目的:探究固肾安胎丸对体外受精-胚胎移植(IVF-ET)术后性激素水平、妊娠成功率的影响.方法:选取南阳市中心医院2020年5月至2022年5月收治的120例行IVF-ET术患者,采取随机数字表法分为对照组和观察组,各60例.对照组患者给予常规西药治疗,观察组患者给予固肾安胎丸联合常规西药治疗.比较两组患者人绒毛膜促性腺激素(HCG)注射日、移植日、种植窗日性激素水平,妊娠成功率及治疗期间的不良反应.结果:观察组患者在移植日、种植窗日血清雌二醇(E2)、孕酮(P)水平均高于对照组,差异具有统计学意义(P＜0.05);两组患者移植日血清E2水平均低于HCG注射日,差异具有统计学意义(P＜0.05);两组患者移植日血清P水平、种植窗日血清E2、P水平均高于HCG注射日,差异具有统计学意义(P＜0.05);两组患者种植窗日血清E2、P水平均高于移植日,差异具有统计学意义(P＜0.05).观察组患者临床妊娠率、持续妊娠率均高于对照组,差异具有统计学意义(P＜0.05).两组患者不良反应发生率比较,差异无统计学意义(P＞0.05).结论:固肾安胎丸可有效调节IVF-ET患者术后性激素水平,提高患者的临床妊娠率和持续妊娠率,且安全性良好.
目的:探讨硝苯地平联合羚羊角口服液治疗重度子痫前期(PE)的效果.方法:选择2020年3月至2021年4月南阳市中心医院接收的84例重度PE患者,并按随机数字表法划分成两组,每组42例.其中将应用硝苯地平治疗的患者纳入对照组,将在对照组基础上加用羚羊角口服液治疗的患者纳入观察组.比较两组患者治疗前及治疗1周后血压、24 h尿蛋白定量(24h pro)、血清凝溶胶蛋白(GSN)、内脂素水平及妊娠结局.结果:观察组患者总有效率明显高于对照组,差异具有统计学意义(P<0.05);观察组患者治疗后血压、24h pro及血清内脂素水平均明显低于对照组,血清GSN水平高于对照组,差异具有统计学意义(P<0.05);观察组患者终止妊娠时间晚于对照组,剖宫产率、围产儿不良结局发生率均明显低于对照组,差异具有统计学意义(P<0.05).结论:对重度PE患者应用硝苯地平联合羚羊角口服液治疗的效果较佳,可降低患者血压及尿蛋白,明显改善妊娠结局,其作用机制之一可能是调节血清GSN、内脂素水平.
Objective To explore the effect of non surgical treatment before periodontal flap surgery on the efficacy of severe periodontitis.Methods 48 patients with severe periodontitis admitted to Zhongshan Traditional Chinese Medicine Hospital from January 2022 to December 2022 were randomly divided into an observation group and a control group,with 24 patients in each group.All patients underwent comprehensive oral examination and clinical evaluation before surgery,including periodontal examination,periodontal pocket depth,loss of periodontal attachment,periodontal X-ray examination,and gingival bleeding index.The control group patients underwent modified periodontal flap surgery directly,while the observation group patients underwent modified periodontal flap surgery after nonsurgical periodontal treatment.Compare the treatment effectiveness and periodontal indicators between two groups of patients.Results The effective rate of treatment in the observation group was higher than that in the control group,and the difference was statistically significant(P＜0.05).Three months after operation,gingival bleeding index,periodontal pocket depth and periodontal attachment loss in the observation group were lower than those in the control group,with statistical significance(P＜0.05).Conclusion Non surgical treatment before periodontal flap surgery can significantly improve the efficacy of patients with severe periodontitis,and has a positive effect on improving periodontal indicators such as gingival bleeding index,periodontal pocket depth,and periodontal attachment loss.
Objective To analyze the research literature of pulse diagnosis in the past 70 years,analyze and summarize its research track and trend.Methods Using natural language processing related technologies,gephi and echarts,the titles and keywords of the literature were mined and analyzed by drawing Theme River map,term co-occurrence network map and emergence detection algorithm.Results The overall study of pulse diagnosis can be divided into four themes:objectification of pulse diagnosis,pulse diagnosis knowledge in classic ancient books,pulse diagnosis knowledge in clinical cases and pulse diagnosis knowledge of famous veteran doctors of traditional Chinese medicine(TCM);The recent hot spots were the reappearance of Renying Cunkou pulse method in Neijing,Li Shimao's experience of"flat pulse syndrome differentiation"and systematic syndrome differentiation pulse.Conclusion The field of pulse diagnosis closely focuses on the two main lines of inheritance and modernization,but pays too much attention to the inheritance and research of classical theories,rarely innovates,and lacks the research perspectives of evidence-based methods and modernization.
目的:分析子宫内膜息肉手术治疗中实施宫腔镜下电刀切除术与冷刀切除术方案对于术后并发症及子宫内膜厚度的影响.方法:选取2020年 1月至2022年5月高州市中医院收治的100例子宫内膜息肉患者,根据手术治疗方案不同进行分组,行宫腔镜下冷刀切除术的50例患者为冷刀组,实施宫腔镜下电刀切除术的50例患者为电刀组.比较两组患者手术及恢复情况、术后并发症发生率、炎症指标及子宫内膜厚度.结果:冷刀组患者手术时间、住院时间短于电刀组,术后出血时间长于电刀组,术中失血量多于电刀组,差异具有统计学意义(P＜0.05).两组患者术后并发症发生率比较,差异无统计学意义(P＞0.05).术后1d,冷刀组患者白细胞介素(IL)-6、肿瘤坏死因子-α(TNF-α)、C反应蛋白(CRP)水平高于电刀组,IL-10水平低于电刀组,差异具有统计学意义(P＜0.05).两组患者子宫内膜厚度比较,差异无统计学意义(P＞0.05).结论:与电刀切除术相比,宫腔镜下冷刀切除术在切除后子宫内膜厚度、术后并发症发生上并无明显差异,但手术时间与住院时间更短,利于患者术后恢复,不过手术中出血量更多,术后炎症因子水平更高,可能存在其他风险,因此在实际应用时当依据情况选择合适的手术方案.
Objective To investigate the effect of the hypothalamic mammalian target of rapamycin(mTOR)signaling pathway on puberty onset in female rats and the possible mechanism of the mTOR signaling pathway.Methods Clean grade female Sprague Dawley(SD)rats were selected and randomly divided into normal(N)group,dimethyl sulfoxide(DMSO)group,and rapamycin(Rapa)group.At the age of 23 days,lateral ventricular catheterization was performed on rats in the DMSO and Rapa groups.At the age of 29 to 35 days,rats in the Rapa group were injected with Rapa into the lateral ventricle,while rats in the DMSO group were injected with an equal amount of DMSO into the lateral ventricle.Rats in the N group received no intervention.The rats were weighed daily and the opening of the vulva was observed from the age of 28 days.On the morning of 35 days old,rats in each group were killed 2 hours after the last lateral ventricular injection.Changes in body mass,opening time of vaginal,development of uterine and ovarian,serum luteinizing hormone(LH),follicle stimulating hormone(FSH),estradiol(E2)levels,and hypothalamic mTOR signaling pathway related genes and protein expression in each group of rats were analyzed.Results After lateral ventricle injection of Rapa,compared with the N group and DMSO group,the expression levels of p-mTOR and p-S6K1 proteins in the hypothalamus in Rapa group rats decreased.The Rapa group rats showed delayed opening of the vaginal,and the serum levels of LH and E2,body mass,uterine wet weight,ovarian wet weight,uterine index,ovarian index and expression level of neuropeptide Y(NPY)gene were significantly higher in Rapa group rats(P＜0.05).Conclusion Inhibiting the mTOR signaling pathway in the hypothalamus through lateral ventricular injection of Rapa can delay the onset of puberty in female rats,and its mechanism may be related to the influence of the mTOR signaling pathway on the expression level of NPY in the hypothalamus.
目的:探讨局部晚期喉癌螺旋断层放疗(HT)与容积旋转调强放疗(VMAT)的剂量学差异与优势.方法:选取2022年1月至2022年12月蚌埠医学院第一附属医院收治的10例晚期喉癌患者,随机分为VMAT组和HT组,各5例.分别予以制定VMAT及HT治疗计划,在满足靶区相同处方剂量的基础上,比较分析两种放疗技术的计划靶区(PTV)剂量参数、危及器官剂量及受照体积参数以及两组治疗计划的机器跳数、计划出束时间.结果:VMAT组高危计划靶区(PTV1)的靶区平均剂量(Dmean)、近似最大剂量(D2)、中位剂量(D50)、靶区覆盖度(D95)、近似最小剂量(D98)、均匀性指数(HI)以及低危计划靶区(PTV2)的Dmean、D2、D50、HI高于HT组,PTV2的适形度指数(CI)低于HT组,差异具有统计学意义(P＜0.05).HT组在降低脑干的最大剂量(Dmax),脊髓的Dmean、Dmax方面优于VMAT组,差异具有统计学意义(P＜0.05).但在降低口腔Dmean和对两侧腮腺低剂量区域V10、尤其V20的保护上,VMAT组有明显优势,差异具有统计学意义(P＜0.05).且VMAT组正常组织的Dmean、V10、V20低于HT组,但V50高于HT组,差异具有统计学意义(P＜0.05).VMAT组机器跳数低于HT组,计划出束时间短于HT组,差异具有统计学意义(P＜0.05).结论:HT、VMAT在局部晚期喉癌中均能满足靶区及危及器官的剂量要求,HT剂量分布适形度、均匀性更好,VMAT在计划实施效率上更有优势.因此应根据患者具体病情科学采取更适宜的放疗方式.
Objective To analyze the value of serum neutrophil gelatinase-associated lipid transport protein(NGAL),cystatin C(Cys-C)and urinary retinol-binding protein(RBP)in the diagnosis of early renal injury.Methods 47 patients with early renal injury treated in Guangdong Province Integrated Traditional Chinese and Western Medicine Hospital from May 2021 to August 2022 were selected as an observation group,and 40 healthy subjects in the same period were selected as a control group.The levels of serum NGAL,Cys-C and RBP were compared between the two groups,the diagnostic value of each index was analyzed,and the correlation between renal injury grade and NGAL,Cys-C,RBP was analyzed.Results The levels of serum NGAL,Cys-C and RBP in the observation group were significantly higher than those in the control group.The abnormal rates of NGAL,Cys-C and RBP in the observation group were significantly higher than those in the control group,the differences were statistically significant(P＜0.05).There was a positive correlation between NGAL,Cys-C,RBP and the grade of renal injury by Spearman correlation analysis(r=0.759,0.683,0.711,P＜0.05).Conclusion The levels of NGAL,Cys-C and RBP in patients with early renal injury will be significantly increased.The combined detection of the three indexes plays a guiding role in the diagnosis and treatment of early renal injury.
骨关节疾病多发生于老年人,但有年轻化趋势,常病情反复、久病难愈.潘力弢教授在临床实践中,博采李一明教授、黄明河教授等众多脾胃病专家之长,结合自己的临床经验,提出"治骨当先实脾胃"的观点,通过调理脾胃来治疗各种骨关节疾病,针药并举,随证化裁,取得较好临床疗效.
目的:探讨排石颗粒与钬激光碎石术联合治疗嵌顿性输尿管结石患者的临床效果.方法:回顾性分析2020年1月至2023年1月期间在庐山市人民医院接受治疗的84例嵌顿性输尿管结石患者的临床资料,将采用钬激光碎石术治疗的42例患者设为对照组,将采用钬激光碎石术联合排石颗粒治疗的42例患者设为观察组.比较两组患者结石清除率、治疗前后的疼痛数字评分法(NRS)评分、炎症因子指标[超敏C反应蛋白(hs-CRP),肿瘤坏死因子-α(TNF-α)]、肾功能指标[血肌酐(Scr)、血尿素氮(BUN)]与不良反应情况.结果:观察组患者的结石清除率为95.24％,高于对照组的76.19％,差异具有统计学意义(P＜0.05);治疗后两组患者的疼痛NRS评分均有下降,且治疗后观察组患者的疼痛NRS评分低于对照组,差异具有统计学意义(P＜0.05);治疗后两组患者的血清hs-CRP、TNF-α水平均有不同程度下降,且治疗后观察组患者的血清hs-CRP、TNF-α水平均低于对照组,差异具有统计学意义(P＜0.05);治疗后两组患者的血清Scr、BUN水平均有不同程度下降,且治疗后观察组患者的血清Scr、BUN水平均低于对照组,差异具有统计学意义(P＜0.05);治疗期间观察组患者的不良反应发生率为2.38％,低于对照组的19.05％,差异具有统计学意义(P＜0.05).结论:采用排石颗粒联合钬激光碎石术治疗嵌顿性输尿管结石具有较好的治疗效果,可提升结石清除率,缓解疼痛程度,降低炎症反应,对促进肾功能恢复有积极意义,不良反应较少,安全性有保障.
Objective To investigate the clinical efficacy of azacytidine combined with all trans retinoic acid(ATRA)in the treatment of medium to high-risk myelodysplastic syndrome(MDS).Methods A retrospective analysis was conducted on 33 patients with medium to high risk MDS admitted to Jiangmen Central Hospital from February 2016 to December 2019 as a control group,who were treated with component blood transfusion,hematopoiesis promotion,and general symptomatic support,and 33 patients with medium to high risk MDS admitted to Jiangmen Central Hospital from January 2020 to January 2023 as an observation group,who were treated with azacitidine combined with ATRA on the basis of the control group.The hemoglobin(Hb),platelet count(PLT),and neutrophil count(ANC)of two groups of patients before and after treatment,as well as the blood transfusion interval,transfusion volume,clinical efficacy,and adverse reactions of the two groups of patients were compared.Results After treatment,the levels of Hb,PLT,and ANC in the observation group were higher than those in the control group,the blood transfusion interval was greater than that in the control group,the blood transfusion volume was less than that in the control group,and the complete remission rate and total response rate were higher than those in the control group,the differences were statistically significant(P＜0.05).During the treatment period,there was no statistically significant difference in the incidence of gastrointestinal reactions between the two groups,the difference was not statistically significant(P＞0.05).The incidence of fever,infection,and bleeding in the observation group were lower than those in the control group,the differences were statistically significant(P＜0.05).Conclusion The combination of azacytidine and ATRA has good efficacy in the treatment of high-risk MDS,which can improve clinical symptoms,prolong blood transfusion intervals,reduce blood transfusion volume,and have high safety.
目的:比较乌拉地尔与硝普钠持续静脉泵入用于高血压急症患者的临床效果.方法:选取2021年8月至2022年8月福建医科大学附属闽东医院收治的60例高血压急症患者,以随机数表法分为乌拉地尔组和硝普钠组,各30例.硝普钠组持续静脉泵入硝普钠治疗,乌拉地尔组持续静脉泵入乌拉地尔治疗.比较两组患者治疗效果,治疗前后血压[舒张压(DBP)、收缩压(SBP)]变化,治疗期间不良反应发生情况.结果:治疗后,硝普钠组患者DBP、SBP低于乌拉地尔组,总有效率、不良反应发生率高于乌拉地尔组,差异均具有统计学意义(P＜0.05).结论:高血压急症的患者持续静脉泵入硝普钠对调节血压水平的作用效果更显著,而应用乌拉地尔治疗可降低不良反应发生风险,临床可根据患者病情选择合理用药方案.
目的:探究推拿联合行为干预治疗儿童原发性夜间遗尿症的临床效果.方法:选取信丰县人民医院2021年4月至2022年9月期间收治的60例儿童原发性夜间遗尿症患儿,根据随机数法分对照组和观察组,各30例.对照组患儿采用行为干预治疗,观察组患儿采用推拿联合行为干预治疗,比较两组患儿的恢复效果、夜尿指标、中医证候指标、负面情绪评分和生活质量.结果:观察组患儿治疗总有效率高于对照组,差异具有统计学意义(P＜0.05);治疗后观察组患儿夜尿次数少于对照组,夜间觉醒程度高于对照组,差异具有统计学意义(P＜0.05);治疗后观察组患儿各项中医证候评分均低于对照组,差异具有统计学意义(P＜0.05);治疗后观察组患儿焦虑自评量表(SAS)、抑郁自评量表(SDS)评分均低于对照组,差异具有统计学意义(P＜0.05);治疗后观察组患儿各项生活质量评分均高于对照组,差异具有统计学意义(P＜0.05).结论:原发性夜间遗尿症患儿,可在推拿联合行为干预下得到改善,患儿于接受治疗后恢复效果对比仅采用行为干预更高,同时不仅能够有效恢复患儿的夜尿症状,且能够改善患儿的负面情绪指标,同时在提高预后生活质量方面具有积极作用.
目的:分析锚钉联合空心钉与切开复位钢板内固定治疗肱骨大结节骨折的效果.方法:选取2019年1月至2022年12月漳浦县医院收治的100例肱骨大结节骨折患者,随机分为对照组和观察组,各50例.对照组接受切开复位钢板内固定治疗,观察组接受锚钉联合空心钉治疗.比较两组患者的住院相关指标、肩关节功能疗效、骨折愈合时间、并发症发生情况.结果:观察组患者术中出血量少于对照组,手术时间、住院时间、骨折愈合时间短于对照组,差异具有统计学意义(P＜0.05).观察组患者肩关节功能疗效优良率高于对照组,差异具有统计学意义(P＜0.05).两组患者并发症发生率比较,差异无统计学意义(P＞0.05).结论:在对肱骨大结节骨折患者进行治疗时,相比于切开复位钢板内固定治疗,采用锚钉联合空心钉治疗不仅术中出血量少、手术操作时间短,而且能显著缩短骨折愈合时间,改善肩关节功能.
Objective To analyze the application value of electrocardiogram in the diagnosis of coronary heart disease.Methods 206 suspected coronary heart disease patients admitted to Longyan First Hospital from January 2021 to June 2022 were included in the study.All patients underwent coronary angiography and electrocardiogram diagnosis,and the diagnostic efficacy of electrocardiogram was analyzed using coronary angiography as the gold standard.Results Out of 206 patients diagnosed by coronary angiography,195 patients were diagnosed with coronary heart disease.The accuracy of electrocardiogram in diagnosing this disease was 97.57％(201/206),specificity was 100.00％(11/11),and sensitivity was 97.44％(190/195).Conclusion Electrocardiogram can effectively diagnose coronary heart disease with high diagnostic efficiency.However,since electrocardiogram diagnosis of coronary heart disease is not intuitive,clinical features still need to be combined during diagnosis to further improve diagnostic efficiency.
目的:探究经尿道前列腺等离子双极电切术(TUPKP)在治疗良性前列腺增生(BPH)中的临床效果.方法:回顾性选取2020年1月至2022年1月泉州医学高等专科学校附属人民医院收治的80例BPH患者,随机分为对照组和观察组,各40例.对照组患者予以经尿道前列腺电切术(TURP)治疗,而观察组患者予以TUPKP治疗.比较两组患者围手术期指标、国际前列腺症状评分表(IPSS)评分、最大尿流率(Qmax)、残余尿量(RUV)、生活质量综合评定量表(GQOLI)评分、并发症发生情况.结果:观察组患者术中出血量少于对照组,手术、住院时间短于对照组,差异具有统计学意义(P＜0.05).术后,观察组患者IPSS评分低于对照组,Qmax高于对照组,差异具有统计学意义(P＜0.05).术后,观察组患者RUV少于对照组,GQOLI评分低于对照组,差异具有统计学意义(P＜0.05).观察组患者并发症总发生率低于对照组,差异具有统计学意义(P＜0.05).结论:TUPKP是一种创新、高效、安全的手术方法,对治疗BPH具有显著的疗效和优越性.
Objective To observe the clinical effect of Maxing Shedan decoction combined with western medicine on bronchial asthma.Methods A total of 80 patients with bronchial asthma admitted to Zhangzhou Changtai District Hospital from January 2021 to January 2023 were selected and divided into two groups,with 40 cases in each group by random number table method.The control group was treated with western medicine,and the observation group was treated with Maxing Shedan decoction combined with Western medicine.The scores of traditional Chinese medicine(TCM)symptoms,sleep disorder scores,disease rehabilitation correlation indexes before and after treatment and therapeutic effects of the two groups were compared.Results After treatment,the TCM symptom score and sleep disorder score in the observation group were lower than those in the control group,the differences were statistically significant(P＜0.05).The symptoms of cough,dyspnea and pulmonary wheezing in the observation group were significantly reduced and disappeared for a shorter time than those in the control group,the differences were statistically significant(P＜0.05).The total effective rate of the observation group was higher than that of the control group,and the difference was statistically significant(P＜0.05).Conclusion The combination of Maxing Shedan decoction and Western medicine can alleviate the severity of symptoms and sleep disorders in patients with bronchial asthma,and shorten the recovery time of the patient's condition.
目的:观察慢性肾功能衰竭治疗中化瘀解毒灌肠液灌肠的疗效.方法:回顾性选取2018年3月至2023年3月周口市中医院肾病科慢性肾功能衰竭患者250例,依据治疗方法分为化瘀解毒灌肠液组(常规性西医治疗基础上给予化瘀解毒灌肠液灌肠)和常规性西医治疗组(常规性西医治疗),各125例.统计分析两组患者肾功能指标、实验室指标、自我管理能力、心理状态、生活质量、临床疗效、并发症发生情况、满意度.结果:治疗后两组患者血肌酐(Cr)、尿素(UA)、肾损伤分子1(KIM-1)、β2微球蛋白(β2-MG)水平均有不同程度下降,且治疗后化瘀解毒灌肠液组患者Cr、UA、KIM-1、β2-MG水平均低于常规性西医治疗组,差异具有统计学意义(P＜0.05);治疗后两组患者血钙(Ca)、血细胞比容(HCT)、血红蛋白(Hb)、促红细胞生成素(EPO)、铁(Fe)、转铁蛋白(TRF)水平均有不同程度提高,血磷(P)、铁蛋白(FER)、铁调素水平均有不同程度下降,且治疗后化瘀解毒灌肠液组患者Ca、HCT、Hb、EPO、Fe、TRF水平高于常规性西医治疗组,P、Hb、FER、铁调素水平低于常规性西医治疗组,差异具有统计学意义(P＜0.05);治疗后两组患者自我管理能力测量表(ESCA)评分均有不同程度提高,焦虑及抑郁评分均有不同程度下降,且治疗后化瘀解毒灌肠液组患者ESCA评分低于常规性西医治疗组,焦虑及抑郁评分均低于常规性西医治疗组,差异具有统计学意义(P＜0.05);治疗后两组患者生活质量各项评分均有不同程度提高,且治疗后化瘀解毒灌肠液组生活质量各项评分均高于常规性西医治疗组,差异具有统计学意义(P＜0.05);化瘀解毒灌肠液组患者治疗总有效率为96.00％,高于常规性西医治疗组的76.00％,差异具有统计学意义(P＜0.05);化瘀解毒灌肠液组患者的并发症发生率为8.00％,低于常规性西医治疗组的28.00％,差异具有统计学意义(P＜0.05);化瘀解毒灌肠液组患者的总满意度为96.00％,高于常规性西医治疗组的68.00％,差异具有统计学意义(P＜0.05).结论:慢性肾功能衰竭治疗中应用化瘀解毒灌肠液可有效提高疗效,改善患者生活质量,且安全性较好.
目的:探究门冬胰岛素与地特胰岛素治疗妊娠期糖尿病的效果.方法:选取2022年1月至2023年1月广州市花都区妇幼保健院(胡忠医院)收治的88例妊娠合并糖尿病患者,随机分为观察组和对照组,各44例.观察组采用门冬胰岛素与地特胰岛素联合治疗,对照组单用门冬胰岛素治疗.比较两组患者血糖水平、围生儿并发症发生情况、分娩方式、产后2 h出血量、产妇满意度.结果:观察组患者糖化血红蛋白(HbA1c)、空腹血糖(FBG)及餐后2 h血糖水平均低于对照组,差异具有统计学意义(P＜0.05).观察组围生儿并发症总发生率低于对照组,差异具有统计学意义(P＜0.05)0观察组患者剖宫产率低于对照组,自然分娩率高于对照组,产钳助产率低于对照组,差异具有统计学意义(P＜0.05).观察组患者产后2 h出血量少于对照组,产妇满意度高于对照组,差异具有统计学意义(P＜0.05).结论:针对妊娠合并糖尿病患者,通过采用门冬胰岛素与地特胰岛素联合治疗,会明显改善患者血糖水平和母婴结局,降低围生儿各项并发症的发生,减少产后2h的出血量.
Objective To investigate the efficacy of trepril combined with sunitinib in the treatment of advanced renal clear cell carcinoma and its effects on vascular endothelial growth factor(VEGF),growth differentiation factor 15(GDF-15),and renal function.Methods A retrospective analysis was conducted on 20 patients with advanced renal clear cell carcinoma admitted to Zhangzhou Hospital Affiliated to Fujian Medical University from January 2019 to January 2021,who were treated with trepril combined with sunitinib.Analyze the patients'quality of life,serum VEGF,GDF-15 levels,renal function indicators,T lymphocyte subgroup levels,incidence of adverse reactions,and clinical efficacy.Results After treatment,the total effective rate of the patients'clinical efficacy was 60％.After treatment,the serum levels of VEGF and GDF-15 in patients were lower than those before treatment,with statistically significant differences(P＜0.05).After treatment,the levels of serum creatinine(Scr),blood urea nitrogen(BUN),and urinary albumin(ALB)in patients were lower than those before treatment,with statistically significant differences(P＜0.05).Before and after treatment,there was no statistically significant difference in the levels of T lymphocyte subsets among patients(P＞0.05).After treatment,the patients'scores in the fields of physiology,psychology,social relations,and environment were higher than those before treatment,and the differences were statistically significant(P＜0.05).During the treatment period,the incidence of adverse reactions in patients was 35％for hematological toxicity,20％for diarrhea,30％for loss of appetite,20％for fever,and 60％for hair loss.Conclusion The combination of trepril and sunitinib has a significant therapeutic effect on advanced renal clear cell carcinoma,and can effectively improve the levels of VEGF,GDF-15,and renal function.
