Bahauddin Zakariya University

This study examines fluid flow and heat transfer in three-dimensional micro-scale porous domains formed by simple cubic (SC), body-centered cubic (BCC), and face-centered cubic (FCC) sphere packings under continuum and slip-flow regimes. A multi-relaxation-time lattice Boltzmann (MRT-LB) model was developed to capture velocity slip and temperature jump at fluid–solid interfaces. In continuum flow, strong flow obstruction and extended low-velocity regions were observed near solid boundaries, whereas slip flow reduced wall-induced stagnation and suppressed trailing-sphere vortices. Thermal results show an early temperature rise in continuum flow, while slip flow leads to lower peak temperatures due to enhanced near-wall convection. The Nusselt number increases with Reynolds number but decreases with Knudsen number and porosity, reflecting reduced effective surface area and intensified temperature jump effects. Friction factors decrease with increasing Reynolds number for all lattice types; however, low-porosity BCC structures exhibit the highest drag due to reduced inlet velocities. Permeability increases with Knudsen number and porosity, with SC and FCC configurations showing greater enhancement because of higher average flow velocities. To reduce computational cost, a deep-learning-based surrogate model was trained to replicate MRT-LB predictions of velocity and temperature fields. The surrogate achieves high accuracy with low prediction error, enabling rapid evaluation of slip-flow heat transfer and efficient parametric design of micro-porous thermal systems.

Fossil fuel reserves depletion necessitates the generation of sustainable energy through hydrogen from water splitting, with efforts focusing on optimizing bifunctional electrocatalysts for improved efficiency. In this study the Fe-doped (1%, 5%, 10%) CoCu2Se4 mesoporous nanosheet array on a Ni foam substrate with varying concentrations using a hydrothermal synthesis. Fe doping in CoCu2Se4 lattice results in structural distortions and electronic modifications. The study discloses the insights of Fe+3 doping in CoCu2Se4 lattice sites lead to electronic modulation, improve conduction and catalytic mechanisms. Fe+3 higher electronegativity facilitates electron redistribution, modulating the band structure and reducing charge recombination losses. The study found that the optimized 5% Fe-doped CoCu2Se4 electrode demonstrated exceptional OER performance with a 216 mV of low overpotential along with a minimal 69.65 mV dec-1 Tafel slope. Additionally, remarkable HER activity having a minimal overpotential of 122 mV along with low Tafel slope up to 89 mV dec-1 was succeeded. Assembled device demonstrated exceptional stability for 40 h, indicating its potential for sustainable water splitting applications. Hence, for sustainable hydrogen production via water splitting, the Fe-doped CoCu2Se4 metals are a promising candidate.

This article employs a comparative feminist-postcolonial spatial close reading of Geetanjali Shree's Tomb of Sand and Arundhati Roy's The Ministry of Utmost Happiness to examine how South Asian women's fiction reimagines space, memory, and the gendered body as sites of resistance against social and ideological divisions. Employing Edward Soja's concept of Thirdspace, this article argues that both novels challenge hegemonic territoriality and expose the absurdity of man-made boundaries. The novels construct fluid and transformative spaces that destabilise dominant patriarchal ideological structures. The gendered body and memory enable the protagonists to dismantle social and national dichotomies and divisions. By bringing these novels into dialogue, the article contributes to feminist postcolonial debates on space and memory. Space is constructed in the novels as retrospective, i.e., recovering a cosmopolitan space-time matrix, or prospective, which builds a future on hope and inclusive community. Both function as alternative realms in which marginalised subjects resist hegemonic structures and reconfigure possibilities of coexistence and human connection.

Abstract Refractory epileptic encephalopathies are defined as the severe, childhood-onset epilepsies associated with drug-resistant periodic seizures, neurodevelopmental disability, behavioral problems, and escalate the risk of sudden unexpected death in epilepsy (SUDEP), especially in Lennox-Gastaut syndrome and Dravet syndrome. Although several anti-seizure drugs are offered, about 20–30% of the patients do not respond well to the treatment, indicating the necessity of new methods of treatment. This is an in-depth analysis of the pharmacology, pharmacokinetics, pharmacodynamics, clinical effectiveness, safety profile, and pharmacokinetic status of the drug, fenfluramine, in refractory developmental and epileptic encephalopathies The mechanism of action of fenfluramine is primarily associated with enhancing serotonergic neurotransmission and modulating sigma-1 receptors, as well as restoring the excitatory-inhibitory balance in neural networks. Other processes of GABAergic enhancement, regulation of glutamatergic signalling, Nrf2, ROS, and possible neuroendocrine effects are discussed. Various Clinical trials have shown that convulsive seizures are reduced significantly by fenfluramine in Dravet syndrome and drop seizures in Lennox-Gastaut syndrome, and cognitive and behavioral and improve the quality of life are emerging. Although echocardiographic monitoring remains a mandatory requirement due to past safety concerns, modern low-dose regimens demonstrate a satisfactory tolerability rate. Fenfluramine is a novel multi-mechanistic anti-seizure drug that has disease-modifying and multi-mechanistic activity. The purpose of this review is to highlights the additional long-term safety evaluation and larger clinical trials are justified in order to establish its place in the management of refractory epilepsy further and to treat the various types of seizures.

Supercapacitors are a family of energy storage devices that have attracted significant attention because of their high power density, quick charge and discharge times, and extended cycle life. For the development of high-performance supercapacitors, electrodes with high specific capacitance values along with good structural stability are essential. In this context, we report the synthesis of a surface oxygen-modified CoAlFe LDH@Fe3O4 heterostructure using a simple hydrothermal route followed by post modification using hydrogen peroxide. High crystallinity and phase purity were confirmed by structural studies employing X-ray diffraction (XRD), and functional groups essential to electrochemical performance were revealed by Fourier-transform infrared spectroscopy (FTIR). XRD and FTIR results confirmed the formation of the heterostructure with the presence of magnetic Fe3O4. In addition, the surface oxygen coordination was found to be significantly improved. Excellent retention, low internal resistance, and better capacitive behavior were demonstrated by electrochemical studies. For the electrochemical evaluation of the heterostructure, a 1 M KOH electrolyte was used. A remarkable specific capacitance value of 1709.6 F g-1 at a current density of 1 A g-1 was achieved. In addition, the heterostructure exhibited excellent durability with 89.39% capacity retention after 10 000 consecutive charge-discharge cycles. A low charge transfer resistance value was confirmed using electrochemical impedance spectroscopy. A scalable and efficient method for creating high-performance supercapacitor electrodes is presented in this study. Additionally, the relationship between surface chemistry and structural order in affecting electrochemical performance is thoroughly examined, providing a fresh perspective on the future of innovative energy materials.