AimThis systematic review and meta-analysis was to evaluate the relationship between body mass index (BMI) and the clinical outcomes in patients with metastatic colorectal cancer (mCRC) undergoing treatment with bevacizumab plus chemotherapy.MethodsThe search for relevant literature was conducted across PubMed, Embase, Cochrane Library, and Web of Science, with the final search date being October 4, 2023. We utilized the weighted mean differences (WMDs), risk ratios (RRs), or Hazard ratios (HRs) as the metric for effect sizes, which were accompanied by 95% confidence intervals (CIs).ResultsA total of 9 studies were included for analysis. The results indicated that non-obese patients with mCRC undergoing treatment with bevacizumab experienced a reduced overall survival (OS) at the six-month compared to their obese counterparts (RR: 0.97, 95% CI: 0.94 to 1.00, p = 0.047). Furthermore, no significant differences in one-year, two-year, and five-year OS, as well as PFS and median OS, were observed between obese and non-obese mCRC patients undergoing treatment with bevacizumab plus chemotherapy.ConclusionThese findings suggest that obesity may play a role in the short-term OS of patients with mCRC undergoing bevacizumab treatment. The clinical implications of these findings underscore the importance of considering patients’ BMI in the context of mCRC care. This study may also help guide personalized treatment strategies and further research into the interplay between obesity, treatment efficacy, and patient survival in mCRC. However, further investigation is warranted to substantiate the findings of this study.

[目的]了解护士组织公民压力对护士工作绩效的影响,并阐释组织认同的中介机制.[方法]采用组织公民压力、组织认同和工作绩效量表对845名护士进行调查.[结果]护士组织公民压力得分为(1.67±0.64)分,处于中等偏下水平;组织认同得分为(3.35±1.17)分,工作绩效得分为(3.72±0.99)分,都处于中等偏上水平.护士的组织公民压力与组织认同(r=-0.336,P＜0.01)、工作绩效(r=-0.168,P＜0.01)呈负相关,组织认同与工作绩效呈正相关(r=0.504,P＜0.01).护士组织公民压力对组织认同具有负向预测作用(β=-0.328,P＜0.01),组织认同对工作绩效具有正向预测作用(β=0.476,P＜0.01).组织认同在组织公民压力与工作绩效的关系之间起中介作用.[结论]护士组织公民压力会破坏其自身对组织的认同感,进而威胁到自身的工作绩效水平.

目的 了解肿瘤患者对新药临床试验的认知度和参与意愿.方法 设计《药物临床实验的认知度与参与意愿调查问卷》,并于2018年5月～6月期间在哈尔滨医科大学附属肿瘤医院内科住院部开展调查,共有616例肿瘤患者完整回答问卷,并当场收回.随后用Epidata软件建立数据库,SPSS软件进行统计分析.结果 患者对临床试验研究的认知程度(OR=2.428)越高、对临床研究的意义认识(OR=1.618)越深入,主动咨询过临床试验(OR=1.759)、希望了解临床研究的相关知识(OR =2.393)、认为临床研究的宣传很重要(OR =2.040)的患者更愿意参与临床试验.结论 肿瘤患者对新药临床研究的认知度和参与意愿较高,希望了解更多的新药临床研究相关信息.

目的 研究预知护理干预对腹腔镜胃癌根治术后生活质量的影响.方法 2012年8月-2016年2月选择在哈尔滨医科大学附属肿瘤医院进行诊治的早期胃癌患者132例,根据随机信封抽签原则分为观察组与对照组各66例,所有患者都给予腹腔镜胃癌根治术,对照组采用传统护理,而观察组采用传统护理同时也提供预知护理干预,观察与记录2组患者预后恢复情况.结果 所有患者的手术都成功完成,无术中严重并发症发生,术后观察组肠鸣音恢复时间、住院时间以及肛门排气时间[(19.03±5.23)h、(76.76±22.30)h、(12.29±1.84)d]短于对照组[(25.98±6.76)h、(89.55±21.84)h和(16.39±1.73)d,均P＜0.05].观察组术后1个月的吻合口瘘、切口感染、肺部感染、肠梗阻、发热并发症发生率为4.5％,对照组为21.2％,观察组术后并发症发生率明显低于对照组(P＜0.05).观察组术后1个月的认知功能、躯体功能、角色功能、情绪功能、社会功能等方面的生活质量评分高于对照组(P＜0.05).结论 预知护理干预在腹腔镜胃癌根治术中的应用能促进患者康复,减少术后并发症的发生,使患者最大限度的从手术中获益,提高其生活质量.

Objective To observe the effect of palliative care mode based on death education on negative emotions and quality of life in patients with advanced gastric cancer.Methods Ninety patients with advanced gastric cancer treated at Cancer Hospital Affiliated to Harbin Medical University from March 2014 to March 2015 were selected and were divided into a study group and a control group according to the random digital table method with 45 cases in each group.The study group were given palliative nursing mode based on death education while the control group were given routine nursing mode.Negative emotions and quality of life were observed in the two groups.Results The SAS scores and SDS scores decreased in both groups after nursing compared with those before nursing (P ＜ 0.05),with the study group lower than the control group (P ＜ 0.05).The scores of quality of life at each function level increased in both groups after nursing compared with before nursing (P ＜ 0.05),with the study group significantly higher than the control group (P ＜ 0.05).Conclusion The palliative care mode based on death education can effectively improve the negative emotions and increase the quality of life in patients with advanced gastric cancer.

Objective Two-incision video-assisted thoracic surger relieved post operative pain when compared with open thoractomy ,while it is rarely reported worldwide ,most thoracic surgeons think it is hard to finish the complicated operation and it is not safe .We compared the safety between open and two -incision VATS.Methods Bwteen Febrary 2009 to December 2011 ,a total of 334 cases with clinical early -staged lung cancer of open thoracotomy were performed ,66 cases were completely performed with 2-incision VATS,17 cases were transferred to open thoracotomy defined as two -incision VATS assisted thoracotomy .We compared and ana-lyzed open thoracotomy with two -incision VATS in operating time ,and pre,post and total period of hospitaliza-tion,postoperative chest tube removal time ,postoperative complications .Results Operating time in the left lower lobe of both traditional open thoracotomy and two -incision VATS was 162.5 ±6.5 and 185.8 ±12.8 minutes re-spectively(P=0.1228),there was no statistical significance for the remaining parts of the lobectomy ,the operat-ing time of open thoracotomy was shorter than two -incision VATS.The overall complication and perioperative mortality rate of open thoracotomy and two -incision VATS were 10.2% and 15.0%(P=0.238),and 2.0%and 0.0%(P=1.000)respectively,there was no statistical significance.Conclusion The lobectomy and lymph node dissections for 2-incision VATS in treating clinical stage I lung cancer is feasible and safe .

Sonodynamic therapy (SDT), a promising modality for cancer treatment, involves the synergistic interaction of ultrasound and some chemical compounds termed sonosensitizers. However, its effect on pancreatic cancer cells remains unclear. In our study, we sought to identify the cytotoxic effects of ultrasound-activated 5-aminolevulinic acid on human pancreatic cancer Capan-1 cells. Cell viability was determined by MTT (3-(4,5-dimethylthiazol-2-yl)-2,5- diphenyltetrazolium bromide) analysis; mitochondrial membrane potential was assessed using the fluorescent probe jc-1; apoptosis was evaluated by flow cytometry; cell morphology was investigated by scanning electron microscopy; apoptosis-related protein expression was analyzed by Western blot assay. We found that SDT significantly decreased the survival rate of cells, and this effect increased with 5-aminolevulinic acid concentration and ultrasound exposure time. The mechanism underlying the effect of SDT involves, in part, the induction of a conspicuous loss in mitochondrial membrane potential and, in part, the induction of apoptosis through upregulation of Bax expression, downregulation of Bcl-2 and increased activation of procaspase-3. These results indicate that the ultrasonically induced cell killing effect could be enhanced by 5-ALA and that the mitochondrial pathway might be involved in the cell damage process. We conclude that SDT is a promising new methodology for pancreatic cancer treatment.

Background: Photodynamic therapy (PDT) is a new treatment for esophageal cancer which has been shown to be effective in the elimination of tumor. However, PDT could induce the activation of nuclear factor-kappa B (NF-κB) in many photosensitizers based PDT, which plays a negative role in PDT. In addition, our previous results have shown that dihydroartemisinin (DHA), which was the most potent one of artemisinin derivatives, has anticancer activity in esophageal cancer cells. Methods: Cell viability was determined by MTT analysis, and apoptosis was evaluated by flow cytometry. Nuclear extract was obtained for determining NF-κB DNA-binding activity, while total protein extract obtained for downstream gene expression by western blot. Results: We demonstrated DHA enhanced PDT-induced growth inhibition and apoptosis in both human esophageal cancer cell lines Eca109 and Ec9706 in vitro. The mechanism was at least partially due to DHA deactivated PDT-induced NF-κB activation, so as to decrease tremendously the expression of its target gene Bcl-2. Conclusion: Our results demonstrate that DHA augments PDT-induced growth inhibition and apoptosis in esophageal cancer cells, and that inactivation of NF-κB activity is a potential mechanism by which DHA sensitizes esophageal cancer cells to PDT-induced growth inhibition and apoptosis.

Dihydroartemisinin (DHA) has recently been shown anti-tumor activity in various cancer cells. However, its effect on esophageal cancer remains unclear. In this study, for the first time, we demonstrated that DHA reduced viability of esophageal cancer cells in a dose-dependent manner. The mechanism was at least partially due to DHA induced apoptosis by upregulating the expression of Bax, downregulating Bcl-2, Bcl-xL and Procaspase-3, and increasing caspase-9 activation, induced cell cycle arrest by downregulating cyclin E, CDK2 and CDK4. Furthermore, we firstly found that DHA induced autophagy in cancer cells. We concluded DHA might be a novel agent against esophageal cancer.