Accurate monitoring of temperature, axial strain, and refractive index is essential for structural health monitoring, industrial process control, and environmental sensing. However, conventional optical fiber sensors often suffer from strong parameter cross-sensitivity and limited discrimination capability when multiple parameters must be measured simultaneously. In this work, a compact multiparameter optical fiber sensing platform based on a cascaded single-mode fiber (SMF), multimode fiber (MMF), and long-period fiber grating (LPFG) structure is proposed and combined with a wavelength-based spectral demodulation strategy. Within this cascaded configuration, multiple characteristic spectral troughs originating from different physical mechanisms coexist in a single transmission spectrum, including multimode interference in the MMF section and resonance coupling induced by the LPFG. Instead of assigning individual sensing elements to different parameters, the proposed approach exploits the distinct and linearly independent responses of multiple spectral troughs to temperature, axial strain, and refractive index. Each trough is therefore represented by a sensitivity vector, forming a multitrough sensitivity framework that enables robust multiparameter discrimination through matrix-based spectral demodulation. Experimental results demonstrate highly linear and repeatable wavelength shifts of three representative troughs under variations of temperature, strain, and refractive index. The measured temperature sensitivities are -0.0733, -0.0833, and -0.0733 nm/degrees C, while the corresponding strain sensitivities reach -0.6706, -0.6916, and -0.8026 nm/m epsilon , all with coefficients of determination exceeding 0.99. Under refractive index modulation, two troughs exhibit negligible responses below 0.0006 nm/%, whereas the third shows a pronounced sensitivity of -0.1426 nm/% with excellent linearity. By exploiting the differential sensitivity characteristics of multiple spectral troughs within a single cascaded fiber structure, effective discrimination of temperature, axial strain, and refractive index is achieved without additional sensing elements or complex optical paths. Long-term stability tests further confirm wavelength fluctuations within +/- 0.01 nm, demonstrating the excellent stability and repeatability of the proposed sensing platform.

Optical fiber multi parameter sensing is fundamentally constrained by cross-sensitivity and the complexity of multi sensor integration. Here, we present a dual-dip heterogeneous long-period fiber grating (LPFG) sensing platform enabled by bending assisted annealing, which introduces anisotropic refractive index redistribution and mode dependent coupling enhancement. This process yields enhanced sensitivity, improved dip contrast, and opposite spectral responses between dual resonance dips, providing intrinsic spectral heterogeneity. To overcome temperature cross sensitivity, a polymer-encapsulated cascaded LPFG-FBG architecture is developed, where the LPFG serves as the microbending sensitive element and the FBG acts as a reference channel. PDMS encapsulation enhances stress transfer and suppresses interfacial slippage, improving linearity and repeatability. As a result, the bending sensitivity increases from -3.44 to -8.97 nm per cm, and the detection limit improves from 0.017 to 0.006 cm. Building on this, a multi parameter sensing paradigm is established by integrating dual dip heterogeneity with LPFGFBG spectral orthogonality. With PAAm functionalization, the platform enables simultaneous and decoupled sensing of temperature, bending, and humidity, demonstrating scalable and versatile multi parameter capability. Overall, this work establishes a minimalistic yet robust paradigm for multi-parameter fiber-optic sensing, offering a scalable strategy for high-performance sensing in structural health monitoring and harsh environments.

Significance Fiber Bragg grating (FBG) sensors have achieved significant breakthroughs in the field of biomarker detection due to their high sensitivity, resistance to electromagnetic interference, and miniaturization capabilities. They can perform highly specific detection of glucose, proteins, nucleic acids, and bacteria through a label-free mechanism. The core of their technology lies in optimizing the evanescent field sensing principle and surface functionalization strategies (such as covalent bond coupling, biotin-streptavidin system), providing real-time dynamic monitoring schemes, and verifying the transformation potential in clinical puncture biopsy and pathogen detection. However, challenges such as multi-parameter cross-sensitivity, insufficient stability of the modification layer, and interference from complex samples still exist. Innovatively integrating nanomaterials, femtosecond laser direct writing technology, and machine learning algorithms will promote the evolution of sensors towards highly integrated and self-calibrating intelligent systems, significantly overcoming the bottlenecks of traditional PCR such as time consumption and reliance on fluorescence labeling, and injecting new vitality into precision medicine. Progress This review systematically summarizes the latest progress in the field of FBG biochemical sensors, especially the breakthroughs in grating structure design, surface functionalization strategies, and multi-parameter decoupling schemes. Innovations in grating configurations (such as tapered fiber gratings and segmented gratings) can break through the limitations of traditional single-parameter measurement (Fig. 5). In addition, the optimization of the etching process selectively removes the cladding while maintaining the integrity of the core, doubling the interaction efficiency between the evanescent field and the environment and laying a structural foundation for high-sensitivity detection. In the field of surface functionalization, covalent bond coupling and oriented immobilization strategies significantly enhance interface stability (Fig. 3). The covalent modification layer constructed by alkylsilanization (APTES) and crosslinking agent (glutaraldehyde) reduces the biomolecular shedding rate by 60%, while the biotin-streptavidin system increases the probe loading density by three times. It is particularly worth noting that the design of the renewable detection interface enables 140 reuses, solving the lifespan bottleneck of traditional modification layers in body fluid environments. A key breakthrough has been made in hardware-level signal decoupling technology for the challenge of multi-parameter cross-sensitivity. The dual-wavelength decoupling architecture eliminates interference by differentiating the temperature/refractive index response characteristics and combining the sensitivity matrix. Orthogonal cascaded gratings suppress the refractive index measurement error to the order of 10-4 RIU through orthogonal polarization design. The differential measurement method achieves a specificity improvement in complex biological solutions, with the interference response of non-target proteins reduced by more than 10 times. The structure-function collaborative innovation of FBG sensors has verified its clinical value in scenarios such as dynamic glucose management, cancer marker screening, and early warning of bacterial infections. The breakthroughs in applications such as microfluidic integration and in vivo puncture detection mark a crucial step forward in the substantive transformation of this technology towards personalized medicine. Conclusions and Prospects The development of FBG sensors will deeply integrate edge intelligent chips with femtosecond laser 3D printing technology, focusing on breaking through sub-500 nm miniaturized grating units and self-decision-making closed-loop systems. By decoupling multi-parameter interference in real time, it provides highly reliable data support for physiological monitoring. The integration of technologies is simultaneously reflected in the synergy between localized surface plasmon resonance (LSPR) and microfluidic chips, promoting the transformation of the detection paradigm from "in vitro" to "in vivo regulation". For implantable applications, an intelligent safety standard framework needs to be established-a unified signal drift correction protocols and biocompatibility certification-to ensure the long-term stability of the clinical environment. Ultimately, intelligent miniaturized collaboration will make sensors the core units of the human body digital twin system. By integrating dynamic data streams of the metabolome/proteome, individual health maps will be drawn, ushering in a new era from "passive treatment" to "active health management".

Machine learning (ML) methods have been widely explored for predicting material properties. However, due to the rapid development of ML techniques and the diversity of available models, performance comparisons between traditional and graph-based machine learning models remain limited. Therefore, we evaluate 11 conventional ML models alongside the graph neural network-based Crystal Graph Convolutional Neural Network (CGCNN) for predicting three key properties—formation energy (Ef), band gap (Eg), and energy above hull (Eh)—across a dataset comprising single perovskites, double perovskites, and their combined structures. The results demonstrate that for single perovskites, CGCNN exhibits gains of over 20% in the root mean square error (RMSE) relative to the second-best model (Gradient Boosting Regression), achieving values of 0.205 eV/atom (Ef), 0.718 eV (Eg), and 0.167 eV/atom (Eh). Prediction accuracy for double perovskites is significantly enhanced by training CGCNN on a combined dataset, particularly for Eh, where the coefficient of determination (R2) improves approximately 68.1-fold compared to models trained exclusively on double-perovskite data. Feature importance analysis via one-shot, permutation-based, and recursive feature elimination (RFE) methods reveals that optimal model performance requires retention of at least the top 20 critical features. Furthermore, feature utilization patterns of CGCNN across different prediction tasks are visualized. This work provides actionable guidelines for model selection and feature engineering in perovskite property prediction, establishing a benchmark for future ML-driven materials discovery.

This study devises an electrically coupled biofilter (BF- MEC) with the intention of achieving the deep treatment of reclaimed water featuring a low carbon- to- nitrogen ratio. An external voltage of 0.55 V is employed in the research, and BF- MEC systems with diverse structures are constructed to optimize the electrochemical structure. The results demonstrate that the system with an electrode spacing of 100 mm and electrodes positioned at the bottom of the system (the C3 device) exhibits the best system efficiency and electrode performance. Without the addition of an external carbon source, the performance of this system is significantly superior to that of the traditional biological filter. After treating the reclaimed water (with an influent Chemical Oxygen Demand (COD) of 74.71 mg/L and Total Nitrogen (TN) of 22.16 mg/L), it meets the standards of industrial water reuse with effluent COD is 3.31 mg/L and TN is 2.81 mg/L, with removal rates reaching as high as 95.5 % and 87.4 % respectively. Moreover, the microbial population richness of this system is notably higher than that of the traditional biological filter. Among them, electroactive microorganisms (such as Bacteroidota) effectively enhance the catalytic kinetics, specifically manifested as a lower Tafel slope (114.65 mV dec(-1)) and charge transfer resistance (30.824 Omega). The findings of this study offer an efficient, low- energy- consuming, and sustainable solution for the deep treatment of reclaimed water, and are expected to facilitate the application of related technologies in practical engineering.

We report a rare earth (RE)-doped quantum dot-based nanoplatform that regulates lysosomal acidification and enhances macrophage-mediated clearance of intracellular pathogens. By co-doping cadmium selenide quantum dots (CdSe QDs) with ytterbium (Yb3+), erbium (Er3+), and europium (Eu3+), we engineered mixed-phase CdSe:Yb/Er/Eu QDs with tailored crystal field symmetry, broad spectral responsiveness (340-800 nm), and efficient upconversion luminescence. These nanoprobes exhibit strong light-harvesting via RE f-f transitions, size-tunable properties, and dual-mode fluorescence imaging capabilities (upconversion/downconversion). In RAW264.7 macrophages, the QDs demonstrated efficient intracellular localization and, upon near-infrared (800 nm) irradiation, produced a robust photothermal effect (Delta T = 12.8 +/- 0.5 degrees C). Photothermal activation for 48 h selectively upregulated lysosomal acidification-related genes-ATP6V1A (1.39 +/- 0.27-fold) and LAMP1 (1.65 +/- 0.39-fold; P < 0.01)-and significantly increased lysosomal enzymatic activity, including a 68 % rise in cathepsin B activity. This physically triggered "photothermal-gene regulation" approach offers a promising therapeutic avenue for restoring lysosomal function and combating intracellular infections such as Brucella.

Real-time and accurate monitoring of humidity and pH is of great significance in daily life and industrial production. Existing humidity and pH measurement suffer from limitations such as low sensitivity, signal crosstalk, complex system structures, and inability to achieve real-time monitoring. In this work, the surface of a polarization maintaining fiber (PMF) was functionalized with a composite humidity-sensitive polymer composed of polyvinyl alcohol (PVA) and carbon nanosheets (CNs). A humidity-sensitive film with a microporous structure was prepared on the PMF cladding through high-temperature rapid film formation and laser processing, enhancing humidity sensitivity and stability. To enable pH sensing, poly(allylamine hydrochloride) (PAH) and poly (acrylic acid) (PAA) were successively adsorbed onto the PMF surface via electrostatic self-assembly, forming a pH-sensitive nanofilm structure. By connecting a temperature-compensated PMF within the same Sagnac loop and combining it with a multi-wavelength matrix, simultaneous real-time monitoring of humidity, pH, and temperature was achieved, effectively solving the issue of temperature crosstalk and extending toward a universal optical fiber multi-parameter measurement platform.

Abstract Mental nanomaterial-mediated photothermal therapy (PTT) offers a prospective therapeutic strategy for solid tumors. However, its clinical application is limited due to insufficient photothermal conversion efficiency for deep-seated tumor and potential cytotoxic. Few photothermal therapy studies have been reported for tumour cells of different morphologies. In this study, CdTeSe/ZnS quantum dots (QDs) generating photoluminescence at 562 nm and 640 nm under 365 nm excitation are presented. The proliferation activity of RAW264.7 cells phagocytosed QDs exhibited a dose-dependent decline, as expected. In vitro, a liquid core fiber loaded with these QDs was utilized for PTT targeting high-grade and low-grade brain glioma cells. In the culture medium of cultured brain glioma cells, the maximum heat around the QDs-fibers under 365 nm laser excitation reached 64.9℃. High-grade U87 glioma cells treated with PTT displayed greater sensitive towards organelle damage compared to low-grade U251 glioma cells. Notably, U87 cells showed significant induction of apoptosis. Therefore, these findings represent further progress towards the applications of QDs-fibers in human solid tumor treatment.

Although perovskite has great potential in optoelectronic devices, the simultaneous satisfaction of material stability and high performance is still an issue that needs to be solved. Most perovskite optoelectronic devices use quantum dot spin coating or the gas-phase growth of perovskite thin films as the photoelectric conversion layer. Due to stability limitations, these materials often experience a significant decrease in photoelectric conversion efficiency when encountering liquid reagents. The self-assembled growth of hybrid perovskite crystals determines superior lattice ordering and stability. There are three types of ionic liquids—[Emim]BF4, EMIMNTF2, and HMITFSI—that can effectively enhance the X-ray photoelectric conversion performance of hybrid perovskite crystal CH3NH3PbI3 (MAPbI3), and the enhancement in the photocurrent leads to an improvement in the sensitivity of X-ray detectors. We soak the perovskite crystals in an ionic liquid and perform two treatment methods: electrification and dilution with ETOH solution. It is interesting to find that MAPbI3 perovskite single crystal materials choose the same optimized ionic liquid species in X-ray detection and photovoltaic power generation applications, and the effect is quite the opposite. Compared with untreated MAPbI3 crystals, the average photocurrent density of Electrify-HMITFSI MAPbI3 increased by 826.85% under X-ray excitation and the sensitivity of X-ray detectors made from these treated MAPbI3 crystals significantly increased by 72.6%, but the intensity of the PL spectrum decreased to 90% of the untreated intensity.

An effective method to improve optical properties of perovskite CsPbI3/Br3 is a long-term goal pursued by re-searchers, such as incorporating, mechanism changing and structure optimizing. However, two significant problems still facing challenges including the complex fabrication process and low modulation efficiency. To contribute these, a method of ionic liquid modulation with respect to the photoluminescence PL intensity and peak position was demonstrated. The micro-structure including the information of crystal and bond in MAPbBr3/ I3 soaking in C8H11F3N2O2 and C7H13N2 center dot BF4 was supported by x-ray diffraction XRD patterns and Raman spectrum. A cube-like shape and size distribution mostly in 600-950 nm was imaged by scanning electron mi-croscope. Then, compared with CsPbI3 before soaking in Hall measurement, the carrier concentration was improved about 46.1%, the mobility and resistivity were lowered around 39.2% and 40.2%, respectively. The modulation of intensity and peak position were confirmed by PL spectrum at room temperature. The absorption enhancement in excited state absorbs range was proved by transient absorption. Finally, the mechanism for optical modulation in this paper was systematically explained. The research method proposed in this paper can simplify the research process and improve the optical properties of the materials at the same time.

This paper investigates the dual-parameter sensing of temperature and strain using a-phase-shifted fiber Bragg gratings (a-PSFBGs). In many practical engineering applications, temperature and strain are often present simultaneously, which can interfere with each other's sensing. To achieve dual-parameter sensing of temperature and strain, two a-PSFBGs are modified with phase-shifted peaks of 1547 nm and 1550 nm, respectively. The a-PSFBG of 1547 nm is wrapped with a heat shrinkable tube to increase its temperature sensing sensitivity by 185.6%, while its strain sensing sensitivity is reduced by 91.083%. The a-PSFBG of 1550 nm is coated with indium tin oxide (ITO) film using the pulsed laser deposition (PLD) method to increase its temperature sensing sensitivity by 22.3%, while its strain sensing sensitivity is reduced by 16.03%. Finally, the two modified a-PSFBGs are cascaded to realize dual-parameter sensing of temperature and strain. The ITO film coating on the surface and heat shrinkable tube wrapping can reduce the interference of external light on the signal light and protect the fiber grating. By setting the optical spectrum analyzer (OSA) accuracy to 0.02 nm, the sensing in-formation can be extracted by scanning within a few nanometers, and the sharp phase-shifted peak of the a-PSFBG helps accurately locate the signal wavelength. The results demonstrate the potential for the practical application of the proposed dual-parameter sensing method.

Perovskite single crystal has a wide application prospect in the field of optoelectronics. Improving the performance and stability of perovskite-based optoelectronic devices has been a long-term goal of academia. Ionic liquids can be used to improve the properties of perovskite as a new generation of environmentally friendly electrolyte materials. In this paper, [Emim]BF4, EMIMNTF2 and HMITFSI ionic liquids were used to improve the properties of MAPbI3 single crystal. MAPbI3 single crystal treated by Ionic liquid is made into photoelectric detector, which can be used as x-ray detector under 1200W X-ray irradiation. The results show that the optical and photoelectric properties of MAPbI3 single crystals are improved effectively by adding ionic liquids.The method proposed in this paper can simplify the research process and improve the optical and photoelectric properties of MAPbI3 SC.

Real-time monitoring of environmental relative humidity (RH) plays a crucial role in ensuring both the quality of industrial production and the quality of life. In this work, polarization maintaining fiber (PMF) was used as carriers to creatively constructed multi-layer film surface functionalization on its cladding surface. The indium tin oxide (ITO) film and polyvinyl alcohol (PVA) doped graphite oxide (GO) composite polymer constitute multi-layer humidity sensitive film, which has the effect of dual absorption of water and improves the humidity sensitivity. Microporous composite polymer films created by laser processing increase the area for water evaporation and absorption, which improve response speed, and reduce recovery time. The surface functionalized PMF sensor exhibits high sensitivity and rapid response to humidity, achieving bidirectional repeated measurement of 0.28 nm/% within 10 s in the measurement range of 30%-90%, rendering it a reliable means for real-time monitoring of humidity.

MAPbBr3 single crystals have attracted much attention because of their high quantum efficiency and photoluminescence (PL) peaks. It has been researched that the crystal has two PL peaks and the additional PL peak comes from the “PbBr2” defect in the crystal. This can be well applied to dual-wavelength lasers. However, the change rule of the PL two peaks intensity is not clear. Herein. Crystals with two PL peaks are obtained by inverse temperature crystallization. We research the crystal structures of MABr and PbBr2 in different proportions, and find that these crystals have varying degrees of defects. Moreover, we confirm that these defects are Schottky defects based on experimental and simulated XRD. The optical properties of the samples are studied, which suggest that the PL intensity is related to the ratio of MABr to PbBr2. The energy level distribution of the crystal is calculated by energy level simulation, which further explains that the 536 nm is generated by “PbBr2” and the 567 nm is generated by MAPbBr3. All the results illustrate that the intensity of two peaks can be adjusted by the ratio of MABr to PbBr2. The maximum intensity is at 536 nm for MABr: PbBr2 = 2 and 567 nm for MABr: PbBr2 = 0.5. We explain this change rule of two peaks intensities from the energy level point of view and obtained MAPbBr3 crystals with high PL intensity corresponding to different wavelengths. This research provides a theoretical basis for the change in PL bimodal intensity, and an experimental reference for perovskite dual-wavelength laser.

The rapid, portable, and in situmeasurement of the ascorbic acid(AA) solution remains a challenge, and there is no suitable way toachieve multiscale regulation of the measurement range and sensitivity.In this work, water-soluble CdTe, CdTe/CdSe, and CdTe/CdSe/ZnS quantumdots (QDs) were used as fluorescence probes (FPs), and the specificsensitivity of photoluminescence (PL) intensity and AA were used asa detection indicator. By changing the concentration of the FP andthe type of core-shell structure, multiscale regulation ofthe measurement range and sensitivity was realized. The same FP withdistinct sensitivity in different measurement ranges is ingeniouslyrealized by double-layer core-shell CdTe/CdSe/ZnS with typeII-I band gap transition, which greatly expanded the application fields.The maximum measurement range was 0-27 & mu;M and the minimumdetection limit was 0.014 & mu;M for three FP systems. The capillarysensor with a honeycomb QD film attached to the inner wall was preparedby drying at room temperature, high-temperature heating, and laserprocessing, which greatly increased the contact area between the QDsand AA and reduced the measurement time. Furthermore, the microfluidicsystem was used to precisely control the deposition area and positionof the film, the concentration of the FP was adjusted and the depositionstatus of the film was observed in real time, so as to achieve real-timein situ rapid detection of the four concentration orders of the AAsolution. This work is of great significance for the rapid, portable,multifield, and in situ real-time detection in the field of biomoleculedetection.

Quantum dots (QDs) laser has become an important way to solve micro-application problems in many fields. However, single wavelength distributed Bragg reflector (DBR) has many limitations in practical applications, such as signal transmission. How to realize multiwavelength DBR lasing output simply is a challenge. To achieve a stable multi-wavelength quantum dots laser in the near-infrared region, the perovskite CsPbI3 QDs laser with DBR structure is developed in this paper. A tetragonal crystal structure with complete bonding information and no defect is explained by X-ray diffractions (XRD) and Raman spectrum. The cross-section morphology of the DBR laser and the surface morphology of QDs is measured by scanning electron microscope (SEM) and transmission electron microscope (TEM), respectively. An elliptical light propagation field and a double wavelength laser radiation are obtained from the finite-difference time-domain (FDTD) simulation. The output of the three wavelength lasers at 770 nm, 823 nm, and 873 nm is measured. The emission time of a DBR laser is about 2 h, and the average fluorescence quantum yield is 60%. The cavity length selection and energy level model are put in place to clearly see the working mechanism. All the results suggest that an effective and stable CsPbI3 quantum dots DBR laser is realized.

In this paper, the graphene tilted Bragg fiber grating (TFBG) sensor is fabricated by pulsed laser deposition (PLD). TFBG's sensitivity to external environmental changes can be improved to a certain extent by coating graphene in TFBG area. The experimental results show that the strain sensitivity of TFBG coated with graphene is 0.48 nm/m epsilon, which is 1.6 times of the strain sensitivity of bare grating. The temperature sensitivity of TFBG coated with graphene is 0.1 nm/degrees Cas same as bare grating. Based on the dual-wavelength matrix method, the Sagnac loop is used to cascade the coated tilted grating with The Bragg grating (FBG), and the temperature and stress sensing characteristics are measured simultaneously.

In this work, core CdTe, core-shell CdTe/CdSe and alloy CdTeSe QDs are synthesized by aqueous solvent. TEM visually shows the rod-shaped core-shell structure with a transverse to longitudinal ratio of 6.5 and the ellipsoidal alloy structure with different crystal planes competing for growth. The XRD and Raman spectra of the three QDs illustrate the characteristics of the internal lattice structure. With the increase of reaction time, CdTe emission maximum (EM) shows a red shift of 84 nm. Stokes shift changes little, and full width half maximum (FWHM) increases slightly. Compared with the CdTe, the red shift of CdTe/CdSe EM is slowly first and then faster, with a total shift of 125 nm. Stokes shift increases obviously. The initial FWHM is larger than CdTe and the widening speed is gradually accelerated. The initial EM of CdTeSe is red shifted compared with CdTe, and the total red shift of EM is 72 nm. Stokes shift increases obviously. The initial FWHM is significantly wider than CdTe. FWHM first decreases and then increases with reaction time. CdTe shows obvious band edge exciton absorbance of photoluminescence excitation (PLE) spectrum between 356 nm and 400 nm. CdTe/CdSe shows double band edge exciton absorption at 354-373 nm and 401-436 nm due to wave function separated of core-shell structure. The PLE spectrum of CdTeSe shows an obvious upward trend at 306-373 nm due to high energy level nonradiation. The average lifetime of CdTe/CdSe increases by 53 ns compared with CdTe due to the spatially separated electrons and holes. The defect state of CdTeSe increases the proportion of fast delay, which is 2 ns shorter than the average lifetime of CdTe. The transition mechanism of core-shell indirect band gap and alloy direct band gap is explained according to the valence bands of each element shown by XPS and the simulation of energy band density of states. The thickness shell and the doping elements can be adjusted to provide rich variation in the optical properties. This provides a more definite direction for the applications of cadmium chalcogenide in the fields of photoelectric devices and biology. (C) 2022 Elsevier B.V. All rights reserved.

The whispering gallery mode (WGM) microcavity has a high-quality factor and small mode volume, for the property of confining photons in a small volume for a long time, which enhances the light-matter interaction. Combining with quantum dots that act as gain medium, it can realize low-threshold and narrow-linewidth microlasers with excellent performance. However, achieving conventional whispering gallery mode lasers still requires complex preparation conditions. Here, we report a narrow linewidth whispering gallery mode lasing from all-inorganic perovskite quantum dots (CsPbBr3 QDs), illustrating facile and cost-effective properties. CsPbBr3 QDs with excellent properties were synthesized by hot injection method and used as gain media for lasers, and microspheres as optical resonators. The whispering gallery mode laser with a quality factor Q of 4791 and a narrow linewidth of 0.11 nm was obtained at room temperature. The WGM microlaser achieved by this paper could be a great application prospects in biotechnology.