The article presents the results of experimental toxicological studies on justification of ademetionine supportive therapy in order to prevent toxic liver damage when using antituberculosis drugs.
The article presents the materials of experimental study of Terizidone in combination with pyridoxine hydrochloride in conditions of single peroral influence on animals in different doses with a view to reveal response of an organism for using in the evaluation of general toxic action of an advanced antituberculous preparation.
The article presents the materials of experimental study of Terizidone preparation in conditions of single peroral influence on animals in different doses with a view to reveal response of an organism for using in the evaluation of general toxic action of an advanced antituberculous preparation.
The article presents the materials of experimental study of Terizidone in combination with pyridoxine hydrochloride in conditions of single peroral influence on animals in different doses with a view to reveal response of an organism for using in the evaluation of general toxic action of an advanced antituberculous preparation.
Toxicological research of combined antitubercular preparation. «Protub-2®» that contains a pyridoxine hydrochloride (vitamin B). It was established, that introduction of pyridoxine hydrochloride in the structure of preparation «Protub-2®» allowed to reduce the majority of toxic effects caused by isoniazid and rifampicin that are parts of studied, preparation.
The information regarding clinical and experimental data about toxic action of antituberculosis drugs produces on human's and animal's organism are presented in article.
Last time in modern antitubercular preparations began to include pyridoxine hydrochloride. Therefore there was a need in preclinical research of the given medicinal forms in comparative aspect. With this purpose we has been lead comparative preclinical research of two medicinal forms: «Protubetam» and «Protubetam Â6» on biochemical parameters.
