本文报告采用《国际疾病分类第10版》(ICD-10)中的精神疾病分类方法,对需终极鉴定新兵107例进行精神疾病终极鉴定.本次终极鉴定结果为,不适宜继续服现役79例(73.8％),返回部队继续服现役28例(26.2％).新兵征、接双方对精神疾病终极鉴定结论无异议105例(98.1％),有异议2例(1.9％).首次医学诊断的新兵精神疾病构成比从高到低依次为适应障碍、分离/转换障碍、心境障碍、精神分裂症/分裂样精神障碍、精神发育迟滞、人格障碍、应激相关障碍、躯体形式障碍、强迫障碍、焦虑症;终极鉴定依次为适应障碍、分离/转换障碍、心境障碍、精神分裂症/分裂样精神障碍、焦虑症、精神发育迟滞、应激相关障碍、强迫障碍.新兵精神障碍主要表现形式为适应障碍、分离/转换障碍、心境障碍、精神分裂症/分裂样精神障碍.新兵入伍45天内终极鉴定37例(34.6％),46～90天51例(47.6％),91～180天19例(17.8％).为了进一步做好新兵精神疾病终极鉴定,有必要对新兵精神疾病终极鉴定标准和程序进行规范和量化.

目的 探讨适应性团体心理训练对新兵心理健康和情绪的影响.方法 采用整群随机抽样的方法,抽取某部2012年入伍新兵180人为研究对象,按照建制连分为实验组(89人)和对照组(91人).对实验组进行每周1次,每次90～ 120 min,共9次的团体心理训练,对照组进行日常教育训练.采用症状自评量表(symptom checklist 90,SCL-90),焦虑自评量表(self-rating anxiety scale,SAS),抑郁自评量表(self-rating depression scale,SDS),特质焦虑问卷(trait anxiety inventory,TAI),比较两组被试干预前后心理健康和情绪的差异.结果 ①与训练前比较,实验组新兵SCL-90得分除躯体化外,其余因子分显著降低(P ＜0.05,P＜0.01);而对照组新兵除躯体化因子分显著降低外(P＜0.05),其余因子得分差异无统计学意义(P＞0.05).②与训练前比较,实验组新兵SAS、SDS、TAI得分均显著降低(P＜0.05,P＜0.01);对照组新兵SDS得分显著提高(P＜0.05).结论 适应性团体心理训练能提高新兵的心理健康水平,帮助新兵缓解焦虑、抑郁情绪.

目的 探讨由低海拔环境急进高海拔环境遂行军事运输任务对汽车兵心理应激与心理弹性的影响,为高原汽车兵心理应激干预提供科学依据.方法 以由低海拔环境急进高海拔环境执行军事运输任务的川藏线某部汽车兵126人为研究对象,选取症状自评量表(SCL-90)、状态-特质焦虑问卷(STAI)、特质应对方式问卷(TCSQ)、艾森克个性问卷(EPQ)、心理弹性量表(CD-RISC)作为心理应激及复原力指标,在执行任务前3d(营区,海拔600 m)、执行任务后第2d(藏区,海拔4100 m)进行团体心理测试.结果 (1)执行任务后,汽车兵SCL-90总均分(1.92±0.67)及各因子分均显著高于执行任务前和常住高原汽车兵(P＜0.05或P＜0.01);CD-RISC中坚韧性、力量、乐观因子分及TCSQ中积极应对因子分均显著低于执行任务前(P＜0.05或P＜0.01);TCSQ中消极应对因子分及STAI中状态焦虑、特质焦虑因子分均显著高于执行任务前(P＜0.05或P＜0.01).(2)执行任务后汽车兵SCL-90总分及STAI因子分与消极应对、稳定性及精神质因子分呈显著正相关(r=0.214 ～0.715,P＜0.01),与积极应对、内外向、掩饰性、坚韧性、乐观性、力量性因子分呈显著负相关(r=-0.169～-0.599,P＜0.01).回归分析结果显示,对执行任务后汽车兵SCL-90总分有显著影响的因素依次为:消极应对、特质焦虑、乐观性、状态焦虑、稳定性、坚韧性、精神质,7个变量的决定系数R2=0.65.结论 急进高海拔环境执行军事运输任务后,汽车兵心理健康水平降低;人格特质、应对方式和心理弹性是影响汽车兵心理应激和心理健康的重要中介调节因素.

目的 探讨综合性心理行为训练对集训期新兵心理应激的干预效果,寻求调控新兵心理应激和促进心理健康的有效方法.方法 以某部集训期新兵为研究对象,随机分为干预组(216人)和对照组(220人).对照组进行常规军事训练;干预组在此基础上进行综合性心理行为训练,共2个月.采用应激反应问卷(SRQ)、状态特质焦虑问卷(STAI)、艾森克个性问卷(EPQ)、特质应对方式问卷(TCSQ)于干预前和干预第60天进行心理应激及相关因素评估.结果 (1)干预组干预前SRQ总分及各因子分与消极应对、状态焦虑、特质焦虑、神经质及精神质呈显著正相关(r=0.113 ～0.698,P均＜0.01),与内外向、掩饰性呈显著负相关(r=-0.188～-0.304,P均＜0.01);多元线性回归分析显示,影响SRQ总分的因素从大到小依次为:消极应对、神经质、状态焦虑、精神质,这4个变量的决定系数R2=0.560.(2)干预组干预第60天SRQ总分和各因子分均显著低于干预前和对照组(P＜0.05,P＜0.01);而在同一时间点上,对照组SRQ总分和各因子分前后比较,差异均无显著性(P＞0.05).结论 新兵心理应激受多因素影响,综合性心理行为训练能有效减轻新兵心理应激,促进心理健康.

Objective To provide references for the plan-making of mental intervention on new recruits through the exploration of the comprehensive psychological behavior training influences on psychological stress and health and relevant factors.Methods 436 new recruits in training period were divided into comprehensive psychological behavior training group (intervention group) and non intervention group (control group).By randomly selected 2 (intervention group,control group) × 2 (Before training and after training) matching design,the questionnaire survey was carried out using stress-reaction questionnaire (SRQ),symptom checklist 90 (SCL-90),eysenck personality questionnaire(EPQ),trait coping style questionaire(TCSQ) at the 15th day and 75th day.t-test between group and matched t-test within group and multiple stepwise regression analysis were carried out.Results (1) The SCL-90 total point of new recruits in intervention group (125.26±36.52)and control group(124.92± 34.79) before the training and the difference of SRQ and TCSQ factor scores had no statistical significance(P＞ 0.05).The difference after the comprehensive psychological behavior training had no statistical significance (P＞ 0.05) as the total points of SCL-90 of intervention group(125.63±36.74) and other factors' score were compared with before.Except for the somatization and force,the total points of SCL-90 (131.21 ± 39.98)and other factor scores of the control group were all higher than what they were in the early period of the training significantly (P＜ 0.01 or P＜0.05).In the later period of group training,from the parallel controlled study among groups we found that except for the somatization and force,the total points of SCL-90 and other factor scores of the control group are all lower than the control group (P＜0.0 or P＜0.05).(2)The total points of intervention group's SCL-90 and SRQ had significant positive correlation with negative coping and stability(r=0.313-0.698,P＜0.01) while it had negative correlation with introversion and extroversion(r=-0.293--0.207,P＜0.01) as well as dissimulation at the later period of group training,however,it did not have significant correlation with positive coping method (P＞0.05).(3) The regression analysis showed that factors significantly affected the total score of SCL-90 respectively was:SRQ total score,negative coping method,stability,introversion-extroversion and psychoticism (P＜ 0.01).Five variables'coefficient of determination R 2 =0.665,F=247.82,P＜ 0.01.Conclusion The comprehensive psychological behavior training could reduce the over psychological stress of new recruits,promote their positive coping attitude and protecting their psychological health.Coping method and personality characteristics are important mediating variable between new recruits' psychological stress and mental health.

目的 探讨野战部队新兵心理素质的特点.方法 采用军人心理素质量表(mental quality questionnaire for armymen,MQQA)、症状自评量表(symptom checklist 90,SCL-90)对2012年某野战部队2 651名新兵进行团体测评,分析新兵心理素质的特点.结果 ①新兵心理素质总分和各维度分均显著高于士兵常模(P＜0.01).②女性新兵心理素质忠诚维度分显著高于男性(P＜0.05).③新兵心理素质得分呈现随年龄的增长逐渐增高的发展趋势:＞19～25岁组在心理素质总分及各维度分上显著高于＞ 17 ～ 19岁组和16 ～ 17岁组(P＜0.01);除勇敢维度外,＞17 ～ 19岁组在心理素质总分及其他维度分上显著高于16 ～ 17岁组(P ＜0.05,P＜0.01).④新兵心理素质得分呈现随文化程度增加逐渐增高的发展趋势:专科及以上组心理素质总分及各维度分显著高于高中(中专)组(P＜0.01);除勇敢维度外,高中(中专)组在心理素质总分及各维度得分显著高于初中及以下组(P＜0.05,P＜0.01).⑤双亲家庭的新兵心理素质总分及各维度分显著高于单亲家庭(P＜0.05,P＜0.01).⑥民主型家庭新兵心理素质总分及各维度分显著高于强制型、放任型和溺爱型家庭(P＜0.05,P＜0.01);强制型家庭新兵忠诚、勇敢、自信、耐挫维度分及总分显著高于溺爱型家庭新兵(P ＜0.05,P＜0.01),勇敢、自信维度分及总分显著高于放任型家庭新兵(P＜0.05,P＜0.01);放任型家庭新兵耐挫维度分显著高于溺爱型家庭新兵(P＜0.05).⑦心理健康组新兵心理素质总分及各维度分显著高于心理不健康组(P＜0.01).结论 野战部队新兵心理素质水平整体较好,呈现性别、年龄、文化、家庭结构和教养方式等差异.

Objective To explore the mental health and its relationship with mental quality of training logistic soldiers in field.Methods Symptom Checklist 90(SCL-90) and Mental Quality Questionnaire for armymen (MQQA) were employed to evaluate the mental health and mental quality of 230 training logistic soldiers in field,and then an analysis was carried out on the characteristics of the training logistic soldiers on mental health and its relationship with mental quality.Results ①The psychological problem's ratio of training soldiers was 21.3％,and the ratio of the male(22.8％) was significantly higher than that of the female(15.2％) (x2 =8.64,P=0.00).In SCL-90,the scores of somatization (1.46 ± 0.63),hostility (1.49 ± 0.75) and psychotism (1.43 ±0.68) were all higher in training soldiers than the army norm.The factor scores of somatization (1.49 ± 0.66)and psychotism(1.46 ± 0.72) in the male training soldiers were considerably higher than those of the male soldiers norm (P ＜ 0.05),but not in the female(P ＞ 0.05).②There existed a significantly negative correlation between the factor scores of the mental quality and that of SCL-90 (P ＜ 0.05,P ＜ 0.01).③The SCL-90 scores existed clear differences in obsessive-compulsive,interpersonal sensitivity,depression,hostility and paranoid ideation among different mental quality groups (P ＜ 0.05).Conclusion The mental health of training logistic soldiers is poor.The mental health is closely related to the mental quality.Therefore,the mental health education and mental quality training should be strengthened to the training logistic soldiers.

OBJECTIVE This study discusses the mental health and related factors of Lebanon peacekeeping medical force,and to provide basis for the psychological health education.METHODS We implemented a series of centralized tests to 54Lebanon peacekeeping medical soldiers with related factor questionnaire,Symptom Checklist (SCL-90),Self-consistency and Congruence Survey (SCCS),State-Trait anxiety Inventory (STAI),and Coping Style.RESULTS (1) The SCL-90 total score and somatization,compulsion,interpersonal sensitivity,anxiety,hostility,psychotic factor scores of Lebanon peacekeeping medical force were significantly lower than the norm Chinese soldiers (P﹤0.01 or P﹤0.05).There was no significant difference (P﹥0.05) in SCCS total score compared with the norm Chinese soldiers,but the disharmony of self-inconsistency,self-agility and self-stiffness factor scores were significantly lower than norm Chinese soldiers (P﹤0.01 or P﹤0.05).And there was no significant difference in state anxiety,trait anxiety scores (P﹥0.05).(2) The SCL-90 total score of peacekeeping medical force and factor scores were significantly positively correlated to immature and mixed response (selfblame,fantasy,escapism,rationalization),but not significantly correlated to the recourse factor score; except psychosis factor,the SCL-90 total score and other scores were significantly negatively correlated to problem-solving factor score.Except somatization,SCL-90 total score and other factor scores were significantly positively correlated to SCCS total score,disharmony of self-inconsistency; SCL-90 total score and factor scores were significantly positively correlated to state-trait factor scores.(3) Multiple linear stepwise regression indicated that the main influencing factors of SCL-90 total score were:selfblame,escapism,state anxiety,SCCS total score.The determination coefficient of the above four variables was R~2=0.43,after checking the equation,F=15.11,P=0.00.CONCLUSION In general,the medical force of peacekeeping in Lebanon is in good mental status; reducing immature coping styles and keeping an appropriate controllable level of anxiety,are beneficial to improve the self-consistency and congruence degree and the level of mental health of peacekeepers.

Objective To detect the changes of brain-derived neurotrophic factor(BDNF)in the development and treatment of depression,and to explore its feasibility in the diagnosis and assess of curative effects on depression.Methods Among the 42 patients who were clinically diagnosed depression,13 ones were severe and 15 ones were moderate.They received the conventional antidepressant treatment for 6 w.Before and after the treatment,the serum BDNF levels were measured by the method of enzyme linked immunosorbent assay(ELISA),and were compared with those of 88 people without depression(control group).Results Compared with the control group,the serum BDNF level of patients with moderate and severe depression significantly decreased(P<0.01).There was a negative correlation between the degree of depression and the BDNF level.After the treatment,the BDNF levels of patients with moderate and severe depression significantly increased(P<0.01).Among the patients with significant improvement in clinical symptoms,their serum BDNF level increased in various degrees,compared with that before the treatment.Conclusion Serum BDNF level can be regarded as a reference index for the clinical diagnosis of depression and particularly therapeutic reaction.

目的 探讨赴黎巴嫩维和军人心理应激及相关影响因素,为维和军人心理健康教育和心理应激干预提供科学依据.方法 采用随机整群抽样法,对181名赴黎巴嫩维和军人应用一般情况问卷、军人心理应激自评问卷(PSET)、自我和谐量表(SCCS)、状态-特质焦虑问卷(STAI)、应对方式问卷、艾森克个性问卷(EPQ)在执行维和任务第14天和第4个月进行测试.结果 ①PSET标准分≥70分者维和初期和中期分别为5.52％和3.32％,差异不显著(P＞0.05)；维和军人自我和谐总分及各因子分均显著低于军人常模(P＜0.05,P＜0.01)；整体个性特点呈低EPQ-N、EPQ-P特征；解决问题、求助因子分显著高于军人常模(P＜0.01),自责、幻想、退避因子分均显著低于军人常模(P＜0.01).②PSET标准分与自我与经验的不和谐、自我和谐总分、情绪稳定性、状态焦虑、特质焦虑、不成熟及混合性应对方式呈显著正相关(P＜0.05,P＜0.01),与其他因子分无显著相关性(P＞0.05).③回归分析显示,对PSET标准分有显著性影响的因子由大到小依次为:状态焦虑、情绪稳定性、自我与经验的不和谐(R2=0.59,F=24.67,P=0.00).结论 维和军人整体心理健康状况较好,维和初期可能是预防应激性心理障碍的关键期,状态焦虑、情绪稳定性、自我与经验的不和谐是造成心理应激的主要因素.

Objective To explore the correlation between personality,coping style and mental health on Chinese peacekeeping medical soldiers in Lebanon,for providing basis of rational developing education programs of mental health.Methods 54 Chinese peacekeeping medical soldiers in Lebanon taking medical support were assessed by Cattell the sixteen personality factor test(16PF),coping style questionnaire,symptom checklist-90(SCL-90) and the questionnaire of the related factors.Results(1)The total score of SCL-90 and the factor scores of somatization,compulsion,interpersonal relationships,anxiety,hostility,psychosis of peacekeeping force taking medical support were significantly lower than the norm of Chinese soldiers(P<0.05).Comparing to the norm of Chinese soldiers,the medical support people showed higher intelligence,stability,excitement,sophistication,self-discipline and lower gregariousness,sensitivity,doubt,anxiety,sexual tension in 16PF.Meanwhile,the factor scores of problem-solving and help were significantly higher than the domestic soldiers norm in coping style questionnaire(P<0.01),however,the factor scores of remorse were lower(P<0.01) and the fantasy,avoidance,rationalization were no significant difference compared with the norm(P>0.05).(2)The total score and factor scores of SCL-90 of medical support staff had a significant positive correlation with immature and mixed coping style(self-blame,fantasy,avoidance,rationalization),while had no significant correlation with the factor scores of help;In addition to the psychosis factor,the total score and other factor scores of SCL-90 showed a significant negative correlation with the factor scores of problem-solving;the total score of SCL-90 showed a significant negative correlation with gregariousness,excitement and sensitivity,while the anxiety,psychosis,and tension was significantly positively correlated(P<0.05).Conclusion Chinese peacekeeping medical soldiers in Lebanon performed well in mental health integratedly and possessed the personality to accomplish peacekeeping mission.the problem-solving and remorse were their main coping style in peacekeeping.As a result,less immature coping are advantage of raising the level of mental health in peacekeeping force for medical support.

我军对执行多样化非战争军事任务部队心理卫勤保障系统的研究正处于起步阶段.部队心理卫勤保障系统是以提高部队战斗力为目的,运用心理学原理,通过科学心理学的方法,锻造军人良好心理素质的心理保障系统[1].在执行多样化非战争军事任务时,军人常需在各种陌生恶劣的环境下完成各种突击任务.灾害场面、任务强度、人身安全威胁等种种强烈刺激,经常性使执行任务者处于急性或慢性心理应激状态,损害他们的心理健康[2].实践证明,建立快速有效的心理卫勤保障系统,并使该系统充分发挥效能,能达到有效降低军人心理应激反应,减少军事应激损伤,促进官兵身心健康的目的.本文根据近几年部队执行非战斗军事任务时我院心理卫勤保障分队随队保障实践经验,结合国内外心理干预的理论和军事心理健康的研究成果,对执行任务军人心理卫勤保障系统的构建进行总结、综述如下.

Objective To investigate the therapeutic effects of whole course medical management,medication compliance and the influence on social function in schizophrenic patients.Methods A paired-control study was performed in 84 male soldier inpatients with first-episode schizophrenia from Mar.2007 to Mar.2008.The patients were randomly divided into experimental group(n=42,treated with whole course medical management) and control group(n=42,only received antipsychotic drugs).The patients of two groups were assessed at enrollment(baseline),discharge,and 3,6 and 12 months after discharge.The treatment compliance was assessed by drug discontinuation rate and persistent treatment time,the therapeutic effect was assessed by Positive and Negative Syndrome Scale(PANSS) and recurrence rate,and the recovery of social function was assessed by Global Assessment Scale(GAS).Results At discharge,the PANSS negative symptom scores were significantly lower in experimental group than in control group(P 0.05).In experimental group,the PANSS total score,PANSS negative and PANSS general psychopathological scores were significantly lower than those in control group since the 3rd month after discharge(P < 0.05 or P < 0.01),the GAS scores and medication compliance were significantly higher than those in control group since the 6th month after discharge(P < 0.05),and the PANSS positive symptom scores and recurrence rate were significantly lower than those in control group in the 12th month(P < 0.05).Conclusion The whole course medical management may effectively improve the psychological symptoms,enhance the medication compliance and long-term effects,reduce the recurrence rate and improve the social function.It could be the first choice as a strategic mode of long term management for servicemen with schizophrenia.

Objective To assess the mental health of recruits in 2009 and to explore the relevant factors,for providing a scientific basis to the implementation of the quality of mental health education and psychological training.Methods In general questionnaire,State-Trait Anxiety Inventory(STAI),Coping Style Questionnaire,Eysenck Personality Questionnaire(EPQ),symptom checklist(SCL-90)were adopted to the implementation of the 1 104 recruits group psychotherapy test.Results(1)Recruits SCL-90 total score and factor scores were significantly lower than the recruits norm(P<0.01),mainly to mature coping style;state-trait anxiety were significantly higher than norm(P<0.05).(2)Neuroticism with the SCL-90 total score and factor scores showed significant negative correlation(P<0.01);immature and mixed coping style,state-trait anxiety scores with the SCL-90 total and factor scores were significant positive correlation(P<0.01).(3)SCL-90 total score as the dependent variable,stepwise linear regression analysis,independent variables into the regression equation:stability,state anxiety,avoidance,waste points,self-blame,social support utilization.For 6 variables,the coefficient of determination r2 = 0.544,test of the equation,F= 121.640,P<0.001.Conclusion For the recruits in 2009 the overall mental health status is good,mainly the mature coping.

院精神病科系成都军区精神疾病专科治疗中心,担负军区绝大部分精神疾病患者的监测、预防和收治任务.在军队精神病患者治疗管理实践中,本科坚持以人为本,为其提供人性化服务.实践证明,此项措施显著提高军队精神病患者临床治愈率,在促进患者临床康复、回归部队、减少精神残疾上起到明显成效,深受体系部队好评.笔者结合本科多年来在军队精神病患者治疗管理中的实践经验,探讨新时期军队精神疾病患者治疗管理中的人文理念.

Objective To quantitatively assess the mental health of recruits in 2009 and related factors in order to provide a scientific basis for the effective implementation in psychological intervention and psychological quality training for the recruits.Methods Symptom Checklist(SCL-90),State-Trait Anxiety Inventory(STAI),Coping Style Questionnaire,Eysenck Personality Questionnaire(EPQ),and the Social Support Scale were used to test the mental state in 1104 recruits.Results(1) The total score and factor scores of SCL-90 in recruits were lower than those in the norm of recruits in 2000(P<0.01).The score of somatization was higher than that in military norm(in 2004),while the score of depression,paranoid,horror,hostility and the total score of SCL-90 were lower than those in military norm (P<0.01 or P<0.05).The factor scores of coping styles such as solving problem,seeking for help were higher(P<0.01),while self-blame,fantasy,avoidance,and rationalization were lower than military norm(P<0.01).The factor scores of state-trait anxiety in recruits were lower than those in national norm(P<0.01).The factor scores of EPQ-P,EPQ-N were lower while of EPQ-E,EPQ-L were higher than military norm(P<0.01).(2)Factor scores of EPQ-P,EPQ-N,mature coping style with the total score and factor scores of SCL-90 showed negative correlation(P<0.01);immature and mixed coping style,state-trait anxiety,EPQ-E,and EPQ-L showed positive correlation(P<0.01).(3)EPQ-N,state-trait anxiety,avoidance,concealment,self-blame and social support utilization ratio in decreasing order were the factors affecting the total score and factor scores of SCL-90(P<0.01).Conclusion Recruits in 2009 were in good mental health,which is related to the character,state-trait anxiety,coping style,and social support.

现代化战争中,军人的心理素质至关重要,因此引发了人们对新兵筛选及新兵心理健康状况监测的重视[1].对新兵进行心理健康监测的目的就是发现心理问题现症患者或新兵精神疾病病史,避免新兵带病入伍;同时对集训期健康或亚健康状态的新兵进行跟踪监测,确定哪些新兵需要进行心理干预,哪些人可能对干预效果好;也有助于对新兵集训结束后军兵种或工种安排提供参考性意见.

执行多样化军事任务是我军在新时期面临的一项新任务.执行任务时,官兵经常性处于急性或慢性心理应激状态[1].如何有效降低任务官兵心理应激反应,减少军事应激损伤,对促进官兵身心健康,提高部队战斗力具有重要意义.目前国内外关于军人执行某一具体军事任务时心理应激及相关影响因素的研究较多[2-3],但多采用横向比较,缺乏纵向跟踪研究,对执行不同性质和类型军事任务军人心理应激之间有何共性和特异性的研究报道相对缺乏.本研究采用量化研究和结构式访谈相结合的方式,对近3年执行过多样化军事任务的1222名军人心理应激及相关影响因素进行纵向跟踪式研究,为任务部队心理健康教育提供科学依据.

Objective To explore the effect of depression on the expression of brain-derived neurotrophic factor(BDNF) in the cerebral cortex,hippocampus and cerebrospinal fluid in order to investigate the relationship between BDNF and the occurrence of depression.Methods The depression model in rats was established with chronic unpredictable stress.The behaviors in Open-Field testing were observed through forced swimming.The expression of BDNF in above-mentioned tissues was examined by immunohistochemical method and ELISA.Results Compared with normal control,the number of BDNF positive cells in the hippocampus and cerebral cortex in depressed rats was decreased markedly.The level of BDNF in the cerebral-spinal fluid,hippocampus and cerebral cortex in normal mice was(6.87±2.44)ng/ml,(11.75±3.60)ng/g and(4.31±1.37)ng/g respectively;and they were markedly higher than those of depressed rats [(4.23±1.54)ng/ml,(8.56±2.45)ng/g and(3.06±0.67)ng/g,P0.01].Conclusion BDNF levels are obviously decreased in the depressed rats,indicating it may be involved in the occurrence of depression.

Objective To investigate the effects of brain-drived neurotrophic factor (BDNF) on the expression of neuronal precursors microtubule-associated protein doublecortin in hippocampus of depressed rats and provide experimental evidence for the effects of BDNF on the proliferation and migration of neuronal precursors. Methods Depressed rat model was established,and 0.5 ug of purified BDNF was injected into rat cerebral ventricle for preparing frozen section. Immunohistochemistry and immunofluorescence were employed to observe the positive expression level and expression site of Doublecortin (DCX). Results Positive cell number of DCX in hippocampus region of BDNF injection group was increased compared with that of non-injection group (P0.05). Conclusion BDNF might affect the differentiation and migration of neuronal precursors via regulating the expression of DCX in hippocampus of depressed rats.