Introduction: Immunosuppressed patients face a significantly higher risk of developing malignant skin tumors compared to the general population, often presenting with numerous, rapidly growing, and aggressive lesions. It can be particularly challenging to treat these tumors, especially in the head and neck region. Electrochemotherapy (ECT) emerges as a viable option for treating multiple tumors simultaneously. This study aims to compare the efficacy, toxicity, and impacts on the quality of life of ECT of nonmelanoma skin cancers (NMSCs) in immunosuppressed patients and nonimmunosuppressed patients. Materials and Methods: A total of 156 tumors (82 target lesions) in 14 immunosuppressed patients and 183 tumors (157 target lesions) in 30 nonimmunosuppressed patients were treated with ECT using intravenous bleomycin according to the European Standard Operating Procedures of ECT (ESOPE) guidelines. Patients were monitored for at least 6 months. A prospective cohort analysis was carried out to compare tumor response, side effects, and quality of life in the two groups. Results: 3 months after ECT, nonimmunosuppressed patients showed a significantly higher tumor response rate ( p = 0.001). After 6 months, a statistically significant difference was not observed between the two groups regarding tumor response. After 3 and 6 months, there was no difference in toxicity, pain, and EQ‐VAS values. Conclusions: Our results suggest that the effectiveness and safety of ECT for treating NMSCs in immunosuppressed patients seems to be comparable to the nonimmunosuppressed patients. The emphasis on prevention, adopting a multidisciplinary approach, and optimizing immunosuppression are crucial to improving the care and management of this patient cohort.

Patients exhibited progressive saddle nose deformity as a result of GPA. To reconstruct the nose, a single-stage open rhinoplasty was conducted involving the placement of an independent L-shaped costal cartilage implant. Graft formation and fixation were performed according to the author-developed method. From 2012 to 2023, seven patients with severe saddle nose deformity underwent implantation of modified L-shaped costal cartilage strut grafts. Except for one complicated case, all patients reported satisfaction with the surgical outcomes. In this study, the visual appeal of the nose and the respiratory capabilities of the patients improved significantly. The L-shaped costal cartilage strut graft is an effective technique for saddle nose deformity correction. This technique provides excellent outcomes, including improved nasal function and aesthetics. Further studies with a larger sample size are needed to confirm these findings. This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 .

Purpose Lentigo maligna (LM), lentigo maligna melanoma (LMM), and acral lentiginous melanoma (ALM) are characterized by irregular borders and manifest on highly visible and/or surgically challenging areas. The challenge in treating these melanomas lies in preserving function and achieving satisfactory esthetic outcomes while ensuring complete surgical excision with an appropriate safety margin. We report three cases of elderly patients with LM, LMM, and ALM treated with electrochemotherapy (ECT).Materials and Methods All patients were treated according to the European Standard Operating Procedures of Electrochemotherapy protocol. Bleomycin was administered intravenously, followed by electroporation to allow better drug uptake into the tumor cells. The safety margin was ensured by electrode repositioning, and follow-up was scheduled regularly.Results Our patients experienced favorable outcomes: two achieved a complete response, with one requiring adjuvant topical imiquimod for suspected residual disease, while the third patient achieved a partial response. No serious adverse events were observed, and cosmetic results were superior compared to extensive surgery.Conclusion ECT appears to be a safe and effective treatment alternative for LM, LMM, and ALM, especially in elderly patients where surgery may lead to significant morbidity. ECT can be used alone or in combination with other therapies, providing a wide safety margin and cosmetically favorable results.

A sugárkezelés indukálta heterotop szövetkalcifikáció az irradiáció rendkívül ritka szövődménye a fej-nyaki régióban. Esetismertetésünkben egy nagy kiterjedésű, kombinált – subcutan és intramuscularis elhelyezkedésű –, sugárkezelés indukálta heterotop kalcifikációt mutatunk be a nyaki régióban. A 80 éves férfi beteg 2 hónapja tartó nyelési nehezítettség és a nyakon kialakult fájdalmas, fekélyszerű elváltozás miatt jelentkezett klinikánkon. 42 évvel ezelőtt T3N0M0-stádiumú glotticus laphámcarcinoma miatt teljes gégeeltávolításban, valamint 80 Gy összdózisú radioterápiában részesült. A szövettani és a CT-vizsgálat kizárta a residualis vagy a másodlagos malignitás lehetőségét. A CT-angiográfia kiterjedt subcutan és intramuscularis kalcifikációt mutatott a nyaki bőrfekély, illetve a hypopharynx falának közvetlen közelében, valamint az arteria carotis communis és az arteria vertebralis kétoldali teljes elzáródását írta le. A sebészi kezelés során a meszesedett terület eltávolítását követően a defektust fasciocutan transzpozíciós lebennyel zártuk. A páciens az elmúlt 48 hónapban tünetmentesnek bizonyult. A sugárkezelés elengedhetetlen szerepet játszik a fej-nyaki régió laphámrákjainak kezelésében. A nagyban deformált posztoperatív anatómia, a kiterjedt hegképződés, a sugárkezelés okozta fibrosis, valamint a bőr és a bőr alatti szövetek kalcifikációja összességében szokatlan, atípusos elváltozások kialakulásához vezethet. Orv Hetil. 2023; 164(10): 383–387.

Abstract Brain abscess is a rare but life-threatening infection of the brain. It often occurs as a complication of infection, trauma, or surgery. This case presents a brain abscess in a 22-month-old boy that developed after a transnasal injury with a foreign body. A minimal-invasive, transnasal, endoscopic-controlled technique was used, during which the foreign object was removed and the abscess drained. Bacteriological samples were obtained and the abscess cavity irrigated. Postoperative care included antibiotics and daily irrigation of the abscess cavity. Follow-up MRI scans showed reduction in abscess size. A spinal drain was inserted temporarily to address rhino-liquorrhoea. The patient remained asymptomatic during one-year of follow-up. This case report highlights the occurrence of a brain abscess in childhood following a transnasal injury and demonstrates a minimal-invasive, transnasal, endoscopic-controlled surgical technique. The findings underscore the importance of considering brain abscess as a potential complication in cases of head trauma, particularly in atypical presentations.

Radiotherapy-induced heterotopic tissue calcification is an exceedingly rare complication in the head and neck region. We report a patient with extensive, radiotherapy-induced, combined subcutaneous and intramuscular, heterotopic calcification of the neck. An 80-year-old male presented with a 2-month history of severe dysphagia and a painful ulcer on the neck 42 years after salvage total laryngectomy following radiotherapy (total dose: 80 Gy) for a T3N0M0 glottic squamous cell carcinoma. We excluded recurrence or secondary malignancy by biopsy and performed computed tomography, which revealed subcutaneous and intramuscular calcification in the area of the skin ulcer and close to the hypopharyngeal wall, moreover, total occlusion of the common carotid and vertebral arteries bilaterally. Surgical correction involved removing the calcified lesions and closure using fasciocutaneous flap transposition. The patient has been asymptomatic for the past 48 months. Radiotherapy plays an essential role in the treatment of patients with head and neck squamous cell carcinoma. Distorted postoperative anatomy, excessive scar formation, radiotherapy-induced fibrosis as well as skin and subcutaneous tissue calcification can present as atypical findings. Orv Hetil. 2023; 164(10): 383-387.

INTRODUCTION:The risk of cutaneous malignancies is significantly higher in immunosuppressed patients compared to the general population. These high-risk skin tumors tend to be aggressive, multiplex, rapidly growing lesions. It is common to see local recurrence after surgical excision. Multiplex tumors are difficult to treat, especially in the head/neck region.OBJECTIVE:Amongst the standard treatment options, electrochemotherapy can be a suitable option. Our aim was to evaluate the efficacy of electrochemotherapy in immunocompromised patients.METHOD:In 9 immunosuppressed patients, 118 (average: 13, n = 5-27) non-melanoma skin tumors were treated with electrochemotherapy with intravenous administration of bleomycin, according to the ESOPE criteria.RESULTS:The median follow-up was 15 months. 6 months after the treatment, the objective response rate was 96%. We observed complete response in 88%, partial response in 8% and progressive disease in 2% of the treated lesions. In 2%, the response was not evaluable.CONCLUSION:In immunocompromised patients, electrochemotherapy is an effective and safe therapeutic option for non-melanoma skin tumors. In order to provide more ideal management for this special sub-group, prevention, multidisciplinary approach and optimized immunosuppressive therapy is essential. Orv Hetil. 2023; 164(37): 1462-1468.

Electrochemotherapy is a widely used locoregional method for the treatment of superficial tumors with different histologies. During treatment, a chemotherapeutic drug, usually bleomycin, is electroporated into the tumor cells, resulting in an increased cytotoxic effect. Beyond its effectiveness, electrochemoterapy is a repeatable and minimally invasive intervention that induces few side effects. The application of electrochemotherapy is expanding with the treatment of deep seated, visceral and benign tumors, and intensive research is in progress in order to investigate its combination with modern systemic therapies.

Familiar controversies in the management of head and neck melanomas are more remarkable in locally advanced cases, and they represent a treatment challenge both surgically and oncologically. In our retrospective study, patients with surgically treated primary malignant melanoma of the head and neck region larger than 3 cm in diameter were included. Five patients met our inclusion criteria. In all cases, wide excision and immediate reconstruction were performed without sentinel lymph node biopsy. The defect on the scalp was covered by a split skin graft, with local flaps chosen for reconstruction on the face on an individual basis. After a 2–6 year follow-up, a good oncological, functional, and esthetic result was achieved. Our results show that in the case of large, locally advanced melanomas, surgical treatment still plays a crucial role that can provide long-term local control and support the effect of systemic treatment.

Bevezetés: A hosszú távon immunszupprimált betegekben a rosszindulatú bőrdaganatok kialakulásának rizikója jóval nagyobb, mint az átlagpopulációban. Ezek a tumorok nagy számban jelentkezhetnek, gyors növekedés és agresszív viselkedés jellemző rájuk. Sebészi kimetszést követően gyakran fordul elő lokális recidíva. A multiplex tumorok sebészi kezelése, különösen a fej-nyak régióban, kihívást jelent. Célkitűzés: Az elektrokemoterápia segítségével egyszerre számos daganat kezelhető. Célul tűztük ki az elektrokemoterápia hatásosságának vizsgálatát immunszupprimált betegekben. Módszer: Klinikánkon 9 immunszupprimált beteg összesen 118 (átlagosan egy betegen 13, n = 5–27) bőrdaganatának elektrokemoterápiás kezelését végeztük el egy alkalommal, intravénás bleomicin adásával az ESOPE-irányelvnek megfelelően. Eredmények: Az átlagos utánkövetési idő 15 hónap volt. A kezelést követően 6 hónappal az objektív tumorválasz 96% volt. A daganatok 88%-a (n = 46) esetén teljes remissziót, 8%-ban (n = 4) parciális remissziót, 2%-ban (n = 1) progresszív betegséget észleltünk, 2%-ban (n = 1) a tumorválasz nem volt megítélhető. Következtetés: Az immunszupprimált betegeken a multiplex nem melanoma bőrdaganatok kezelésére az elektrokemoterápia hatásos és biztonságos terápiának bizonyult. Ennek a betegpopulációnak a jobb ellátása és gondozása érdekében a prevenció, a multidiszciplináris szemléletmód és az immunszuppresszió optimalizálása kiemelten fontos. Orv Hetil. 2023; 164(37): 1462–1468.

Based on large international multicentre trials sentinel lymph node biopsy was found clinically relevant in intermediate thickness melanomas, furthermore sentinel lymph node positivity proved to be the single most important factor in overall survival. However, there is an ongoing debate in the literature regarding the need of sentinel lymph node biopsy in thin (<1mm) and thick (>4mm) melanomas. We aimed to analyse the clinicopathologic predictors of SNB positivity and the possible advantages of the procedure.

Electrochemotherapy (ECT) has evolved significantly during the last decade, expanding treatment indications from superficial skin lesions to advanced-stage, deep-seated tumors in hard-to-reach areas. Electrodes have also shown steady technological improvement throughout the years. Besides standard and VEG (variable geometry electrode) electrodes, the introduction of laparoscopic electrodes has brought on a new era in ECT treatment, making the minimally invasive approach a reality. The exact role of ECT in the oncological dashboard is yet to be determined; however, increased tumor response, pain relief, and a low number of adverse events may yield the way for more widespread application of the technique with possible further inclusion of ECT in international oncological guidelines. The aim of this review is to give an overview on the current status of ECT in deep-seated tumor treatment and shed light on its emerging role in local anticancer therapy.

The aim of the current prospective pilot study exclusively for deep-seated soft tissue sarcomas (STS) was to evaluate efficacy and safety of bleomycin-based ECT using VEG (variable electrode geometry) electrodes. During a 2-year period, seven surgically inoperable STSs were treated at the University of Szeged, Department of Surgery in Hungary. Electrode placement was determined by software planning using preoperative imaging (CT/MRI) and intraoperative ultrasound. Intravenous bleomycin (15.000 IU/m(2)) was administered 8 min before first pulse generation which lasted up to 40 min. Tumour response was evaluated through CT/MRI 2 months after treatment as per RECIST v.1.1. Five male-and 2 female patients were treated with fibromyxoid sarcoma (n = 2), epitheloid sarcoma (n = 3), liposarcoma (n = 1) and myofibroblastic sarcoma (n = 1) with median age of 54 years (49-88). Median tumour diameter, tumour volume and tumour depth was 5.9 cm (3.7-22.5), 131.13 cm(3) (35.6-2456.22) and 6.18 cm (3.74-18.18), respectively. Median operative time was 75 min (35-180), median hospital stay 2 days (2-20). Two month follow-up confirmed partial response in 5 patients, while stable disease in 1 patient, and progressive disease in 1 case as per RECIST v.1.1. Grade 2 ulceration was experienced in four cases, and a transient left musculus quadriceps femoris plegia occured in one patient. Local control of deep-seated STSs with BLM-based VEG ECT holds a promising perspective and our results may serve as a practical guide for further investigation and treatment planning.

Összefoglaló. Bevezetés: Az orrmelléküreg-daganatok kezelésében a legfrissebb nemzetközi ajánlások alapján továbbra is a sebészi reszekció az elsődlegesen választandó módszer. Bár az endoszkópos technikák fejlődésével a külső feltárással járó műtétek bizonyos esetekben háttérbe szorultak, napjainkban még mindig a Weber-Fergusson-féle metszést tartják a legszélesebb feltárást biztosító technikának, annak ellenére is, hogy a módszer stigmatizáló hegeket és deformitásokat hagy a páciensek arcán. Módszer: A "facial degloving" eljárást mint alternatív, hegmentes technikát először az 1970-es években publikálták, azóta számos módosítását írták le. A szerzők az orrmelléküregi tumorok eltávolítására már 8 éve kizárólag az általuk módosított technikát alkalmazzák. 2012 és 2019 között Klinikánkon 34 beteg esett át a módosított "facial degloving" műtéten. A módszer alapja egy felső szájpitvari behatolásból a középarc területén kialakított oszteoplasztikus lebeny, melynek felemelésével széles rálátás nyílik az orrüregre és melléküregeire, valamint az elülső koponyaalapra is. A műtéti terület a daganat eltávolítását követően jó kozmetikai eredménnyel rekonstruálható. Eredmények: A szerzők akusztikus rinometriai vizsgálatokkal és az arckifejezéseket ábrázoló posztoperatív képi dokumentációval támasztották alá eredményeiket. Az operált oldalon sem az orrbemenet beszűkülését (orrlégzés gátoltsága), sem pedig az arcmozgás zavarait, az arc aszimmetriáját nem észlelték. Betegeik túlélését Kaplan-Meier-görbén ábrázolták. Megbeszélés, következtetés: Habár az eredeti "facial degloving" technikának számos módosítását publikálták, az itt bemutatott módszer (oszteoplasztikus lebeny, melyben a középarc lágy részeinek integritása megtartott) rövidebb hospitalizációs időt és kevesebb komplikációt eredményezett. A bemutatott módosított "facial degloving" technika véleményünk szerint megfelelő és biztonságos sebészi reszekciót biztosít orrmelléküregi rosszindulatú daganatok esetén, továbbá kombinálható endoszkópos technikákkal, és szükség esetén nyitott műtétté alakítható, akár orbitalis kiterjesztéssel. Orv Hetil. 2021; 162(10): 392-398. SUMMARY INTRODUCTION The widely used external approach (Weber-Fergusson's incision) for the removal of maxillo-ethmoidal tumors leaves stigmatizing scars and deformities on the patient's face. As an alternative technique, the scarless facial degloving approach was first described in the 1970's, and since then, several modifications have been developed. METHOD We have been using our modified facial degloving technique for eight years now with maxillo-ethmoidal tumors. Between 2012 and 2019, 34 consecutive patients have been operated with our modified facial degloving approach at the Department of Oto-Rhino-Laryngology and Head-Neck Surgery, University of Szeged, Hungary. We describe our method which provides a wide surgical approach via an osteoplastic flap for the whole nasal and paranasal region, with good cosmetic results. RESULTS AND CONCLUSION We have evaluated our results with acoustic rhinometry and photo-documentation of the facial mimic postoperatively. Neither narrowing of the nasal cavity on the operated side (loss of nasal breathing function), nor facial movement dysfunction was visible in our patients. We represent our patients' survival in Kaplan-Meier curve. Although several modifications of the original facial degloving approach have been published, in our technique, the novel osteoplastic flap and the intact soft tissue of the nasal and midfacial region results in shorter hospitalization time and fewer complications. Our modified facial degloving technique offers proper and safe surgical resection for tumors of the maxillo-ethmoid region. It can be routinely combined with endoscopic techniques, and, if necessary, can be converted to an open approach. Orv Hetil. 2021; 162(10): 392-398.

Bone-anchored hearing aids (BAHAs) have been used for multiple types of hearing loss both in pediatric and adult cases. In the last decades, the percutaneous BAHA® Connect System (Cochlear Ltd., Sydney, Australia) was replaced by the fully implanted transcutaneous, magnet-based BAHA® Attract System (Cochlear Ltd., Sydney, Australia). Since the implantable part of the Attract device is fully covered with soft tissue, skin complications that were frequently observed in the percutaneous system, could be eliminated. As an outcome of this important advantage of the Attract System, conversion of the percutaneous into a transcutaneous system should be considered. In the following methodology report, a possible surgical technique is described. The method can easily be adopted to different conditions in which the replacement of the percutaneous device is necessary.

In this case presentation, the authors discuss the prevalence, diagnosis and surgical treatment of the exceedingly rare primary laryngeal melanoma. The importance of immunohistochemical investigations is emphasised since the condition tends to mimic laryngeal carcinomas. Laryngeal melanomas have a very poor prognosis; their five-year survival is less than 10% in international literature. However, the patient presented in this article is still asymptomatic and has no metastases 7 years after the removal of the lesion with transoral laser microsurgery.

Introduction: For the treatment of asymmetry of the midface due to permanent peripheral facial nerve palsy of different etiologies - which means a great psychical burden for the patients - several surgical solutions have been described. Aim: Our goal was to elaborate a minimally invasive surgical technique, that, on one hand, restores an adequate nasolabial fold, which is the most determinative keystone of facial symmetry. On the other hand, our technique can give an appropriate lift for the malar fat pad with shorter operative time and burden, with much lower complication rate and shorter recovery period compared to the classic static sling suspension techniques. Method: Out method is based on the formation of a neo-nasolabial fold, which is then suspended to the temporal fascia by permanent threads thus restoring facial symmetry and giving a lifting effect on the midfacial soft tissues as well. Results: Between 2014 and 2017, six patients had been operated with this nasolabial lifting technique of the malar fat pad without any major complications under local anesthesia on an outpatient basis at our Department. Conclusions: As our surgical exploration is minimal, the postoperative period is shorter, no visible scars remain on the face and the complication rate is negligible. If necessary, suspension could easily be adjusted, and as the technique is reversible, no other possible facial reconstruction methods are excluded. Our method can symmetrize the face in resting position completely on the long term, which is the most important issue for our patients according to their feedback. Orv Hetil. 2019; 160(22): 869-872.

Squamous cell papilloma (SCP) is generally a human papillomavirus (HPV) induced exophytic or endophytic proliferation on the surface of the skin, oral cavity, larynx, esophagus, cervix, vagina, and anal canal. The endophytic type SCP can cause differential diagnostic difficulties with keratoacanthoma, inverted follicular keratosis, and squamous cell carcinoma; however, these lesions are not associated with HPV infection. The authors present a female patient who noticed an extremely rapidly growing tumor destructing the left lower eyelid. The histological analysis of the biopsy sample revealed a virus-induced squamoproliferative lesion. The eyelid affected was completely removed, and the histological examination resulted in a HPV induced endophytic squamous cell papilloma. The tarsus and the conjunctiva were replaced by a chondromucosal graft harvested from the nasal septum, while the skin defect could be closed directly. Restoration of the eyelid function has been achieved with satisfying functional and cosmetic results.

Abstract: Introduction: For the treatment of asymmetry of the midface due to permanent peripheral facial nerve palsy of different etiologies – which means a great psychical burden for the patients – several surgical solutions have been described. Aim: Our goal was to elaborate a minimally invasive surgical technique, that, on one hand, restores an adequate nasolabial fold, which is the most determinative keystone of facial symmetry. On the other hand, our technique can give an appropriate lift for the malar fat pad with shorter operative time and burden, with much lower complication rate and shorter recovery period compared to the classic static sling suspension techniques. Method: Out method is based on the formation of a neo-nasolabial fold, which is then suspended to the temporal fascia by permanent threads thus restoring facial symmetry and giving a lifting effect on the midfacial soft tissues as well. Results: Between 2014 and 2017, six patients had been operated with this nasolabial lifting technique of the malar fat pad without any major complications under local anesthesia on an outpatient basis at our Department. Conclusions: As our surgical exploration is minimal, the postoperative period is shorter, no visible scars remain on the face and the complication rate is negligible. If necessary, suspension could easily be adjusted, and as the technique is reversible, no other possible facial reconstruction methods are excluded. Our method can symmetrize the face in resting position completely on the long term, which is the most important issue for our patients according to their feedback. Orv Hetil. 2019; 160(22): 869–872.

The structure and thermal and photochemical decomposition of the synthetic precursor 5-chloro-3-trifluoromethyl-1,2,4-thiadiazole (1) have been investigated for the first time by mid-infrared, Raman, ultraviolet and He I photoelectron spectroscopy. Spectroscopies, supported by quantum-chemical calculations using the B3LYP and SAC-CI methods, provided a detailed investigation into the vibrational and electronic character of the molecule. Thermal stability and photochemical decomposition of I have been studied in the gas phase and solid matrix, respectively. Flash vacuum thermolysis of the molecule produced fast quantitatively CF3CN, ClCN, and sulfur. However, UV irradiation of 1 in solid argon matrix at selected wavelengths of 213, 228, 240, and 250 nm resulted in a retro-cycloaddition reaction leading to the formation of a novel nitrile sulfide, CF3CNS (2), and ClCN. The structure of 2 was computed at the B3LYP and CCSD(T)/aug-cc-pVTZ levels, and its IR identification was supported by quantum chemical calculations. (C) 2018 Elsevier B.V. All rights reserved.