Mikroplastik (<5 mm) merupakan polutan emergen di ekosistem perairan yang berpotensi menimbulkan efek toksik pada organisme akuatik, termasuk gangguan fisiologis, stres oksidatif, dan peningkatan mortalitas ikan. Penelitian ini bertujuan menganalisis cemaran mikroplastik serta gambaran histologis organ insang dan usus ikan di perairan Pulau Baai, Provinsi Bengkulu. Analisis mikroplastik menggunakan larutan KOH 10%, sedangkan histologi menggunakan metode parafin dengan pewarnaan Hematoksilin-Eosin. Sampel ikan terdiri atas empat spesies, yaitu tongkol, selar, gulama, dan kape-kape, masing-masing sebanyak 20 ekor. Hasil penelitian menunjukkan keberadaan mikroplastik pada kedua organ dengan kelimpahan berkisar 98–287 partikel/gram; jumlah tertinggi ditemukan pada ikan tongkol dengan rata-rata 139 partikel/gram. Bentuk mikroplastik yang teridentifikasi meliputi filamen, fragmen, dan film, dengan filamen sebagai bentuk dominan. Warna mikroplastik yang paling banyak ditemukan adalah hitam dan transparan. Analisis histologis insang menunjukkan perubahan struktural berupa hiperplasia, pengangkatan epitelium, pemendekan lamela sekunder, fusi lamela primer, edema, dan lisis. Histologis usus menunjukkan kerusakan berupa lisis, erosi vili, abnormalitas sel goblet, serta terlepasnya epitel mukosa dari lamina propria. Kerusakan struktur jaringan tersebut dapat dipengaruhi adanya tekanan lingkungan di perairan laut Bengkulu yang diduga dipengaruhi oleh paparan berbagai bahan pencemar, termasuk mikroplastik sebagai salah satu kontaminan potensial di ekosistem perairan.

Mungkus fish is a culturally and economically important fish in Bengkulu. However, the accurate species name of the existing Mungkus fish in Bengkulu province remains unclear. Our research aimed to accurately identify the species of Mungkus fish by using a molecular approach. The DNA Barcoding method, using the Cytochrome c oxidase subunit 1 (COI) gene sequence, was employed for species identification and phylogenetic analysis. The DNA of 12 fin tissue samples, chosen from eight main rivers, was extracted using the Phenol-Chloroform method. The target DNA was amplified using the paired primers Fish-BCL and Fish-BCH before sequencing. The sequence data were then analyzed by using bioinformatic tools. This study successfully identifies three species of Mungkus fish in Bengkulu (Sicyopterus lagochepalus, Sicyopterus squamossissimus, and Sicyopterus cynocephalus), with similarity to GenBank data> 99.00%. ASAP analysis supports the species delimitation, which clustered into three species. Bayesian Inference phylogenetic analysis clearly resolved all samples into three distinct clades. The analysis also unveiled clear haplotype divergence among Sicyopterus species, indicating both shared and species-specific genetic lineages. Close genetic affinity was observed among S. lagocephalus populations from Bengkulu, Maluku, and the Philippines, whereas S. cynocephalus showed regional differentiation from Gorontalo populations. These findings provide taxonomic clarity that is fundamental for future sustainable management and conservation planning of Mungkus fisheries in Bengkulu Province.

The aquatic environment is crucial for fish survival because fish require appropriate aquatic environment. Artisanal gold mining generates heavy metal waste in Lebong Regency, polluting the river flows. Heavy metals released into the aquatic environment generate water pollution problems due to their toxicity, persistence, and bio-accumulation in organism. The aim of this study was to investigate the histology of fish gill organs in the river contamined by heavy metals. Fish samples were taken by purposive sampling. Histological sections using the paraffin method and hematoxylin-eosin staining. The result of mercury detected in water is 0.01mg/L, exceeded maximum limit in river based on class II water quality standard (0.002mg/L). Histopathology of gills H. nemurus and T. Tricopterus fish (HAI scores <20) showed slight alterations such as epithelial lifting, secondary lamella fusion, and hyperplasia. Rasbora sp., M.circumcinctus, and O.niloticus gills fish (HAI scores>100) had severe irreversible damage, marked by telangiectasis at the tips of the secondary lamella. This is due to the presence of heavy metal contaminants in the water, that causes histopathological damage to fish gills. Parasitic infections were also discovered in some fish gills, impairing their function for respiratory and excretory organs which can be caused by low water quality.

Background: Liver has many functions in the metabolic system and detoxification of substances that are harmful to the body. Chemical intoxication due to drug use might induce liver damage. A histology examination can indicate liver damage induced by a chemical substance, as well as the condition of tissue structure and function associated with the disease. This study aims to investigate the hepatoprotective effect of mix infusion of hibiscus flowers and soursop leaves on the liver histological structure in mice induced by hyperuricemia using potassium oxonate. Methodology: This study used an experimental group design, involving 8-week-old mice. The groups were divided as follows: A1 (control), A2 (Potassium oxonate), A3 (allopurinol), A4 (infusion 25 %), A5 (infusion 35 %), and A6 (infusion 45 %). Histological image was examined using an optilab with five fields of view. Findings: The study's revealed that the control group had a normal liver histology structure, whereas the hyperuricemia treatment group experienced significant liver damage, including congestion and leukocyte infiltration, and the allopurinol treatment group experienced significant damage, including leukocyte infiltration and necrosis. Therapy with a combined infusion of hibiscus flowers and soursop leaves shown a hepatoprotective effect. Based on histological analysis, the 25 % concentration provided the greatest hepatoprotective impact when compared to other infusion concentration. Mix infusion of hibiscus flowers and soursop leaves demonstrates heproprotective activity in hyperuricemia mice induced by potassium oxonate. Contribution: This study demonstrates that the mix infusion of hibiscus flowers and soursop leaves has the potential to be a hepatoprotective agent, but further research is needed regarding long-term effects

The Serawai tribe is one of the indigenous communities in Bengkulu, Indonesia, with the second-largest population after the Rejang tribe. As part of the Malayan Mongoloid group, the Serawai tribe exhibits unique cultural, linguistic, and physical characteristics. These physical traits, influenced by genetic factors, can provide valuable insights for various scientific and forensic applications. This study aims to analyze the foot arch and toe patterns of the Serawai tribe in Bengkulu. Data were collected from December 2021 to February 2022 in Pematang Gubernur Village, Bengkulu City, using interviews and direct surveys involving Serawai individuals who met the inclusion criteria. The collected data were analyzed using the Chi-Square test. A total of 100 participants fulfilled the study requirements. The analysis revealed three distinct arch patterns, with the dominant being the High Arch (74.64%). Additionally, there are six patterns of the tip of the toes, with the dominant being the Greek (32.83%). However, no statistically significant correlation was found between gender and foot arch or toe patterns.

Prevalensi hiperurisemia mengalami peningkatan dalam beberapa dekade terakhir yang seringkali disebabkan oleh pola makan dengan kandungan makanan tinggi purin. Purin juga terdapat dalam DNA sel tubuh yang akan juga dirombak, sehingga kadar asam urat dalam darah dapat semakin tinggi karena asupan dari makanan. Kadar asam urat dapat diturunkan dengan obat anti-hiperurisemia, salah satunya allopurinol, namun penggunaan jangka panjang dapat mengakibatkan efek berbahaya pada organ tubuh. Bunga kembang sepatu (Hibiscus rosa-sinensis L.) dan daun sirsak (Annona muricata L.) mengandung metabolit sekunder yang berpotensi sebagai anti-hiperurisemia. Tujuan dari penelitian ini untuk mengetahui keefektivitasan infusa kombinasi bunga kembang sepatu dan daun sirsak terhadap kadar asam urat mencit yang diinduksi hiperurisemia. Mencit dibagi menjadi 6 kelompok perlakuan, K0 (kontrol negative), K1 kontrol hiperurisemia (kalium oksonat dan jus hati ayam), K2 (kontrol positif menggunakan allopurinol 10mg/kgBB), K3 (infusa 25%), K4 (infusa 35%), K5 (infusa 45%). Berdasarkan hasil penelitian menunjukkan bahwa kombinasi infusa bunga kembang sepatu-daun sirsak dapat menurunkan kadar asam urat darah mencit jantan strain DDY yang diinduksi hiperurisemia menggunakan kalium oksonat dan jus hati ayam. Kelompok K2 (kontrol positif) menggunakan allopurinol terjadi penurunan kadar asam urat sebesar 56,2%. Sedangkan menggunakan infusa dapat menurunkan kadar asam urat mencit dengan konsentrasi terbaik 25% jika dibandingkan dengan kelompok konsentrasi infusa yang lain, dengan persentase penurunan kadar asam urat darah sebesar 44,11%. Hal ini menunjukkan bahwa infusa kombinasi bunga kembang sepatu dan daun sirsak memiliki potensi sebagai anti hiperurisemia.

The subterranean termite Coptotermes curvignathus is a type of insect that damages wood until it is porous and destroyed. Until now, termites are chemically controlled but negatively impact the environment, so bioinsecticides such as from Usnea barbata lichen are needed. This study aims to determine the bioactivity of U extract. Barbata as a bioinsecticide for subterranean termites C. curvignathus. The experiment used Completely Randomizd Design with 7 treatments (concentrations of 0%, 5%, 10%, 15%, 20%, 25%, and Termicon) and 3 replicates. The extract was prepared from 300 g of U barbata powder, macerated in 7 days in 96% ethanol in a ratio of 1:10 (300 g/3 L). Mortality and feed weight loss were observed for 7 days. The extracts contained alkaloids, flavonoids, terpenoids, steroids, saponins, and tannins. The phytochemicals were analyzed descriptively, and a lethal concentration value of 50% (LC50) was determined by probit analysis. Data on termite mortality percentage and feed loss percentage were analyzed using ANOVA at a 5% confidence level. If the Fcalct > Ftable, Duncan's further test was carried out. The results showed that the extract contained alkaloids, steroids, tannins, and saponins. The mortality of subterranean termites was indicated by an LC value of 50-72 hours of 19.32%. Statistically, U. barbata extract affected mortality but did not differ significantly in the feed weight loss of C. curvignathus subterranean termites. Keywords: bioactivity, Coptotermes curvignathus, insecticide, Usnea barbata

Peternakan di Indonesia cenderung rentan terhadap berbagai jenis penyakit. Salah satu ancaman penyakit pada hewan ternak terhadap kesehatan manusia yaitu zoonosis. Salah satu cara untuk mengidentifikasi parasit gastrointestinal dari ternak yaitu dengan melakukan pemeriksaan atau pengujian feses sapi secara rutin. Pentingnya mengetahui jenis cacing yang menginfeksi ternak agar dapat segera dilakukan pengobatan dengan jenis obat antiparasit yang tepat, sehingga pengobatannya menjadi lebih efektif. Sehingga tujuan penelitian ini untuk memeriksa feses sapi untuk mengetahui infeksi jenis cacing. Sampel feses sapi didapatkan dari Laboratorium Peternakan Universitas Bengkulu dan UPTD Pembibitan dan Pakan Ternak (PPT) Bengkulu menggunakan sapi jenis Peranakan Ongole (PO) dan sapi bali. Metode yang digunakan dalam penelitian ini dengan dua metode yaitu metode natif dan sedimentasi. Hasil penelitian yang didapatkan menunjukkan bahwa 3 individu sapi menunjukkan positif terinfeksi berbagai jenis cacing. Hasil metode natif ditemukan beberapa jenis cacing yang paling banyak berupa nematoda yang meliputi A. lumbricoides, Strongyloides papillosus, Strongylid dan Toxocara spp., trematoda berupa Schistosoma bovis, dan cestode berupa Taenia sp. Sedangkan dengan metode sedimentasi juga menunjukkan lebih banyak positif terinfeksi trematoda yang meliputi Schistosoma sp., Fasciola sp, Eurytrema spp, Paramphistomum sp, serta cestoda berupa Taenia sp. Pola pemeliharaan sapi secara intensif mampu menekan penyebaran parasit cacing jauh lebih baik jika dibandingkan dengan pola pemeliharaan sapi secara semi intensif.

This community service activity aims to increase public knowledge, especially among women who live around the gold mine in Lebong Regency, about the harmful effects of mercury on health because women who live around gold mines will have a double risk of being exposed to mercury both from mines and from using unsafe cosmetics. The method of implementing this community service activity used the educational method with several stages, including location surveys, coordination with participants, the stage of educational activities, and the evaluation stage by filling out a questionnaire. The partners for this community service activity were women (mothers) who live around the gold mine in Lebong Regency. The results of this community service activity showed that almost all participants still lack information regarding the effects of mercury on health; many did not know that mercury can cause abnormalities in pregnant women which impact the fetus and baby, as well as the impact of damage to the nerves, brain, and other vital organs of the body other. The existence of this service activity could add insight and knowledge to participants. The evaluation results showed that the participants were satisfied with implementing this activity and expect other educational activities to add new insights and knowledge due to limited information.

The aim of this research was to reveal the natural foods of S. cynocephalus from Padang Guci River, Kaur Regency. This research was conducted by using stratified random sampling by catching 75 individuals from its habitat divided by 3 stations such as Station I (upstream), Station II (middle stream) and Station III (downstream). Sampling was conducted using fishing trap and fishing net and then stomach dissection was done in Laboratory of Biology, FMIPA UNIB to identify food variety, body ratio, digestive tract ratio and frequency of food occurrences of fish samples (each 25 samples per station). In addition, water quality parameters were also measured. Based on the result, the data showed that there is a different in body development of mungkus fish which in Station I was positive allometry. In contrast, station II and III showed negative allometry. Based on frequency of food occurrence. The highest occurrence was Cosmarium decoratum (72 %) and the lowest was Synedra. All obtained food were classified as algae. Analysis of digestive tract and body ratio revealed that S. cynocephalus was categorized as herbivore fish with the ratio 3.72-5.34. The measurement of abiotic factor indicated that all parameters were still fulfil water quality standard to support the sustainability of Mungkus life in Padang Guci River.

Penyakit yang dapat disebabkan akibat penggunaan alat selam secara bersama yang tidak aseptik yaitu Infeksi Saluran Pernapasan Akut (ISPA). ISPA merupakan penyakit yang menginfeksi saluran pernapasan atas dan menginfeksi seluruh bagian pernapasan bawah (alveoli). ISPA dapat menular melalui droplet mengandung virus atau bakteri terhirup oleh orang sehat. Penggunaan alat selam secara langsung akan bersentuhan dengan bagian mulut dan hidung, apabila perawatan alat penyelaman kurang tepat akan menimbulkan adanya risiko penularan ISPA. Kelompok penyelam di Pulau Enggano menggunakan alat selam bersama untuk aktivitas mencari ikan dan menyewakan untuk para wisatawan. Namun para penyelam masih minim pengetahuan terkait dampak risiko penyakit dari penggunaan alat selam bersama. Kegiatan dihadiri oleh perwakilan 5 kelompok penyelam yang ada di Pulau Enggano. Kegiatan pengabdian meliputi pembukaan, sosialisasi, pelatihan mengenai cara membersihkan alat selam yang benar, tanya jawab, evaluasi kegiatan, dan penutupan. Hasil evaluasi dari kegiatan ini, kelompok penyelam menilai sangat bermanfaat dan membantu meningkatkan pengetahuan peserta. Para penyelam menjadi sadar akan pentingnya kebersihan dan perawatan alat selamnya. Secara umum, berdasarkan hasil evaluasi, menunjukkan bahwa masyarakat puas dengan pelaksanaan kegiatan ini dan mengucapkan terima kasih atas penyerahan alat dan bahan pembersih alat selam untuk kelompok penyelam. Pemahaman dan penerapan aseptik pada alat selam ini perlu dilakukan secara berkelanjutan agar menjadi nilai lebih untuk kelompok penyelam. Tidak hanya untuk kesehatan para penyelam yang mencari ikan namun juga untuk wisatawan yang hendak menggunakan alat selam. Diseases that can be caused by sharing diving equipment that is not aseptic are Acute Respiratory Infections (ARI). ARI is a disease that infects the upper respiratory tract and infects the entire lower respiratory tract (alveoli). ARI can be transmitted through droplets containing viruses or bacteria inhaled by healthy people. Using diving equipment will directly come into contact with the mouth and nose, if the diving equipment is not maintained properly it will pose a risk of transmitting ARI. Groups of divers on Enggano Island use diving equipment together for fishing activities and rent them out to tourists. However, divers still lack knowledge regarding the impact of disease risks from using shared diving equipment. The activity was attended by representatives of 5 diving groups on Enggano Island. Service activities include opening, socialization, training on how to properly clean diving equipment, questions and answers, activity evaluation, and closing. As a result of the evaluation of this activity, the diving group considered it very useful and helped increase the participants' knowledge. Divers become aware of the importance of cleanliness and maintenance of their diving equipment. In general, based on the evaluation results, it showed that the community was satisfied with the implementation of this activity and expressed their gratitude for the delivery of diving equipment and cleaning materials to the diving group. The understanding and application of aseptics in diving equipment needs to be carried out on an ongoing basis so that it becomes an added value for groups of divers. Not only for the health of divers looking for fish but also for tourists who want to use diving equipment.

ABSTRAK Down Syndrome merupakan kelainan genetik autosomal karena kelebihan pada jumlah kromosom21 (Trisomi). Salah satu kekhasan pada penyandang down syndrome adalah mulut selalu terbuka, bibir memiliki celah dan relatif tebal. Tujuan dari penelitian ini adalah untuk menganalisis karakteristik pola sidik bibir pada penyandang down syndrome. Penelitian dilakukan pada bulan Desember 2021-Februari 2022 menggunakan metode wawancara dan pendataan langsung terhadap siswa penyandang down syndrome yang memenuhi syarat inklusi dari beberapa sekolah di Kota Bengkulu. Identifikasi pola sidik bibir mengacu pada klasifikasi menurut Suzuki dan Tsuchihashi. Data dianalisis menggunakan uji Chi-square pada program SPSS versi 22. Hasil penelitian menunjukkan bahwa pada siswa penyandang down syndrome ditemukan dua pola sidik bibir yaitu tipe I dan tipe II dengan pola dominan pada tipe I. Persentase pola sidik bibir tipe I pada siswa laki-laki sebesar 66,7% dan pada siswa perempuan 57,1%. Pola sidik bibir tipe II pada siswa laki-laki sebesar 33,3% dan pada siswa perempuan 42,9%. Berdasarkan hasil analisis menggunakan uji Chi-square, tidak terdapat hubungan antara pola sidik bibir dengan rasio tebal bibir dan panjang bibir, serta tidak terdapat hubungan antara pola sidik bibir dengan kemampuan berbicara, kemampuan berjalan, kemampuan menggenggam pena dan kemampuan menulis pada siswa penyandang down syndrome dari beberapa sekolah di kota Bengkulu. Pola sidik bibir dominan tipe I dan II yang ditemukan pada siswa penyandang down syndrome juga umum ditemukan pada non-down syndrome. Kata Kunci: Cheiloscopy, Down syndrome, Pola sidik bibir ABSTRACT An excess of chromosomal number 21 (Trisomy) causes the autosomal genetic disease known as down syndrome. One of the characteristics of people with down syndrome is that their lips have a gap and are rather thick, and their mouths are always open. This study's objective was to examine the characteristics of down syndrome students' lip print patterns. The study was carried out at multiple schools in Bengkulu City between December 2021 and February 2022 using interviews and direct data collecting on Down syndrome pupils with inclusion requirements. The classification of Suzuki and Tsuchihashi is used to identify lip print patterns. The Chi-square test was used to examine the data in SPSS version 22. Data were analyzed using the Chi-square test in the SPSS version 22. The findings indicated that students with Down syndrome had type I and type II lip print patterns, with type I predominating. Male students had a type I lip print pattern prevalence of 66.7%, compared to 57.1% for female students. 33.3% of male students have type II lip print patterns, compared to 42.9% of female students. According to the Chi-square analysis, there is no correlation between lip print patterns, the ratio of lip thickness to lip length, and speaking, walking, pen grasping, and writing abilities in down syndrome from various schools in Bengkulu city. Since the dominating lip print pattern of types I and II observed in down syndrome students is also frequently shown in non-down syndrome individuals, this pattern cannot be used to predict specific motor skills in down syndrome students. Keywords: Cheiloscopy, Down syndrome, Lip print patterns

Fish have habitats that are easily exposed to contamination from the environment such as heavy metal waste which can cause changes in the structure and function of body tissues. One type of waste that enters the river in the Lebong Regency River is gold mining processing waste that uses mercury and cyanide. Heavy metals can enter organisms and accumulation and biomagnification of mercury can occur in the bodies of aquatic biota such as fish. There has been no research related to fish histology in the Lebong gold mining area, so the aim of this research was to determine the histological condition of the liver organs of several fish in the form of Hemibagrus nemurus, Rasbora sp, Trichogaster trichopterus, and Macrognathus circumcinctus in the Air Kotok river in the gold mining area of Lebong Regency. The research was conducted using the paraffin method with hematoxylin-eosin staining. Data were analyzed descriptively qualitatively based on the histology of the fish liver. The results of the research on the liver histology, it shows damage to the fish liver structure which includes vacuolization, congestion, pyknosis, dilated sinusoids, melanomacrophages and leukocyte infiltration. The damage to the hepatocytes of this fish can be used as a bio-indicator of exposure to toxic substances in the Air Kotok river, one of which is heavy metal activity from gold mining, which can be a threat to the health and survival of the fish.Keywords: Bengkulu, gold mining waste, heavy metal, hepa

Beberapa suku masyarakat di Indonesia diketahui memiliki karakter fenotipe yang khas. Karakter ini dapat dipengaruhi oleh faktor genetik. Salah satu suku masyarakat di Indonesia adalah suku Lembak. Masyarakat suku Lembak merupakan salah satu suku asli yang mendiami wilayah Provinsi Bengkulu. Suku ini merupakan bagian dari ras Malayan Mongoloid. Penelitian ini bertujuan untuk mengkaji karakteristik masyarakat suku Lembak berdasarkan fenotipe pola lengkung telapak kaki dan pola ujung jari kaki pada masyarakat suku Lembak di Desa Pulau Panggung, Bengkulu. Teknik pengambilan data dalam penelitian ini adalah purposive sampling. Pengambilan data dilakukan terhadap 100 orang masyarakat suku Lembak yang telah memenuhi syarat inklusi. Jenis penelitian ini termasuk penelitian deskriptif analisis melalui wawancara dan survei langsung dengan melakukan pencetakan telapak kaki dan pengamatan bentuk ujung jari kaki masing-masing individu. Data yang diperoleh ditabulasi dan dianalisis menggunakan uji Chi-square. Hasil penelitian menunjukkan bahwa terdapat tiga pola lengkung telapak kaki dengan pola dominan yaitu normal arch (89%) dan ditemukan enam dari sepuluh pola ujung jari kaki (Aboriginal, African, Egyptian, Greek, Mongolian dan Orient) dengan pola dominan pada pola orient (42%). Analisis statistik menggunakan uji Chi-square menunjukkan bahwa tidak terdapat hubungan yang signifikan antara pola lengkung telapak kaki, ujung jari kaki dengan perbedaan jenis kelamin, serta pola lengkung kaki dengan ujung jari kaki. Karakteristik kaki pada masyarakat suku Lembak di Desa Pulau Panggung didominasi pola lengkung kaki normal arch dan pola ujung jari kaki orient.

Kadar glukosa darah adalah jumlah kandungan glukosa yang ada pada plasma darah. Pengukuran kadar glukosa darah puasa merupakan salah satu metode untuk mengidentifikasi penyakit diabetes melitus pada seseorang. Bengkuang memiliki serat larut air yang dapat memperlambat absorpsi glukosa sehingga dapat menurunkan kadar glukosa darah. Lobak putih memiliki kesamaan jenis dengan bengkuang yaitu merupakan jenis tanaman umbi yang diharapkan memiliki efek yang sama dalam menurunkan kadar glukosa darah. Penelitian ini bertujuan untuk mengetahui pengaruh pemberian perasan lobak putih dan bengkuang terhadap kadar glukosa darah mencit yang diinduksi aloksan sebagai model diabetes. Mencit dibagi menjadi 8 kelompok dengan pembagian secara random dan dipuasakan selama 8 jam, pada hari ke–0 diukur kadar glukosa darahnya sebagai kadar glukosa darah awal. Kelompok I sebagai kontrol normal yang tidak diberi induksi aloksan dan diberi aquades. Pada kelompok II-VI, mencit diinduksi aloksan dengan dosis 200 mg/kg BB secara intraperitoneal. Setelah aloksan diinduksikan, diukur kadar glukosa darah mencit pada hari ke-3. Setelah didapati kadar glukosa darah mencit yang tinggi, kelompok mencit II diberi aquades, kelompok III diberi glibenklamid 0,013 mg/20 gBB mencit, kelompok IV diberi perasan lobak putih 0,1 ml/20 gBB, kelompok V diberi perasan lobak putih dan bengkuang 2:1, kelompok VI diberi perasan lobak putih dan bengkuang 1:1, kelompok VII diberi perasan lobak putih dan bengkuang 1:2, kelompok VIII diberi perasan bengkuang 0,1 ml/20 gBB. Pemberian perasan lobak putih dan bengkuang dapat menurunkan kadar glukosa darah.

Allopurinol is used to reduce total uric acid levels in the body into oxypurinol which can inhibit xanthine oxidase. Allopurinol inhibits the precursors of uric acid formation, xanthine, and hypoxanthine. However, consumption of the drugs can cause side effects on the liver. The aim of the research was to determine the effect of allopurinol induction on the liver histopathology of male mice (Mus musculus) DDY strain. The method used in this research was an experimental design used post-test only that was divided into 4 groups of 4 mice per group. The control group (P0) was given 0.5% Na-CMC, and groups I, II, and III (P1, P2, and P3) were induced by allopurinol at 10 mg/kg BW, 20 mg/kg BW, and 30 mg/kg BW for 14 days. Allopurinol induction was performed by oral gavage. The results of the research showed that treatment with allopurinol caused changes in the mice’s body weight, liver index, liver morphology, and histological structure of the liver tissue, including necrosis, steatosis, leukocyte infiltration, binuclear hepatocytes, hepatocyte swelling, congestion, sinusoid dilatation, and hemorrhage. The level of liver damage increased in line with the dose used. This research indicated that the higher the allopurinol level, the higher the level of alteration in the liver section structure. Long-term use of allopurinol can cause damage to the structure of mice liver (liver toxicity).

Sampah seringkali dianggap sebagai suatu masalah dan penyebab terjadinya pencemaran hingga penyebab bencana seperti banjir. Hal ini disebabkan karena sampah belum dikelola dengan baik dan kurangnya kesadaran masyarakat. Tujuan dari kegiatan pengabdian ini adalah untuk melakukan pelatihan pengelolaan sampah terpadu pada masyarakat Desa Rindu Hati. Pengelolaan sampah terpadu dengan menggunakan prinsip 3R yaitu pembatasan (Reduce) dengan meminimalisir pemakaian benda-benda yang bisa menghasilkan sampah seperti benda yang sekali pakai. Guna-ulang (Reuse) dengan cara menggunakannya kembali serta Daur-ulang (Recycle) yaitu menggunakan sampah-sampah tertentu untuk diolah menjadi barang yang lebih berguna tentunya hal ini dapat mengurangi efek buruk dari sampah. Kegiatan pengabdian ini dilakukan dengan cara melakukan pengelolaan sampah organik yang diolah menjadi pupuk kompos serta sampah anorganik seperti plastik, botol, kaleng dan sejenisnya dapat digunakan untuk pembuatan produk kerajinan tangan yang dapat memiliki nilai jual tinggi. Hal ini menjadi sebuah peluang di Desa Wisata Rindu Hati yang banyak dikunjungi oleh wisatawan, sampah dapat diolah menjadi produk kerajinan yang dapat dijual kembali pada wisatawan dan dapat meningkatkan perekonomian masyarakat di desa Rindu Hati.

Makrofauna merupakan sekelompok hewan yang memiliki peran sebagai bioindikator terhadap kesuburan tanah. Penelitian ini bertujuan untuk mengetahui keanekaragaman makrofauna tanah di perkebunan kelapa sawit PT Agricinal Bengkulu Utara. Pengambilan sampel dan pengukuran faktor ekologi dilakukan di lahan perkebunan kelapa sawit PT Agricinal Bengkulu Utara pada bulan Februari 2021. Penentuan titik sampling dilakukan dengan teknik simpel Random Sampling yaitu sebanyak 5 titik sampel, dimana pada setiap titik sampel masing-masing dipasang 6 perangkap jebakan dengan jarak 10 m. Pengambilan sampel dilakukan dengan metode pit fall trap (Jebakan) dan hand shorting. Sampel yang diperoleh di identifikasi di laboratorium Biologi Universitas Muhammadiyah Bengkulu dan dianalisis dengan menggunakan indeks keanekaragman jenis Shannon-Wiener. Berdasarkan hasil penelitan yang telah dilakukan ditemukan sebanyak 14 spesies yaitu Atractomorpha crenulata, Tarbinkieulus portentus, Gryllotalpa orientalis, Eyprepocnemis plorary, Oxya yezonensis, Paraponera clavata, Oecophylla smaragdina, Acanthocephala terminalis, Blattela asahinai, Periplanaeta americana, Achatina fulica, Scolopendra morsitans, Trigoniulus corallines, Lumbricus terrestis. Hasil perhitungan nilai indeks keanekaragaman (H’) didapatkan hasil dengan nilai indeks keanekaragamannya yaitu 1.065811. Dengan demikian dapat disimpulkan bahwa keanekaragman makrofauna tanah di lahan perkebunan kelapa sawit PT Agricinal dikategorikan sedang (1 ≤ H ≤ 3).Macrofauna is a group of animals that have a role as a bioindicator of soil fertility. This study aims to determine the diversity of soil macrofauna in the oil palm plantation of PT Agricinal Bengkulu Utara. Sampling and measurement of ecological factors were carried out on the oil palm plantation of PT Agricinal Bengkulu Utara in February 2021. Determination of sampling points was carried out using a simple random sampling technique of 5 sample points, where at each sample point 6 traps were installed with a distance of 10 meters. Sampling was carried out using the pit fall trap and hand shorting method. The samples obtained were identified in the Biology laboratory of the University of Muhammadiyah Bengkulu and analyzed using the Shannon-Wiener species diversity index. Based on the results of the research that has been carried out, there were found as many as 14 species, namely Atractomorpha crenulata, Tarbinkieulus portentus, Gryllotalpa orientalis, Eyprepocnemis plorary, Oxya yezonensis, Paraponera clavata, Oecophylla smaragdina, Acanthocephala terminalis, Blattela asahigonica, Periplanaeta Lumbricus terrestis. The results of the calculation of the diversity index value (H') are obtained with the diversity index value of 1.065811. Thus, it can be concluded that the soil macrofauna diversity in PT Agricinal's oil palm plantations is categorized as moderate (1 ≤ H ≤ 3).

Media pembelajaran interaktif sangat diperlukan untuk membantu proses belajar mengajar, khususnya pada saat era pandemi COVID-19 yang lebih banyak menggunakan daring. Salah satu jenis media pembelajaran interaktif yang dapat digunakan secara efektif, efisien dan mudah yaitu aplikasi iSpring Suite 9 yang dapat digunakan terintegrasi dengan power point. Masih banyaknya guru yang belum mengetahui dan memahami penggunaan media pembelajaran interaktif dengan baik, sehingga tujuan dari kegiatan pengabdian masyarakat ini adalah melakukan sosialisasi kepada guru mengenai media pembelajaran iSpring Suite 9 di Pondok Pesantren Modern Darussalam Kabupaten Kepahiang, Provinsi Bengkulu. Kegiatan sosialisasi ini dilakukan dengan cara demo, yaitu pemberian penjelasan penggunaan iSpring serta dilanjutkan dengan praktek penggunaan media iSpring. Kegiatan sosialisai ini diikuti oleh guru dari berbagai bidang studi di Pondok Pesantren, sehingga ada banyak model atau beragam bentuk media yang dapat dihasilkan oleh guru. Pelaksanaan kegiatan berjalan dengan baik dan lancar serta sesuai dengan tahapan yang direncanakan. Adanya sosialisasi ini mampu membantu meningkatkan ketrampilan dan pengetahuan guru mengenai penggunaan salah satu aplikasi dalam penyusunan bahan ajar maupun dalam membuat media pembelajaran

Uric acid levels in the blood can be lowered by taking anti-hyperuricemic drugs, but long-term use can have serious effects on the body. Therefore, we need medicines made from natural ingredients that have a compound that can reduce uric acid levels with a low effect. The purpose of this study was to determine the effect of hibiscus flower infusion on uric acid levels. The research method is experimental research with a Completely Randomized Design (CRD). Mice were divided into 6 treatment groups, the negative control group (normal) A0 was given 0.5% Na-CMC, A1 was hyperuricemia control (induction of potassium oxonate 250mg/kgBW and chicken liver juice), A2-A5 was treated with hyperuricemia. The treatment group A2 was given allopurinol 10mg/kgBW, A3-A5 was given hibiscus flower infusion at a dose of 20%, 30%, and 40%, respectively. The results showed that hibiscus flower infusion at doses of 20%, 30%, and 40% was able to reduce blood uric acid levels in male white mice induced by potassium oxonate and chicken liver juice. Hibiscus flower infusion has the potential to reduce uric acid levels in mice optimally at a dose of 20%, which is 80.8% of hyperuricemia control.