Objective To investigate the changes of inflammatory factors in the serum of patients with acute bronchial asthma.Methods Totally 92 patients with bronchial asthma were divided into two groups according to the degree of severity of acute bronchial asthma,including healthy people as the controls.Lung function and serum interleukin (IL)-6,IL-17,tumor necrosis factor α(TNF-α)and interferon gamma (IFN-γ),transforming growth factorβ2 (TGF-β2)level were detected.Results Compared with the control group,the IL-6,IL-17 and TNF-αin the asthma group were significantly increased,while IFN-γ was significantly lower (P < 0.01 ),and there was no significant difference between the 3 groups of TGF-β2 (P > 0.05 ).There were positive correlations between the severity of asthma and IL-6,TNF-a and IL-17 (r = 0.970,0.868,0.723,P < 0.05 ).Severity of asthma was negatively correlated with FEV1/FVC and IFN-gamma (-0.957,-0.934,P <0.05),and not correlated with TGF-B2 (r =0.321,P >0.05).Conclusion The increase of serum inflammatory factors in patients with bronchial asthma is closely related to the incidence of asthma,and it is of certain reference value for the assessment of the severity of asthma.

Objective To investigate the diagnostic value of autofluorescence bronchoscopy in lung diseases.Methods A total of 168 patients were detected by using both white light bronchoscopy(WLB) mode and autofluorescence bronchoscopy(WFB) mode of Pentax SAFE-3000 bronchoscopy.Biopsies of the positive regions were taken for pathologic examination.Results Totally 128 of 168 patients had abnormal changes in WLB mode, 144 patients had abnormal changes in AFB mode.The pathologic diagnoses for 168 biopsy specimens were as follows: bronchogenic carcinoma in 97 cases, pulmonary inflammation in 40 cases, tuberculosis in 19 cases and pulmonary sarcoidosis in 12 cases.The respective sensitivities of WLB and AFB were 81.44% and 95.88% (x2=12.071,P=0.000) in bronchogenic carcinoma, and the respective specificities did not show significant difference (x2=2.250,P=0.134).The differences of sensitivities and specificities of WLB and AFB in pulmonary inflammation, tuberculosis, and pulmonary sarcoidosis were not statistically significant (P>0.05).Conclusion The value of WLB and AFB in the diagnosis of lung inflammation, tuberculosis and sarcoidosis is equivalent.The sensitivity of AFB in diagnosing lung cancer was higher than WLB.

呼吸衰竭是呼吸临床危重症，各种疾病最终均并发呼吸衰竭，从而引起严重呼吸功能障碍，此时机体存在不同程度的组织低氧及二氧化碳潴留，易引起其他器官相继出现功能障碍；而组织低氧时，无法通过有氧呼吸获得足够的能量，因此组织细胞增强糖酵解，导致血乳酸（LAC）浓度增高，可能诱发高碳酸血症。在此过程中，血乳酸和动脉血气各项指标均有相应变化，且两者之间具有一定的相关性。

Blood lactate concentration reacted to body tissue perfusion is a sensitive marker for cells under hypoxia.It increased significantly when the body is in a poor perfusion and low oxygen.When hypoperfusion has been controled ef-fectively,and hypoxia quickly has been corrected,the level of lactic acid in vivo decreased rapidly.The lack of oxygen is a major aspect of respiratory failure pathophysiological changes,which causing the blood lactic acid increased,further-more blood lactic acidosis.The purpose of this review is to detect blood lactic acid and to analyse of the test results.In the end,we summarized clinical significance of blood lactic acid in the common disease of respiratory failure and pro-vided rational clinical therapy for such diseases.