1,2,3-triazole attracts attention because of the ability opening ring to form α-diazoimin and intramolecular rearrangements with the formation of various heterocyclic systems. Previously the interaction of the 1H-1,2,3-triazole-5-ol sodium salt with amine hydrochloride leading to the formation of isomeric 1,2,3-triazoles was studied. In this paper we present a research of the interaction of 4-acetyl-1,2,3-triazole-5-ol sodium salt with hydrazine derivatives. As result 5-methyl-1,2,3-triazol-4-phenylcarboxamide-phenylamide and bis-5,5’-dimethyl-[1,1’]bi[[1,2,3]triazolyl]-4,4’-dicarboxylic acid derivatives were synthesized.

A series of 1,2,3-triazole derivatives have been synthesized and their cytotoxic effect on glioma cells have been studied. A new method for the synthesis of 1-R-5-methyl-1 H -[1,2,3]triazole-4-carboxamides via transformation of sodium 4-acetyl-1-phenyl-1 H -[1,2,3]triazolate under the action of primary amine hydrochlorides is proposed.

A series of 1,2,3-triazole derivatives was prepared and their cytotoxic actions on glioma cell cultures were studied. Amethod for the synthesis of 1-R-5-methyl- (1) H-[1,2,3]triazole-4-carboxamides is presented, based on transformation of 4-acetyl-1-phenyl- (1) H-[1,2,3]-triazolate sodium using primary amine hydrochlorides.