The article presents data concerning structural changes of the intercellular substance in the adenohypophysis, thymus, adrenal glands, kidneys and aggregate lymphoid nodules of the ileum during experimental burn disease in rats and its treatment by means of combined hyperosmolar solutions. Hyperosmolar solutions administered intravenously were found to protect the vascular wall, and Lactoprotein-S in this situation causes membranoplastic transformation of the intercellular substance in the viscera.

Summary: on the experimental model of the local thermal bum we investigated reactive changes of the pituitary-adrenal system in rats. In burned rat installed nonspecific destructive changes parenchymal and stromal elements of the adenohypophysis and adrenal glands. Changes characterized three phases of the development of organ dysfunction: 1-3 days - microcirculatory disorders and degenerative changes of initiation; 7-14 day - the progression of degenerative changes and stabilization; 21- 30 day - activation of regenerative processes and hemodynamics. In the pathogenesis of burn injury leading place has regional hemodynamic changes. Microcirculation disturbance cause ischemic cell injury, development of dystrophic disorders and in critical hypoxia caused tissue necrosis.