L'invention concerne un dispositif destine a etre positionne a l'interieur d'une lumiere corporelle, adjacent a l'embouchure d'un anevrisme s'etendant a partir de la lumiere corporelle, pour entrainer une thrombose de l'anevrisme tout en maintenant un ecoulement de sang sensiblement normal a travers un vaisseau sanguin. Ce dispositif comprend : une seule boucle fermee de filament elastique pouvant etre configuree entre : (i) une premiere configuration deployee longitudinalement, contractee radialement et lateralement, pour un deplacement le long d'un vaisseau sanguin et (ii) une seconde configuration contractee longitudinalement, deployee radialement et lateralement, pour une reception a l'interieur d'un vaisseau sanguin, la seconde configuration fournissant (a) une seule face de limitation d'ecoulement configuree pour recouvrir l'embouchure de l'anevrisme et obstruer l'ecoulement de sang vers l'anevrisme tout en permettant un ecoulement de sang sensiblement normal a travers le vaisseau sanguin et (b) au moins un pied pour maintenir l'unique face de limitation d'ecoulement adjacente a l'embouchure de l'anevrisme, le ou les pieds etant configures de facon a maintenir un ecoulement de sang sensiblement normal a travers le vaisseau sanguin.

Salmonella is one of the most important causes of foodborne disease throughout the world. In recent years there have been documented outbreaks of Salmonella infection in humans associated with pet treats of animal origin; in particular pig ear pet treats in Canada and the United States. The main objectives of this study were to determine the degree of Salmonella contamination in dried pig ear dog treats on sale in Limerick City, Ireland and to examine pet dogs for Salmonella carriage. Over a 12month period, from October 2008 to September 2009, 102 pig ear pet treats were sampled using both a conventional culture detection method and a PCR method. Salmonella was detected in 24.5% of samples by the culture method, while 28.4% tested positive using a PCR method. Resistance to at least one antimicrobial agent was observed in 50% of Salmonella isolates. Salmonella was not detected in any of 86 rectal swabs from dogs attending 2 different veterinary clinics between February and April and August and October of that period. The contaminated ears were traced back to a single distributor. This study emphasises that there is a long term continuing risk of human exposure to Salmonella associated with pig ear treats.

This paper describes a 16-bit 250 MS/s ADC fabricated on a 0.18 BiCMOS process. The ADC has an integrated input buffer with a new linearization technique that improves its distortion by 5-10 dB and lowers its power consumption by 70% relative to the state of the art. It demonstrates a new background calibration technique to correct the residue amplifier (RA) gain errors and lower its power consumption. This summing node sampling (SNS) calibration technique is based on sampling the summing-node voltage of the residue amplifier and using it with the corresponding residue to estimate the amplifier open loop gain. The ADC achieves an SNDR of 76.5 dB and consumes 850 mW from a 1.8 V supply, while the input buffer consumes 150 mW from a 3 V supply. Up to 125 MS/s, the SFDR is greater than 100 dB for input frequencies up to 100 MHz and 90 dB up to 300 MHz input frequency. At 250 MS/s, the SFDR is greater than 95 dB up to 100MHz and 85 dB up to 300 MHz.

Wireless communication applications have driven the development of high-resolution A/D converters (ADCs) with high sample rates, good AC performance and IF sampling capability to enable wider cellular coverage, more carriers, and to simplify the system design. We describe a 16b ADC with a sample rate up to 250MS/s that employs background calibration of the residue amplifier (RA) gain errors. The ADC has an integrated input buffer and is fabricated on a 0.18µm BiCMOS process. When the input buffer is bypassed, the SNR is 77.5dB and the SFDR is 90dB at 10MHz input frequency. With the input buffer, the SNR is 76dB and the SFDR is 95dB. The ADC consumes 850mW from a 1.8V supply, and the input buffer consumes 150mW from a 3V supply. The input span is 2.6Vp-p and the jitter is 60fs.

This paper describes a 14-bit, 125 MS/s IF/RF sampling pipelined A/D converter (ADC) that is implemented in a 0.35 mu m BiCMOS process. The ADC has a sample-and-hold circuit that is integrated in the first pipeline stage, which removes the need for a dedicated sample-and-hold amplifier (i.e., "SHA-less"). It also has a sampling buffer that is turned off during the hold clock phases to save power. To accurately estimate and minimize the clock jitter, a new jitter simulation technique was used whose results were verified on silicon. The measured silicon results indicate the highest published IF sampling performance to date and prove the viability of the "SHA-less" architecture for IF/RF sampling ADCs. The ADC is calibration-free and achieves a DNL of less than 0.2 LSB and INL of 0.8 LSB. The SNR is 75 dB below Nyquist, and stays above 71 dB up to 500 MHz. The low-frequency SFDR is about 100 dB, and stays above 90 dB up to about 300 MHz. This is also the first ADC to achieve 14-bit level performance for input signal frequencies up to 500 MHz and to have a total RMS jitter of only 50 fs.

This paper describes a 14-bit 80-MSPS ADC with 100-dB SFDR at 70-MHz input frequency in a 0.35-mum single-well BiCMOS technology drawing 1.2 W from a dual 3.3 V/5.0 V supply. Key barriers to high dynamic range in pipeline ADCs at high clock rates and some methods to overcome these barriers will be presented. These methods include a sampling front-end without the use of a designated Sample and Hold (S/H). A BiCMOS switching input buffer is used along with the strategic use of BiCMOS design techniques. Also, calibration is combined with capacitor shuffling to maximize linearity with minimal noise impact

Heavy, bingelike patterns of exposure to ethanol during a portion of the early postnatal period in the rat, a time of rodent brain development corresponding to the human third trimester, has been shown to deplete cerebellar neurons and to produce deficits in cerebellar-dependent tasks. In the current study, we examined the impact of more moderate ethanol exposure, during an extended portion of the rat third trimester equivalent, on cerebellar-dependent learning (eyeblink conditioning) and deep cerebellar nuclei neuron numbers. Neonatal rats received 0, 1, 2, or 3 g/kg/day of ethanol in milk formula via a single intragastric intubation each day across postnatal days 2–11, or were left untreated. Peak BACs for ethanol-exposed rats were 50, 150, and 225 mg/dl, respectively. Rats underwent eyeblink conditioning as young adults (70 days of age) and deep cerebellar nuclei neuron numbers were assessed at 100 days of age. In Experiment 1, all rats showed normal responsiveness to periorbital stimulation prior to conditioning. The 3-g/kg/day group was impaired in eyeblink conditioning and possessed fewer deep cerebellar nuclei neurons. A trend toward impairment was observed in the 2-g/kg/day group. However, the 0-g/kg/day group was also impaired in eyeblink conditioning. In Experiment 2, the unconditioned stimulus pretest phase was eliminated, the 0-g/kg/day group learned normally, and both the 2- and 3-g/kg/day groups were again impaired. These results suggest that more moderate doses of ethanol during the rat third-trimester equivalent can produce long-term effects on the cerebellum.

Abstract The long-range goal of the Z-Pinch IFE program is to produce an economically-attractive power plant using high-yield z-pinch-driven targets (~3GJ) with low rep-rate per chamber (~0.1 Hz). The present mainline choice for a Z-Pinch IFE power plant uses an LTD (Linear Transformer Driver) repetitive pulsed power driver, a Recyclable Transmission Line (RTL), a dynamic hohlraum z-pinch-driven target, and a thick-liquid wall chamber. The RTL connects the pulsed power driver directly to the z-pinch-driven target, and is made from frozen coolant or a material that is easily separable from the coolant (such as carbon steel). The RTL is destroyed by the fusion explosion, but the RTL materials are recycled, and a new RTL is inserted on each shot. A development path for Z-Pinch IFE has been created that complements and leverages the NNSA DP ICF program. Funding by a U.S. Congressional initiative of $4M for FY04 through NNSA DP is supporting assessment and initial research on (1) RTLs, (2) repetitive pulsed power drivers, (3) shock mitigation [because of the high yield targets], (4) planning for a proof-of-principle full RTL cycle demonstration [with a 1 MA, 1 MV, 100 ns, 0.1 Hz driver], (5) IFE target studies for multi-GJ yield targets, and (6) z-pinch IFE power plant engineering and technology development. Initial results from all areas of this research are discussed.