The article considers application of complex immunoglobulin preparation in comprehensive treatment of acute obstructive bronchitis in children of infancy age with purpose to develop intestinal local immunity. The complex immunoglobulin preparation is a pharmaceutical for enteric application derived from donor blood. In contrast, with normal human immunoglobulin, the preparation includes immunoglobulines of three classes (50% IgG, 25% IgM, 25% IgA) and is characterized by increased content of antibodies to different pathogenic and opportunistic agents.

In the article a possibility of using the complex immunologic preparation (CIP) for infants in arms when they fell ill keen bronchitis to create local immunity in bowels. It is made of donor blood and includes 50 % IgG, 25 % IgA, 25 % lgM. It contains a high level of antibodies for intestinal bacteria and other microorganism.

In 1997-2000 period has been observed 94 children (54 boys and 40 girls), were illing bronchial asthma, been intested Mycoplasma pneumoniae. In complex of the treatment of 74 children after period was used antibiotics, pre-scripted in differenlschcmes: (azitromycin one five days course, one five days with immunocorrectors, two five days course and ten days courses with intervalof 10 days between them; erythromicinin standart course and treatment; roxithromicinone 10 day course with immunocorrector and 22 children received antibiotics others groups (penicil-lining rows or aminoglicozides). Calamnesis surl'cillance seemded to be a best results were received after using so two 10 day course azitromycin and courses azitromycin or roxitromycin with the immunocorrectors.

As many as 21 children suffering from infectious endocarditis (IE) were examined for the clinical and morphological picture of the disease. The patients' age ranged from 2 to 15 years. In 15 children, IE developed in association with different congenital diseases; in one patient, in the presence of rheumatic heart disease, and in 5 patients, in unaffected heart valves. The sectional material was examined in 19 cases whereas the operational material in 2 cases. Analysis of the data obtained has shown that early diagnosis of IE (primary and secondary) may not infrequently be fairly difficult, which is likely to result in the late administration of antibacterial therapy. In addition to the involvement of the valvular apparatus of the heart, the majority of the patients demonstrated the signs of focal myocarditis and postmyocarditic cardiosclerosis, which is one of the causes of the development of refractory heart insufficiency. IE children mostly die from heart insufficiency and thromboembolism.

The immune status was estimated comprehensively and indicators of the level I and II tests of T and B components of the immunity system were defined in 120 children with thymomegaly (group I), in 30 children with unenlarged thymus (group II), and in 40 practically healthy children with unestablished size of the thymus, with a favourable family and personal disease history, who had never fallen ill before the immunologic examination (group III). The children belonging to groups I and II were examined at the acute disease period, during convalescence and clinical wellbeing. It has been established that during the acute bronchopulmonary disease, the group I and II children manifested the same regularities of immune response to the action of an antigenic stimulus. However, at the period of the clinical wellbeing, the group II children showed a higher lymphocytosis, impairment of the ratio of the T lymphocyte subpopulations, an increase of the EAC--RFC count, and a decline of the level of serum thymic factor. It is assumed that in the group I children, the system of immunologic defence is of weak safety within the first 3 years of life.

Ultrasound research methods were applied in 32 children with the clinical signs of infectious endocarditis (IE). The patients' age varied from 3 to 16 years. In 5 patients, IE turned out primary in the intact valves whereas in 27 patients, it superadded on different congenital heart disease. In 10 patients, IE had developed before surgical correction of the diseases and in 17, within different times after operation. The direct and indirect echo-signs of IE were delineated. The direct echo-signs included vegetations which were discovered in 22 out of the 32 patients. The indirect echo-signs included the signs of regurgitation in the externally unchanged or minimally changed cusps of the valves and blood drop at the level of the ventricles in connection with the defect reshunting in the interventricular septum. The data obtained are in good agreement with the clinical picture, surgical and morbid anatomy data.

The clinico-morphological alterations were analyzed in 6 deceased children with congenital carditis. Morbid anatomy examination demonstrated that all the patients had marked alterations on the part of the heart while 4 cases manifested associated injuries to the heart and to the brain. In half of the children, the disease had run its course in combination with immunodeficiency. In 2 cases, there was an etiological relationship between congenital carditis and intrauterine enterovirus Coxsackie infection which had been uneventful in pregnant mothers. In congenital carditis, the prognosis may be often unfavourable.