Е. Е. Буйко | AMiner学者主页

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20212022

论文（3）

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1ХИМИКО-ФАРМАКОЛОГИЧЕСКОЕ ИССЛЕДОВАНИЕ СУБСТАНЦИИ ГУМИНОВЫХ ВЕЩЕСТВ УГЛЯ ДЛЯ ЦЕЛЕЙ ПРИМЕНЕНИЯ В ПИЩЕВОЙ И ФАРМАЦЕВТИЧЕСКОЙ ПРОМЫШЛЕННОСТИ

ЗЫКОВА М.В.,БРАТИШКО К.А.,ЛОГВИНОВА Л.А.,ИВАНОВ В.В.,БУЙКО Е.Е.,ДАНИЛЕЦ М.Г.,ТРОФИМОВА Е.С.,ЛИГАЧЕВА А.А.,ЗИМА А.П., РАБЦЕВИЧ Е.С.,УФАНДЕЕВ А.А., МИХАЛЁВ Д.А.,

2023Химия в интересах устойчивого развития（2023）

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2Airway Smooth Muscles Contractions in Metabolic Syndrome

Birulina Yu. G.,Ivanov V. V.,Buiko E. E.,Dzyuman A. N.,Nosarev A. V.,Voronkova O. V., Vol’khina M. O.,Gusakova S. V.

We studied contractile responses of isolated airway smooth muscle segments from rats with metabolic syndrome. Metabolic syndrome was induced in rats by high-fat and high-carbohydrate diet. It was shown that metabolic syndrome was associated with an increase of bronchoconstrictor action of cholinergic receptor activator carbacholine (0.1-100 μM) and a decrease of the dilatory effect of β2-adrenoreceptor activator salbutamol (0.1-100 μM). The observed effects of agonists are epithelium-dependent. Disorders in contractile activity in the airway smooth muscles were accompanied by bronchial epithelium destruction, immune inflammation in the bronchial wall, muscular and peribronchial adipose tissue hypertrophy.

2022Bulletin of Experimental Biology and Medicine（2022）

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3Markery Sistemnogo Vospaleniya U Krys V Modeli Diet-Inducirovannogo Metabolicheskogo Sindroma

Ю. Г. Бирулина,О. В. Воронкова,В. В. Иванов,Е. Е. Буйко, М. М. Щербакова,Н. А. Чернышов,Е. А. Мотлохова

Sistemnoe vospalenie lezhit v osnove patogeneza mnogih hronicheskih neinfekcionnyh zabolevanij, v tom chisle takih, kak saharnyj diabet 2-go tipa, ozhirenie, metabolicheskij sindrom (MS). Cel'yu raboty bylo ocenit' izmeneniya parametrov sistemnoj vospalitel'noj reakcii u krys v modeli diet-inducirovannogo MS. Issledovanie vypolneno na 33 krysah-samcah Wistar, raspredelennyh na kontrol'nuyu i eksperimental'nuyu gruppy. Krysy kontrol'noj gruppy (n = 15) nahodilis' na standartnoj diete. Krysy eksperimental'noj gruppy (n = 18) v techenie 12 nedel' nahodilis' na vysokozhirovoj i vysokouglevodnoj diete. Dlya ocenki intensivnosti vospalitel'nogo processa na fone metabolicheskih narushenij opredelyali obshchee kolichestvo i morfologicheskij sostav lejkocitov krovi, koncentraciyu obshchego belka, S-reaktivnogo belka, koncentraciyu citokinov IL6, IL10, TNFα, insulina i leptina. V obrazcah zhirovoj tkani ocenivali uroven' produkcii aktivnyh form kisloroda. V rezul'tate provedennogo eksperimenta u krys s MS byli zaregistrirovany obshchie priznaki vospaleniya: reaktivnyj lejkocitoz, giperproteinemiya, povyshenie koncentracii S-reaktivnogo belka v 2,6 raza (r = 0,001), IL10 — v 3,7 raza (r = 0,029), TNFα — v 4,2 raza (r = 0,035). Vyyavlennye izmeneniya proiskhodili na fone povysheniya metabolicheskoj aktivnosti visceral'noj zhirovoj tkani, o chem svidetel'stvovali giperleptinemiya i vysokaya intensivnost' processov svobodnoradikal'nogo okisleniya. Byli obnaruzheny polozhitel'nye korrelyacionnye vzaimosvyazi mezhdu urovnyami leptina i insulina v krovi (r = 0,701; r = 0,001), a takzhe mezhdu syvorotochnoj koncentraciej leptina i IL10 (r = 0,523; r = 0,012). Takim obrazom, vysokozhirovaya i vysokouglevodnaya dieta naryadu s metabolicheskimi narusheniyami pozvolyaet vosproizvesti rannie priznaki sistemnogo vospaleniya, harakternye dlya MS i ozhireniya.

2022Вестник Российского государственного медицинского университета

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