目的 观察山楂消脂胶囊治疗原发性高血压并颈动脉硬化(痰瘀互结证)的临床疗效.方法 将79例符合标准的患者随机分为观察组39例和对照组40例,对照组给予常规药物治疗,观察组在对照组基础上加服山楂消脂胶囊,疗程均为6个月.观察两组治疗前后中医证候疗效、颈动脉内膜中层厚度(IMT)、臂踝脉搏波传导速度(baPWV)和踝臂指数(ABI)、同型半胱氨酸(HCY)和脂蛋白相关磷脂酶A2(Lp-PLA2)及安全性指标变化情况.结果 中医证候疗效方面,观察组总有效率87.18％,优于对照组67.50％(P<0.05);治疗后,两组baPWV、ABI和HCY均有改善(P<0.01),观察组均优于对照组(P<0.01);对照组IMT、Lp-PLA2改善不明显(P>0.05),观察组有改善(P<0.01),优于对照组(P<0.05).安全性评价方面,两组肝肾功能及肌酸激酶均未出现明显异常.结论 山楂消脂胶囊对原发性高血压并颈动脉硬化(痰瘀互结证)的中医证候及颈动脉硬化相关指标有显著疗效,使用安全.

目的 比较观察桃仁四物汤配方颗粒与传统汤剂治疗闭合性桡骨远端骨折早期气滞血瘀证患者的临床疗效.方法 将120例符合纳入标准的患者随机分为传统汤剂试验组(40例)、配方颗粒试验组(40例)和对照组(40例),对照组在手法复位夹板外固定常规治疗基础上给予注射用七叶皂苷钠治疗,传统汤剂组与配方颗粒组分别在对照组基础上加用桃仁四物汤传统汤剂与配方颗粒剂治疗,疗程均为7天.观察比较3组患者治疗前后的中医证候疗效、疼痛、压痛评分及肿胀度.结果 治疗后,在中医证候疗效方面,传统汤剂组有效率为92.5％,配方颗粒组为95.0％,对照组为77.5％,两两比较,配方颗粒组和传统汤剂组在中医证候疗效改善方面均优于对照组;在疼痛、压痛评分及肿胀度方面,3组均有改善,配方颗粒组与传统汤剂组均优于对照组.而配方颗粒组与传统汤剂组比较,治疗前后各项指标差异无统计学意义.结论 桃仁四物汤配方颗粒与传统汤剂对闭合性桡骨远端骨折早期肿痛的临床疗效相似,可在临床推广应用.

目的 观察苓桂术甘汤配方颗粒加味治疗慢性射血分数降低心力衰竭属阳虚水泛证患者的临床疗效.方法 将77例符合纳入标准的患者随机分为治疗组39例和对照组38例,对照组给予常规西药治疗,治疗组在对照组基础上加用苓桂术甘汤配方颗粒加味治疗,疗程均为4周.观察2组患者治疗前后的中医证候积分、心功能分级比较、6分钟步行试验(6-MWT)、左室射血分数(LVEF)及血浆N末端B型利钠肽原(NT-proBNP)水平.结果 治疗后,在中医证候疗效方面,治疗组总有效率为87.18％,优于对照组的71.05％(P<0.05);在心功能分级比较方面,治疗组总有效率为92.31％,优于对照组的78.95％(P<0.05);2组的6 min步行距离、LVEF、NT-proBNP均有改善,且治疗组均优于对照组(P<0.05).结论 苓桂术甘汤配方颗粒加味可有效缓解慢性射血分数降低心力衰竭属阳虚水泛证患者的中医证候,改善心功能,提高LVEF,降低NT-proBNP水平,值得临床推广应用.

Objective: To observe the clinical effect of dispensing granules of Yiqi Qiangxin prescription combined with western medicine for patients with chronic heart failure (CHF) of water diffusion due to yang deficiency type. Methods:Divided 80 cases of CHF patients who met the inclusion criteria into the observation group and the control group randomly, 40 cases in each group. The control group was treated with routine western medicine, while the observation group additionally received dispensing granules of Yiqi Qiangxin prescription for treatment. Courses of treatment in both groups were four weeks. Observed the changes of Chinese medicine symptom scores of patients before and after treatment, 6-minute walking distance, scores of quality of life and changes of N-terminal pro-B-type natriuretic peptide (NT-pro BNP) in plasma in the two groups. Results: After treatment, the total effective rate was 92.50％ in the observation group and 75.00％ in the control group, difference being significant (P＜ 0.05). The observation group was superior to the control group in improving palpitation, asthma, edema of face and limbs, oliguria, chest tightness, and aversion to cold and cold extremities (P＜ 0.05, P＜ 0.01). There were no significant differences being found in tiredness, fatigue, dysphoria and abdominal distension (P＞0.05). 6-minute walking distance and quality of life in the two groups were both improved (P＜ 0.05), and the improvement of the previous two indexes in the observation group was better than that in the control group (P＜ 0.05). Levels of NT-pro BNP in the two groups were both decreased when compared with those before treatment (P＜ 0.05), and the level of NT-pro BNP in the observation group was lower than that in the control group (P＜ 0.05). Conclusion:The therapy of dispensing granules of Yiqi Qiangxin prescription combined with western medicine for CHF of water diffusion due to yang deficiency type has significant effects in improving clinical symptoms, increasing the 6-minute walking distance, reducing level of NT-pro BNP, and improving quality of life of patients. The dispensing granules are easy to take, have good patient compliance and are suitable for long-term drug treatment of patients with chronic diseases. It is an ideal dosage form for exerting the advantages of Chinese medicine in the treatment of CHF.

目的:探讨佛山市中医院三水医院(以下简称"我院")药品不良反应(adverse drug reaction,ADR)发生特点与规律,为临床安全用药提供参考.方法:收集2015—2017年我院监测与上报的ADR报告268例,对患者的性别与年龄、引发严重的ADR的药品及相关信息、引发ADR的药物种类分布、引发ADR病例数排序居前10位的药品、ADR累及器官和(或)系统及临床表现、引发ADR的给药途径及ADR的科室分布等进行统计分析.结果:268例ADR中,严重的ADR有28例(占10.45％);涉及药品120种,抗感染药引发ADR例次数排序居首位(80例次,占总例次数283例次的28.27％),其次为中枢神经系统用药(79例次,占总例次数283例次的27.92％);引发ADR例次数排序居前3位的药品为复方骨肽注射液、注射用七叶皂苷钠和注射用头孢他啶;ADR主要累及皮肤及其附件(224例次,占总例次数459例次的48.80％);引发ADR的给药途径以静脉滴注/注射为主(197例次,占总例次数276例次的71.38％);门急诊上报ADR病例数最多(71例).结论:临床应重视和加强ADR监测,以减少或避免ADR的发生,保障患者用药安全.

Objective To observe the clinical efficacy of Xiaozhi Yanggan tea on mixed hyperlipidemia with Phlegm-damp obstruction type. Methods According to the inclusion criteria,a total of 80 cases of mixed hy-perlipidemia were randomly divided into treatment group and control group,with 40 cases in each group. All pa-tients were treated with Atorvastatin Calcium capsule and those in the treatment group were additionally treated with Xiaozhi Yanggan tea,for a total of 12 weeks. Two groups of patients were observed for the integral of Tradition-al Chinese Medicine(TCM)syndrome,the change of blood lipids and safety. Results After treatment,the total effective rate for TCM syndrome was 95.00% in treatment group,which was better than 75.00% in control group (P < 0. 05). TC,LDL-C and non-HDL-C levels in the treatment group were lower than those in the control group (P < 0. 05). HDL-C was higher than that in the control group(P < 0.05). TG in the treatment group were lower than that before(P < 0. 05),while it was not obvious in the control group(P > 0.05). No obvious abnormality in hepatorenal function and creatine kinase in the two groups after treatment. Conclusion Xiaozhi Yanggan tea was an effective and safe therapy for mixed hyperlipidemia with Phlegm-damp obstruction type.

Objective:To investigate the characteristics and regularity of adverse drug reactions(ADRs)in a hospital and provide a basis for rational drug use in clinic.Methods:A total of 211 cases of ADRs reported in this hospital from 2013 to 2014 were analyzed statistically in respect of the gender and age of patients,serious ADRs,kinds of drugs involved,route of administration,organs or systems involved in ADR as well as the clini-cal manifestation of ADRs.Results:Of the 211 cases of ADRs,15 were serious(7.11%). A total of 76 kinds of drugs were involved,of which ADRs,induced by anti-infective agents was prominent(115 cases,54.50%),sec-onded with Chinese patent medicines(44 cases,20.85%). There were 182 cases(86.26%)of ADRs were caused by intravenous drip. The most common clinical manifestations included the lesions of skin and its ap-pendages(143 cases,67.77%).Conclusion:The monitoring on anti-infective agents and intravenous administra-tion as well as training and report of monitoring on serious ADRs should be strengthened.

目的:探讨中药制剂质量控制研究的发展趋势.方法:查阅近年有关中药制剂质量控制研究的相关文献,对其研究现状进行评述,总结与归纳中药制剂质量控制的新技术和新方法.结果:目前以单一化学指标成分为中心的质量控制模式已不适合中药现代化发展要求,而以多指标成分和生物活性测定的质量控制模式成为其新的发展趋势.结论:多指标成分和生物活性测定的质量控制模式能较为真实地反映中药制剂的“内在”“综合”质量,能更好地确保民众用药安全、有效.