PURPOSE:To evaluate the incidence and factors associated with oropharyngeal dysphagia (OD) three months after intensive care unit (ICU) discharge in patients who underwent invasive mechanical ventilation (IMV). METHODS:This was a post-hoc analysis of a prospective multicenter cohort study conducted across ten clinical-surgical ICUs in Brazil. Adult survivors (age > 18 years) with ICU stays ≥72 h and who needed IMV were included. The primary outcome was the incidence of OD, assessed by the Functional Oral Intake Scale (FOIS) during structured telephone interviews. Secondary outcomes included quality of life, measured by the Short Form Health Survey version 2, and rehospitalization. RESULTS:Among 360 patients, the incidence of OD 3 months after ICU discharge was 24.17%. Educational attainment (adjusted risk ratio [aRR] per 1 year increase, 0.95; 95% confidence interval [CI] 0.92-0.99), risk of death at ICU admission (aRR per 1% increase, 1.99; 95% CI, 1.06-3.77), acute respiratory distress syndrome [ARDS] diagnosis at ICU admission (aRR, 0.21; 95% CI, 0.06-0.71), and length of mechanical ventilation (aRR per 1 day increase, 1.02; 95%CI, 1.01-1.03) were associated with OD. Patients with OD reported significantly worse physical and mental quality-of-life scores. The incidence of rehospitalization did not differ significantly between patients with and without OD. CONCLUSIONS:OD 3 months after ICU discharge is a common condition among ICU survivors who required IMV. Educational level, severity of illness at ICU admission, ARDS diagnosis at ICU admission, and length of mechanical ventilation are key associated variables.

Background Educational access is key in empowering persons living with intellectual disabilities. Nevertheless, internationally, Persons with Intellectual Disabilities continue to experience marginalization and discrimination in accessing higher education.Methods This study undertakes a SWOT (Strengths, Weaknesses, Opportunities and Threats) analysis of three programmes for Persons with Intellectual Disabilities, located in higher education settings in Chile, Ireland and Australia. The project adopted a critical realist perspective focusing on its notions of reality as stratified and the pre-existence of social forms influencing the shapes of programmes, their outputs and outcomes.Findings The analysis indicates that programmes may be embedded differently within universities allowing for different levels of stability. Enrollment in such programmes can also be advantageous to Persons with Intellectual Disabilities. Awarding university-endorsed certifications (Chile) or qualifications aligning with national standards (Ireland), upon programme completion, promote programme credibility and can justify costs associated with the programme. While university administrative efficiencies can facilitate inclusion they can also hinder the flexibility needed to cater to the varied range of needs of Persons with Intellectual Disabilities.Conclusions The SWOT analysis suggests that when universities adjust their academic environments, to be sensitive and inclusive of the needs of Persons with Intellectual Disabilities, they have the capacity to assimilate and function with varying degrees of peer and staff support in such settings.

OBJECTIVES:This study aimed to evaluate long-term pulmonary function, cardiopulmonary exercise capacity, chest CT findings, and health-related quality of life (HRQoL) in survivors of COVID-19 complicated by acute respiratory distress syndrome (ARDS). DESIGN, SETTING, AND PATIENTS:This is a multicentric case-control study conducted from February 2023 to December of 2023. Pulmonary function tests, cardiopulmonary exercise testing (CPET), chest CT, and HRQoL (using EuroQol 5D three-level [EQ-5D-3L]) were performed at least 12 months after hospital discharge among cases (COVID-19 complicated by ARDS) and at the time of inclusion among controls (family members/friends matched for sex and age). INTERVENTIONS:None. MEASUREMENTS AND MAIN RESULTS:A total of 114 COVID-19 ARDS survivors and 115 controls were included. The mean age was 54 years and 52.4% of the participants were men. Time from hospital discharge to evaluation was 22 months (20.99-41.41 mo) among cases. Persistent symptoms, including memory loss (48.2%), fatigue (42.1%), and anxiety (31.6%), were reported by 73.6% of the COVID-19 ARDS survivors. Cases had significantly reduced pulmonary function, with lower diffusing capacity for carbon monoxide (DLCO) of 6.85 mmol/min/Kpa (5.44-8.37 mmol/min/Kpa) vs. 7.36 mmol/min/Kpa (6.43-8.96 mmol/min/Kpa; p = 0.012) and % of predicted DLCO of 81.0% (70.2-90.4%) vs. 89.3% (78.9-99.9%; p < 0.001), compared with controls, as well as a higher frequency of moderate to severe DLCO impairment (10.5% vs. 0.8%; p = 0.002). In CPET, cases demonstrated lower peak oxygen consumption (21.9 mL/kg/min [18.2-29 mL/kg/min] vs. 25.8 mL/kg/min [21.6-31.9 mL/kg/min]; p < 0.001). Chest CT revealed a greater prevalence of ground-glass opacities in cases (53.5% vs. 16.5%; p < 0.001) and emphysema (6.1% vs. 0%; p = 0.043). HRQoL, using EQ-5D-3L utility scores, were significantly lower in cases, with worse mobility (p < 0.001), self-care (p < 0.001), and anxiety/depression (p = 0.04) dimension scores compared with controls. CONCLUSIONS:COVID-19 ARDS survivors exhibit significant long-term impairments in pulmonary function, exercise capacity, and quality of life and abnormal chest CT findings compared with family controls with same sex and age.

Abstract Background The long-term effects of mild COVID-19 infection on Health-related Quality of Life (HRQoL) are not yet well understood. The study objective was to assess HRQoL and factors associated with its worsening 12 months after mild SARS-CoV-2 infection. Methods Multicenter prospective cohort study in Brazil between January 2022 and December 2023. Pasrticipants were ≥ 18 years outpatients for symptomatic SARS-CoV-2 infection confirmed by either RT-PCR or antigen test were included. Telephone interviews conducted at 1, 3, 6, 9 and 12 months after COVID-19 diagnosis. The primary outcome was the HRQoL utility score assessed using the EuroQol-5D-3L (EQ-5D-3L) at 12 months. The patients were categorized into two groups: worsened the EQ-5D-3L and stable/improved in 12 months. Factors associated with worsening or stable/improvement 12 months after COVID-19 were analyzed using Generalized Estimating Equations. Results A total of 1174 participants were screened; of these, 1081 were enrolled, and 989 were included in the analysis, with 337 (34%) in the worsened group and 652 (66%) in the stable/imporved group. The median age was 39 (interquartile range, 31-50) years, 69% were women, 45% were health workers, and 84% had no comorbidities (Table 1). In the worsened group, a decline in HRQoL (as measured by EQ-5D-3L with a mean score=0.9) was evident as early as 3 months post- infection (mean score=0.8), being pronounced at 12 months (mean score=0.71, Figure 1). In the stable/improved group, the EQ-5D-3L in 3 months was the same as the previous quality of life (mean score=0.86 in both), with a increase in 12 months (mean score= 0.9, Figure 1). Male sex [0.03 (0.02;0.04)], age 60 and older [-0.03 (-0.04; -0.01)], obesity [-0.04 (-0.05; - 0.03)], Charlson comorbidity Index (CCI) ≥ 1 [-0.05 (-0.06; -0.03)], and history of mental health disease [-0.07 (-0.08;-0.06)] were associated with worsened quality of life at 12 months. Conclusion This study shows mild covid-19´s lasting impact on long-term quality of life. The worsened group declined consistently, while the stable/improved group remained stable or improved. Older age, female sex, obesity, and comorbidities or mental health disease were linked to worsened outcomes Disclosures Marciane Maria Rover, MD, Hospital Moinhos de Vento: work at Hospital Moinhos de Vento, which received a research grant from the Brazilian Ministry of Health for the conduction of this study. Fernando Scolari, PhD, Hospital Moinhos de Vento: work at Hospital Moinhos de Vento, which received a research grant from the Brazilian Ministry of Health for the conduction of this study. Geraldine Trott, PhD, Hospital Moinhos de Vento: work at Hospital Moinhos de Vento, which received a research grant from the Brazilian Ministry of Health for the conduction of this study. Mariana Motta Dias Silva, MSc, Hospital Moinhos de Vento: work at Hospital Moinhos de Vento, which received a research grant from the Brazilian Ministry of Health for the conduction of this study. Aline Paula Miozzo, PhD, Hospital Moinhos de Vento: work at Hospital Moinhos de Vento, which received a research grant from the Brazilian Ministry of Health for the conduction of this study. Denise de Souza, MSc, Hospital Moinhos de Vento: work at Hospital Moinhos de Vento, which received a research grant from the Brazilian Ministry of Health for the conduction of this study. Rosa da Rosa Minho Santos, n/a, Hospital Moinhos de Vento: work at Hospital Moinhos de Vento, which received a research grant from the Brazilian Ministry of Health for the conduction of this study. Emelyn de Souza Roldao, n/a, Hospital Moinhos de Vento: work at Hospital Moinhos de Vento, which received a research grant from the Brazilian Ministry of Health for the conduction of this study. Gabriela Soares Rech, MSc, Hospital Moinhos de Vento: work at Hospital Moinhos de Vento, which received a research grant from the Brazilian Ministry of Health for the conduction of this study. Raine Fogliati De Carli Schardosim, PhD, Hospital Moinhos de Vento: work at Hospital Moinhos de Vento, which received a research grant from the Brazilian Ministry of Health for the conduction of this study. Duane Mocellin, MSc, Hospital Moinhos de Vento: work at Hospital Moinhos de Vento, which received a research grant from the Brazilian Ministry of Health for the conduction of this study. Jennifer Menna Barreto Souza, n/a, Hospital Moinhos de Vento: work at Hospital Moinhos de Vento, which received a research grant from the Brazilian Ministry of Health for the conduction of this study. Gabrielle Nunes da Silva, PhD, Hospital Moinhos de Vento: work at Hospital Moinhos de Vento, which received a research grant from the Brazilian Ministry of Health for the conduction of this study. Carolina Rothmann Itaqui, n/a, Hospital Moinhos de Vento: work at Hospital Moinhos de Vento, which received a research grant from the Brazilian Ministry of Health for the conduction of this study. Caroline Cabral Robinson, PhD, Hospital Moinhos de Vento: work at Hospital Moinhos de Vento, which received a research grant from the Brazilian Ministry of Health for the conduction of this study. Carisi Anne Polanczyk, PhD, Hospital Moinhos de Vento: work at Hospital Moinhos de Vento, which received a research grant from the Brazilian Ministry of Health for the conduction of this study. Regis Goulart Rosa, MD, PhD, Hospital Moinhos de Vento: work at Hospital Moinhos de Vento, which received a research grant from the Brazilian Ministry of Health for the conduction of this study.

The lingering effects of COVID-19 may impair survivors' long-term health-related quality of life (HRQoL). However, multicentre studies focusing on the Omicron variant, particularly in middle- and low-income settings, are scarce. We conducted a prospective cohort study across 24 Brazilian hospitals between December 2021 and March 2024, when Omicron was the predominant variant. Adult COVID-19 survivors were followed for 12 months via telephone interviews. The primary outcome was HRQoL at 12 months, assessed using the EuroQol five-dimension three-level questionnaire (EQ-5D-3L; range -0.17 to 1.0). All-cause mortality was a secondary outcome. Among 649 participants (47.9% women; median age 71 years), the median EQ-5D-3L utility score at 12 months was 0.69 (IQR 0.41-0.80), and survival was 86.6%. Factors associated with lower HRQoL included female sex, age ≥ 60 years, Charlson comorbidity index ≥ 1, and need for respiratory support. Mortality was associated with age ≥ 60 years (HR 2.81), CCI ≥ 2 (HR 2.17), need for low-flow oxygen therapy (HR 2.03), and BMI ≥ 25 kg/m² (HR 0.58). One year after hospitalization, Omicron survivors in Brazil showed impaired HRQoL and high mortality. Older age, comorbidities, and need for oxygen therapy were linked to worse outcomes. Long-term support strategies are needed for these vulnerable populations.

OBJECTIVE:To assess the impact of a multicomponent intervention on the health-related quality of life of patients with hypoxemic respiratory failure requiring invasive mechanical ventilation. METHODS:A cluster stepped-wedge randomized clinical trial will be conducted in intensive care units across Brazil. Intensive care units with ≥ 8 beds and the capacity to admit patients with acute hypoxemic respiratory failure will be included. Within each intensive care unit, adult patients with acute hypoxemic respiratory failure requiring invasive mechanical ventilation, in whom SARS-CoV-2 infection is part of the differential diagnosis, will be enrolled. The intervention consists of a telemedicine-based quality improvement program focused on disability prevention and rehabilitation strategies, implemented during the patient's intensive care unit stay, continued through ward admission, and extending up to 2 months post-hospital discharge. The primary outcome is health-related quality of life assessed using the EuroQol 5-Dimension 3-Level scale 90 days after discharge from the hospital. Secondary outcomes include rehospitalization within 30 days from hospital discharge, as well as all-cause mortality, anxiety, depression, cognitive impairment, new disabilities for instrumental activities of daily living, and return to work or studies 90 days after discharge from the hospital. RESULTS:The study protocol has been approved by the research ethics committees of all participant institutions. It was registered at ClinicalTrials.gov (NCT06343545) before the first participant was included. We aim to disseminate the findings through conferences and peer-reviewed journals. CONCLUSION:The "Tele-Rehab MV trial" may provide further information on the role of early multicomponent interventions aimed at disability prevention and rehabilitation for critically ill patients with acute hypoxemic respiratory failure.

This study aimed to identify phenotypes of long COVID symptoms in adults following Omicron infection and assess their association with health-related quality of life (HRQoL). We analyzed three prospective observational studies in Brazil, enrolling adult patients who sought care for symptomatic Omicron infection between December 2021 and March 2023. The infection was confirmed by either an antigen test or reverse transcriptase polymerase chain reaction. Long COVID symptoms were assessed three months after enrollment through structured interviews. Phenotypes of Long COVID-19 were identified using a machine learning-based clustering approach. Exploratory analyses were conducted to examine predisposing factors and health-related quality of life utilities, measured by EQ-5D-3 L, associated with each phenotype. A total of 2,989 patients were analyzed (39

RESUMO Fundamento: As evidências acerca das sequelas a longo prazo após internação por síndrome do desconforto respiratório agudo por COVID-19 ainda são escassas. Objetivo: Avaliar alterações nas funções pulmonar, cardíaca e renal e na qualidade de vida após internação por síndrome do desconforto respiratório agudo secundária à COVID-19. Métodos: Trata-se de estudo multicêntrico, caso-controle, incluindo 220 participantes. Os casos serão definidos como pacientes hospitalizados por síndrome do desconforto respiratório agudo devido à COVID-19. No Grupo Controle, serão selecionados indivíduos sem histórico de hospitalização nos últimos 12 meses ou sintomas a longo prazo de COVID-19. Todos os indivíduos serão submetidos à espirometria pulmonar com teste de difusão pelo monóxido de carbono, tomografia de tórax, ressonância magnética cardíaca e renal com gadolínio, ergoespirometria, creatinina sérica e urinária, proteínas totais e microalbuminúria urinária, além de questionários de qualidade de vida. Os casos serão avaliados 12 meses após a alta hospitalar e os controles, 90 dias após a inclusão no estudo. Para todas as análises estatísticas, será assumido como significativo o valor p < 0,05. Resultados: O desfecho primário do estudo foi definido com a capacidade de difusão pulmonar aferida para o monóxido de carbono a partir de 12 meses. Os demais parâmetros das funções pulmonar, cardíacas e renal e da qualidade de vida foram definidos como desfechos secundários. Conclusão: Este estudo visa determinar as sequelas a longo prazo nas funções pulmonar, cardíaca e renal e na qualidade de vida de pacientes internados por síndrome do desconforto respiratório agudo devido à COVID-19 na população brasileira.

Abstract Purpose To assess the effects of flexible ICU visitation on the one-year prevalences of posttraumatic stress, anxiety and depression symptoms among family members of critically ill patients. Methods This is a secondary analysis of a cluster-crossover randomized clinical trial that evaluated a flexible visitation model in the ICU (12 hours/day) compared to a restrictive visitation model (median 1.5 hours/day) in 36 Brazilian ICUs. In the present analysis, family members were assessed 12 months after inclusion in the study for the following outcomes: post-traumatic stress symptoms measured by the Impact Event Scale-6 and anxiety and depression symptoms measured by the Hospital Anxiety and Depression Scale. Results A total of 519 family members were analyzed (288 in the flexible visitation group and 231 in the restrictive visitation group). Three-hundred sixty-nine (71.1%) were women, and the mean age was 46.7 years. Compared to family members in the restrictive visitation group, family members in the flexible visitation group had a significantly lower prevalence of post-traumatic stress symptoms (21.0% vs. 30.5%; prevalence ratio [PR], 0.70; 95% confidence interval [CI], 0.54–0.92; p = 0.01). The prevalence of anxiety (28.9% vs. 33.2%; PR 0.92; 95% CI, 0.71–1.19; p = 0.54) and depression symptoms (19.2% vs. 25.0%; PR, 0.79; 95% CI, 0.61–1.04; p = 0.05) did not differ significantly between the groups. Conclusion Flexible ICU visitation, compared to the restrictive visitation, was associated with a significant reduction in the one-year prevalence of post-traumatic stress symptoms in family members. TRIAL REGISTRATION: ClinicalTrials.gov Identifier: NCT02932358 Trial protocol: 10.1136/bmjopen-2017-021193

The aim of this study was to assess the effects of flexible intensive care unit (ICU) visitation on the 1-year prevalence of post-traumatic stress, anxiety and depression symptoms among family members of critically ill patients. This is a long-term outcome analysis of a cluster-crossover randomized clinical trial that evaluated a flexible visitation model in the ICU (12 h/day) compared to a restrictive visitation model (median 1.5 h/day) in 36 Brazilian ICUs. In this analysis, family members were assessed 12 months after patient discharge from the ICU for the following outcomes: post-traumatic stress symptoms measured by the Impact Event Scale-6 and anxiety and depression symptoms measured by the Hospital Anxiety and Depression Scale. A total of 519 family members were analyzed (288 in the flexible visitation group and 231 in the restrictive visitation group). Three-hundred sixty-nine (71.1

To identify the prevalence and associated factors of cognitive dysfunction, 1 year after ICU discharge, among adult patients, and it´s relation with quality of life. Multicenter, prospective cohort study including ICUs of 10 tertiary hospitals in Brazil, between May 2014 and December 2018. The patients included were 452 adult ICU survivors (median age 60; 47.6

BackgroundResearch on post-secondary training for individuals with intellectual disabilities has generally focused on programs, with little consideration of the structures and mechanisms that give rise to them. This article adopts a critical realist perspective to comparatively analyse and theorise about the contextual structures contributing to the introduction of post-secondary training programs in universities for individuals with intellectual disabilities.MethodSix stages in critical realist explanatory research were followed. They include (1) description, (2) analytical resolution, (3) abduction/theoretical redescription, (4) retroduction, (5) comparison between different theories and abstractions, and (6) concretisation and contextualisation.ResultsHistorical, socio-political, and educational policy structures and mechanisms, indicated three program typologies: program as niche, as a generalisable prototype, and as an evolutionary response to evolving conditions.ConclusionsBy developing explanations about preconditions, the study draws out nuanced sub-types occurring within a single university-based program, theorises on trajectories for success, and lays the groundwork for future empirical and conceptual development.

RATIONALE:Evidence about long-term sequelae after hospitalization for acute respiratory distress syndrome due to COVID-19 is still scarce.PURPOSE:To evaluate changes in pulmonary, cardiac, and renal function and in quality of life after hospitalization for acute respiratory distress syndrome secondary to COVID-19.METHODS:This will be a multicenter case-control study of 220 participants. Eligible are patients who are hospitalized for acute respiratory distress syndrome due to COVID-19. In the control group, individuals with no history of hospitalization in the last 12 months or long-term symptoms of COVID-19 will be selected. All individuals will be subjected to pulmonary spirometry with a carbon monoxide diffusion test, chest tomography, cardiac and renal magnetic resonance imaging with gadolinium, ergospirometry, serum and urinary creatinine, total protein, and urinary microalbuminuria, in addition to quality-of-life questionnaires. Patients will be evaluated 12 months after hospital discharge, and controls will be evaluated within 90 days of inclusion in the study. For all the statistical analyses, p < 0.05 is the threshold for significance.RESULTS:The primary outcome of the study will be the pulmonary diffusing capacity for carbon monoxide measured after 12 months. The other parameters of pulmonary, cardiac, and renal function and quality of life are secondary outcomes.CONCLUSION:This study aims to determine the long-term sequelae of pulmonary, cardiac, and renal function and the quality of life of patients hospitalized for acute respiratory distress syndrome due to COVID-19 in the Brazilian population.

[This corrects the article DOI: 10.1016/j.jvacx.2024.100579.].

This paper focuses on post-secondary programmes for individuals with intellectual impairments within university settings in Chile, Ireland, and Australia. Actor-Network Theory (ANT) is adopted to explain how programmes are developed and sustained through relationships between human and non-human actors. Findings show that for all the university embedded programmes, parent-actors initiated network development. These different programmes were then sustained by other actor-networks, each with its distinct emphasis. In the Chilean network, the university's strong, dynamic support made it a catalyst and social change leader in higher education inclusion across employers and broader society In the Irish network, a strong university actor drove extensive relationships with community and employers who also provided training support. In the Australian network, government played a key role, shaping networks through compliance and funding requirements. These findings contribute to the sustainable development efforts of future programmes.

This chapter describes experiences of inclusion from the perspective of young adults with Down syndrome, participating in an intensive education to work (EtW) training programme. The programme, designed by a non-governmental organisation (NGO), was conducted within a private university in Australia working in partnership with the NGO.Drawing from a broader formative evaluation of the programme, the case study investigated how inclusion was described and understood by the student participants and individuals involved in facilitating or supporting the programme. Data collection involved conducting a focus group interview with student participants and face-to-face interviews with their teachers, a student volunteer and two university lecturers who interacted with students in the programme. The findings have been used to improve the processes of the programme currently undergoing its third iteration.Findings suggest the need to consider at least two levels of provision in the development of equitable education for individuals participating in this programme. These include considering their voices at the level of programme design, and secondly, deliberately facilitating disability confidence programs for university students and staff.The study notes that embedding education to employment training programs for individuals with intellectual disabilities within university settings provide them with opportunities to experience and access higher education; however, more investigations are needed to ascertain what equitable higher education in practice means for them.

Realist evaluation has gained prominence in the field of evaluation in recent years. Its theory-driven approach to explaining how and why programmes work or not makes it attractive to many novices, early career researchers, and organizations implementing various programmes globally and relevant to policymakers and programme implementers. While realist evaluation seeks to be pragmatic, adopting principles and methods that can be used to help focus an evaluation, its deep ontological and epistemological foundations make its application in real-life situations challenging. In this paper, we seek to unpack the key tenets scaffolding the practical application of realist evaluation. Although Pawson and Tilley foreground realist evaluation in applied scientific realism, we argue that an amalgam of scientific and critical realist principles underpins realist evaluation. We unpack these principles and illustrate how they fit into each other to provide a cogent theoretical foundation for realist evaluation.

To assess the association between acute disease severity and 1-year quality of life in patients discharged after hospitalisation due to coronavirus disease 2019 (COVID-19). We conducted a prospective cohort study nested in 5 randomised clinical trials between March 2020 and March 2022 at 84 sites in Brazil. Adult post-hospitalisation COVID-19 patients were followed for 1 year. The primary outcome was the utility score of EuroQol five-dimension three-level (EQ-5D-3L). Secondary outcomes included all-cause mortality, major cardiovascular events, and new disabilities in instrumental activities of daily living. Adjusted generalised estimating equations were used to assess the association between outcomes and acute disease severity according to the highest level on a modified ordinal scale during hospital stay (2: no oxygen therapy; 3: oxygen by mask or nasal prongs; 4: high-flow nasal cannula oxygen therapy or non-invasive ventilation; 5: mechanical ventilation). 1508 COVID-19 survivors were enrolled. Primary outcome data were available for 1156 participants. At 1 year, compared with severity score 2, severity score 5 was associated with lower EQ-5D-3L utility scores (0.7 vs 0.84; adjusted difference, − 0.1 [95% CI − 0.15 to − 0.06]); and worse results for all-cause mortality (7.9% vs 1.2%; adjusted difference, 7.1% [95% CI 2.5%–11.8%]), major cardiovascular events (5.6% vs 2.3%; adjusted difference, 2.6% [95% CI 0.6%–4.6%]), and new disabilities (40.4% vs 23.5%; adjusted difference, 15.5% [95% CI 8.5%–22.5]). Severity scores 3 and 4 did not differ consistently from score 2. COVID-19 patients who needed mechanical ventilation during hospitalisation have lower 1-year quality of life than COVID-19 patients who did not need mechanical ventilation during hospitalisation.

Resumo Fundamento O impacto em longo prazo da hospitalização por COVID-19 sobre a saúde física, mental e cognitiva dos pacientes requer mais investigação. Objetivos Este artigo visa avaliar os fatores associados com a qualidade de vida e desfechos cardiovasculares e não cardiovasculares 12 meses após a internação hospitalar por COVID-19. Métodos Este estudo multicêntrico prospectivo pretende incluir 611 pacientes internados por COVID-19 (NCT05165979). Entrevistas telefônicas centralizadas estão programadas para ocorrer em três, seis, nove e 12 meses após a alta hospitalar. O desfecho primário é definido como o escore de utilidade de qualidade de vida relacionada à saúde avaliada pelo questionário EuroQol-5D-3L (EQ-5D-3L) aos 12 meses. Desfechos secundários são definidos como o EQ-5D-3L aos três, seis e nove meses, retorno ao trabalho ou à escola, sintomas persistentes, novas incapacidades em atividades instrumentais diárias, déficit cognitivo, ansiedade, depressão, e sintomas de transtorno do estresse pós-traumático, eventos cardiovasculares maiores, reinternação, e mortalidade por todas as causas aos três, seis, nove e 12 meses após a infecção pelo SARS-CoV-2. Um valor de p<0,05 será considerado estatisticamente significativo para as análises. Resultados O desfecho primário será apresentado como frequência do escore EQ-5D-3L 12 meses após a internação por COVID-19. Uma subanálise para identificar possíveis associações das variáveis independentes com desfechos do estudo será apresentada. Conclusão Este estudo determinará o impacto da COVID-19 sobre a qualidade de vida e de desfechos cardiovasculares e não cardiovasculares de pacientes internados 12 meses após a alta, e fornecerá novas informações ao sistema público de saúde no Brasil.