Large language models (LLMs) have revolutionized natural language processing, enabling unprecedented capabilities in reasoning, planning, and tool utilization. Enterprises are increasingly adopting LLM-powered agents to automate complex workflows, from meeting summarization (e.g., Microsoft Copilot) to supply chain optimization and customer service orchestration. However, deploying agentic AI systems in enterprise settings introduces unique challenges, including decision making under uncertainty, multi-agent collaboration, security vulnerabilities, and trust gaps in mission-critical applications. This workshop aims to bridge the gap between academia and industry to explore LLM-driven agentic systems tailored for enterprise needs. We focus on three pillars: 1) emerging architectures that enable dynamic task decomposition and tool invocation; 2) domain-specific applications such as case studies in supply chain and employee productivity domain; 3) evaluation and governance such as the AAEF (Agentic Application Evaluation Framework) and security strategies.

This workshop introduces generative AI applications for enterprise, with a focus on retrieval-augmented generation (RAG) systems. Generative AI is a field of artificial intelligence that can create new content and solve complex problems. RAG systems are a novel generative AI technique that combines information retrieval with text generation to generate rich and diverse responses. RAG systems can leverage enterprise data, which is often specific, structured, and dynamic, to provide customized solutions for various domains. However, enterprise data also poses challenges such as scalability, security, and data quality. This workshop convenes researchers and practitioners to explore RAG and other generative AI systems in real-world enterprise scenarios, fostering knowledge exchange, collaboration, and identification of future directions. Relevant to the CIKM community, the workshop intersects with core areas of data science and machine learning, offering potential benefits across various domains.

Although deep neural networks have been widely employed and proven effective in sentiment analysis tasks, it remains challenging for model developers to assess their models for erroneous predictions that might exist prior to deployment. Once deployed, emergent errors can be hard to identify in prediction run-time and impossible to trace back to their sources. To address such gaps, in this paper we propose an error detection framework for sentiment analysis based on explainable features. We perform global-level feature validation with human-in-the-loop assessment, followed by an integration of global and local-level feature contribution analysis. Experimental results show that, given limited human-in-the-loop intervention, our method is able to identify erroneous model predictions on unseen data with high precision.

Current research in machine learning for radiology is focused mostly on images There exists limited work in investigating intelligent interactive systems for radiology. To address this limitation, we introduce a realistic and information-rich task of Visual Dialog in radiology, specific to chest X-ray images Using MIMIC-CXR, an openly available database of chest X-ray images, we construct both a synthetic and a real-world dataset and provide baseline scores achieved by state-of-the-art models. We show that incorporating medical history of the patient leads to better performance in answering questions as opposed to conventional visual question answering model which looks only at the image. While our experiments show promising results, they indicate that the task is extremely challenging with significant scope for improvement. We make both the datasets (synthetic and gold standard) and the associated code publicly available to the research community.

Literature-based Discovery (LBD) aims to discover new knowledge automatically from large collections of literature. Scientific literature is growing at an exponential rate, making it difficult for researchers to stay current in their discipline and easy to miss knowledge necessary to advance their research. LBD can facilitate hypothesis testing and generation and thus accelerate scientific progress. Neural networks have demonstrated improved performance on LBD-related tasks but are yet to be applied to it. We propose four graph-based, neural network methods to perform open and closed LBD. We compared our methods with those used by the state-of-the-art LION LBD system on the same evaluations to replicate recently published findings in cancer biology. We also applied them to a time-sliced dataset of human-curated peer-reviewed biological interactions. These evaluations and the metrics they employ represent performance on real-world knowledge advances and are thus robust indicators of approach efficacy. In the first experiments, our best methods performed 2-4 times better than the baselines in closed discovery and 2-3 times better in open discovery. In the second, our best methods performed almost 2 times better than the baselines in open discovery. These results are strong indications that neural LBD is potentially a very effective approach for generating new scientific discoveries from existing literature. The code for our models and other information can be found at: https://github.com/cambridgeltl/nn_for_LBD.

Biases in data, such as gender and racial stereotypes, are propagated through intelligent systems and amplified at end-user applications. Existing studies detect and quantify biases based on pre-defined attributes. However, in real practices, it is difficult to gather a comprehensive list of sensitive concepts for various categories of biases. We propose a general methodology to quantify dataset biases by measuring the difference of its data distribution with a reference dataset using Maximum Mean Discrepancy. For the case of natural language data, we show that lexicon-based features quantify explicit stereotypes, while deep learning-based features further capture implicit stereotypes represented by complex semantics. Our method provides a more flexible way to detect potential biases.

Recent work in clinical AI has been focusing on solving tasks that involve both image understanding and reading comprehension. In this study, we further pursue this line of research and introduce the first Visual Dialog task in Radiology, which adds complexity to existing tasks. We present our data collection strategy for both silver and gold-standard datasets for chest x-ray images and discuss associated challenges. We evaluate a Stacked Attention Network model, commonly used for Visual Question answering in medical domain, and provide baseline results indicating the difficulty of the task.

Writing is a fundamental task in our daily life. Existing writing improvement tools mostly focus on low-level grammar error correction, rather than enhancing users' writing styles at the cognitive level. In this work, we present a computational approach that allows learners to have fast but effective learning experience with the help of automatic style transfer, visual stylometry analytics, machine teaching and practice. Our system provides a perfect fusion of vividly visualized style features and principles along with informative examples, which together can shape and drive personalized cognitive learning experience. We demonstrate the effectiveness of our system in a scenario of learning from William Shakespeare.

MOTIVATION:The overwhelming size and rapid growth of the biomedical literature make it impossible for scientists to read all studies related to their work, potentially leading to missed connections and wasted time and resources. Literature-based discovery (LBD) aims to alleviate these issues by identifying implicit links between disjoint parts of the literature. While LBD has been studied in depth since its introduction three decades ago, there has been limited work making use of recent advances in biomedical text processing methods in LBD. RESULTS:We present LION LBD, a literature-based discovery system that enables researchers to navigate published information and supports hypothesis generation and testing. The system is built with a particular focus on the molecular biology of cancer using state-of-the-art machine learning and natural language processing methods, including named entity recognition and grounding to domain ontologies covering a wide range of entity types and a novel approach to detecting references to the hallmarks of cancer in text. LION LBD implements a broad selection of co-occurrence based metrics for analyzing the strength of entity associations, and its design allows real-time search to discover indirect associations between entities in a database of tens of millions of publications while preserving the ability of users to explore each mention in its original context in the literature. Evaluations of the system demonstrate its ability to identify undiscovered links and rank relevant concepts highly among potential connections. AVAILABILITY AND IMPLEMENTATION:The LION LBD system is available via a web-based user interface and a programmable API, and all components of the system are made available under open licenses from the project home page http://lbd.lionproject.net. SUPPLEMENTARY INFORMATION:Supplementary data are available at Bioinformatics online.

Successful human interactions are based on becoming aware of other's emotion and making adaptations accordingly. However, understanding emotion is a complex task that has generated countless debates among researchers over the past decades. The abstractive nature of human emotion highlights the need for a new data-driven approach that can better describe and compare across fine-grained emotional states. In this study, we propose Seemo, a novel neural embedding framework, which allows us to map human emotions into vector space representations. Seemo is trained using Twitter data and is evaluated on two fundamental use cases in traditional emotion research: determining the underlying dimensions of emotions and identifying the set of basic emotions. The evaluation reveals that on both tasks Seemo can generate results consistent with the mainstream theories. Results also show that the vector space representation of Seemo can effectively decode the important relationships between emotions that were usually not explicitly presented.

Medical image analysis practitioners have embraced big data methodologies. This has created a need for large annotated datasets. The source of big data is typically large image collections and clinical reports recorded for these images. In many cases, however, building algorithms aimed at segmentation and detection of disease requires a training dataset with markings of the areas of interest on the image that match with the described anomalies. This process of annotation is expensive and needs the involvement of clinicians. In this work we propose two separate deep neural network architectures for automatic marking of a region of interest (ROI) on the image best representing a finding location, given a textual report or a set of keywords. One architecture consists of LSTM and CNN components and is trained end to end with images, matching text, and markings of ROIs for those images. The output layer estimates the coordinates of the vertices of a polygonal region. The second architecture uses a network pre-trained on a large dataset of the same image types for learning feature representations of the findings of interest. We show that for a variety of findings from chest X-ray images, both proposed architectures learn to estimate the ROI, as validated by clinical annotations. There is a clear advantage obtained from the architecture with pre-trained imaging network. The centroids of the ROIs marked by this network were on average at a distance equivalent to 5.1% of the image width from the centroids of the ground truth ROIs.

Chatbot has become an important solution to rapidly increasing customer care demands on social media in recent years. However, current work on chatbot for customer care ignores a key to impact user experience - tones. In this work, we create a novel tone-aware chatbot that generates toned responses to user requests on social media. We first conduct a formative research, in which the effects of tones are studied. Significant and various influences of different tones on user experience are uncovered in the study. With the knowledge of effects of tones, we design a deep learning based chatbot that takes tone information into account. We train our system on over 1.5 million real customer care conversations collected from Twitter. The evaluation reveals that our tone-aware chatbot generates as appropriate responses to user requests as human agents. More importantly, our chatbot is perceived to be even more empathetic than human agents.

Link prediction in biomedical graphs has several important applications including predicting Drug-Target Interactions (DTI), Protein-Protein Interaction (PPI) prediction and Literature-Based Discovery (LBD). It can be done using a classifier to output the probability of link formation between nodes. Recently several works have used neural networks to create node representations which allow rich inputs to neural classifiers. Preliminary works were done on this and report promising results. However they did not use realistic settings like time-slicing, evaluate performances with comprehensive metrics or explain when or why neural network methods outperform. We investigated how inputs from four node representation algorithms affect performance of a neural link predictor on random- and time-sliced biomedical graphs of real-world sizes (∼ 6 million edges) containing information relevant to DTI, PPI and LBD. We compared the performance of the neural link predictor to those of established baselines and report performance across five metrics.

Much of the critical information in a patient's electronic health record (EHR) is hidden in unstructured text. As such, there is an increasing role for automated text extraction and summarization to make this information available in a way that can be quickly and easily understood. While many clinical note text extraction techniques have been examined, most existing techniques are either narrowly targeted or focus primarily on concept-level extraction, potentially missing important contextual information. In contrast, in this work we examine the extraction of several clinical categories at the phrase level, attempting to provide the necessary context while still keeping the extracted elements concise. To do so, we employ a three-stage pipeline which extracts categorized phrases of interest using clinical concepts as anchor points. Results suggest the proposed method achieves performance comparable to that of individual human annotators.

EMR systems are intended to improve patient-centered care management and hospital administrative processing. However, the information stored in EMRs can be disorganized, incomplete, or inconsistent, creating problems at the patient and system level. We present a technology that reconciles inconsistencies between clinical diagnoses and administrative records by analyzing free-text notes, problem lists and recorded diagnoses in real time. A fully integrated pipeline has been developed for efficient, knowledge-driven extraction, normalization, and matching of disease terms among structured and unstructured data, with modular precision of 94-98% on over 1000 patients. This cognitive data review tool improves the path from diagnosis to documentation, facilitating accurate and timely clinical and administrative decision-making.

Users are rapidly turning to social media to request and receive customer service; however, a majority of these requests were not addressed timely or even not addressed at all. To overcome the problem, we create a new conversational system to automatically generate responses for users requests on social media. Our system is integrated with state-of-the-art deep learning techniques and is trained by nearly 1M Twitter conversations between users and agents from over 60 brands. The evaluation reveals that over 40% of the requests are emotional, and the system is about as good as human agents in showing empathy to help users cope with emotional situations. Results also show our system outperforms information retrieval system based on both human judgments and an automatic evaluation metric.

MOTIVATION:To understand the molecular mechanisms involved in cancer development, significant efforts are being invested in cancer research. This has resulted in millions of scientific articles. An efficient and thorough review of the existing literature is crucially important to drive new research. This time-demanding task can be supported by emerging computational approaches based on text mining which offer a great opportunity to organize and retrieve the desired information efficiently from sizable databases. One way to organize existing knowledge on cancer is to utilize the widely accepted framework of the Hallmarks of Cancer. These hallmarks refer to the alterations in cell behaviour that characterize the cancer cell. RESULTS:We created an extensive Hallmarks of Cancer taxonomy and developed automatic text mining methodology and a tool (CHAT) capable of retrieving and organizing millions of cancer-related references from PubMed into the taxonomy. The efficiency and accuracy of the tool was evaluated intrinsically as well as extrinsically by case studies. The correlations identified by the tool show that it offers a great potential to organize and correctly classify cancer-related literature. Furthermore, the tool can be useful, for example, in identifying hallmarks associated with extrinsic factors, biomarkers and therapeutics targets. AVAILABILITY AND IMPLEMENTATION:CHAT can be accessed at: http://chat.lionproject.net. The corpus of hallmark-annotated PubMed abstracts and the software are available at: http://chat.lionproject.net/about. CONTACT:simon.baker@cl.cam.ac.uk. SUPPLEMENTARY INFORMATION:Supplementary data are available at Bioinformatics online.

BACKGROUND:In silico drug-target interaction (DTI) prediction plays an integral role in drug repositioning: the discovery of new uses for existing drugs. One popular method of drug repositioning is network-based DTI prediction, which uses complex network theory to predict DTIs from a drug-target network. Currently, most network-based DTI prediction is based on machine learning - methods such as Restricted Boltzmann Machines (RBM) or Support Vector Machines (SVM). These methods require additional information about the characteristics of drugs, targets and DTIs, such as chemical structure, genome sequence, binding types, causes of interactions, etc., and do not perform satisfactorily when such information is unavailable. We propose a new, alternative method for DTI prediction that makes use of only network topology information attempting to solve this problem. RESULTS:We compare our method for DTI prediction against the well-known RBM approach. We show that when applied to the MATADOR database, our approach based on node neighborhoods yield higher precision for high-ranking predictions than RBM when no information regarding DTI types is available. CONCLUSION:This demonstrates that approaches purely based on network topology provide a more suitable approach to DTI prediction in the many real-life situations where little or no prior knowledge is available about the characteristics of drugs, targets, or their interactions.

As medical imaging datasets grow, we are approaching the era of big data for radiologic decision support systems. This requires renewed efforts in dataset curation and labeling. We propose a methodology for weak labeling of medical images for attributes such as anatomy and disease that relies on image to sentence transformation. The methodology consists of three models, a convolutional neural network that is trained on a coarse classification task and acts as an image feature generator, a language model to map sentences to a fixed length space, and a multi-layer perceptron that acts as a function approximator to map images to the sentence space. The transform model is trained on matched image-sentence pairs on a dataset of echocardiography studies. For a given image, labels are extracted from the closest sentences to the output of the image-sentence transform. We show that the resulting solution has an 78.2% accuracy in labeling Doppler images with aortic stenosis. We also show that the retrieved sentences are consistent with the true sentences in terms of meaning with an average BLEU score of 0.34, matching the current highly performing machine translation solutions.