Objective:To systematically review the clinical efficacy of intravenous omega-3 fatty acids supplemented for septic patients.Methods:The relevant randomized controlled trails (RCTs) from 1 January 2000 to 31 January 2023 were searched in online databases, including CNKI, WanFang Data, SinoMed, PubMed, EMBase, Web of Science and Cochrane Library. The primary outcome was the 28-day mortality. The secondary outcome included the length of ICU stay, the length of hospital stays and the length of mechanical ventilation. The quality of these included studies was evaluated by the modified Jadad score scale. The bias was assessed by the Cochrane risk-of-bias tool for randomized trial. The data was analyzed using RevMan 5.4.Results:Forty-six relevant literatures were obtained from initial literature retrieve and were screened systematically after preliminary screening. A total of 5 RCT studies involving 266 patients met all inclusion criteria and were enrolled systematic review. Meta-analysis indicated that intravenous administration of omega-3 fatty acids reduced the 28-day mortality [RR=0.52, 95%CI (0.33, 0.83), P=0.006]. And the length of ICU stay was reduced for patients received intravenous omega-3 fatty acids [MD=-4.40, 95%CI (-8.68, -0.13), P=0.04]. In addition, there was no difference on the duration of mechanical ventilation between the two groups [MD=-1.29, 95%CI (-3.70, 1.13), P=0.30].Conclusion:Intravenous supplementation of omega-3 fatty acids effectively reduce short-term mortality of patients with sepsis, shorten the length of stay in ICU, which has a positive effect on improving the clinical outcome of patients with sepsis, but its impact on the duration of mechanical ventilation is not significant.

自2019年底新型冠状病毒感染(coronavirus disease 2019, COVID-19) (以下简称新冠感染）在全球范围内爆发以来，因其传播速度快、致病性强的特性，造成了破坏性的医疗、经济和社会负担。自2022年以来奥密克戎变异株已经成为全球主要毒株 [1]。其传播性更强、发生免疫逃逸的可能性更大，感染者除出现咽部不适、咳嗽和发热等主要症状外，还可能伴有恶心、腹泻、胃纳减退等消化道症状 [2]，严重者快速进展为急性呼吸窘迫综合征、脓毒症休克和多器官功能衰竭 [3]。其中，老年、合并慢性基础性疾病和免疫力低下的感染者更易进展为重症。部分患者会因消化道症状导致营养素摄入不足或吸收障碍而引发营养不良。对于重症患者而言，大量炎性因子的释放引发免疫-内分泌-代谢的瀑布级联反应，造成代谢功能严重失调，加重营养不良的发生发展 [4,5]。国家卫生健康委员会最新公布的《新型冠状病毒感染诊疗方案（试行第十版）》指出，应当加强支持治疗，保证充分能量摄入 [3]。医学营养治疗应当贯穿新冠感染的预防、治疗和恢复全过程。

2020年新冠疫情席卷全球,在疫情冲击下,急诊患者急剧增加、医疗资源紧缺等问题日趋严重.随着疫情的逐步控制和政策的转变,我们已经进入了一个新的时代——"后疫情时代".在应对疫情的过程中,传统急诊医疗体系由于信息化、智能化水平不高的缺陷更显突出.后疫情时代我国急诊医疗体系应加速向信息化、智能化的方向转变,解决传统急诊医疗体系信息传输障碍、院前院内协同不足、人工智能、大数据等智能化技术应用不足等主要问题迫在眉睫.在5G、人工智能、物联网等新兴技术的飞速发展的前提下,聚焦急诊医疗核心需求,以信息化技术为基础,以智能化技术为导向,是促进后疫情时代智能急诊医疗体系发展的重要途径.

Objective:To discuss the application of 5G-satellite fusion communication technology in pre-hospital treatment of wounded people in the Luxian earthquake in 2021.Methods:We retrospectively analyzed the process of treatment of the wounded people in the Luxian earthquake, and summarized the application effect and characteristics of the emergency medical rescue mode supported by 5G-satellite fusion communication in the treatment of wounded people at the disaster site.Results:Emergency video communication was established by 5G and satellite links, connecting the disaster site headquarter with the rear expert team of Sichuan Provincial People's Hospital, and an operation was completed for a 69-year-old patient with femoral neck fracture. Under the guidance of the fusion communication system, the emergency medical rescue order was quickly established. More than 80 wounded people were treated through remote consultation, of whom 38 were moderately injured and 11 were seriously injured. Ten operations were completed, and there were no casualties.Conclusion:The emergency medical rescue model based on 5G-satellite fusion communication is the improvement of 5G emergency medical rescue system in 2019 Changning earthquake. It is the first practical experience of 5G-satellite fusion communication for disaster rescue in China. The high-quality medical resources of rear hospitals could be used for prehospital treatment, which provide reference for the information construction of prehospital first aid worldwide.

突发急性传染病是指在短时间内突然发生，重症和死亡比例高，早期识别困难，缺乏特异和有效的防治手段，易导致大规模暴发流行、构成突发公共卫生事件，造成或可能造成严重的社会、经济和政治影响，须采取紧急措施应对的传染病。随着经济贸易的全球化和人口流动的加剧，传染病呈现出全球性流行和蔓延的趋势，特別是一些突发急性传染病如鼠疫、高致病性禽流感、埃博拉、新冠肺炎等在世界各地的传播流行，预示着传染病已成为全球性危机。在当前新冠肺炎疫情防控形势下，国内外各级医疗机构应对突发急性传染病能力有了极大提高，建立了系统的防控流程和工作机制。院前转运作为救治的首要环节，对于传染病的控制至关重要，但我国幅员辽阔，各地医疗应急机构的建设水平不一，传染患者转运能力有一定的差别，提示我们在今后相当长的时间里传染病患者院前转运体系的进一步完善仍然是疾病预防控制工作的重点之一。在回顾分析2003年SARS、2005年四川人感染猪链球菌病、2009年甲型H1N1流感大流行、2013年人感染H7N9禽流感、2014年西非埃博拉疫情、2015年中东呼吸综合征和2019年至今的新冠肺炎防治经验的基础上，结合国内外针对突发急性传染病院前转运相关研究进展做一梳理。

Traumatic rib fractures are the most common injury in thoracic trauma. Previously，the patients with traumatic rib fractures were mostly treated non-surgically，of which 50%，especially those combined with flail chest presented chronic pain or chest wall deformities and over 30% had long-term disabilities，being unable to retain a full-time job. In the past two decades，thanks to the development of internal fixation material technology，the surgical treatment of rib fractures has achieved good outcomes. However，there are still some problems in clinical treatment，including inconsistency in surgical treatment and quality control in medical services. The current consensuses on the management of regional traumatic rib fractures published at home and abroad mainly focus on the guidance of the overall treatment decisions and plans，and relevant clinical guidelines abroad lacks progress in surgical treatment of rib fractures in recent years. Therefore，the Chinese Society of Traumatology affiliated to Chinese Medical Association and Chinese College of Trauma Surgeons affiliated to Chinese Medical Doctor Association，in conjunction with national multidisciplinary experts，formulate the Chinese Consensus for Surgical Treatment of Traumatic Rib Fractures（2021）following the principle of evidence-based medicine，scientific nature and practicality. This expert consensus puts forward some clear，applicable，and graded recommendations from aspects of preoperative imaging evaluation，surgical indications，timing of surgery，surgical methods，rib fracture sites for surgical fixation，internal fixation methods and material selections，treatment of combined injuries in rib fractures，in order to provide references for surgical treatment of traumatic rib fractures.

Objective To explore the efficacy of a combination regimen by Lopinave/Litonawe (LPV/r), emtricitabine and tenofovir alafenamide fumarate (FTC/TAF) for the treatment of novel coronavirus pneumonia (NCP).Methods We design the protocol as a real world study, which includes two groups: prospective intervention cohort (T1) and historical control group (T2). For T1 group, ninety patients will be enrolled who are diagnosed as NCP. All patients in T1 group will receive standard therapies following the recommendation in the guidelines of National Commission of Health, and they will be administered an anti-virus regimen includes LPV/r and FTC/TAF. The T2 group will enroll patients who have received single regimen includes LPV/r. The major outcome is the survival rate of patients. Secondary outcomes are the time of seroconversion of RNA, ARDS progression rate and length of hospital stay.Conclusions The results of this real world study might provide clinical practitioners a high efficiency and fast antivirus regimen for NCP. In addition, the conduction of this study will accelerate screening for other new effective therapeutic method.

Objective:To explore the possibility of using Lopinave/Litonawe (LPV/r) as treatment for novel coronavirus 2019-nCov pneumonia by systematically review earlier coronavirus studies.Methods:Systematically retrieve relevant clinical studies from Chinese and English databases such as CNKI,VIP, Wangfang Data,CBM,PubMed, Web of Science,EMBASE. In addition, information from Chinese biomedical journals, WHO, US CDC, Chinese CDC websites and the references from published relevant articles were retrieved. The inclusion period is from January 2003 to January 24, 2020. The criteria for inclusion are: (1) studies that aim to compare LPV/r and placebo/standard for SARS, MERS; (2) studies that include at least one clinical outcome; (3) studies with diagnosis criteria meeting WHO requirement on SARS or MERS; (4) data from multiple reports but originated from one study, where we extract information from all reports; (5) guidelines, includes: national or academic guidelines/experts 'consensus. The exclude criteria are: 1) only have abstracts but no full information; 2) in vitro studies. Two reviewers independently review articles and extract data on study design, patients, diagnosis criteria, regimen, and clinical outcomes (mortality, morbidity, quality of life, steroids dosage, chest image and adverse responses).Results:Two hundred and thirty potential article were found by screening, and narrow down to forty-four articles for evaluation and finally four studies were included. The results of included studies indicate the early use of LPV/r regimen can reduce the mortality of SARS and MERS, and reduce steroids dosing.Conclusions:ILPV/r can be used as a component of experimental regimen for treat 2019-nCoV pneumonia. It strongly suggests that initiating real world studies to explore the true clinical effects of LPV/r on 2019-nCoV patients.

目的 系统评价omega-3脂肪酸用于肿瘤恶液质患者口服营养补充(ONS)的临床疗效.方法 全面检索PubMed、EMbase、Web of Science、中国知网、万方数据库和SinoMed等数据库,搜索关于含omega-3脂肪酸营养补充治疗肿瘤恶液质患者的随机对照试验.检索时间为2000年1月1日至2020年7月4日.对符合纳入标准的研究进行质量评价,按照Cochrane 5.1手册标准及改良的Jadad评分量表对纳入的研究进行偏倚风险评估和文献质量评价,最后应用RevMan5.3软件进行数据合并及meta分析.结果 初筛获得316篇文献,通过阅读标题和摘要进一步筛选获得54篇文献,最终纳入7项随机对照试验,共901例患者.Meta分析结果显示:含omega-3脂肪酸营养补充与对照组相比,患者体重明显增加(MD=2.4kg,95％CI=2.26～2.53kg,P<0.001);生活质量明显改善(MD=4.71,95％CI=3.99～5.42,P<0.001).然而患者的去脂体重与对照组相比,无显著差异(MD=-0.79kg,95％CI=-2.09～0.51,P=0.23);生存时间定性分析结果显示,含omega-3脂肪酸的ONS并不能延缓肿瘤恶液质病程,也不能延长患者生存时间.结论 含omega-3脂肪酸的口服营养补充有可能改善肿瘤恶液质患者的生活质量.

目的 调查紧急医学救援人员在救援现场进行初级创伤救治(PTC)的能力,为应急培训演练提供循证医学证据.方法 模拟突发公共性事件批量危重伤员救治现场,对四川省市(州)、县级救援人员进行横断面调查,对其初级创伤救治表现进行测评分析.结果 ①287名救援演练人员纳入调查.②初级创伤救治能力总体得分中位数57.14(53.57,82.14);各维度得分:初级评估42.86(42.86,85.71),组织协同58.33(50,75),循环管理70.59(64.71,76.47),呼吸管理36.36(27.27,81.82),次级评估77.78(66.67,88.89).各职业分层:临床医生83.93(82.14,87.50),护士87.50(82.14,89.29),医技53.57(50,57.59),公卫医生53.57(50,57.14),卫生管理55.36(50,57.14).各职称分层:初级63.39(53.57,83.93),中级58.93(53.57,83.93),高级55.36(50,58.93).③各维度间测评得分比较,初级评估与分配任务、循环管理、次级评估比较,组织协同与循环管理、呼吸管理、次级评估比较,循环管理与呼吸管理、次级评估比较,呼吸管理与次级评估比较;临床医生、护士与医技、公卫医生、卫生管理比较,初级、中级与高级比较,均P<0.05,差异有统计学意义.结论 模拟灾害批量危重伤员的救援场景,对救援人员的PTC技能行为进行数据化考评,为灾难救援演练提供一种数据考评模式.救援人员现场PTC总体能力一般;初级评估和呼吸管理维度能力较差,应重点提升;组织协同维度能力一般,应进行强化训练;高级职称人员,医技、公卫医生及卫生管理人员是重点培训人群.

目的 调查省紧急医学救援人员现场检伤胜任力,为应急培训演练提供参考.方法 模拟批量伤员救援场景,对四川省市(州)、县级救援人员进行横断面调查,对其现场表现进行测评分析.结果 ①共纳入287名被调查人员;②现场检伤胜任力总体得分中位数M(P25,P75)21.15(11.54,38.46),各维度得分:进入现场55.56(33.33,88.89),伤票统计28.57(14.29,85.71),检伤流程16.67(0,83.33),现场急救0(0,20),撤离现场0(0,16.67),二次检伤0(0,0),维持呼吸0(0,0),稳定循环0(0,0).职业分层得分:医技34.62(15.38,40.38),公卫医生32.69(15.38,39.42),护士32.69(13.46,38.46),临床医生27.88(15.38,40.38),卫生管理11.54(3.85,19.23).职称分层得分:初级32.69(15.38,38.46),中级25(15.38,40.38),高级11.54(3.85,19.23);③维持呼吸、稳定循环与进入现场、检伤流程、现场急救、撤离现场、伤票统计比较,二次检伤与进入现场、检伤流程、伤票统计比较,现场急救、撤离现场与进入现场、检伤流程、伤票统计比较,进入现场与检伤流程、伤票统计比较,卫生管理与临床医生、护士、医技、公卫医生比较,高级与初级、中级职称比较,P<0.05,差异均有统计学意义.结论 本次调查人员现场检伤胜任力严重不足,应针对薄弱人员开展针对性培训,救援演练可为应急培训提供测评模式.

<span id="ChDivSummary" name="ChDivSummary" class="abstract-text">目的:调查评估紧急医学救援人员进入现场前装备配置行为能力,为应急培训演练的重点人员和侧重方向提供参考。方法:通过特别重大突发事件批量伤员救援现场情景模拟,对四川省30支市（州）、县级救援队伍的救援人员装备配置行为进行横断面调查,对其完成情况进行测评分析。结果:纳入调查287名救援人员,装备配置总体得分中位数M （P25, P75）为55.56（44.44, 100）,防护器材33.33（16.67, 100）,医疗器材100（100, 100）。职业分层得分,卫生管理55.56（0, 83.33）,临床医生55.56（44.44, 91.67）;职称分层得分,高级44.44（0, 77.78）,中级55.56（44.44, 100）,初级55.56（44.44, 100）。防护器材与医疗器材间比较,卫生管理与临床医生间比较,高级与中级、初级间比较,差异有统计学意义。结论:本次被调查医学救援人员,防护器材配置较差,对灾难现场的安全防护观念和防护器材使用训练不足;需对能力不足人员进行针对性培训。</span>

Compound amino acid injection, as the source of nitrogen in parenteral nutrition, is administrated to patients with compromised gastrointestinal function or whose nutritional needs cannot be satisfied via the GI tract.Therefore, compound amino acid injection is crucial in nutrition therapies.However, a consensus does not exist in China regarding its indications, formulations, dosages, and the timing of administration.Experts in the field are recruited by the Chinese Society for Parenteral and Enteral Nutrition (CSPEN) and the Chinese Society of Nutritional Oncology ( CSNO) to formulate a consensus paper.The current paper aims to provide standardized guidance for clinical use of compound amino acid injection.The consensus paper is a composite of systematically reviewing pertinent literature, Chinese clinical practice, and multiple sessions of debate, discussion, and composition, with reference to guidelines from American Society for Parenteral and Enteral Nutrition ( ASPEN), European Society for Clinical Nutrition and Metabolism ( ESPEN), CSPEN, and CSNO.This consensus presents 10 recommendations for protein needs and appropriate compound amino acid injection formulas to serve varied patients.

<span id="ChDivSummary" name="ChDivSummary" class="abstract-text">目的:调查评估紧急医学救援人员灾难现场救援胜任力,为应急培训演练的重点方向提供参考。方法:模拟特别重大突发事件批量伤员救援现场,对四川省市（州）、县级救援人员演练表现进行横断面调查,对其完成现场救援表现进行定量测评分析。结果:纳入调查287名救援演练人员,胜任力总体测评得分中位数M （P25, P75）为33.81（26.62, 41.37）,各模块测评得分:任务评估11.11（3.70, 22.22）,装备配置55.56（44.44, 100）,流程执行22.92（18.75, 33.33）,信息联络19.57（13.04, 28.26）,现场检伤21.15（11.54, 38.46）,搜救搬运38.71（25.81, 74.19）,生命支持57.14（53.57, 82.14）,社会动员11.11（0, 22.22）。社会动员、任务评估与装备配置、流程执行、信息联络、现场检伤、搜救搬运、生命支持间比较,信息联络、现场检伤、流程执行与装备配置、搜救搬运、生命支持间比较,生命支持与装备配置、搜救搬运间比较,差异有统计学意义。结论:本次被调查医学救援人员,现场救援胜任力总体较差,管理类模块胜任力严重不足,医疗类模块中现场检伤表现严重不足,搜救搬运较差,装备配置与生命支持表现一般。情景演练的定量测评可为提升现场救援胜任力提供一种培训和评价模式。</span>

目的 本研究旨在系统评价以富马酸替诺福韦二吡呋酯(tenofovir disoproxil fumarate,TDF)为基石(backbone)的抗反转录病毒方案(antiretroviral therapy,ART),与以替诺福韦艾拉酚胺(tenofovir alafenamide,TAF)为基石的ART方案对于非初治(experienced treatment)HIV感染者的长期有效性和安全性的影响.方法 在PubMed,EMBASE,Web of Science,Cochrane Library和中国生物医学文献数据库检索相关临床随机对照试验(randomized controlled trial,RCT),时间范围为2003-2019年.患者纳入标准:①HIV-1感染者,接受过抗病毒治疗(experienced treatment);②入组时的病毒载量(viral load,VL)<50 copies/ml;③eGFR>50 ml/min;④≥12岁的儿童及成年人;5)随访时间≥96周,排除标准:①HIV-1初诊患者(naive);②VL≥50 copies/ml;③<12岁的儿童;④妊娠;⑤合并丙肝/乙肝.有效性评价指标采用病毒抑制成功率,同时采用符合方案分析(Per-protocol Analysis,PP分析)和意向性分析(Intention-to-treat Analysis,ITT分析),若两者结果不一致,以ITT分析结果作为最终结论.安全性评价指标包括:骨密度变化、肾脏功能变化及药物相关的退出率.采用Rev Man 5.3进行Meta分析.结果 通过文献检索,发现潜在相关文章84篇,初筛后获得62篇文章,最终纳入3个研究,包含2729例患者.PP分析中,TAF方案与TDF方案对患者的病毒抑制成功率相似(RR=0.99,95％CI:0.98～1.00,P=0.25),ITT分析的结果与PP分析一致.三项研究均报告了患者的骨密度指标,但均采用骨密度均数变化曲线方式报告,无法进行数据合并,对3个研究进行定性系统评价,TAF治疗后患者的骨密度均显著增加,TDF则显著降低.三项研究均报告了患者肾功能指标(urine protein to creatinine ratio,UACR)变化情况,但数值报告的方式不一致,无法进行数据合并,行定性评价,结果显示TAF治疗后患者的肾功能显著好于TDF方案.TAF组患者退出率较TDF组有降低趋势,但差异不显著(RR=0.75,95％CI:0.52～1.11,P=0.15),对药物相关退出率做亚组分析,两组方案结果相似(RR=2.71,95％CI:0.30～24.45,P=0.38).结论 以TAF为基石和以TDF为基石的ART方案用于非初治HIV感染者长期治疗的有效性相似.在肾功能、骨密度以及耐受性等方面,TAF方案均优于TDF方案,显示出其长期安全性的优势,但限于样本量和观察时间,上述结论尚待更多高质量RCT进一步验证.

The advantages of 5G communication,including large bandwidth,low latency and wide connection,and rapid transmission,have proved to be vital in facilitating emergency medical rescue.On June 17th,2019,an earthquake occurred in Channing,Yibin,Sichuan Province.Sichuan Provincial People's Hospital initiated the Emergency Medical Rescue System for the rescue operation in the disastrous area.This was the first use of 5G emergency medical rescue worldwide.Remote consultations,injury assessments and helicopter transfers were carried out for the critical patients.Our rescue system have been effective and efficient in rapid responding,information transmission and the coordination of medical resources,which has led to the best possible medical decisions and treatments.However,there were challenges found in the application of this system:the stability of 5G signal,the optimization of the configuration of 5G ambulances,and the survival rate and self guarantee in the field.In conclusion,this practice of 5G emergency medical system provides a new paradigm and valuable experiences for the improvements in disaster rescue in China and worldwide.

目的 调查四川省紧急医学救援人员在救援现场进行信息收集和联络资源的能力,为应急培训演练提供证据.方法 模拟突发公共性事件批量危重伤员救治现场,对四川省各市(州)、县级救援人员进行横断面调查,使用现场信息联络能力评分量表对其表现进行测评,因得分分布不符合正态分布,使用中位数及其四分位间距描述得分,多个计量资料间比较采用秩和检验.结果 共纳入287名救援演练人员.信息联络能力总体得分M (P25,P75)为19.57(13.04,28.26).各维度得分分别为:安全区域设置为0(0,10),现场危险识别为0(0,16.67),对外联络协调为50(0,50),对内协调指挥为50 (16.67,50),现场灾情统计为40(10,70),现场资源状况为0(0,0),现场增援需求为0(0,0).按照职业进行分层:临床医生为19.57 (12.50,28.26),护士为19.57 (14.13,34.78),医技为25 (14.67,32.61),公卫医生为21.74(14.13,30.44),卫生管理为17.39 (9.78,21.74).按照职称分层:中级为21.74 (13.04,28.26),高级为17.39 (10.33,23.91).分别对不同维度、不同职业、不同职称得分进行比较,差异均有统计学意义(P＜0.05).结论 本次调查结果显示,四川省各市(州)、县级紧急医学救援人员存在现场信息联络总体能力不足,需针对能力不足人员进行培训,培训内容重点为现场资源状况、现场增援需求、安全区域设置、现场危险识别维度能力.

急腹症是一组以急性腹痛为起病表现的急诊疾病,既包含急性单纯性阑尾炎等简单疾病,也包括消化道穿孔、重症急性胰腺炎等可能危及生命的复杂疾病.在有限的时间内,依据患者对症状的描述快速对急腹症进行准确分诊,识别和筛选危重患者,并进行优先处理,是一待解决的重要问题.计算机技术的发展使得利用人工智能(artificial intelligence,AI)技术建立急腹症快速分诊系统成为了可能.急腹症智能分诊系统的研究主要包括以下几个方面:①根据医学教材以及病例诊断的文本信息建立知识图谱;②根据患者主诉,实现医学术语到知识图谱中概念的归一化;③利用深度学习的方法训练模型,使计算机判别不同的急腹症;④在医院以及急救中心等场所部署训练后的AI模型进行测试并基于临床使用效果和反馈进行优化,使得系统对急腹症诊断的准确率达到可接受的水平(根据一般标准为:F≥94%).在开发过程中,自然语言处理是急腹症人工智能分诊系统建立所必需的核心技术.本文综述了近年来自然语言处理领域中的最新技术进展,并讨论了将其应用于构建急腹症快速智能辅助诊断系统的前景.此系统的开发可以作为范式推广到其他疾病,优化患者的就诊流程,提高急诊效率.

目的:调查阿坝州人群用药史及不同类型胃病患者其Hp感染情况,以了解Hp的流行现状及影响因素,以期为患者提供有效的健康管理策略.方法:在阿坝藏族自治州自然村落的常住村民招募志愿者,进行通过14 C尿素呼气试验检测Hp感染情况,行胃镜检查明确上消化道病变性质.结果:共招募志愿者552名,长期反复服药不增加易感性,但反复服药消炎止痛药和降压降糖药使感染率有增加.存在胃部疾病或者其他消化不良症状者的Hp感染率明显高.

目的 评价集束化护理干预措施在新生儿呼吸机相关肺炎中的应用效果.方法 选取2014年~2015年于我院行机械通气治疗的新生儿114例作为研究对象,将其分为采取集束化护理的观察组与接受常规护理的对照组,将两组护理效果作以比较.结果 观察组机械通气时间、住院时间分别为(104.6±4.3)h、(13.7±2.2)d短于对照组(136.5±4.7)h、(22.4±3.9)d,差异有统计学意义(P<0.05);观察组呼吸机相关肺炎发生率为7.0%低于对照组19.3%(P<0.05).结论 对于行机械通气治疗的新生儿采取集束化护理可尽早实现气管插管拔管,缩短患者住院时间,降低呼吸机相关肺炎发生率.