BACKGROUND:The effect of prehabilitation on reducing the level of postoperative stress and facilitating recovery has been proven to be controversial in previous studies involving patients with cancer. This review contributes to the improvement of an intervention programme by qualitatively integrating the prehabilitation experiences of patients with cancer. OBJECTIVE:This review aimed to integrate the individual experiences of patients with cancer who had received prehabilitation interventions to identify the barriers and facilitators to implementation, which can be used to understand patients' adherence behaviours. DESIGN:This was a qualitative evidence synthesis review. METHODS:Articles were systematically searched from inception to February 18, 2025, using four English databases and three Chinese databases. Keywords and Medical Subject Headings were used to identify potential studies written in both Chinese and English. This study was performed using the Joanna Briggs Institute qualitative systematic review methodology. RESULTS:Twenty-five articles were included in this review. Guided by the Theoretical Domains Framework (TDF), eight synthesised findings were extracted, focusing on the representation of factors influencing the adherence of patients with cancer to prehabilitation, including the domains of knowledge (two facilitators), reinforcement (two facilitators), beliefs about consequences (two facilitators), beliefs about capabilities (two barriers), environmental context and resources (two barriers, one intervention preference factor), social influence (one facilitator, one intervention preference factor), emotion (one barrier, one facilitator) and behavioural regulation (one facilitators, two intervention preference factors). CONCLUSION:Our findings indicate that the adherence to prehabilitation among patients with cancer is shaped by a dynamic interplay of determinants. Structured assessments, self-monitoring, tailored interventions and tele-prehabilitation can improve patients' self-efficacy, perceived benefits and access to resources, which in turn can facilitate their completion of prehabilitation. IMPACT:This study deepens our understanding of behaviours related to adherence to prehabilitation among patients with cancer and provides valuable guidance for the formulation and optimisation of subsequent prehabilitation intervention programmes. REPORTING:ENTREQ. PATIENT OR PUBLIC CONTRIBUTION:No patient or public contributions. TRIAL REGISTRATION:PROSPERO CRD: 42024553972.

BackgroundComplex health care environments present moral dilemmas for clinical nurses and nursing students that challenge their professional development as well as their physical and mental health. Ethical sensitivity (ES) is seen as a prerequisite that enables clinical nurses to make appropriate ethical decisions when facing a dilemma; therefore, ES should be a development focus for nursing students.PurposeThe aim of this study is to conduct a systematic evaluation of existing instruments to assess moral sensitivity (MS) or ES in nursing students. We subsequently provide recommendations of the proper research tools that can be used in future studies based on our study results.MethodsA systematic literature search across nine databases from their inception to November 17, 2024 was first conducted. Two researchers then independently screened these studies, which were published in English or Chinese. The studies evaluated were designed to develop or validate a scale used to measure ES or MS among nursing students. The COnsensus-based Standards for the Selection of Health Measurement INstruments (COSMIN) guidelines were followed to evaluate both the methodological quality and the quality of the psychometric properties of the identified tools. Finally, data synthesis was performed.ResultsWe ultimately included 13 assessment tools used for the assessment of ES or MS among nursing students. Only one tool was rated A, and four tools were rated C and not recommended for use. The remaining tools were rated B, and they have potential for assessing MS and ES among nursing students.ConclusionA majority of the tools included in this study still require further revision to enhance their quality prior to their effective use in MS and ES assessments. The COSMIN guidelines indicated that future studies should describe the development and validation of measurement tools in detail and improve their current data analysis methods.

AIMS:Preoperative body mass index (BMI) has been shown to be an important prognostic factor after lobectomy in patients with lung cancer. However, few studies have investigated the relationship between preoperative BMI and overall mortality in these patients. In this study, we aimed to identify the range of BMI that heralds a favorable prognosis in patients who have undergone lobectomy for lung cancer. METHODS:The association between BMI and overall survival was examined using primary data from an affiliated hospital database and fitted adjusted Cox regression models. The restricted cubic spline (RCS) method was used to report the relationship between preoperative BMI and overall mortality. Fully adjusted models were stratified by and adjusted for sex, age, disease stage, respiratory function, and adjuvant chemotherapy. RESULTS:Of 3307 patients identified to have undergone radical resection of lung cancer between November 2009 and July 2019, 2365 underwent lobectomy and 558 died. BMI had a J-shaped association with overall mortality; we estimated that the overall mortality risk reached a nadir at BMI values of 23.2-29.4, with an inverse association below 23.2 (hazard ratio 0.104 per 5-unit decrease; 95% confidence interval 0.089-0.119), a positive association above 29.4 (hazard ratio 0.022 per 5-unit increase; 95% confidence interval 0.004-0.040), and the lowest mortality at 25.7. CONCLUSION:Preoperative BMI is an important prognostic factor after lobectomy in patients with lung cancer. A BMI of 23.2-29.4 has a prognostic benefit.

OBJECTIVES:To explore the chain-mediating roles of negative emotions and caregiver readiness between self-efficacy and e-health literacy among caregivers of patients with lung cancer. BACKGROUND:With the rise of Internet health services, caregivers of patients with lung cancer, who are one of the health decision makers, are encountering new challenges. In order to develop appropriate interventions, it is necessary to explore in depth the various influencing factors associated with them. DESIGN:A cross-sectional survey. METHODS:A total of 293 caregivers of patients with lung cancer were recruited between November 2023 and April 2024 through a convenience sampling method. These participants completed the demographic data questionnaire, General Self-Efficacy Scale (GSES), Hospital Anxiety and Depression Scale (HADS), Caregivers Preparedness Scale (CPS), and eHealth Literacy Scale (eHEALS). Independent samples t-tests and a one-way ANOVA were employed to identify the primary influencing factors. Structural equation modelling was employed to detect the mediating effects of negative emotions and caregiver readiness. REPORTING METHOD:The STROBE checklist was used for this study. RESULTS:The total e-health literacy score of caregivers of patients with lung cancer was 29.65 ± 7.11, and there was a correlation between self-efficacy, negative emotions, caregiver readiness, and e-health literacy. The results of the path analysis showed that negative emotions and caregiver readiness had chain-mediating roles between self-efficacy and e-health literacy among caregivers of patients with lung cancer, with the total indirect effect accounting for 31.17% of the total effect. CONCLUSIONS:Caregivers of patients with lung cancer exhibit moderate levels of e-health literacy. This research suggests that self-efficacy not only has a direct and positive influence on e-health literacy but may also amplify it by mediating the interplay between negative emotions and caregiver readiness. RELEVANCE TO CLINICAL PRACTICE:Healthcare providers should be cognizant of the negative emotions and readiness displayed by family caregivers in the hospital setting to aid them in cultivating strong health literacy for more efficient management of illness care tasks. PATIENT OR PUBLIC CONTRIBUTION:Nurses at the hospitals assisted us in collecting data from family caregivers of patients with lung cancer, and the caregivers actively cooperated in completing the questionnaires.

目的 评价PDCA循环在腹腔镜下胆囊切除术围手术期预防使用抗菌药物发挥的作用并进行药物经济学分析.方法 采用回顾性分析方法,随机抽取合肥市第二人民医院根据发生不合理用药的真正或根本原因采取PDCA循环干预前(2019年5-6月)、第1轮PDCA循环干预后(2020年5-6月)、第2轮PDCA循环干预后(2021年5-6月)进行腹腔镜下胆囊切除术的出院患者各80例,对患者进行预防使用抗菌药物的合理性进行点评.对比干预前及第1、2轮PDCA循环干预后患者的一般情况、抗菌药物使用情况、临床疗效、治疗成本,并采用成本-效果分析法及敏感度分析法评价PDCA循环的药物经济学意义.结果 第2轮PDCA循环干预后,抗菌药物使用不合理率、抗菌药物金额占比、抗菌药物使用天数、用药频度、药物利用指数、人均抗菌药物使用频次、抗菌药物总用量、抗菌药物费用、药品总金额、住院总费用较干预前均显著下降/减少(P＜0.05).成本-效果分析结果提示,第2轮PDCA循环干预后的药物经济学效果最佳;敏感度分析结果趋势一致,证实研究结果可靠.结论 PDCA循环促进了腹腔镜下胆囊切除术围手术期预防使用抗菌药物的合理应用,降低了抗菌药物费用,减轻了患者就医的经济负担.

BackgroundMany studies have focused on undergraduate nursing students’ professional identity (PI), but freshman nursing students (FNSs) have been ignored, and the relationship between interpersonal self-support (ISS) and PI is unknown. This study was designed to determine the patterns of ISS and its association with PI among Chinese FNSs.MethodsA cross-sectional survey was conducted among 358 FNSs recruited from two nursing colleges in southeast China. Students completed the Sociodemographic Characteristics Questionnaire, the Interpersonal Self-Support Scale for Adolescent Students, and the Professional Identity Questionnaire for Nurse Students. Latent profile analysis (LPA) was used to determine the patterns of ISS among freshmen. The Bolck–Croon–Hagenaars method was used to examine the influencing role of ISS in PI.ResultsLPA indicated that ISS could be classified into three subgroups: the ISS-Individualist group (7.54% of the total sample), ISS-Dependent group (63.13% of the total sample), and ISS-Extrovert group (29.33% of the total sample). Overall, these three profiles differed significantly in the five dimensions of ISS and PI (p < 0.05). The results of pairwise comparisons examined the positive role of the ISS-Extrovert group on the promotion of PI among FNSs.ConclusionThese findings emphasize the need for the promotion of PI and ISS among Chinese FNSs. Freshman students need more confidence and general communication knowledge to maintain harmonious social relationships with others. Parent-teacher association could be applied to nursing education to guide FNSs’ positive development of ISS.

细胞色素450(CYP450)是以血红素为辅助基团,广泛分布于生物体内的一个B族细胞色素家族蛋白酶.其中CYP2C19参与众多内源性及外源性物质代谢.本文通过检索近年国内外相关文献,系统性概述了CYP2C19基因的多态性在冠心病患者健康管理方面的应用效果,从而更好的指导临床合理用药,规避心血管事件等不良反应的发生,以期为冠心病患者的健康管理提供依据.

目的 探讨保和丸"异病同治"非酒精性脂肪肝(non-alcoholic fatty liver disease,NAFLD)和功能性消化不良(functional dyspepsia,FD)的潜在分子机制.方法 基于 TCMSP 平台搜集保和丸的化学成分和对应靶点;基于 GeneCards等数据库搜集NAFLD和FD疾病靶点;将化学成分对应靶点与疾病靶点取交集获得保和丸治疗NAFLD和FD的交集靶点."药物-成分-靶点"网络基于Cytoscape 3.8.0 软件建立;交集靶点的蛋白互作网络基于String平台建立.GO功能和KEGG通路富集分析基于R语言进行;分子对接验证基于AutoDock Vina软件进行.结果 共获得保和丸治疗NAFLD和FD的交集靶点112 个.筛选出木犀草素等 6 种核心成分,肿瘤蛋白p53(tumor protein p53,TP53)等8 个核心靶点.GO功能共富集2 456 个条目,主要涉及营养、甾体激素等因素;KEGG共富集 162 条通路,包括白介素(interleukin,IL)-17、缺氧诱导因子(hypoxia-inducible factor,HIF)-1 等.分子对接初步验证了以上网络药理学结果.结论 保和丸核心成分木犀草素等可作用于TP53 等核心靶点,通过调控IL-17、HIF-1 等信号通路,发挥"异病同治"NAFLD和FD的作用.

全面质量管理(TQM)是一种综合性的质量管理方法,已经在许多领域得到了广泛的应用.在体检中心外联部(组),TQM可以帮助提升服务质量、提高工作效率、提高团检客户满意度、增强员工参与和责任感,以及提高体检中心整体市场竞争力与健康管理水平.通过优化工作流程、建立严格的质量控制和考核机制、培训员工、加强团检客户沟通,并实施持续改进等措施,体检中心外联可以不断提高服务质量和效率,并赢得在市场竞争中的优势.本文介绍了全面质量管理在我院体检中心外联质量控制中的应用,阐述了TQM在体检中心外联中的优势和重要性,并提出了一些实施TQM的具体措施和建议.为了提高体检中心外联的服务质量和竞争力,建议在实践中积极推广全面质量管理方法,不断改进和完善服务过程,以满足团检客户的需求和期望,提高整个体检中心的综合实力和健康管理水平.

为挖掘复方中苍耳类药材抗肿瘤的用药规律,并探讨核心药物抗肿瘤的分子机制,通过检索《肿瘤方剂大辞典》等资料,筛选治疗肿瘤的含苍耳类药材的复方制剂,基于关联规则和系统聚类,分析用药规律并获取核心药物组.基于中药系统药理学分析平台筛选核心药物组的化学成分及对应靶点;检索GeneCards等数据库获取肿瘤疾病靶点;二者取交集后获得药物、疾病交集靶点.构建核心药物组抗肿瘤的"中药-成分-靶点"网络及交集靶点的蛋白互作网络.基于R语言行基因本体(gene ontology,GO)功能与京都基因和基因组百科全书(Kyoto encyclopedia of genes and genomes,KEGG)通路富集分析,基于AutoDock Vina软件行分子对接验证.结果表明:共筛选出相关复方118首.基于数据挖掘结果综合分析,将苍耳子等10味中药作为核心药物组.网络药理学分析共获得交集靶点144个,筛选出β-谷甾醇等5种核心成分,TP53(tumor antigen P53)等5个关键靶点,涉及通路174条,主要包括PI3K-Akt(phosphatidylinositol 3 kinase/protein kinase B)、P53、肿瘤坏死因子等信号通路.分子对接提示核心成分与关键靶点结合活性强烈.可见,数据挖掘初步揭示了含苍耳类药材复方的抗肿瘤用药规律,获取了核心药物组;其核心成分β-谷甾醇等可通过作用于TP53等靶点,调控PI3K-Akt等信号通路,发挥抗肿瘤作用.

Objective To investigate the value of transcutaneous non-invasive acupoint electrical stimulation in the treatment of sudden deafness. Methods Ninety patients with sudden deafness in one ear who were hospitalized in the Department of Otolaryngology,Head and Neck Surgery, The First Affiliated Hospital of Anhui Medical University from August 1, 2019, to December 31, 2020, were selected and divided into three groups according to the random number table method, drug + acupoint electrical stimulation group, drug+ hyperbaric oxygen treatment group, and control group（drug treatment group）. The drug group was given hormones, improved microcirculation combined with neurotrophic drugs. The electrical stimulation group used our patented product for acupoint stimulation.Three groups of acupuncture points were selected, namely, the acupuncture point of the Tinggong + Yifeng, the acupuncture point of the Tinggong + Zhongzhu, and the acupuncture point of the Zhongzhu + Yifeng, each group was treated for 15 minutes, twice a day for15 days. The drug + hyperbaric oxygen group added hyperbaric oxygen treatment once a day for 15 days. The efficacy of the three groups was compared at the end of the 15-days treatment. Results At the end of 15 days of treatment, the total effective rate of pure tone hearing threshold in the drug + acupoint electrical stimulation group was 76.67%, the cure rate was 40%, and the effective rate of post-sudden deafness tinnitus treatment was 83.33%. The total effective rate of pure tone hearing threshold in the drug + hyperbaric oxygen group was 40.0%, the cure rate was 16.67%, and the effective rate of post-sudden deafness tinnitus treatment was 52.63%. The total effective rate of audiology in the drug-only group was 43.33%, the cure rate was 3.33% and the effective rate of tinnitus after sudden deafness treatment was 45.45%. The total effective rate and cure rate of pure tone hearing threshold in the drug+acupoint electrical stimulation group were significantly greater than those in the other two groups（P＜0.05）, and the effective rate of tinnitus treatment after sudden deafness was also considerably better than those in the other two groups（P＜0.05）. Conclusion Non-invasive acupoint electrical stimulation has a good effect on treating sudden deafness and deserves further clinical exploration.

Blended learning is increasingly being adopted, and yet a gap remains in the related literature pertaining to its skill performance, learning engagement and inner experience in undergraduate surgical nursing skills course. To investigate the changes in skills performance and learning engagement in the application of blended learning, and what it actually brings to nursing students. The study uses a historical control, two-armed, mixed and quasi-experimental design. The blended learning version of the course was offered to the 2019 class of 334 nursing undergraduates. Quantitative and qualitative data were collected after the course to obtain a comprehensive understanding of the course effects compared with the 304 nursing undergraduates of grade 2017 who adapted traditional learning. Quantitative data were analyzed by descriptive and inferential statistics using IBM SPSS 26.0, and qualitative data were encoded using Nvivo11.0. There were significant differences in skill performance and learning engagement between the class of 2017 and 2019 (p < 0.001). Combined with further analysis of the interview data, 3 first-level nodes and 8 secondary nodes were determined. Students’ opinions, comments and suggestions on the application of blended learning are refreshing. Moving forward with blended learning: opportunities and challenges go hand in hand. Researchers need to continually modify their research designs to respond to variable educational environments.

目的 提示临床注射用美罗培南联合注射用盐酸万古霉素使用过程中需加以关注可能引起的粒系骨髓抑制不良反应.方法 报道1例脑出血术后患者治疗期间发生严重粒系骨髓抑制,通过不良反应相关性分析鉴别该患者粒系骨髓抑制不良反应发生的可能药物.结果 患者不良反应严重程度为骨髓抑制程度Ⅳ级,排除患者病情和合并用药情况,判断引起患者严重骨髓抑制的药物为联用的抗菌药物注射用美罗培南和注射用盐酸万古霉素,不良反应相关性评价为"很可能",立即予以停药并对症处理后患者好转.结论 联合使用的注射用美罗培南和注射用盐酸万古霉素引起的Ⅳ级骨髓抑制不良反应报道少见,临床药物治疗过程中应加以识别.

Objective To understand nurses’ perceptions of prehabilitation of breast cancer, and to provide references for construction and implementation of scientific and feasible prehabilitation intervention scheme.Methods According to qualitative research design, semi-structured interviews were carried out from July to August 2022 among 11 nurses worked in breast surgery department from two tertiary hospitals in Anhui province.And Colaizzi seven-step analysis method was employed to analyze the data.Results Twelve themes were extracted from four aspects including nurses’ perceptions of prehabilitation of breast cancer, intervention themes of prehabilitation of breast cancer, nurses’ attitudes of prehabilitation of breast cancer, and nurses’ advice of implementation of prehabilitation of breast cancer.Conclusions Nurses’ knowledge of prehabilitation of breast cancer were limited.Their attitudes to prehabilitation were two-sided.In the future, it is necessary to construct and implement multidisciplinary and multi-modal prehabilitation intervention scheme among patients with breast cancer based on evidence ecosystem theory from the aspect of psychological intervention, exercise, lifestyle change and so on of the breast cancer patients.

目的 以优慕课平台为基础,将Sandwich教学法应用于专升本外科护理学教学中,并探讨该教学模式的效果.方法 以安庆医药高等专科学校2020级护理专升本的92名学生为研究对象,在优慕课平台的基础之上,使用Sandwich教学法对外科护理学部分内容开展教学,评价学生平台及课堂学习情况、教学后的学生成绩,观察教学前后学生的学业自我效能感与学习积极主动性变化.结果 学生平台学习效果较好,学生学业自我效能得分情况,实施后均高于实施前,且差异均有统计学意义(P均<0.05);学习积极主动性总分及学习驱动力、学习目标、深入学习和扎实学习维度数据比较在教学实施前后均有统计学差异(P<0.05).结论 以优慕课平台为基础的Sandwich教学法具有一定可行性,有助于提高学生的学习积极主动性和学业自我效能感,能有效提升外科护理学的教学效果.

Background Nowadays, the effect of body image (BI) on negative affect among nursing college students has been ignored. This study used person-centered methods to evaluate the profiles of body appreciation (BA) among Chinese nursing students. We explored the predictive factors of these profiles and examined the difference in negative affect among the profiles. Methods A cross-sectional survey study was conducted in a university in Anhui province, China. Five hundred and forty-one Chinese nursing students from a nursing college of a larger university completed this survey. Participants completed the Sociodemographic Characteristics Questionnaire, the Self-concept Clarity Scale, the Body Appreciation Scale-2, and the Depression Anxiety Stress Scale. Latent profile analysis was employed to classify the BA profiles, and multinomial logistic regression analysis were conducted using the three-step regression and Bolck-Croon- Hagenaars method to test the relationship between the latent profiles of BA, several covariates (including gender, age, year of schooling, residence, academic achievement level, interpersonal relationship status, whether the student is an only child, duration of use of social media platforms, body mass index (BMI), and self-concept clarity (SCC)), and negative affect. Results Analysis resulted in a four-profile model that included a “low BA” group (14.42%), an “upper medium BA” group (36.41%), a “lower medium BA” group (36.97%), and a “high BA” group (12.20%). SCC, years of schooling, interpersonal relationship status, and BMI were found to be the predictive factors of BA profiles. The four profiles differed in levels of stress, depression, and anxiety. Conclusion Our study showed that more than half of nursing students were dissatisfied with their BI and the predictive factors evaluated and negative affect were associated with the profiles of BA. Nursing faculties should take measures to help students develop a more appropriate awareness of nursing aesthetics, a healthier lifestyle, a better interpersonal relationship with family members and peers, and a clearer self-concept to promote body appreciation and reduce negative affect related to BI.

目的 调查胆胰外科围术期使用质子泵抑制剂(PPIs)预防应激性溃疡(SU)的情况,评价其合理性,为PPIs的合理应用提供参考.方法 采用回顾性调查研究的方法,收集某院 2020 年 6月1日至 8月31日胆胰外科围术期使用了PPIs 的患者信息,统计PPIs的使用率、用药指征,随后评价有用药指征病例的药物遴选、用药时机、用法用量等情况.结果 623 例次手术,有530 例次 478 名患者预防使用了PPIs(85.07%).其中无PPIs用药指征的为 268 例次(50.57%),262 例次有用药指征病例产生不合理用药情况 642 例次(98.32%),主要为遴选药物不适宜、用药时机不适宜、用药频次不适宜、疗程过长等,仅 11例次(1.68%)相对合理.结论 该院胆胰外科围术期使用 PPIs 预防SU不合理现象显著,医师应从严把控用药指征,药师应加强前置性处方审核,共同促进药物合理使用.

To explore the potential molecular mechanism of upper and middle and lower gout formula in treating gout arthritis（GA）.Active components and corresponding targets of upper and middle and lower gout formula were mined by searching pharmacology analysis platform of TCM system;GA disease targets were mined by searching DisGeNET、GeneCards、DrugBank and other databases;The intersection target genes of drugs and GA were obtained by Venn package of R language.The network of drug-component-target was constructed and the core components were screened by Cytoscape 3.8.0.The protein interaction network of intersecting targets was constructed by String platform and the core target genes were screened.GO function and KEGG pathway enrichment analysis were performed by R language and molecular docking was performed by the AutoDock Vina software.A total of 45 intersection target genes of upper and middle and lower gout formula and GA were mined.Quercetin,baicalein,wogonin and other 7 core components and recombinant human chemokine 8（CXCL8）,interleukin（IL）-1β and other 3 core target genes were screened out.A total of 1561 items were enriched in GO function,mainly involving response to lipopolysaccharide,caveola and oxidoreductase activity.A total of 120 items were enriched in KEGG pathway,such as AGE-RAGE,IL-17,and so on.The molecular docking results showed the core components had good binding activity with the target portein.The core components of upper and middle and lower gout formula,including quercetin,baicalein,wogonin,ect.,can egulate AGERAGE,IL-17 and other signaling pathways by acting on core targets such as CXCL8,IL-1β,etc.,and play a role in treating GA.

目的 采用网络药理学和分子对接探讨痛风舒片治疗痛风的潜在作用机制.方法 检索中药系统药理学分析平台挖掘痛风舒片关键成分和对应靶点;检索PharmGKB、GeneCards、OMIM、TTD、DrugBank数据库,筛选痛风疾病靶点,使用R软件Venn包,获取痛风舒片与痛风的交集靶点基因.使用Cytoscape 3.8.0软件构建"中药复方成分–靶点"网络图并筛选药物核心成分;使用String平台获取交集靶点基因的蛋白互作(PPI)网络,并使用Cytoscape 3.8.0软件筛选核心靶点基因.应用R软件对交集靶点基因进行GO功能和KEGG通路富集分析,应用AutoDock Vina软件进行分子对接.结果 共挖掘出痛风舒片关键成分38种,对应靶点164个,痛风疾病靶点1554个,二者交集靶点基因66个.筛选出核心成分6种(槲皮素、β-谷甾醇、芦荟大黄素、高车前素、泽兰黄醇素、海波拉亭),核心靶点基因6种[V-rel网状内皮细胞过多症病毒癌基因同源物A(RELA)、白细胞介素-1β(IL-1β)、蛋白激酶B1(AKT1)、丝裂原活化蛋白激酶1(MAPK1)、NF-κB抑制因子α(NFKBIA)、肿瘤蛋白p53(TP53)].GO功能共富集1963个条目,其中生物过程1830个(涉及对脂多糖的反应等),细胞组分27个(涉及膜筏等),分子功能106个(涉及磷酸酶结合等);KEGG通路共富集154个条目,如白细胞介素(IL)-17、肿瘤坏死因子(TNF)等信号通路.所有核心成分与核心靶点蛋白的结合能均<?5 kcal/mol,大部分结合能<?7 kcal/mol.结论 痛风舒片中核心成分槲皮素、β-谷甾醇、芦荟大黄素等可通过作用于RELA、IL-1β、AKT1等核心靶点基因,对IL-17、TNF等信号通路进行调控,从而发挥治疗痛风的作用.