 ± 0.3 years, 58.2% (n = 590) were diagnosed with COVID-19, and 49.4% (n = 500) had family members who were infected with SARS-CoV-2. Nearly 98% of the included participants took measures to prevent SARS-CoV-2 infection. A COVID-19 diagnosis was positively associated with feelings of hopelessness (OR = 1.68, 95% CI: 1.20–2.35), probable anxiety (OR = 6.42, 95% CI: 2.18–24.61), possible depression (OR = 2.56, 95% CI: 1.07–6.70), and physical symptoms (OR = 6.28, 95% CI: 1.63–42.03) after adjusting for sociodemographic and health characteristics, while the associations presented no statistical significance when family members’ SARS-CoV-2 infection status and perceived health risks were introduced into the models. Conclusions. Our results suggested that pregnant and postpartum women may experience physical and mental health challenges when they or their family members contracted COVID-19 in the context of a considerable shift in COVID-19 management. Early detection of poor health status and its risk factors for vulnerable groups during shifts in health policy and administrative practice is very necessary, and health services, including easy access to psychosocial support and obstetric counselling, should be prioritized.

Objective: To discuss and analyze the effectiveness of the application of perineal wound model in teaching midwife interns. Methods: The research subjects in this study were 40 midwife interns who enrolled in our hospital from January 2020 to December 2022, which were divided into a control group (consisted of 20 interns, taught with the conventional method) and a research group (consisted of 20 participants, taught with the perineal wound model) using the random number table method. The outcomes of these two groups were compared. Results: The examination results of the research group were better than control group (P < 0.05); the interns of the research group were more satisfied towards the teaching method compared to the control group (P < 0.05). Conclusion: Applying the perineal wound model in teaching midwife interns could effectively improve their examination achievements and teaching satisfaction, which brings a significant clinical value.

Objective: To observe the clinical effect of different frequencies of transcutaneous electrical acupoint stimulation in treating postpartum pelvic girdle pain and promoting postpartum rehabilitation. Methods: From January to September 2022, 300 patients with pelvic girdle pain after spontaneous delivery in a hospital in Shaanxi Province were selected and randomly divided into three groups, low frequency, high frequency, and alternating frequency, with 100 cases in each group. In addition to routine postpartum care and psychological counseling, the three groups received transcutaneous electrical acupoint stimulation at low-frequency (2 Hz,) high-frequency (100 Hz), and alternating frequency (2/100 Hz), respectively. The differences in initial pain, pain scores before and after treatment, satisfaction with analgesic effect, and postpartum rehabilitation effect were evaluated among the three groups of patients. Results: There was a significant correlation between maternal age and postpartum pelvic girdle pain (P < 0.001), but no correlation was observed between newborn birth weight and postpartum pelvic girdle pain (P > 0.05). After 1d/2d of treatment, the pain scores and rehabilitation effect of patients in the alternating-frequency group and low-frequency group were significantly better than those in the high-frequency group, and the postpartum curative effect of patients in the alternating-frequency group was the best, followed by the low-frequency group, and the high-frequency group; the differences were statistically significant (P < 0.001). Among the three groups, the alternating-frequency group had the highest satisfaction with the analgesic effect and the highest rate of selecting the same analgesic regimen the next time; the differences were statistically significant (P < 0.001). Conclusion: Transcutaneous electrical acupoint stimulation at different frequencies is safe and effective in treating postpartum pelvic girdle pain and beneficial to postpartum rehabilitation. Sparse-dense wave stimulation is effective in treating postpartum pelvic girdle pain. It has the best effect in promoting postpartum rehabilitation and the highest patient satisfaction. Therefore, its application in clinical practice is highly recommended.

Objective: To analyze the effect of Internet+ nursing practice to promote exclusive breastfeeding. Methods: 60 new mothers were selected from our hospital between February 2021 and February 2022, randomly divided into two groups, the control group and the observation group. Conventional care was given to the control group and the Internet+ care was given to the observation group. The healing of perineal wounds, breastfeeding rate as well as the nursing satisfaction of both groups were compared with each other. Results: The perineal wound healing rate was 100.00% in the observation group and 83.33% in the control group, the healing rate was higher in the observation group (P < 0.05). 80.00%, with higher nursing satisfaction in the observation group (P < 0.05). Conclusion: Internet+ nursing guidance during the perinatal care of mothers can improve the success rate of breastfeeding and achieve higher nursing satisfaction.

目的 探讨妇产科住院医师规范化培训中应用模拟医学教学法(SBME)联合多媒体教学的临床效果.方法 选取300例妇产科住院医师作为培训对象,根据培训方法不同分为对照组与观察组,各150例,均采用多媒体教学,观察组在以上基础上给予SBME,共培训4周.评价两组临床能力与综合素质的变化.结果 培训后两组理论考核评分、技能操作评分及综合素质评分均提高(P<0.05),且观察组提高程度高于对照组(P<0.05).结论 SBME联合多媒体教学应用于妇产科住院医师培训中,有利于培养住院医师的临床能力及综合素质,能有效提高妇产科规范化培训效果.

OBJECTIVE:To explore the clinical effects of aspirin combined with low-molecular-weight heparin (LMWH) in the treatment of patients with severe preeclampsia and the combination's influence on pregnancy outcomes.METHODS:From October 2018 to June 2020, 104 patients with severe preeclampsia who underwent treatment in our hospital were recruited as the study cohort and divided into two groups according to different treatment scheme each patient underwent. In the research group (RG), the 54 patients were administered aspirin combined with LMWH, and the other 50 patients in the control group (CG) were administered routine treatment. The total effective rates were compared between the two groups. The blood pressure, coagulation function, hemorheology, and renal function indexes were compared before and after the therapy. The Apgar scores of the newborns and the incidences of adverse pregnancy outcomes were measured at 1 and 5 minutes after the births.RESULTS:After the therapy, the systolic blood pressure (SBP) and the diastolic blood pressure (DBP) in the RG were lower than they were in the CG. The PT and APTT in the RG were significantly higher than they were in the CG, and the FIB and D-D were significantly lower than they were in the CG. After the treatment, the hematocrit, the erythrocyte sedimentation rate, and the plasma viscosity in the RG were significantly lower than they were in the CG. The 24 h UP, BUN, UA, and Scr levels in the RG were significantly lower than they were in the CG. The Apgar scores of the newborns in the RG were significantly higher than they were in the CG at 1 min and 5 min after the births. After the therapy, the incidence of adverse pregnancy outcomes in the RG was significantly lower than it was in the CG, and the total effective rate in the RG was significantly higher than it was in the CG.CONCLUSION:Aspirin combined with LMWH can effectively improve the clinical efficacy, the coagulation function, the renal function, and the blood pressure levels, and the combination can reduce adverse pregnancy outcomes in severe preeclampsia patients.

目的 探讨医护一体化工作模式在产科急危重症护理中的应用效果.方法 选取2018年6月至2020年6月我院产科收治的300例急危重症患者为研究对象,按照不同护理方法将其分为观察组和对照组,各150例.对照组给予常规护理干预,观察组给予医护一体化工作模式干预.比较两组患者的护理质量、抢救治疗相关指标、生活质量评分.结果 观察组患者的基础护理、健康教育、危重护理及护理文书质量评分均高于对照组(P<0.05).观察组患者的抢救治疗时长、开始下床活动时间、住院时间均短于对照组(P<0.05).干预后,两组的SF-36量表各项评分均升高,且观察组高于对照组(P<0.05).结论 医护一体化工作模式在产科急危重症护理中的应用效果显著,能够改善患者的护理质量和生活质量.

BackgroundGestational diabetes mellitus (GDM) is increasingly common in pregnancy. This study's purpose was to identify the expression of XIST and manifest the potential mechanism of XIST in GDM.MethodsNinety-three patients with GDM and 93 normal pregnant women were included in this investigation. qRT-PCR was conducted to evaluate the expression of miR-497-5p and XIST and the relationship between XIST and fasting blood glucose (FBG) was explored by Pearson assay. The clinical diagnosis of XIST on GDM patients was validated by the receiver operator characteristic (ROC) curve. Cell counting kit-8 (CCK-8) was applied to elucidate cell viability. Luciferase reporter assay was performed to document the relationship among XIST, miR-497-5p, and FOXO1.ResultsThe expression of XIST was increased in GDM patients and HTR-8/SVneo cell models caused by high glucose (HG). The expression of XIST was associated with the FBG levels and appeared to be a feasible indicator in discriminating GDM patients. The expression of miR-497-5p was prominently reduced in GDM patients and cell models. Inhibition of XIST might alleviate the adverse function of HG on cell viability via sponging miR-497-5p. FOXO1 was proved to be a downstream target gene of miR-497-5p.ConclusionsOverexpression of XIST and downregulation of miR-497-5p were indicated in this publication. XIST might serve as a promising diagnostic marker for GDM patients. XIST/miR-497-5p/FOXO1 axis played a critical role in the regulation of trophoblast cells.

目的 探讨黄芪多糖对放射治疗和化学治疗宫颈癌患者免疫功能和不良反应的影响.方法 选择2016年5月至2018年5月陕西省人民医院收治的130例宫颈癌患者为研究对象,根据随机数表法均分为对照组与观察组,每组65例.2组患者均给予相同的化学治疗和放射治疗方案,在此基础上,观察组患者给予黄芪多糖治疗.分别于治疗前及治疗后检测2组患者CD3+、CD4+、CD8+、CD4+/CD8+、调节性T细胞(Treg)、髓源性抑制细胞(MDSC)、白细胞计数(WBC)、红细胞计数(RBC)、血小板计数(BPC)水平.治疗后评估2组患者临床疗效,并观察2组患者不良反应发生情况.结果 观察组和对照组患者治疗总有效率分别为64.62％ (42/65)、44.62％ (29/65),观察组患者治疗总有效率高于对照组(Z =5.245,P＜0.05).治疗前2组患者CD3+、CD4+、CD8+、CD4 +/CD8+、Treg、MDSC水平比较差异无统计学意义(P＞0.05);对照组患者治疗后Treg、MDSC水平低于治疗前(P＜0.05),对照组患者治疗前后CD3+、CD4+、CD8+、CD4 +/CD8+水平比较差异无统计学意义(P＞0.05);与治疗前比较,观察组患者治疗后CD3+、CD4+、CI4 +/CD8+水平升高,CD8+、Treg、MDSC水平降低(P＜0.05);治疗后,观察组患者CD3+、CD4+、CD4 +/CD8+水平高于对照组,CD8+、Treg、MDSC水平低于对照组(P＜0.05).治疗前2组患者WBC、RBC、BPC比较差异无统计学意义(P＞0.05),2组患者治疗后WBC、RBC、BPC低于治疗前(P＜0.05);治疗后,观察组患者WBC、RBC、BPC多于对照组(P＜0.05).观察组患者白细胞减少、血小板减少、骨髓抑制、肝功能异常、肾功能异常及胃肠道反应发生率均低于对照组(P＜0.05).结论 黄芪多糖可显著改善放射治疗和化学治疗宫颈癌患者的免疫功能,减少不良反应,提高治疗效果.

珂立苏是一种从健康新生小牛肺中分离提取的天然肺表面活性物质ps制剂,它能降低肺泡气液界面表面张力,使肺泡扩张和稳定,改善肺的顺应性,促进气体交换,减轻NRDS患儿症状,降低给氧浓度,缩短人工呼吸机的应用时间,降低病死率,我科用珂立苏治疗的NRDS的患儿取得明显疗效,现报道如下. 资料与方法 1.一般资料.