The antacid effectiveness of: dihydroxy aluminum sodium carbonate, aluminum hydroxide, calcium carbonate, and sodium bicarbonate in humans has been compared. Samples of gastric contents were- removed over a seventy-five-minute period and evalated for pH and free and total acidity. The usefulness of the four antacids, based upon controlled pH in the order of their decreasing effectiveness, was as follows: dihydroxy aluminum sodium carbonate, aluminum hydroxide, calcium carbonate, and sodium bicarbonate.

The effect of a series of antacid materials upon uropepsin output was evaluated in a group of 15 normal adults. The antacids, namely, sodium bicarbonate, calcium carbonate, magnesium hydroxide, hydrated magnesium aluminate-sulfate activated (HMAS), and bismuth subsalicylate, were administered on the comparable basis of acid consuming power (ACP). Urine specimens, both control and test, were evaluated for total proteolytic activity. Statistical analysis of the results showed all test materials, except calcium carbonate, to have elicited significant decreases (P < 0.05) in uropepsin excretion. The effect of a series of antacid materials upon uropepsin output was evaluated in a group of 15 normal adults. The antacids, namely, sodium bicarbonate, calcium carbonate, magnesium hydroxide, hydrated magnesium aluminate-sulfate activated (HMAS), and bismuth subsalicylate, were administered on the comparable basis of acid consuming power (ACP). Urine specimens, both control and test, were evaluated for total proteolytic activity. Statistical analysis of the results showed all test materials, except calcium carbonate, to have elicited significant decreases (P < 0.05) in uropepsin excretion.

The effects of sodium fumarate, sodium citrate, and sodium tartrate when fed to rabbits for 150 days at concentrations equivalent to 5.0% of the organic acids in the diet were investigated. Particular attention was given to the possible appearance of testicular toxicity.

The Journal of PeriodontologyVolume 34, Issue 4 p. 334-337 Effect of Enzyme-Toothpastes upon Oral Hygiene Jos. W. E. Harrisson, Jos. W. E. Harrisson From LaWall and Harrisson, Research Laboratories, Inc., 1921 Walnut Street, Philadelphia 3, Pennsylvania.Search for more papers by this authorG. B. Salisbury, G. B. Salisbury From LaWall and Harrisson, Research Laboratories, Inc., 1921 Walnut Street, Philadelphia 3, Pennsylvania.Search for more papers by this authorD. D. Abbott, D. D. Abbott From LaWall and Harrisson, Research Laboratories, Inc., 1921 Walnut Street, Philadelphia 3, Pennsylvania.Search for more papers by this authorE. W. Packman, E. W. Packman From LaWall and Harrisson, Research Laboratories, Inc., 1921 Walnut Street, Philadelphia 3, Pennsylvania.Search for more papers by this author Jos. W. E. Harrisson, Jos. W. E. Harrisson From LaWall and Harrisson, Research Laboratories, Inc., 1921 Walnut Street, Philadelphia 3, Pennsylvania.Search for more papers by this authorG. B. Salisbury, G. B. Salisbury From LaWall and Harrisson, Research Laboratories, Inc., 1921 Walnut Street, Philadelphia 3, Pennsylvania.Search for more papers by this authorD. D. Abbott, D. D. Abbott From LaWall and Harrisson, Research Laboratories, Inc., 1921 Walnut Street, Philadelphia 3, Pennsylvania.Search for more papers by this authorE. W. Packman, E. W. Packman From LaWall and Harrisson, Research Laboratories, Inc., 1921 Walnut Street, Philadelphia 3, Pennsylvania.Search for more papers by this author First published: 01 July 1963 https://doi.org/10.1902/jop.1963.34.4.334Citations: 23 This study was made under a research grant by the American Chicle Company, New York. The authors wish to acknowledge the enthusiastic support of Dr. Robert Heggie, Vice President and Director of Research. AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Citing Literature Volume34, Issue4July 1963Pages 334-337 RelatedInformation

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTInsecticide-Rodenticide Toxicology, The Acute Oral Toxicity in Rats of Several Diet-Arsenic Trioxide MixturesE. W. Packman, D. D. Abbott, and J. W. E. HarrisonCite this: J. Agric. Food Chem. 1961, 9, 4, 271–272Publication Date (Print):July 1, 1961Publication History Published online1 May 2002Published inissue 1 July 1961https://pubs.acs.org/doi/10.1021/jf60116a008https://doi.org/10.1021/jf60116a008research-articleACS PublicationsRequest reuse permissionsArticle Views70Altmetric-Citations1LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts

The effects of dihydroxy aluminum sodium carbonate (DASC), aluminum hydroxide, calcium carbonate, and sodium bicarbonate, upon the proteolytic activity and volume of gastric secretion of the histamine-stimulated, pyloric-ligated rabbit have been studied. The probable clinical importance of the several factors that were observed has prompted the formulation of an “Index of Effectiveness” to be used as a means of evaluating gastric antacids. This index employs four factors: the maintenance of pH within the range of 3 to 5.5, in vitro acid consuming power, proteolytic activity, and the volume of the gastric secretion. Using this index, the antacids in order of decreasing effectiveness were: dihydroxy aluminum sodium carbonate, calcium carbonate, sodium bicarbonate, and aluminum hydroxide.

The degree of absorption at various time intervals of acetylsalicylic acid and acetophenetidin following the administration of tablets containing these substances, varies within the individual subject from day to day as widely as it does between different subjects. This variation in response between tablets can be influenced by differences in their physical properties or composition; however, it is also probable that the great differences which do occur may be due to the widely varying physiologic state of the subject.

1 l-Desmethoxyreserpine (alpha desmethoxyreserpine) a new ester alkaloid isolated from Rauwolfia canescens, was examined for its pharmacologic effects upon rodents and dogs. This alkaloid possesses hypotensive and tranquilizing effects comparable to reserpine. In addition, it produces hypothermia, increased salivation, miosis, and increased gastric acid secretion.

The present official methods of analysis for magnesium citrate solution are involved and tedious. The assays for total citric acid and for magnesium oxide have been simplified without sacrificing accuracy to any degree. Use has been made of a cation exchange resin to convert the total acid to a titratable form. Citric acid may then be calculated directly. The magnesium oxide has been determined by a titration employing disodium ethylenediaminetetraacetate. The combination of these two procedures for the analysis of magnesium citrate solution allows a great saving of time with an accuracy equal to or better than that achieved using the official methods.