目的 探讨Kinect体感交互技术对低视力儿童康复的效果.方法 选择2021年5月至2022年5月从泉州特殊教育学校筛查60例低视力儿童,按随机数字表法分成观察组(30例)和对照组(30例).两组患儿均给予常规视觉康复和感统训练治疗,观察组在对照组基础上加用Kinect体感交互技术强化训练.评估两组患儿训练前后低视力生活质量量表中文版(CLVQOL)各项分值,采用配对样本t检验对结果进行统计学分析.结果 训练前,两组患儿CLVQOL各项评分比较无统计学意义(P>0.05).连续训练6个月后,观察组患儿CL

目的 探讨基于Kinect体感交互技术的康复训练对低视力儿童感觉统合的影响.方法 采用方便抽样法,于2021年5月—2022年5月选取泉州特殊教育学校的60例低视力患儿作为研究对象.按照随机数字表法分为观察组与对照组,每组30例.2组患儿均给予常规视觉康复和感觉统合训练治疗,观察组患儿在对照组基础上加用Kinect体感交互技术强化训练.评估2组患儿训练前后儿童感觉统合能力发展评定量表(SIFS)各维度得分,并对结果进行统计学分析.结果 训练前,2组患儿SIFS中前庭感觉、触觉防御、本体感、学习能力得分比较,差异均无统计学意义(P＞0.05).训练后,观察组患儿前庭感觉、触觉防御、本体感、学习能力得分明显高于训练前,且高于同期对照组,差异均有统计学意义(P＜0.05).结论 应用Kinect体感交互技术实现的康复训练能够提高低视力儿童感觉统合水平.

目的 探讨基于"国际功能、残疾和健康分类"理念下感觉统合及残余视力感知觉联合康复训练对低视力儿童发育行为的影响.方法 选取2020年5月至2021年5月泉州盲校筛查的60名低视力儿童作为研究对象,依据随机数字表法将其分成观察组(30例)和对照组(30例).观察组儿童在使用各种助视器的同时进行感觉统合及残余视力感知觉联合康复训练,对照组仅使用助视器.所有儿童训练前后分别采用儿童感觉统合能力发展评定量表(SIFS)及Gesell发育诊断量表(GDDS)进行评估.两组儿童训练前后的SIFS及GDDS评分采用配对样本t检验对结果进行统计学分析.结果 两组儿童训练前的前庭感、触觉防御、本体感、学习能力、适应性行为、大动作、精细动作、语言、个人-社会性行为评分比较,差异无统计学意义(P>0.05).观察组训练6个月后的前庭感、触觉防御、本体感、学习能力、适应性行为、大动作、精细动作、语言、个人-社会性行为评分均高于对照组,差异均有统计学意义(P<0.05).结论 感觉统合及残余视力感知觉联合康复训练能够提高低视力儿童的发育行为.

目的 探讨感觉统合训练联合助视器对低视力患儿生活质量的影响.方法 选取2018年9月至2019年6月在该院眼视光门诊筛查低视力患儿40例,随机分为观察组和对照组,各20例.对照组采用助视器进行助视训练,观察组在对照组基础上进行感觉统合训练.比较两组训练前后儿童感觉统合能力发展评定量表(SIFS)及Achenbach儿童行为量表(CBCL)评分情况.结果 两组训练前SIFS评分及CBCL评分比较,差异均无统计学意义(P>0.05).观察组训练后SIFS评分明显高于对照组,而CBCL评分明显低于对照组,差异均有统计学意义(P<0.05).结论 感觉统合训练联合助视器能够改善低视力患儿康复效果,提高其生活质量.

Objective:To investigate the association between breast cancer susceptibility gene 1 (BRCA1)-related ring domain protein 1 (BARD1) gene polymorphism and risk of nephroblastoma.Methods:One hundred and eight newly diagnosed nephroblastoma patients in our hospital from July 2014 to July 2019 were included as observation group, and 300 healthy children who received health examination in our hospital physical examination center at the same time were included as control group. There was no significant difference in gender and age between the two groups ( P> 0.05). The genetic polymorphisms of rs7585356 GNA, rs6435862 TNG and rs3768716 ANG loci in BARD1 gene of the two groups were determined and their correlation with susceptibility to nephroblastoma in children was analyzed. Results:After adjusting for sex and age, homozygote AA mutation significantly increased the risk of nephroblastoma at rs7585356 locus [odds ratio ( OR) (95% CI): 2.04 (1.09-2.93)] compared with wild homozygote genotype GG. The risk of nephroblastoma in Genetic risk score (GRS) of 1-3 group was 1.94 times higher than that in o score of group (95% CI: 1.11-3.34). The risk of nephroblastoma in group scored 4-6 was 2.64 times higher than that in group scored 1-3 (95% CI: 1.23-5.62). Conclusion:BARD1 gene polymorphism may increase the risk of nephroblastoma in children.

Objective To investigate the clinical feasibility of early intervention for high-risk newborns with cerebral palsy.Methods A total of 104 cases of newborns with high risk of cerebral palsy were selected as observation group,and 105 cases of newborns with high risk of cerebral palsy were selected as control group;the control group only received basic newborn parenting guidance,the observation group received early intervention.Incidence of neonatal cerebral palsy in the two groups were observed,and major risk factor of cerebral palsy were analyzed.Results The overall incidence of cerebral palsy in high-risk newborns was 3.9％ in control group and 18.2％ in observation group,the difference was statistically significant (P ＜ 0.05).There was no significant difference among the incidences of cerebral palsy in newborns caused by each high-risk factors (all P ＞ 0.05).Conclusions Early intervention can significantly reduce the incidence of cerebral palsy in the newborns with high-risk of cerebral palsy;premature birth,asphyxia,hypoxic-ischemic encephalopathy and other factors have almost equal pcthogenic risk,with which newborns need to be given full attention clinically.

BACKGROUND:Several studies have demonstrated that astaxanthin has a good neuroprotective effect; however, the treatment effects of astaxanthin on newborns with hypoxic-ischemic brain damage have not been reported. OBJECTIVE: To build newborn rat models of hypoxic-ischemic brain damage, and investigate the neuroprotective effects of astaxanthin and the ways of action. METHODS: Thirty newborn Sprague-Dawley rats aged 7 days out of 98 were randomly taken as sham-operated group. The rest of rats were subjected to ligature of the left carotid artery for 2 hours and then placed in the hypoxic box containing 92% special standard gas and 8% oxygen to establish the models of hypoxic-ischemic brain damage. The rats in the sham-operated group only underwent separation of the carotid arteries, without hypoxic-ischemic treatment. Rat models of hypoxic-ischemic brain damage were randomly divided into hypoxic-ischemic brain damage and astaxanthin-treated groups, with 30 rats in each group. The rats in the astaxanthin-treated group were intraperitionaly injected with 80 mg/kg astaxanthin after hypoxic-ischemic brain damage. RESULTS AND CONLUSION:Compared with the sham-operated group, the expression levels of p-Akt, p-GSK3β and cleaved-caspase-3 protein in the parietal cortex of ischemic damage area of rats were significantly increased, whereas Bcl-2 protein expression was significantly decreased in the hypoxic-ischemic brain damage group (alP < 0.05). Compared with the hypoxic-ischemic brain damage group, astaxanthin treatment significantly reduced the expression level of apoptosis-related protein cleaved-caspase 3 protein (P < 0.05), significantly increased the expression level of Bcl-2 protein (P < 0.05), and significantly reduced the number of apoptotic cels&nbsp;in the hypoxic-ischemic brain area(P < 0.05). These findings suggest that astaxanthin can distinctly improve the prognosis and ways of action of hypoxic-ischemic brain damage in newborn rats which associates with up-regulation of Akt/GSK3β signaling pathways.

目的观察β受体阻滞剂美托洛尔静脉注射用于交感风暴的临床疗效及安全性。方法将65例各种器质性心脏病合并交感风暴患者随机分为干预组35例和对照组30例。对照组仅予以利多卡因和/或胺碘酮静脉注射以及电复律等常规治疗,干预组在对照组治疗基础上予以美托洛尔静脉推注治疗。观察2组心律失常转复成功率、电复律次数,房室传导阻滞、低血压(血压<90/60mmHg)以及心力衰竭发生情况。结果干预组心律失常转复成功率、房室传导阻滞发生率高于对照组,电复律次数低于对照组,差异均有统计学意义(P<0.05)。2组低血压发生率、心力衰竭发生或加重率比较差异无统计学意义(P>0.05)。结论对于各种器质性心脏病合并交感风暴患者,在常规治疗基础上及时、足量地予以β受体阻滞剂美托洛尔静脉注射治疗是有效和安全的。

目的观察分析鸡尾酒疗法[硝酸甘油、利多卡因、合贝爽(盐酸地尔硫注射液)]对防治桡动脉痉挛(RAS)的临床疗效及其安全性。方法将经桡动脉冠状动脉介入检查或治疗的住院患者共897例,随机分为鸡尾酒治疗组(485例)和对照组(412例)。对照组患者经动脉鞘管注射硝酸甘油、利多卡因等常规处理,治疗组患者在上述治疗基础上经动脉鞘管注射合贝爽。结果治疗组RAS发生率为3.92%,显著低于对照组的11.41%(P<0.05)。结论对于经桡动脉冠状动脉介入检查或治疗的手术过程中,常规使用鸡尾酒疗法是有效和安全的。

目的:观察胺碘酮治疗儿童早搏的疗效及不良作用。方法:采用先负荷量后小剂量维持方法治疗48例小儿频发早搏,用药前后进行心电图、心肌酶谱等检查,并作T3、T4检查,观察心律失常疗效和常见的不良作用。结果:早搏治疗1周时的总有效率为64.6%,1个月总有效率为83.3%,3个月总有效率达91.7%。治疗期间少数病儿出现甲状腺肿大(T3、T4、TSH均正常)、食欲减退等不良作用,在药物剂量减少或停药后均自行消失。结论:小剂量胺碘酮维持治疗小儿频发早搏是有效和安全的。