Universidad Privada San Juan Bautista is a private university in the city of Lima, Peru. It offers 16 career programs categorized in 4 schools..
Parastomal hernia (PSH) is a common complication after stoma creation and may present emergently with obstruction, incarceration, or ischemia. While minimally invasive surgery (MIS, laparoscopic or robotic) shows benefits in elective PSH repair, data in emergencies are limited. This study compared outcomes following open versus MIS emergent PSH repair. In this retrospective cohort using ACS-NSQIP, patients undergoing emergent open, laparoscopic, or robotic PSH repair were identified. Surgical approach was categorized as open or MIS. A 3:1 propensity score–matched analysis balanced demographic, comorbidity, physiologic, laboratory, and operative variables. Primary outcome was 30-day overall postoperative complications; secondary outcomes included wound, medical, and surgical complications, return to the operating room (OR), length of stay, and readmission. Multivariate logistic regression identified predictors of complications. Of 303 patients (249 open, 54 MIS), 192 were analyzed after matching (144 open, 48 MIS) with balanced baseline characteristics. MIS repair had lower overall complications than open repair (22.9
Porcine reproductive and respiratory syndrome (PRRS) is a globally distributed disease caused by Betaarterivirus europensis (PRRSV-1) and Betaarterivirus americense (PRRSV-2). Its clinical presentation ranges from subclinical infection to severe disease, depending on viral evolution and the emergence of novel variants. The aim of this study was to characterize the genetic diversity and identify recombination events in the ORF7 (nucleocapsid, N) gene of ten PRRSV-2 strains circulating in pig farms in Lima, Peru. Bioinformatic analyses were performed using DNAMAN v10.0, MEGA 6, BepiPred-2.0, DnaSP v6, and RDP v4.101. Phylogenetic analysis revealed two well-defined lineages: eight strains clustered within lineage 1A (NADC34-like), and two within lineage 5A (VR2332-like), demonstrating the co-circulation of genetically distinct variants in the region. Comparative sequence analysis identified significant amino acid substitutions in eight strains (15, 16, 17, 20, 21, 22, 23, and 24), with strain 24 being the most divergent, accumulating multiple substitutions, including T81I, R109S, I115F, R116S, and A119K within the C-terminal region encompassing antigenic domains I-V. B-cell epitope prediction using BepiPred-2.0 identified six epitope patterns (A-F) comprising nine potential B-cell epitope regions (positions 5-19, 33-72, 33-73, 84-85, 87-98, 84-98, 87-97, 84, and 119). Patterns B, E, and F exhibited four to five predicted epitope sites and corresponded to strains 21, 22, 23, and 24. Recombination analysis using RDP v4.101 detected a statistically robust recombination event in strain 18_montana2020-R (lineage 5A), with strain 24_montana2020-WT (lineage 1A) identified as the putative major parent (100% similarity) and the vaccine-like VR2332 strain (lineage 5A) as the minor parent (99.3% similarity). Secondary evidence of the same recombination event was observed in strain 19_montana2020-R. Genetic diversity analysis of the ORF7 gene identified 50 polymorphic nucleotide sites and 52 mutations. Overall, these findings demonstrate substantial genetic variability in the ORF7 gene of PRRSV-2 circulating in Lima, Peru, characterized by lineage co-circulation and inter-lineage recombination. Continuous molecular surveillance is warranted to monitor viral evolution, assess potential antigenic implications, and support effective PRRS control strategies in the Peruvian swine industry. Keywords: ORF7 gene (N); lineage 1A; lineage 5A; genetic diversity; recombination; PRRSV-2
El suicidio constituye un problema de salud pública global de naturaleza multifactorial y creciente prevalencia en población joven. Ante ello, el presente estudio tuvo como objetivo determinar si las habilidades sociales (HHSS) actúan como factores protectores frente a la ideación suicida negativa en universitarios de Lima. Se empleó un diseño no experimental, correlacional y transversal, con una muestra no probabilística de 843 estudiantes de diversas carreras universitarias. Se aplicaron el Cuestionario de Habilidades Sociales (CHASO) y el Inventario de Ideación Suicida Positiva y Negativa (PANSI). Los resultados revelaron una predominancia de niveles bajos de ideación suicida negativa (68.9%) y niveles medios de habilidades sociales (72.7%). Se encontró una correlación negativa moderada y significativa entre HHSS e ideación suicida negativa (r = -.554, p < .001), y una correlación positiva moderada con la ideación suicida positiva (r = .431, p < .001). Un modelo de regresión múltiple mostró que las dimensiones mantener la calma ante las críticas, afrontar las críticas, expresar sentimientos positivos y rechazar peticiones explicaron conjuntamente el 33.1% de la varianza en la ideación suicida negativa (R² ajustado = .331, p < .001). Se concluye que el desarrollo de habilidades sociales en el ámbito universitario podría constituir una estrategia preventiva eficaz frente a la conducta suicida.
