The University of Kirkuk (Arabic: جامعة كركوك) is an Iraqi university established in 2003 in Kirkuk, Iraq.The University of Kirkuk included eight faculties/colleges when it was established in 2003. These were Engineering, Medicine, Law, Management & Economics, Science, Education, Nursing, and Agriculture. These Faculties has changed much since its inception, represented by the achievements of the mixed ethnic/religious students, in the various disciplines as well as academic/research programs provided by the faculty. After the creation of three new Colleges/Faculties of Medicine, Engineering and Agriculture, the college of Education was established with its five Departments: Qur'anic Sciences, Geography, Physical Education, Kurdish language, and Turkish Language. The Faculty of Sciences was established with four Departments: Biology, Physics, Chemistry, and Earth Sciences. In (2007-2008) the Faculty of Management and Economics was established to include the Departments of Business Administration and Statistics. Besides the development of the Faculty of Medicine with its nine disciplines/Branches: Microbiologist, Biochemistry, Surgery, Anatomy, Diseases, Internal Medicine, Physiology Medicine, Community Medicine. In the academic year (2008-2009), the Branch of Child Medicine was established. In the academic year (2009-2010), the Department of Mechanical Engineering was introduced to the College of Engineering. The UoK intends to exercise its best efforts to develop a cooperation program, establishing ties of friendship, promoting mutual academic/research collaboration, cultural and personnel/training exchanges, and working toward more specific and binding agreements..
This study reports the synthesis, characterization, and multi-performance evaluation of Dy3+-doped Sr2MgSi2O7 (SMSDx; x = 1, 3, 5, 7, and 9 mol%) nanophosphors prepared via a solution auto-combustion method using Aloe vera gel as fuel. Rietveld-refined PXRD patterns showed a dominating tetragonal phase (P-42(1) m, JCPDS Card No. 42-0932) next to a minor monoclinic phase (P2(1)/a, JCPDS Card No. 75-1736) with no notable peak shifts but varying intensity, suggesting effective Dy3+ replacement. While HRTEM projected an interplanar d-spacing of 0.285 nm, FESEM and TEM studies found quasi-spherical particles in the 29.85 nm range. Sr2+, Mg2+, Si4+, O2-, and Dy3+'s existence and oxidation states were verified by XPS and EDS. Increasing dopant concentration adjusted optical band gap values from 4.76 eV to 4.80 eV; Raman spectra showed changes in Si-O-Si and Mg-O vibrational modes caused by local lattice distortion. With SMSD3 displaying the greatest intensity, photoluminescence experiments under 352 nm excitation showed strong emissions at 483 nm (F-4(9/2) -> H-6(15/2)), 575 nm (F-4(9/2) -> H-6(13/2)), and 662 nm (F-4(9/2) -> H-6(11/2)). With a Q-value of about 6, showing dipole-dipole interaction, Dexter's hypothesis verified the concentration quenching process. Suitable for cool white-light phosphors, chromaticity study put all samples in the yellow-to-near-white area with CCT values between 4500 and 6000 K. A DOS study indicates that the interactions between the oxygen 2p and metal d orbitals govern the transitions. Additionally, DFT calculations revealed distinct electrical properties for each phase, with phase I exhibiting a direct band gap of 4.602 eV, while phase II has an indirect band gap of 4.969 eV. Conventional powder dusting forensic assessment revealed obvious Type-III level latent fingerprint visibility on surfaces, including ceramic, glass, and metal. Electrochemical sensing through CV and impedance studies, using SMSD-modified SPCEs revealed significant redox response, especially for SMSD9, with anodic/cathodic peaks at 0.57 V/0.31 V and large current densities for paracetamol oxidation, verifying diffusion-adsorption controlled two-electron, two-proton transfer. The Liner dynamic range (LDR) and limit of detection obtained for paracetamol were 0-10 mu M and 0.2945 mu M respectively. The sensor demonstrated commendable recovery (similar to 92.4 %) for paracetamol from acidified real water samples over a 15-day period, confirming its precision, dependability, and short-term operational stability in practical settings. The results show SMSDx nanophosphors as flexible nanophosphors linking luminous, forensic, and electrochemical domains-providing a hopeful answer to the rising need for application-integrated multifunctional materials.
The present study reports the isolation, screening and characterization of diverse yeast strains from different geographical regions for the valorization of waste palm oil mill effluent (POME) for biosurfactant production. A total of 192 yeast strains were isolated from different samples and screened for biosurfactant production, among which 57 yeasts demonstrated biosurfactant activity on POME via the drop-collapse method. The highest proportion of positive isolates (9.3
This study evaluated the antibacterial potential of a novel metabolite, a lansoprazole-like structure (LPZS), derived from the marine actinomycete Streptomyces huiliensis (PQ285591) against Staphylococcus aureus (MSSA). Out of 30 marine isolates from the Mediterranean Sea, S. huiliensis exhibited the most potent bioactivity. The purified metabolite, identified via NMR, TLC, HPLC, and GC–MS, demonstrated a significant minimum inhibitory concentration (MIC) of 0.5 μg/mL against S. aureus in vitro. The in vivo efficacy and safety were assessed using 120 African catfish (Clarias gariepinus) challenged with S. aureus (1.6 × 10⁶ CFU/mL). Treatment with LPZS (100 μg/mL) significantly (p < 0.05) mitigated infection-induced mortality and clinical symptoms. Furthermore, LPZS administration improved hepatorenal biomarkers, enhanced nonspecific immune responses (lysozyme and nitric oxide), and bolstered antioxidant capacity. Histopathological examination confirmed that LPZS effectively reversed tissue damage in the liver, kidney, and spleen. These findings suggest that LPZS is a safe and potent antibacterial agent, offering a promising therapeutic alternative for managing staphylococcal infections in aquaculture.
One of the most common comorbidities of rheumatoid arthritis is depression, which is an independent mood disorder. This study aims to examine the blood levels of some biochemical markers in rheumatoid arthritis patients with and without depression compared to healthy group. This study included three groups: rheumatoid arthritis patients with depression, rheumatoid arthritis patients without depression, and a healthy group. The results showed that patients groups had significantly (P ≤ 0.05) higher activity of acetylcholine esterase and ceruloplasmine, carbonyl, ischemic modified albumin (IMA), interleukin 6 (IL-6), tumor necrosis factor α (TNF-α ), Haptoglobin, and Cupper, and significantly (P ≤ 0.05) lower levels of total protein, albumin, globulin, thiol, iron, and zinc than control group. Free amino was significantly (P ≤ 0.05) lower in patients with depression group compared to the control and significantly (P ≤ 0.05) increases in patients with Rheumatoid arthritis without depression compared to control. Serotonin was significantly (P ≤ 0.05) lower in patients with depression group compared to the control and significantly (P ≤ 0.05) increases in patients with Rheumatoid arthritis, the study suggests that the presence of depression in Rheumatoid arthritis patients is associated with additional biochemical changes that may reflect more severe or complex pathophysiological interactions. The lower levels of serotonin and free amino in Rheumatoid arthritis patients with depression indicate a potential link between mood disturbances and biochemical imbalances.
Angiogenesis is a crucial and critical process in growth and development that has received study attention in recent decades. Angiogenesis inhibitors are one of the cornerstones of modern anticancer treatments, tumour develop resistance to drugs rapidly, thus providing new agents is crucial for patient's survival. The study investigated the effect of different concentrations of the novel 4-chloro-phenyl-carbothioamide derivative using different angiogenesis assays. The present study examined the potential antiangiogenic, antioxidant, and cytotoxic properties of a carbothioamide indole derivative and assessed VEGF gene expression. The tested indole derivative's antiangiogenic efficacy was assessed using the ex-n Press vivo rat aorta ring (RAR) assay. The DPPH test for scavenging activity was utilized to clarify the most likely cause of its antiangiogenic action. The MTT assay assessed the proliferation of the HUVEC cell line while the expression of the VEGF gene in the colon cancer (HCT116) cell line was analysed. The evaluated drug exhibited antiangiogenic efficacy with an IC50 value of 17.99 & micro;g/ml in the RAR assay. The drug successfully reduced the DPPH free radical in a concentration-dependent manner (IC50 = 100.30 & micro;g/ml). The evaluated drug exhibited negligible to non-toxic effects on the HUVEC cell line, with an IC50 value of 733.60 mu g/ml. It significantly downregulates the VEGF gene expression in HCT116 cells at 400 & micro;g/ml. In conclusion, the 2-NHC compound exhibited significant antioxidant and anti-angiogenesis effects with minimum toxicity against normal human cells. 2-NHC appears to downregulate the VEGF gene expression in colon cancer cell lines.
