"HSR24-154: Real-World Clinical Outcomes in Patients With Advanced/Metastatic Melanoma and Brain Metastases Treated With Pembrolizumab Monotherapy—An Analysis of the ADOReg German Skin Cancer Registry" published on 05 Apr 2024 by National Comprehensive Cancer Network.

The data that support the findings of this study are available on request from the corresponding author. The data are not publicly available due to privacy or ethical restrictions.

We report a female patient, today 72 years old. She was referred to our department in 2004 with one solitary non-ulcerated nodular lesion under the right knee of approximately 0.5 cm in diameter. N...

Die heilsame Wirkung des Sonnenlichts war teilweise schon im Altertum bekannt und fand in der zweiten Hälfte des 19. Jahrhunderts wieder zunehmend Beachtung. Den Beginn der modernen Phototherapien markiert die Entwicklung einer Apparatur zur ultravioletten Bestrahlung der Hauttuberkulose durch Finnsen zu Beginn des zwanzigsten Jahrhunderts. Zur Therapie von Hauterkrankungen finden beinahe ausschließlich die spektralen Bereiche unterhalb des sichtbaren Lichtes (ultraviolett) Anwendung. Seit den 1970er Jahren stehen zunehmend leistungsfähige künstliche Strahlenquellen bereit für die Therapie mit UVB, UVA und die Kombination von UVA mit Photosensibilisatoren (Photochemotherapie). Hohe strukturelle und prozedurale Qualitätsstandards sind unabdingbare Voraussetzung für die Durchführung einer gleichermaßen wirkungsvollen wie auch sicheren Phototherapie. Die Leitlinie formuliert den aktuellen Konsens führender Experten auf dem Gebiet der Phototherapie in Bezug auf die Indikationen für die jeweiligen Therapieverfahren, deren Gegenanzeigen und Nebenwirkungen und insbesondere für die Wahl der korrekten Dosis zu Beginn und im Verlauf einer Therapie sowie das Management von Nebenwirkungen.

JDDG: Journal der Deutschen Dermatologischen GesellschaftVolume 12, Issue 12 p. 1156-1157 ADO ADOReg – wissenschaftliches Register der Arbeitsgemeinschaft Dermatologische Onkologie Ulrike Leiter Tübingen, Ulrike Leiter TübingenSearch for more papers by this authorMichael Weichenthal Kiel, Corresponding Author Michael Weichenthal Kiel Korrespondenzanschrift Prof. Dr. med. Michael Weichenthal Universitäts-Hautklinik Kiel Schittenhelmstraße 7 24105 Kiel E-mail: mweichenthal@dermatology.uni-kiel.deSearch for more papers by this author Ulrike Leiter Tübingen, Ulrike Leiter TübingenSearch for more papers by this authorMichael Weichenthal Kiel, Corresponding Author Michael Weichenthal Kiel Korrespondenzanschrift Prof. Dr. med. Michael Weichenthal Universitäts-Hautklinik Kiel Schittenhelmstraße 7 24105 Kiel E-mail: mweichenthal@dermatology.uni-kiel.deSearch for more papers by this author First published: 05 December 2014 https://doi.org/10.1111/ddg.12556Citations: 2Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat No abstract is available for this article.Citing Literature Volume12, Issue12December 2014Pages 1156-1157 RelatedInformation

JDDG: Journal der Deutschen Dermatologischen GesellschaftVolume 11, Issue 11 p. 1057-1064 Original Article Erregerspektrum des chronischen Ulcus cruris: Ergebnisse einer multizentrischen Untersuchung dermatologischer Wundzentren im regionalen Vergleich Finja Jockenhöfer, Finja Jockenhöfer Klinik und Poliklinik für Dermatologie, Venerologie und Allergologie, Universitätsklinikum EssenSearch for more papers by this authorHarald Gollnick, Harald Gollnick Klinik und Poliklinik für Dermatologie und Venerologie, Universitätsklinikum MagdeburgSearch for more papers by this authorKatharina Herberger, Katharina Herberger Institut für Versorgungsforschung in der Dermatologie und bei Pflegeberufen, Universitätsklinikum Hamburg-EppendorfSearch for more papers by this authorGeorg Isbary, Georg Isbary Klinik für Dermatologie, Allergologie und Umweltmedizin, Klinikum Schwabing MünchenSearch for more papers by this authorRegina Renner, Regina Renner Hautklinik, Universitätsklinikum ErlangenSearch for more papers by this authorMarkus Stücker, Markus Stücker Venenzentrum, St. Maria-Hilf-Krankenhaus, Universitätsklinikum BochumSearch for more papers by this authorEva Valesky, Eva Valesky Klinik für Dermatologie, Venerologie und Allergologie, Universitätsklinikum Frankfurt a.M.Search for more papers by this authorUwe Wollina, Uwe Wollina Klinik für Dermatologie und Allergologie, Krankenhaus Dresden-Friedrichstadt, Städtisches Klinikum, DresdenSearch for more papers by this authorMichael Weichenthal, Michael Weichenthal Klinik und Poliklinik für Dermatologie und Venerologie, Universitätsklinikum KielSearch for more papers by this authorSigrid Karrer, Sigrid Karrer Klinik und Poliklinik für Dermatologie und Venerologie, Universitätsklinikum RegensburgSearch for more papers by this authorJoachim Klode, Joachim Klode Klinik und Poliklinik für Dermatologie, Venerologie und Allergologie, Universitätsklinikum EssenSearch for more papers by this authorJoachim Dissemond, Joachim Dissemond Klinik und Poliklinik für Dermatologie, Venerologie und Allergologie, Universitätsklinikum EssenSearch for more papers by this author Finja Jockenhöfer, Finja Jockenhöfer Klinik und Poliklinik für Dermatologie, Venerologie und Allergologie, Universitätsklinikum EssenSearch for more papers by this authorHarald Gollnick, Harald Gollnick Klinik und Poliklinik für Dermatologie und Venerologie, Universitätsklinikum MagdeburgSearch for more papers by this authorKatharina Herberger, Katharina Herberger Institut für Versorgungsforschung in der Dermatologie und bei Pflegeberufen, Universitätsklinikum Hamburg-EppendorfSearch for more papers by this authorGeorg Isbary, Georg Isbary Klinik für Dermatologie, Allergologie und Umweltmedizin, Klinikum Schwabing MünchenSearch for more papers by this authorRegina Renner, Regina Renner Hautklinik, Universitätsklinikum ErlangenSearch for more papers by this authorMarkus Stücker, Markus Stücker Venenzentrum, St. Maria-Hilf-Krankenhaus, Universitätsklinikum BochumSearch for more papers by this authorEva Valesky, Eva Valesky Klinik für Dermatologie, Venerologie und Allergologie, Universitätsklinikum Frankfurt a.M.Search for more papers by this authorUwe Wollina, Uwe Wollina Klinik für Dermatologie und Allergologie, Krankenhaus Dresden-Friedrichstadt, Städtisches Klinikum, DresdenSearch for more papers by this authorMichael Weichenthal, Michael Weichenthal Klinik und Poliklinik für Dermatologie und Venerologie, Universitätsklinikum KielSearch for more papers by this authorSigrid Karrer, Sigrid Karrer Klinik und Poliklinik für Dermatologie und Venerologie, Universitätsklinikum RegensburgSearch for more papers by this authorJoachim Klode, Joachim Klode Klinik und Poliklinik für Dermatologie, Venerologie und Allergologie, Universitätsklinikum EssenSearch for more papers by this authorJoachim Dissemond, Joachim Dissemond Klinik und Poliklinik für Dermatologie, Venerologie und Allergologie, Universitätsklinikum EssenSearch for more papers by this author First published: 14 October 2013 https://doi.org/10.1111/ddg.12170_supplCitations: 10AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat Citing Literature Volume11, Issue11November 2013Pages 1057-1064 RelatedInformation

– Angelika Stary (Austria) Sexually Transmitted Infection and Global Migration – Christopher Griffi ths (UK) Psoriasis: More Than One Disease? – Jenny Kim (USA) Acne and Acneiform Diseases (Inducer of Follicular Infl ammation) – John Voorhees (USA) Aging Skin – Jürgen Schauber (Germany) Antimicrobial Peptides: More Than Epidermal Antibiotics – Katsuto Tamai (Japan) Regeneration and Repair – Markus Frank (USA) Stem Cells in Skin Cancer – Miroslav Blumenberg (USA) Skinomics: Molecular Profi ling as a Diagnostic Tool – Seung Hun Lee (Korea) Disorders of the Epidermal Barrier – Stephan Wagner (Austria) Melanoma: Do We Need a New Classifi cation?

The pathogenesis of Crohn′s disease (CD), an idiopathic inflammatory bowel disease, is attributed, in part, to intestinal bacteria that may initiate and perpetuate mucosal inflammation in genetically susceptible individuals. Paneth cells (PC) are the major source of antimicrobial peptides in the small intestine, including human α-defensins HD5 and HD6. We tested the hypothesis that reduced expression of PC α-defensins compromises mucosal host defenses and predisposes patients to CD of the ileum. We report that patients with CD of the ileum have reduced antibacterial activity in their intestinal mucosal extracts. These specimens also showed decreased expression of PC α-defensins, whereas the expression of eight other PC products either remained unchanged or increased when compared with controls. The specific decrease of α-defensins was independent of the degree of inflammation in the specimens and was not observed in either CD of the colon, ulcerative colitis, or pouchitis. The functional consequence of α-defensin expression levels was examined by using a transgenic mouse model, where we found changes in HD5 expression levels, comparable to those observed in CD, had a pronounced impact on the luminal microbiota. Thus, the specific deficiency of PC defensins that characterizes ileal CD may compromise innate immune defenses of the ileal mucosa and initiate and/or perpetuate this disease.

The major genetic risk region for psoriasis, PSORS1, is assumed to extend from CDSN telomeric of HLA-C to MICB centromeric of HLA-B on 6p21.3. Within that region, HLA-C, corneodesmosin (CDSN) and HCR are the loci reported to confer the highest risk of disease. To further investigate this susceptibility region, 530 patients with familial chronic plaque psoriasis (age of onset <40) and 696 healthy controls were genotyped for single nucleotide polymorphisms (SNP) located in this area. 80 SNPs were selected, encompassing 1,923 kb on 6p21.3 from CDSN to BTNL2. SNP genotyping was done by TaqMan® technology. For casecontrol analysis, odds ratios and p-values were calculated for single markers and marker haplotypes. Several regions in the investigated area yielded highly signifi cant association with psoriasis (CDSN, HCR, POU5F1, HCG2-II, KIA0055hom, MICA, P5-1, MICB; all p<0.00001), for single marker as well as for twoand three marker haplotypes. However, familybased transmission disequilibrium tests yielded the highest transmitted: non-transmitted ratios for the area ranging from HCG2-II to MICB. Together with our previous results, these data indicate either that the PSORS1 gene is more centromerically located than previously assumed, or that multiple genes in the PSORS1 region contribute to psoriasis susceptibility. 136

Bernhardt, J; Boldeman, C; Breitbart, E W; Breitbart, M; Christophers, E; Elvers, H; Gefeller, O; Henseler, T; Hutzler, D; Johnson, S; Karsa, L; Kölmel, K; Latif, M; Matthes, R; McKinlay, A F; Murphy, G; Newton, J A; Petres, J; Plentz, K; Repacholi, M; Sebastian, G; Shafir, R; Stein, A; Tilgen, W; Ullen, H; Weichenthal, M Author Information

Flow cytometric analysis of T-cell surface markers in peripheral blood has revealed abnormal patterns in patients with cutaneous T-cell lymphomas (CTCL). Here we investigated CD7, CD25, CD45RO and CD45RA expression on CD4+ T-lymphocytes in patients with CTCL stage I/II and III/IV and in patients with severe inflammatory skin diseases (ISD), as well as in healthy controls. Only late stage CTCL (III/IV) showed a lymphocytosis with a distinct surface marker pattern: CD3+, CD4+, CD8-, CD7-, CD45RO+, CD45RA-. Early stage CTCL (I/II) showed normal lymphocyte counts, a normal T-helper cell expression of CD7, CD45RO and CD45RA, and a slightly increased percentage of CD4+ CD25+ lymphocytes, which was also found in ISD. It is concluded that flow cytometric analysis of the above T-cell surface markers may be useful in the diagnosis of patients with late stage CTCL. However it does not allow us to distinguish patients with early stage CTCL from patients with ISD or controls.