Kütahya Dumlupınar University is a public university in Kütahya, Turkey. The university began to operate as a new institution under the name of Kütahya Dumlupınar University on 3 July 1992, with the force of governmental decree numbered 3837; before it's been a part of the Anadolu University with The Faculty of Kütahya Economics and Administrative Sciences which was established on 12 October 1974 as The Business Administration High School of Kütahya under the name of The Economics and Commercial Sciences Academy of Eskişehir.The university has established and is keeping up close ties with universities abroad including University of Virginia in the United States, Brunel University in the United Kingdom, University of Pécs in Hungary and universities located at the member states of the former Soviet Union. Moreover, DPU hosts or takes part in the conferences, symposia, and cultural events organized by the collaborating institutions. Also the university is a member of the European University Association..
Based on the unified shear deformation theory, this paper presents the free vibration analysis of linear, isotropic, homogeneous beams resting on a Winkler elastic foundation. Unlike existing transfer matrix formulations that operate on four-variable state-space systems, the present work establishes a six-variable state-space framework in which an arbitrary shear strain function is incorporated into the formulation solely through integral coefficients, enabling the unified treatment of seven distinct shear deformation models without theory-specific rederivation. The governing equations and boundary conditions are derived using energy principles. Natural frequencies are determined using the initial value method via both exact transfer matrix (ETM) and approximate transfer matrix (ATM). Since the analytical derivation of the ETM involves a sixth-order characteristic polynomial with prohibitively complex expressions, an ATM is constructed using a three-term truncated matricant series expansion, thereby eliminating the need for eigenvalue extraction. A correction methodology based on the chain property is proposed to ensure convergence to the exact solution. The formulation reduces the frequency determinant from a 6 × 6 system to a 3 × 3 system for each boundary condition. Systematic comparisons across different shear deformation theories, boundary conditions, slenderness ratios, and foundation stiffness values confirm the accuracy and reliability of the proposed approach, with ATM results converging to the ETM reference within less than 0.25
In this study, a new lossless grounded simulator (GS) suitable for a capacitance multiplier is proposed. This GS realizes capacitance multiplier, simulated inductor, and frequency-dependent negative resistor by an appropriate selection of passive components. This GS includes a minimum number of passive elements and does not require any passive component matching. The capacitance multiplier choice contains a grounded capacitor; thus, its implementation is easy in an integrated circuit process. The proposed capacitance multiplier consumes about 1.3 mW of power. The operating frequency range of the proposed capacitance multiplier for a multiplication factor of 100 extends from about 6 Hz to 2.2 MHz. A band-pass filter as an application is given. Numerous time- and frequency-domain simulations are included to verify the theory. In addition, experimental results obtained with AD844 devices further confirm the validity of the proposed approach.
Astaxanthin (AX) is a potent antioxidant and an anti-inflammatory carotenoid. Research examining whether AX could counteract exercise-induced muscle damage and improve exercise capacity has reported inconsistent results. The aim of this study was to test the efficacy of high-dose versus low-dose AX supplementation for four weeks on muscle damage markers, total antioxidant status, and a subjective marker of muscle pain following exhaustive exercise. A total of 24 active males were randomly assigned to one of the three groups: an AX12 group (12 mg·day-1; n = 8), an AX36 group (36 mg·day-1; n = 9) or a placebo group (PLC, n = 7). After four weeks of supplementation, blood samples were collected at rest, and at 2, 24, 48, and 72 h following eccentric arm exercise performed at 85% of the predetermined one-repetition maximum to assess muscle damage markers and total antioxidant status, and muscle pain levels were evaluated using a Numerical Visual Pain Scale0-10. Creatine kinase activity was significantly lower in AX groups compared to the PLC group at 24, 48, and 72 h post-exercise (p < 0.05), with no difference between both AX groups (p > 0.05). At 24, 48, and 72 h post-exercise, lactate dehydrogenase activity in the PLC group was higher than in AX12 and AX36 groups, averaging 2.2 and 2.8 times higher, respectively; however, these differences were not statistically significant (p > 0.05). A significant time effect of the muscle pain score was noted at 2, 24, 48, and 72 h post-exercise (p < 0.001), with no significant differences among the supplementation protocols (p > 0.05). In conclusion, four-week AX supplementation at a dose of 12 or 36 mg·day-1 similarly reduces plasma creatine kinase activity following exhaustive exercise, yet its impact on muscle pain and antioxidant status remains limited.
In this study, nickel-cobalt@functionalized multi-walled carbon nanoparticles (NiCo@f-MWCNT NPs) were synthesized, analysed, and used for hydrogen generation via methanolysis on NaBH 4 . For the NPs synthesis, two steps were conducted (i.e., i: MWCNT was functionalized in an acid medium to support NPs (f-MWCNT); ii: NiCo NPs were synthesized and supplemented with f-MWCNT). Various characterization techniques were used to examine the morphological structure of NiCo@f-MWCNT NPs. The transmission electron microscope (TEM) results showed that the NPs were sized as 3.941 ± 1.094 nm with a spherical structure. The X-ray diffraction analysis (XRD) results indicated an average crystalline size of 1.46 nm. The evaluation of the catalytic performance for hydrogen production revealed that the turnover frequency (TOF) was calculated to be 2934.4 min − 1 with activation energy (Ea) and enthalpy (∆H) of 39.29 kJ/mol and 36.74 kJ/mol, respectively, which indicates high viability for hydrogen transport and generation application and processes.
The present study aims to investigate the putative protective role of curcumin (CUR) against oxidative stress and lung damage caused by a heavy metal mixture (Cd+As) with cadmium (Cd) + arsenic (As). Wistar albino rats were randomly divided into five experimental groups: Control, 0.44 + 5.55 mg/kg Cd+As, 100 mg/kg CUR, 100 CUR + Cd+As, and 200 CUR + Cd+As groups. The Cd+As increased malondialdehyde levels and oxidative stress. However, it also led to a decrease in levels of glutathione (GSH), superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) in lung tissue homogenates. Different doses of CUR effectively prevented Cd+As-induced lipid peroxidation and suppression of antioxidant capacity in lung tissue. Also, lung tissue administered Cd+As showed elevated levels of congestion, inflammation, alveolar damage, and apoptosis, as evidenced by decreased Bcl-2 and increased expression levels of Bax and caspase-3. The high dose remarkably improved lung injury in Cd+As-injected rats, better than the low dose. The results show that CUR treatment is effective in protecting against Cd+As-induced lipid peroxidation and reducing the negative effects of metal mixture on antioxidant status. This study suggests that CUR may be a potential new approach for the prevention/treatment of Cd+As-induced pulmonary toxicity and possibly other lung diseases associated with oxidative stress and inflammation. Furthermore, in silico studies on how CUR and Cd+As treatments affect the activities of the enzymes CAT and GPx1 showed that ROS induced by Cd+As treatment caused changes in the enzymes CAT and GPx1, while CAT was modulated by CUR treatment, whereas GPx1 was not modulated.
