Objective: To explore the relationship between FLAIR vascular hyperintensities (FVH) and the early neurofunctional status of patients with acute middle cerebral artery infarction after intravenous thrombolysis.Methods: One hundred and seventeen patients divided into FVH-positive (n = 86) and FVH-negative groups (n = 31). We compared the demo-graphics, cerebrovascular disease risk factors, neurological examinations and imaging examinations between the two groups, and analyzed the relationship between the changes of the National Institutes of Health Stroke Scale (NIHSS) scores and the inci-dence of FVH.Results: In the FVH-positive group, the decline of the average NIHSS scores obtained 24 hours after intravenous thrombolytic therapy were significantly less than that of the FVH-negative group. Also, the average 24-hour follow-up NIHSS scores were significantly higher in the FVH-positive group than that of the negative group. There were no significant differences between the FVH-positive group and the FVH-negative group in age, gender, risk factors for cerebrovascular disease, length of hospitaliza-tion, the baseline NIHSS scores and the NIHSS scores at discharge.Conclusions: FVH can be applied to predict the short-term clinical efficacy of intravenous thrombolytic therapy in patients with acute middle cerebral infarction, which would help to assist in the selection of patients who might benefit more from thrombolytic therapy.

目的 探讨弥散加权成像(DWI)、灌注加权成像(PWI)及磁共振波谱成像(MRS)定量指标在颅内结核诊断中的价值.方法 收集本院2017年7月—2018年7月临床确诊为颅内结核的36例患者(其中脑膜结核11例,脑实质结核8例,混合型颅内结核17例)和8例低级别胶质瘤患者为研究对象,在治疗前或术前进行头颅MRI常规及功能影像学检查,分析其影像学表现,测量并计算脑实质结核和低级别胶质瘤病灶的DWI相对表观弥散系数(rADC)、PWI相对脑血流量(rCBF)、相对脑血容量(rCBV)及MRS的Cho/Cr、Cho/NAA,并分析其差异性.结果 (1)颅内结核MRI表现具有一定特征性,MRI能清晰显示病变及其周围情况;(2)DWI:脑实质结核rADC值(1.305±0.114)小于低级别胶质瘤(1.447±0.051);(3)PWI:脑实质结核rCBF(0.580±0.038)及rCBV(0.497±0.019)分别小于低级别胶质瘤(1.745±0.040)及(1.856±0.073);(4)MRS:脑实质结核Cho/Cr(1.793±0.038)及Cho/NAA(1.417±0.080)分别小于低级别胶质瘤(2.339±0.076)及(2.193±0.048);以上结果比较差异均具有统计学意义,P<0.05.结论 功能磁共振成像诊断颅内结核具有一定临床价值 :DWI 的 rADC、PWI 的 rCBF 和 rCBV 及 MRS 的 Cho/Cr 和 Cho/NAA 能够为鉴别脑实质结核和低级别胶质瘤提供依据.

目的 分析心脏核磁共振成像在病毒性心肌炎中的诊断价值.方法 选取2017年1月至2019年1月74例医院收治经临床诊断确诊为病毒性心肌炎患者,所有患者均行心脏核磁共振成像检查,将心脏核磁共振成像诊断结果与心内膜心肌活检诊断结果进行对照分析.结果 心脏核磁共振成像检查发现68例病毒性心肌炎患者,诊断准确率为91.9％;6例误诊患者中4例误诊为心脏瓣膜病,2例误诊为甲亢性心脏病.74例患者中有42例患者伴随心肌损伤,44例患者伴随左心室功能障碍,40例T2加权信号增强.结论 心脏核磁共振成像在病毒性心肌炎的临床诊断中具有较高的诊断准确率,有助于患者早期得到有效的治疗.

Objective:To study the CT and MRI findings of Kimura's disease in head and neck.Methods:The CT and MRI findings of 6 cases of Kimura's disease in head and neck confirmed by surgery or biopsy were retrospectively analyzed.Results:In the group of 6 cases,they were more common in young and middle-aged male patients.These lesions were located around ear in 2 cases,in cheek in 1 case,in submandibular area in 1 case,in parotid gland area in 1 case,and under scalp in 1 case;and all of them showed painless mass.The CT findings of 3 cases showed unilateral or bilateral,single or multiple soft tissue mass with moderate or slightly high density (homogeneous or heterogeneous) and clear margin (or local unclear margin),getting adjacent subcutaneous tissue involved;lesions showed varying degrees of enhancement after contrast media administration.The MRI findings of 3 cases showed the lesions were manifested as moderate or slightly high signal on T1WI,and high signal on T2WI in contrast to signal of adjacent muscle;moderate to avid enhancement was found in most lesions.All lesions in this study group were accompanied by multiple peripheral lymph nodes enlargement and laboratory examination of positive findings of peripheral blood eosinophils increasing;the local subcutaneous fat layer atrophy might be found in the affected side.Conclusions:The CT and MRIfindings of Kimura's disease in head and neck have certain characteristics.Combined with clinical history and laboratory examination,the diagnostic accuracy of Kimura's disease can be improved.

Objective To investigate the clinical value of MRI in the diagnosis of kimura's disease in head and neck. Methods In our hospital from April of 2010 to April of 2016, 43 patients with head and neck Kimura disease were selected as the object of study. All patients underwent MRI examination and lesions, patients clinical manifestations and MRI findings and pathology were recorded. Results In 43 patients, 59 lesions were found, of which 37 cases were located in the ipsilatesal side, and the lesions were in the bilateral side in 6 cases. The main lesions were in the parotid gland and subcutaneous tumors (11 cases), parotid gland (9 cases), right parotid gland and right ear (7 cases), left and right parotid gland (7 cases), bilateral parotid and submandibular gland (6 cases), right parotid gland and temporal subsutaneous region mass (3 cases). MRI examination showed that 59 lesions (94.92%) had 56 lesions infiltrated into the subcutaneous tissue, resulting in a diffuse mass, with a clear border and irregular shape of the lesion. Conclusion The clinical diagnosis of Kimura disease needs to be combined with relevant laboratory examination and clinical manifestations . MRI is more accurate in the diagnosis of head and neck Kimura disease, so, it is worthy of wide clinical application.

目的：探讨非离子型造影剂与离子型造影剂在肝脏肿瘤CT扫描中的应用。方法选取行CT扫描的肝脏肿瘤患者90例，根据使用造影剂的不同分为两组。对照组予离子型造影剂，实验组予以非离子型造影剂，扫描后比较两组患者的扫描效果、不良反应情况以及造影后肾功能。结果与对照组相比较，实验组的扫描效果更显著（P＜0.05），不良反应降低（P＜0.05），造影后2、7 d的肾功能影响较低（P＜0.05）。结论非离子型造影剂较离子型造影剂在肝脏肿瘤的扫描效果更显著，不良反应发生率低，且对患者的肾功能损伤小，值得临床推广。

Objectives 1) To deduce T2, the inverse of the transverse relaxation rate (R2), in the hippocampus of healthy adults; 2) to investigate the brain iron deposition in Alzheimer’s disease (AD) patients and age-matched healthy controls using T2-values. Methods T2-weighted data from the bilateral-hippocampi of ten AD patients and sixty healthy controls were collected at six echo time points using multi-slice multi-echo turbo spin echo (MSME-TSE) imaging on a 3.0 T MR-scanner, followed by the neuropsychological testing. The correlations between T2-values and Mini-Mental State Examination (MMSE) scores were investigated on group-wise basis (covariates in the group-wise analyses: gender, age, side and healthy/AD). Results There were no significant differences in hippocampal T2-values on intra-gender and inter-gender basis (P > 0.05). Hippocampal T2-values of both sides were similar (right: 85.2±2.4 milliseconds; left: 85.3±2.5 milliseconds). The bilateral hippocampal T2 values correlated moderately with age (right: r = -0.59; left: -0.58; P < 0.001). The AD-group had significantly lower T2-values in the hippocampus when compared to normal controls (P < 0.001) and such low T2-values had a strong positive correlation with the MMSE score (R 2 = 0.97; P < 0.05). Conclusion Patients with AD showed significantly lower T2 values, which can be attributed to the increased iron depositions in the hippocampus. A positive correlation between T2-values and cognition scores suggests that quantitative T2 can be used in the early diagnosis of AD and in the monitoring of the treatment response.

Objective: To investigate the three-dimensional segmentation method and the differences of regional pattern between AD and normal aging based on the MRI hippocampal shape analysis to provide effective evidence to assist the early diagnosis of AD.Methods: 20 AD patients and 60 health persons were included in this study.3D structure images were obtained on a 3.0 T high-resolution MR imaging system.Data were processed to create three-dimensional active appearance model of hippocampus.Three-dimensional segmentation and automatic identification were carried out in the hippocampus for each individual brain MR images with this model,and the hippocampal statistical shape model respectively for control group and AD group was established,which could compare the difference of hippocampal shape between AD group and control group.Results: There was no significant difference between conventional hand-drawing ROIs and 3D segmentation and auto-detected method in the measurement of hippocampal volume(P0.05).Hippocampal head atrophy was found in AD patients(P0.05).Conclusions: Hippocampal three-dimensional segmentation and automatic identification method based on active appearance model in brain MR image is accurate and reliable;the feature of hippocampal head atrophy can be used as a basis for diagnosis of AD.

Objective: To analyze and evaluate the value of using GE LightSpeed 64-detector volume CT scanning technology in the diagnosis of acute appendicitis.Methods: We have retrospectively analyzed the CT features of 30 cases with acute appendicitis confirmed by operation and pathology.Results: 7 cases of acute simple appendicitis,appendectomy appendix peripheral inflammation in 16 cases,bleeding or gangrenous appendicitis in 4 cases,3 cases with periappendicular abscess.The diagnosis accuracy was 100%(P0.05).Conclusion: Application of multislice spiral CT scan technology combined with the multiplanar reconstruction can reveal the landscape of appendix in most cases with satisfactory,to achieve a more accurate diagnosis of acute appendicitis.

To investigate the clinical significance of the application of 320-row CT angiography with low-dose prospective ECG-triggered target scanning in children with complex congenital heart disease (CHD), and to compare with the results from transthoracic echocardiography (TTE). 22 patients (male 12 cases, female 10 cases, average age: 18 months, range: 14 days–9 years, average weight: 13 kg) received an examination through 320-row CT angiography with low-dose prospective ECG-triggered volume target scan mode and transthoracic echocardiography. The center of phase window for data collection in this study was set to 40% of the R–R interval. Of these, 18 patients received surgery and 4 patients received conventional cardiac angiography (CCA). The diagnostic accuracy of 320-row CTA was calculated according to the examination results from surgical and/or cardiac angiography. The overall quality score for CTA images was divided into five levels. The results were compared with the research data of radiation doses obtained from patients with congenital heart disease who had received CT angiography. Complex congenital heart disease was confirmed by surgical or CCA in each of 22 patients, with 42 cases of large vascular malformations outside the heart cavity, and 26 of intracardiac malformations. The diagnostic accuracy of 320-row CT angiography and transthoracic echocardiography for large vascular malformation outside the heart cavity was 95.2 and 80.9%, respectively; for intracardiac malformation the accuracy was 88.5 and 100.0%, respectively. There was significant difference between 320-row CT and transthoracic echocardiography in the diagnosis of large vascular malformation outside the heart cavity ( P < 0.05) with better results in 320-row CT, and no significant difference was found in the diagnosis of intracardiac malformation ( P > 0.05). The average subjective image quality score was 4.4 ± 0.7 points. The average effective dose was 0.42 ± 0.08 mSv. 320-row CT enables direct visualization of the vascular configuration and shape of the aorta, pulmonary artery, and other large vessels to diagnose extracardiac vascular malformations. Combined with transthoracic echocardiography, 320-row CT is a promising technology that may be able to replace catheter based angiography to evaluate congenital cardiovascular malformations.

Objective: The accuracy of diagnosis of intracranial aneurysms by subtraction computed tomography angiography (CTA) was compared with conventional non-subtracted CTA and with digital subtraction angiography (DSA).Methods: 56 patients with spontaneous subarachnoid hemorrhage (SAH) and suspected intracranial aneurysms were evaluated from September 2009 to January 2010. All underwent 320-detector row volume CT-CTA examinations. Non-contrast CT of each patient's head with the same scan range was performed before the routine CTA scan as the mask image for subtraction. The subtraction CTA volume data was obtained by subtracting the mask image volume data from the conventional non-subtracted CTA volume data. Subtraction and conventional CTA volume data were transmitted to a VOXAR workstation and two physicians with experience in diagnostic imaging of the nervous system independently carried out image post-processing and judged the results. Neurosurgeons performed endovascular treatment or surgical clipping based on information available through the CTA alone.Results: In 42 patients, 51 aneurysms were detected by DSA. On a per-aneurysm basis, the diagnostic sensitivity of subtraction CTA was 98.9% for physician 1 and 100% for physician 2. The sensitivity of conventional CTA was 93.7% for physician 1 and 92.6% for physician 2. There was excellent inter-observer agreement (kappa = 0.84, 95% confidence interval 0.82-0.85). The overall sensitivity, specificity, positive predictive and negative predictive values of subtraction CTA were all 100%. The overall sensitivity, specificity, positive predictive and negative predictive values of non-subtracted CTA were 94%, 100%, 100% and 76%, respectively. Therapeutic decisions could be made for all 42 patients based on subtraction CTA images, whereas conventional non-subtracted CTA provided sufficient information to make therapeutic decisions for only 35 patients.Conclusion: Conventional CTA has lower sensitivity for the detection of very small aneurysms and aneurysms adjacent to the skull when compared to subtraction CTA. Subtraction CTA performed on a 320-detector row volume CT is an accurate diagnostic tool that provides data equivalent to that obtained with three-dimensional-DSA for the detection of intracranial aneurysms. c 2011 Elsevier Ireland Ltd. All rights reserved.

Objective To evaluate the relation between myocardial bridge and the formation of coronary atherosclerotic plaque.Methods One thousand two hundred and thirty consecutive subjects who underwent coronary CT angiography(CTA) were included in this study.The prevalence,precise location,depth,length,compression of myocardial bridge during both the systolic phase and diastolic phase,and concomitant atheromatous changes were evaluated.The group of subjects with myocardial bridge was compared with another subgroup,the control group,which included subjects without myocardial bridge in the probability of atherosclerotic plaque.Results From a total of 1 230 subjects,356 subjects(28.9%) were found to have one myocardial bridge each.The mid left anterior descending artery(LAD) was the most common coronary artery involved(220/356).A significant difference was found between the LAD myocardial bridge group and the control group regarding presence of atheromatous changes in a similar LAD segment proximal to the myocardial bridge(P0.005) and in the severity of atheromatous changes in these segments(mild,P0.01;moderate,P0.02;and severe,P0.001).The presence of stenosis in the tunneled coronary correlated with the thickness and length of the bridge.Conclusion The anatomic relation between tunneled coronary segment and myocardium can be precisely displayed on 64-slice spiral CT coronary angiography,and it should be considered as the first-choice examination for the detection of myocardial bridge.Myocardial bridge predisposes to the development of athero-sclerosis in the coronary artery segment proximal to the bridge.This may indicate that myocardial bridge should be considered as an anatomic risk factor in the evaluation of CAD.

Aim. The aim of this study was to evaluate the veracity and sensitivity of in-vivo imaging system (IVIS) for inspection of tumor dynamic morphology.Methods. Mouse melanoma cells (B16-F10-luc-G5) in 100 mu L media were seeded into a 96-well plate by 1:2 serial dilution from 10 000 cells (well #1) to 78 cells (well #8). The plate was imaged using IVIS system to evaluate its sensitivity for luminescence. Ten Bablc mice with tumor cells were injected subcutaneously (1x10(5) in 100 mu L) and tumor luminescence was detected by IVIS at Day 0, Day 3, Day 5, Day 7 and Day 9.Results. As few as 78 tumor cells were detectable by IVIS. A strong correlation between number of tumor cells and bioluminescence (R-2=0.99) was also demonstrated. Tumor luminescence were observed in all mice by IVIS at all days, and there was significant difference (P<0.01) between each two days from Day 0 to Day 9. Moreover, tumor dynamic morphology could be monitored by IVIS when it is invisible.Conclusion. Compared with conventional methods, with high veracity and sensitivity, IVIS system should be recommended as an effective method for inspection of tumor dynamic morphology.