The climatotherapy for atopic dermatitis is a classical dermatological in-clinic therapy carried through in special positive therapeutically proven rough and stimulating climate areas; primarily the North Sea climate and certain mountain valley locations over 1500 m above sea-level This is an extensively proven therapeuticum which has, in comparison to the dermatological therapies that can be applied at home, as a rule less side effects and above all an aditionally long lasting-time effect. Latter being of particular importance regarding chronical diseases that can't be achieved by other therapies. Therefore the climatotherapy for atopic dermatitis represents an all entailing therapy form and is additionally anyway the most complete therapy. A climatotherapy for atopic dermatitis can only be performed in rough and stimulating climate zones with additionally special insolation-, thermic-hygric- and allergen-poor aerosol conditions. On the one hand the organism is generally stabilized by those climatic conditions, on the other hand constitutionally damaged skin is positively effected by direct climate factors. Because every single climate has its specific positive effect, the therapeutical immediate - and long-lasting time effect of a climate has to be proven scientifically by, follow-up studies. Direct causalities between characteristics of single climate elements and the course of atopic dermatitis are scientifically very difficult to register and therefore require extensive tabulations and many comparable studies. In our own study in the mountain valley of Davos, 1560 m above sea level in the Swiss Alpes, for the first time a significant causality between pruritus in atopic dermatitis and single meteorological factors could be proven. This study only showes one particular aspect of the complete causality in a specific climate. As long as formal, intensive knowledge about crucial effects of the single climate factors - because of basic, methodical problems regarding the registration of various causalities - is missing, the research studies concerning the influence of the climate on the course of the disease have to be based on the therapeutical results and therefore on the complete effect of a specific climate.

A case of erythema annulare centrifugum-type psoriasis in a 58-year-old white woman with a history of chronic plaque psoriasis is described. Initial failure of antipsoriatic treatments and an untypical histology complicated the diagnosis. After several trials acitretin at a low maintenance dose combined with oral fish oil and topical calcitriol led to sustained long-term remission. The spectrum of clinical differentiation of this rare disease, the histological characteristics and its nosological classification are discussed. It is suggested that this dermatosis represents a variant of acute psoriasis, rather than a variant of pustular psoriasis.

Lichtempfindlichkeitsreaktionen umfassen eine Reihe differenter dermatologischer Krankheitsbilder. Lichtallergien im engeren Sinne sind Hautkrankheiten, bei denen es unter Einwirkung von nicht-ionisierender elektromagnetischer Strahlung (meist Ultraviolett (UV)-A/-B-Strahlung, gelegentlich auch sichtbares Licht) zu allergischen Reaktionen an der Haut kommt. Dazu zählen Lichturtikaria, eine Immunglobulin-E-ver-mittelte allergische Sofortreaktion, photoallergisches Kontaktekzem und photoallergisches (Arznei-) Exanthem, zellvermittelte allergische Spättypreaktionen auf dem Boden einer Photosensibilisierung, chronische aktinische Dermatitis und die Polymorphe Lichtdermatose. Weiterhin gibt es nichtallergische Unverträglichkeitsreaktionen der Haut auf Licht, wie vor allem exogene und endogene phototoxische Reaktionen, aber auch das auf einem Gendefekt beruhende Xeroderma pigmentosum oder die mit UV-Licht-Unverträglichkeit einhergehende Autoimmunkrankheit Lupus Erythematodes.

Die Abhängigkeit des atopischen Ekzems von meteorologischen Bedingungen wurde mit Hilfe von Fragebogen zur Juckreizstärke, Wetterempfinden sowie meteorologischen Messungen bei insgesamt 2106 Patienten mit atopischem Ekzem in Davos, Schweizer Hochgebirge, untersucht. Die Beobachtungsperiode betrug 7 Jahre. Es konnten hochsignifikante Korrelationen zwischen der Pruritusstärke und der Ausprägung meteorologischer Einzelparameter, insbesondere eine negative Beziehung zwischen der Stärke des Pruritus und der Höhe der Lufttemperatur, des Luftdampfdrucks und der Sonnenscheindauer ermittelt werden, darüber hinaus erhöhte subjektive Empfindlichkeitsraten der Patienten für Luftfeuchtigkeit und Lufttrockenheit. Damit wurden erstmals Daten erhoben, die die besondere Relevanz der atmosphärischen Umwelt für die Symptomausprägung beim atopischen Ekzem belegen. Die Ergebnisse lassen vor allem darauf schließen, dass ein mittlerer thermisch-hygrischer Bereich, bei dem sich der Wärmeübergang an der Hautoberfläche und der epidermale Wassergehalt die Balance halten, therapeutisch günstige Einflüsse besitzt. Die eingeschränkte klimatische Toleranz ist Folge der gestörten kutanen Barriere beim atopischen Ekzem.

The frequent clinical observation that the course of atopic eczema, a skin disease involving a disturbed cutaneous barrier function, is influenced by climate and weather motivated us to analyse these relationships biometrically. In the Swiss high-mountain area of Davos the intensity of itching experienced by patients with atopic eczema was evaluated and compared to 15 single meteorological variables recorded daily during an entire 7-year observation period. By means of univariate analyses and multiple regressions, itch intensity was found to be correlated with some meteorological variables. A clear-cut inverse correlation exists with air temperature (coefficient of correlation: –0.235, P<0.001), but the effects of water vapour pressure, air pressure and hours of sunshine are less pronounced. The results show that itching in atopic eczema is significantly dependent on meteorological conditions. The data suggest that, in patients with atopic eczema, a certain range of thermo-hygric atmospheric conditions with a balance of heat and water loss on the skin surface is essential for the skin to feel comfortable.

No AccessJournal of UrologyCLINICAL UROLOGY: Case Reports1 May 2001TRIPE PALMS AND MALIGNANT ACANTHOSIS NIGRICANS: CUTANEOUS SIGNS OF IMMINENT METASTASIS IN BLADDER CANCER? M. MÖHRENSCHLAGER, E. VOCKS, D.B. WESSNER, J. NÄHRIG, and J. RING M. MÖHRENSCHLAGERM. MÖHRENSCHLAGER , E. VOCKSE. VOCKS , D.B. WESSNERD.B. WESSNER , J. NÄHRIGJ. NÄHRIG , and J. RINGJ. RING View All Author Informationhttps://doi.org/10.1016/S0022-5347(05)66369-0AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "TRIPE PALMS AND MALIGNANT ACANTHOSIS NIGRICANS: CUTANEOUS SIGNS OF IMMINENT METASTASIS IN BLADDER CANCER?." The Journal of Urology, 165(5), pp. 1629–1630 References 1 : Acanthosis nigricans associated with transitional cell carcinoma of the urinary bladder. Int J Dermatol1994; 33: 433. Google Scholar 2 : Urothelkarzinom-assoziierte Acanthosis nigricans—–eine symptomatische Therapie mit Calcipotriol. Hautarzt1999; 50: 593. Google Scholar 3 : Tripe palms and malignancy. J Clin Oncol1989; 7: 669. Google Scholar From the Departments of Dermatology and Allergy Biederstein and Pathology, Technical University of Munich, Munich, Germany© 2001 by American Urological Association, Inc.FiguresReferencesRelatedDetailsCited byLin J, Wang W, Yen C, Yu I and Chen P (2018) Prurigo Nodularis as Initial Presentation of Metastatic Transitional Cell Carcinoma of the BladderJournal of Urology, VOL. 168, NO. 2, (631-632), Online publication date: 1-Aug-2002. Volume 165Issue 5May 2001Page: 1629-1630 Advertisement Copyright & Permissions© 2001 by American Urological Association, Inc.Keywordsbladderneoplasm metastasisbladder neoplasmsacanthosis nigricansMetricsAuthor Information M. MÖHRENSCHLAGER More articles by this author E. VOCKS More articles by this author D.B. WESSNER More articles by this author J. NÄHRIG More articles by this author J. RING More articles by this author Expand All Advertisement PDF downloadLoading ...

BACKGROUND AND OBJECTIVE:Actinic prurigo (AP) is a hereditary photodermatoses with typical symptoms and is quite common in North- and South-America. The key genetic factor appears to be a Native American background. In Europeans this type of AP is extremely rare; some dispute if this disease exists in Caucasians. Some newer publications postulate that these patients share HLA markers with the Native Americans. The most important differential diagnosis for AP is polymorphic light eruption which can be excluded relatively accurately by the clinical picture, typical histology and HLA pattern.PATIENTS/METHODS:The case of a female patient of Mayan ancestry living in Germany is presented.CONCLUSIONS:Since in literature sometimes cases from Europe are diagnosed as AP this is a problem of naming the disease. It would be helpful to integrate the terms hereditary or hereditaria into the name of the disease in indians.

The present study was designed to evaluate basic differences in surface structure and viscoelastic properties of nonatopic versus atopic skin and facultative acute changes following ultraviolet irradiation. Therefore, biophysical measurements by means of profilometry and cutometry were carried out on sun-protected unaffected gluteal skin areas in both groups before and 24 h after single UVA and UVB irradiations. The results indicate that the clinically unaffected skin of patients with atopic eczema differs from normal skin in terms of increased roughness parameters, but not concerning depth of furrows or viscoelastic properties (viscosity and biological elasticity, cutometrically calculated). Single UVA irradiation with 50 J/cm2 induced neither measurable changes in the skin’s surface structure nor in its viscoelastic properties in both groups after 24 h. However, irradiation with a single erythemogenic dose of 1 MED UVB was followed by a short-term significant increase in the depths of furrows and decrease in biological elasticity in normal and atopic skin, accompanied by an increase in viscosity in normal skin.

A 12-year-old girl developed a myxoid liposarcoma on the inner side of her right thigh. Liposarcomas are extremely rare at this age compared to benign lipoblastomas, which are the most frequent tumors of fatty tissue in childhood. The prognosis of myxoid liposarcoma is good, especially when, as in this patient, the tumor is located in the subcutis where a large and deep excision is possible and often curative.