目的 探讨淋巴管内皮细胞透明质酸受体1(LYVE-1)、淋巴管密度致(lLVD)、血管内皮生长因子C(VEGF -C)在宫颈鳞癌组织中的表达及其在宫颈鳞癌发生发展、侵袭及淋巴转移中的作用.方法 采用免疫组织化学技术检测LYVE-1、VEGF-C在15例正常宫颈鳞状上皮、15例CIN Ⅲ及76例宫颈鳞癌中的表达,通过LYVE-1的表达计数LVD,统计分析LVD、VEGF-C的表达水平与临床病理参数间的关系及其相关性.结果 ①从正常宫颈上皮、CIN Ⅲ到宫颈鳞癌,LVD逐渐增高(P＜0.05).LVD与宫颈鳞癌的临床分期、淋巴转移、病理分级和肿瘤大小有关,差异有统计学意义(P＜0.05).②从正常宫颈上皮、CIN Ⅲ到宫颈鳞癌,VEGF-C阳性率逐渐增高(P＜0.05).VEGF-C的表达与宫颈鳞癌的临床分期、淋巴结转移、病理分级和肿瘤大小有关,差异有统计学意义(P＜0.05).③Spearman相关分析发现,VEGF-C的表达与LVD之间呈正相关(r=0.719,P＜0.05).结论 淋巴管生成在宫颈鳞癌淋巴转移过程中发挥了重要作用.LYVE-1、LVD及VEGF-C与宫颈鳞癌的进展及淋巴转移相关,LYVE-1的表达水平及VEGF-C表达水平可作为判断病情进展和肿瘤转移的指标之一.
Objective:To investigate the relative factors of high risk Human Papillomavirus(HR-HPV) Infection ,in order to provide clue and basis for prevation and treat. Methods:Select 176 cases to hospital with the degree of good women, conducted a questionnaire survey to collect patients with cervical secretions, using the the HC2 method of detection of HR-HPV DNA and cervical cell samples for quantitative detection of HPV infection type and DNA;;SPSS statistical software to do multi-factor statistical analysis of single factor and binary logistic Results:In 176 investigated cases, 104 cases were infected with HR-HPV(positive rate was 59.1%). Stata and spss13.0 showed that the relate factors of infection were age, income, age of first sexual activity, frequency of sexual activity, quantity of sexual partner, times of pregnancy, IUD,passive smoking and drinking. In these factors, age of first sexual activity, passive smoking and drinking are protective fectors. Conclusion:The infections of HR-HPV were related with sexual activity.
Objective To detect and analyze the pathogenic characteristics and clinical features of gestational reproductive tract infections and to provide a reliable basis for clinical therapy.Methods 1492 pregnant woman and 1500 no-pregnant patients were selected,vaginal secretions were examined by routine smear,and the PH of vaginal secretions were measured and the pathogens were tested,the Infection types of the two groups were analyzed.Results In 1492 cases of pregnant patients with lower genital tract infections,bacterial vaginosis(BV) and vulvovaginal candida disease(VVC) mixed infection rate was the highest(55.43%).In the single pathogen infections,BV was the highest(17.56%),and followed was VVC(11.46%).Reproductive tract infections in all age groups during pregnancy showed that 26 to 30-year-old pregnant women were the highest infection rate crowd in all age groups.For 1500 cases of non-pregnancy patients with infection,BV infection rate was highest(29.80%),and followed was VVC(22.27%).There was significant difference between the two groups.BV and VVC mixed infection rate of pregnancy group was higher than that in non-pregnant group,the rest pathogen infections rates of pregnancy group were lower than those in non-pregnant group.Conclusion BV and VVC mixed infection is the most common type of infection in gestational reproductive tract infections.It could provide individualized programs for clinical treatment according to the characteristics of the disease and improve the therapeutic effect.
目的探讨不同时期异位妊娠发病相关因素的差异。方法对123例(前期组)和161例(后期组)的异位妊娠患者的相关因素进行回顾性对比分析。结果20岁以下、20-25岁、36岁以上3个年龄段不同时期异位妊娠的比较有显著性差异(P<0.05);后期组平均人流次数较前期组升高,而前期组平均分娩次数高于后期组(P<0.05);后期组在校学生构成比占4.35%,高于前期组(P<0.05);后期组生殖道感染史41.25%和前次异位妊娠史10.56%明显高于前期组(P<0.01)。结论在校学生患异位妊娠的机会在逐年增加,应加强其性知识和性病防治知识教育以降低异位妊娠发生率。
临床护理路径是依据每日标准护理计划,为患者所设定的住院护理模式,它由患者每一诊断的常规护理计划综合而成,能指导护士有预见性地工作,同时也使患者明确自己的护理目标,自觉参与到疾病护理之中,主动配合护士的工作,增加了依从性,并以最经济的方式取得最佳治疗效果[1].
为探讨白带涂片快速染色法(CTB法)在阴道炎诊断中的价值,选择2007年3—4月在我院门诊就诊的2550例患者的阴道分泌物进行涂片,运用CTB涂片染色法检测技术进行病原体检测。结果霉菌检出率最高(48.94%);滴虫(8.39%),线索细胞(19.57%),滴虫+霉菌(5.21%);阴道炎患者的阴道清洁度大都在Ⅲ~Ⅳ度。运用CTB技术进行阴道分泌物涂片检查,方法简便,检出率高,阴道清洁度较差。
细菌性阴道病(BV)是妇科门诊最常见的疾病之一,感染率高,且易复发[1,2].曾被命名为嗜血杆菌阴道病,加德纳尔菌阴道病,非特异性阴道炎,目前称细菌性阴道病.称细菌性是由于生殖道内正常菌群数量减少,而存在大量的厌氧菌群, 厌氧菌繁殖同时产生胺类物质,碱化阴道,使阴道分泌物增多而呈氨臭味.1984年的瑞典专题国际学术会议正式命名为"细菌性阴道病".其发病机理,致病因子尚不清楚.据有关资料报道其传播途径并非完全由性接触传播,未婚亦有报道.本文对细菌性阴道病与常见阴道炎的相关性探讨如下.
念珠菌性阴道炎是妇科门诊的常见疾病之一,其发病近年有上升趋势.为了了解念珠菌性阴道炎的发病概况,提高其治愈率,降低复发率.本文做了如下的调查研究.
为探讨水针疗法分娩镇痛的疗效及对母儿的影响,将100例产妇随机分为观察组和对照组,观察组产妇宫口开大3cm以上进入活跃期后选择第五腰椎棘突旁开2cm,向下2cm,四点皮内注入注射用水0.5ml,观察组不予处理,观察两组镇痛效果、产程时间、分娩方式、产时出血量及新生儿Apgar评分等情况.结果观察组镇痛效果总有效率达88%,高于对照组,差异有极显著性(P＜0.01).观察组第一产程及总产程时间均短于对照组(P＜0.05),产时出血量少于对照组(P＜0.05).两组分娩方式及对新生儿影响均无差异(P＞0.05).认为水针疗法用于分娩镇痛有一定疗效且方法简单易行,对母儿无影响,值得产科推广应用.
