Results of an experimental toxicological study on anti-tubercular drugs Isoniazid and Rifampicin at their combined administration are reported . It made it possible to establish antagonistic effect of rifampicin to lethal doses of isoniazid and to elicit a decrease in toxicity of the of isoniazid and rifampicin combination when administrated at the evening time..

The article presents the results of experimental biological modelling of single and subacute introduction of Ciprofloxacin to the rabbits. State of an organism of animals was estimated by biochemical, hematological, hemostatic and morphologic indices. Introduction of preparation samples was intravenous, according to the Instruction of medical use. Main result of the experiments is determination of toxic effects that are typical for fluorinequinolone and developed on the background of multiple introduction of preparation in the doses higher than therapeutic.

The article presents the results of experimental biological modelling of single and subacute introduction of Ciprofloxacin to the rabbits. State of an organism of animals was estimated by biochemical, hematological, hemostatic and morphologic indices. Introduction of preparation samples was intravenous, according to the Instruction of medical use. Main result of the experiments is determination of toxic effects that are typical for fluorinequinolone and developed on the background of multiple introduction of preparation in the doses higher than therapeutic.

The article presents the materials of experimental study of Terizidone in combination with pyridoxine hydrochloride in conditions of single peroral influence on animals in different doses with a view to reveal response of an organism for using in the evaluation of general toxic action of an advanced antituberculous preparation.

An. experimental research, of infusion solution of Metronidazole at single and repeated administration to the animals (rabbits) was carried out. Distinct signs of toxicity of the researched pattern. in the dose that is ten times higher than maximum, daily dose were determined. It concerns statistically reliably changed hematologic, biochemical and. electrophysiological indices that are typical for Metronidazole in particular. Only the fact of increase of content of creatinine in blood serum in 2 weeks after the administration, of the preparation should be registered but in this case it can be the signal to stop further administration, of the preparation.

The article presents the materials of experimental study of Terizidone preparation in conditions of single peroral influence on animals in different doses with a view to reveal response of an organism for using in the evaluation of general toxic action of an advanced antituberculous preparation.

The article presents the materials of experimental study of Terizidone in combination with pyridoxine hydrochloride in conditions of single peroral influence on animals in different doses with a view to reveal response of an organism for using in the evaluation of general toxic action of an advanced antituberculous preparation.

An. experimental research, of infusion solution of Metronidazole at single and repeated administration to the animals (rabbits) was carried out. Distinct signs of toxicity of the researched pattern. in the dose that is ten times higher than maximum, daily dose were determined. It concerns statistically reliably changed hematologic, biochemical and. electrophysiological indices that are typical for Metronidazole in particular. Only the fact of increase of content of creatinine in blood serum in 2 weeks after the administration, of the preparation should be registered but in this case it can be the signal to stop further administration, of the preparation.

We carried out an experimental research of infusion solution of potassium, and magnesium asparaginate at the single and. repeated introduction to the animals (rabbits). We determined the fact of the demonstration of toxic features of the preparation at single introduction in shock doze (243,5 mg/kg): increase of hepatic enzymes activity and. of some other biochemical indices, decrease of cardiac beat rhythm and. appearance of plural extrasystoles.

We carried out an experimental research of infusion solution of potassium, and magnesium asparaginate at the single and. repeated introduction to the animals (rabbits). We determined the fact of the demonstration of toxic features of the preparation at single introduction in shock doze (243,5 mg/kg): increase of hepatic enzymes activity and. of some other biochemical indices, decrease of cardiac beat rhythm and. appearance of plural extrasystoles.

The article presents the data on the appearance of significant changes in the condition of animals' organisms during quarterly daily intragastric administration, of polyvitaminic preparation of compound composition in a dose of 600 mg/kg and also on the lack of the changes at the administration in recommended, therapeutic dose. The preparation is not mutagenic.

The article presents the results of experimental study of the biological model of single intragastric introduction of multivitamin set in different doses, which signify the response of the organism in the form of changes in a number of indices of animals condition.