The big interest represents studying of an is functional-metabolic condition of uniform elements of blood at toxic conditions as they objectively enough reflect the general status of an organism and represent itself as the progressing mechanism endogenous intoxication. In the model of acute peritonitis found that the use of the drug with antioxidant activity etoksidola improves lipid cell membranes as cardiomyocytes, and red blood cells and platelets. Normalization of the lipid spectrum cytomembranes leads to improved functional status of red blood cells and platelets, which leads to improvement of the rheological properties of blood microcirculation processes, thus providing additional treatment options for toxic cardiomyopathy. The revealed essential updatings of a fatty metabolism in fabric structures of a myocardium at endogenous the intoxications connected with infringement of the basic electrophysiological functions of cages of heart, certainly, are one of the major pathogenetic factors of formation of toxic defeat of heart.

This paper discusses some of the mechanisms of myocardial damage during the development of endogenous intoxication, peritoneal origin. The basis of the experimental work were studies conducted on 10 adult mongrel adult dogs that simulated fecal peritonitis. Received laboratory-diagnostic indicators showed the development of endogenous intoxication. It is shown that in case of peritonitis activated processes of lipid peroxidation products, which are endotoxins. Increase in the serum content of lipid peroxidation products, and increase the activity of enzymes detoxify reactive oxygen species are nonspecific tests endotoxemia. It is shown that the breakdown products of lipids (aldehydes, dialdehydes, epoxides) have a damaging effect on the different structures of heart cells: proteins, nucleic acids, etc. When endotoxicosis myocardium becomes the target of secondary damage to the complex morphological and functional changes in the body.