Ghazi University (Urdu: غازی یونیورسٹی) is a university in Dera Ghazi Khan, Punjab, Pakistan. The university was established in 2012 at the initiative of the Chief Minister of the Punjab Muhammad Shahbaz Sharif. It is named after Baloch mercenary Ghazi Khan.The university is situated in the center of city near pull daat and college chowk. There are two buildings of this university. One is at college chowk where students are recently studying and other is at Airport road. The campus at College road is called City Campus and the Campus at Airport road is called airport campus. The Airport campus is under construction..
Damnacanthal (DAM) is a naturally occurring anthraquinone with notable anticancer activity. In this study, five DAM derivatives (WM1–WM5) have been theoretically investigated, and the results are compared with the reference DAM molecule (R) to elucidate structural relationships governing biological activity and drug efficacy. WM3 displayed the highest λmax, and the lowest excitation energy, attributed to the strong electron-withdrawing bromo substituent in the acceptor moiety. The WM4 molecule showed the lowest LUMO energy and bandgap among all. Furthermore, structure-based molecular docking against the CHK1 receptor demonstrated that all derivatives (WM1–WM5) possess stronger binding affinities than the reference compound and the co-crystallized ligand, supporting their enhanced anticancer potential. Strong charge transfer and H-bonding interactions are made possible by the synergistic action of electron-donating OH groups and an electron-withdrawing aldehyde group in WM4, which results in increased biological activity. So, overall, these findings highlight WM4 as a promising optoelectronic and anticancer candidate, offering valuable insights for the rational design of DAM-based therapeutic agents. WM4 exhibits the best performance despite differences in optoelectronic parameters. It integrates the highest docking affinity with advantageous electronic characteristics like low reduced energy bandgap (high reactivity and potential interaction), making it the most promising candidate for anticancer activity. Density functional theory (DFT) and time-dependent DFT (TD-DFT) were used to conduct computational studies of WM1–WM5 and the reference molecule (R). The B3LYP/6-311G(d,p) level of theory was used for all geometric optimization, excited-state evaluations, and electronic property simulations. The CPCM model was used to investigate the effects of chloroform solvent on adsorption. Different parameters like optimal geometries, binding energies, excitation energies, frontier molecular orbitals (FMOs), transition density matrices (TDMs), molecular electrostatic potential (MEP), and density of states (DOS) were evaluated. Structure-based virtual screening was carried out by using the CHKl receptor to investigate drug-protein interactions. Docking simulations were performed to evaluate binding affinities and interaction patterns by utilizing AutoDock Vina.
The present work describes a green approach to the synthesis of silver nanoparticles (AgNPs) using Syzygium cumini leaves. This plant leaves extract offers strong capping and reducing abilities in the synthesis process. After synthesis, these nanoparticles were characterized by using different experimental tools to determine the particle size, chemical stability, morphology, crystallinity, optical response, and functional groups. AgNPs exhibited an absorbance peak at 440 nm via UV-visible spectroscopy. The DLS study reported an average particle size about 20 nm and a zeta potential of -29 mV. XRD confirmed that these particles have a face-centered cubic structure. AgNP expressed good antibacterial activity against Escherichia coli and Staphylococcus aureus. Furthermore, AgNPs revealed higher photocatalytic degradation (90%) of the methylene blue (MB) dye under sunlight.
Soil, water, and air contamination threatens agricultural sustainability and poses serious risks to human health. Long-term irrigation with sewage water (SW) leads to the accumulation of heavy metals in agricultural soils, with lead (Pb) being among the most prevalent contaminants. This pot experiment evaluated the bioremediation potential of calcium sulfate (CaSO₄) in alleviating Pb stress in tomato plants. Experimental treatments included (i) irrigation with fresh water (FW), (ii) with sewage water (SW), (iii) with SW + 0.75
Crop productivity is affected by agronomic practices such as Seed rate, fertilizer and irrigation application. A field trial with different agronomic practices was laid out to improve canola productivity and alleviate drought stress with potassium. The experiment included three factors, Factor A: irrigation regimes i.e. I0 = Conventional (control), I1 = Vegetative + bud formation + flowering, I-2 = Vegetative + bud formation + grain development, I-3 = Vegetative + flowering + grain development, I-4 = Bud formation + flowering + grain development), Factor B: exogenous application of potassium (K1= recommended and K2= split application of 1/3 soil + 1/3 fertigation + 1/3 foliar), and Factor C: seed rates (S-1= recommended (2 kg per acre) and S-2= reduced (1.5 kg per acre). Results showed that a dramatic response of irrigation regimes was noticed under the potassium application and seed rate. Maximum antioxidant activity of SOD, POD, and CAT was measured in the I0 treatment (conventional irrigation) with the exogenous application of potassium (K2) and reduced seed rate (S-2). Exogenous application of potassium significantly improved the grain yield (2.5%) and biological yield (1.85%) when compared with the recommended treatment (K-1). The same trend was also noticed for reduced seed rate. Grain yield and biological yield (3.38% and 2.61%) increased significantly with reduced seed rate when compared with the recommended seed rate, respectively. It is concluded that by improving agronomic practices like with the exogenous application of potassium with reduced seed rate under I3 treatment (vegetative + flowering + grain development stage).
The skin is the most significant organ in the human body. It provides defence against heat, sunburn, injury, and sickness. Furthermore, it maintains the thermoregulation of our body and water while also serving as a reservoir for vitamin D and lipids. The epidermis is composed of three distinct cell types. Squamous cells constitute the majority of the epidermis, which is thin and flat. They create melanin, the pigment responsible for the natural colour of the skin. Melanocytes increase melanin production in response to sunlight, resulting in skin darkening or tanning. The dermis contains blood and lymphatic veins, hair follicles, and glands. The study's goal is to look at the structure and algebraic features of seven drugs used to treat skin cancer. These are: cobimetinib, glasdegib, imiquimod, fluorouracil, and vismodegib. This is accomplished utilizing the NM-polynomials and neighbourhood degree-based topological descriptors method. Topological descriptors continue to be the primary strategy in drug design, because of substantial improvements in the field. Descrip, tors, when used in conjunction with QSPR models, provide numerical representations of a molecule's chemical properties. Chemical composition data Topological indices are mathematical representations that establish a connection between the chemical composition of a substance and its corresponding physical properties. We use the study's results to estimate five physicochemical properties of skin cancer treatment drugs: their density, enthalpy, polar surface area, molar volume, and flash point. These properties are estimated using linear and cubic regression analysis.
