Objective:To explore and analyze the clinical impact of citicoline sodium tablets combined with dopamine hydrazine treatment on patients with Parkinson's disease and mild cognitive impairment.Methods:80 patients with Parkinson's disease and mild cognitive impairment admitted to our hospital from September 2022 to July 2023 were randomly divided into a control group(treated with dopamine,n=40 cases)and an observation group(treated with citicoline sodium tablets and dopamine,n=40 cases)using a random number table method.Explore and analyze the clinical efficacy of two groups.Results:After intervention,the MMSE score,MoCA score,ADL score,clinical effective rate,serum levels of serotonin,norepinephrine,and dopamine in the observation group were higher than those in the control group,and there was a statistical difference between the two groups(P＜0.05);The incidence of adverse events after intervention in the observation group was significantly lower than that in the control group,and there was a statistical difference between the two groups(P＜0.05).Conclusion:The combination of citicoline sodium tablets and dopamine hydrazine in the treatment of mild cognitive impairment patients with Parkinson's disease can significantly improve their cognitive function,enhance their ability to take care of themselves in daily life,regulate and optimize the expression level of neurotransmitters,and has high clinical efficacy and safety,which is worth recommending.
目的:探究头孢哌酮舒巴坦对支气管扩张症者炎症指标、肺功能的影响.方法:选取2020年5月至2022年5月我院收治的80例支气管扩张症患者,按随机数字表法分为两组,各40例.对照组采用乙酰半胱氨酸,观察组在此基础上加用头孢哌酮舒巴坦.比较两组的炎症指标[C-反应蛋白(CRP)、白介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)]、肺功能[第1秒用力呼气容积(FEV1)、用力肺活量(FVC)、最大呼气流量(PEF)]、咳痰量及呼吸困难(mMRC)评分、不良反应.结果:两组治疗2周的TNF-α、CRP、IL-6水平比治疗前低,观察组比对照组低(P＜0.05).两组治疗2周的PEF、FEV1、FVC比治疗前高,观察组比对照组高(P＜0.05).两组治疗2周的咳痰量、mMRC评分较治疗前低,观察组较对照组低(P＜0.05).两组不良反应比较,差异无统计学意义(P＞0.05).结论:头孢哌酮舒巴坦可减轻支气管扩张症者的炎症反应,提高其肺功能,减轻病症,且不增加不良反应.
目的:探讨腰椎管狭窄症(DLSS)采取单侧双通道内镜(UBE)下椎板开窗减压术治疗的效果.方法:选择DLSS患者70例进行研究,根据治疗方法不同分为两组,每组35例,包括对照组(传统开放减压术)与观察组(UBE椎板开窗减压术).比较效果.结果:观察组优良率高于对照组,差异显著(P＜0.05);观察组手术时间、手术出血量、术后下床活动时间、住院时间、并发症率均低于对照组,差异显著(P＜0.05);术前,两组疼痛、改良ODI评分无明显差异(P＞0.05),术后1天、术后3个月、术后6个月,观察组疼痛、改良ODI评分均低于对照组,差异显著(P＜0.05);术前,两组生活质量无明显差异(P＞0.05),术后6个月,观察组生活质量评分高于对照组,差异显著(P＜0.05).结论:与传统开放减压术治疗DLSS比较,UBE椎板开窗减压术治疗可缩短手术时间与恢复时间,减少手术出血与并发症发生,同时可更好地缓解术后疼痛,提高患者生活质量,改善腰椎功能,提高临床效果,值得应用.
目的:子宫肌瘤患者于米非司酮治疗基础上,联合桂枝茯苓胶囊行中西医联合治疗,对促进患者子宫肌瘤体积缩小、改善血清激素水平和保证治疗安全性的价值探究.方法:收录2021年1月—2023年1月期间我院子宫肌瘤患者,共计70例,以随机数字表法做分组处理,就不同组别实施差异性治疗方案,展开对比分析.组别命名为对照组、观察组,样本量组间纳入相当,对应给予米非司酮治疗、桂枝茯苓胶囊联合米非司酮治疗.结果:评价两组疗效,观察组为94.29％,明显高于对照组的77.14％,P＜0.05于治疗前后评价两组子宫及肌瘤体积,治疗前组间差异较小,治疗后两组指标均有所改善,且子宫体积参数、肌瘤体积参数均以观察组更低,P＜0.05.于治疗前后评价两组血清激素水平,治疗前组间差异较小,治疗后两组指标均有所改善,且各项指标均以观察组更低,P＜0.05.统计两组并发症发生情况,观察组为8.57％,明显低于对照组28.57％,P＜0.05.于治疗前后评价两组中医证候积分,治疗前组间差异较小,治疗后两组症状均有所好转,且积分值均以观察组更低,P＜0.05.结论:子宫肌瘤患者于米非司酮治疗基础上,联合桂枝茯苓胶囊行中西医联合治疗,对促进患者子宫肌瘤体积缩小、改善血清激素水平和保证治疗安全性的价值显著.
目的:探讨布地奈德联合特布他林治疗儿童喘息性肺炎的应用价值.方法:选择本院2021年1月—2023年3月收治的138例儿童喘息性肺炎患者为研究对象,随机分组,分为观察组(69例)和对照组(69例);对照组患者给特布他林治疗,观察组在对照组基础上给予布地奈德治疗,比较两组治疗效果.结果:观察组治疗总有效率更高(x2=6.900,P=0.009);观察组各项症状缓解时间及住院时间低于对照组(P＜0.05);治疗后,观察组患者的PaO2水平高于对照组(P＜0.05);观察组患者的PaCO2水平低于对照组(P＜0.05);治疗后,观察组患者的CRP、WBC以及EOS指标低于对照组(P＜0.05);两组患者治疗期间的不良反应发生率对比差异不大(x2=0.697,P=0.404).结论:布地奈德联合特布他林治疗儿童喘息性肺炎的效果良好,可在未来临床中加以应用和推广.
目的:分析补血益母丸联合短效避孕药对多次人工流产子宫内膜修复生育力保护及激素水平恢复的影响.方法:选取2020年8月—2022年8月本院收治的70例多次人工流产患者,按简单随机法分为两组,各35例.对照组给予短效避孕药治疗,观察组联合补血益母丸治疗.记录两组月经转归情况(首次月经转归时间、术后阴道出血天数及阴道出血量),对比两组治疗前后子宫内膜厚度、性激素[促卵泡生成素(FSH)、促黄体生成素(LH)及雌二醇(E2)]水平,统计用药期间不良反应发生率.结果:观察组月经转归时间及阴道出血天数均较对照组短,阴道出血量少于对照组,差异有统计学意义(P＜0.05).两组治疗前的性激素相关指标水平对比无显著差异(P＞0.05);与对照组相比,观察组治疗后的E2、FSH、LH水平较低(P＜0.05).两组治疗前的子宫内膜厚度对比无显著差异(P＞0.05);与对照组相比,观察组治疗后的子宫内膜厚度较大(P＜0.05).两组不良反应发生率(11.43％VS8.57％)对比,差异无统计学意义(P＞0.05).结论:补血益母丸联合短效避孕药应用于多次人工流产患者中可提高子宫内膜修复生育力的保护效果,改善雌激素水平,促进月经的转归,安全有效.
Objective:Through analysis,to identify the influencing factors that affect the accuracy of emergency triage.By improving and optimizing the influencing factors,we can achieve precise optimization of the emergency triage mode based on information systems and indirectly improve the accuracy of triage.Methods:Through data review,we selected the period from September 1,2022 to November 30,2022.772 emergency patients with misdiagnosis in the emergency department of our hospital were selected as the subjects of this survey.The related factors affecting the error of triage were analyzed and optimized.Results:Through multi factor regression analysis,the factors that affect the accuracy of emergency triage include respiratory rate,systolic blood pressure,heart rate,diastolic blood pressure,age,oxygen saturation and other factors.Conclusion:Through the analysis and optimization of factors affecting the accuracy of triage,accurate optimization of the emergency triage mode of the information system can be achieved,which can save resources,optimize the labor cost,improve the accuracy of emergency triage and the success rate of e-mergency critical treatment,and also achieve double satisfaction of emergency medical workers and patients by strengthening the quality of medical care.
目的:分析胃肠手术后预防恶心呕吐发生应用多拉司琼药物的应用效果.方法:选取2020年8月—2022年8月本院收治的行胃肠手术治疗患者60例为研究对象,并基于随机数字表法分为对照组与研究组,对照组术后采取常规止吐干预,研究组接受多拉司琼药物干预.对比观察两组术后不同时间节点恶心呕吐发生情况、生理舒适度及术后恢复情况变化.结果:分析术后6h、术后12h、术后24h及术后48h恶心呕吐发生情况发现,研究组术后恶心呕吐发生率显著低于对照组(P＜0.05);分析术后6h、术后12h、术后24h及术后48h舒适度评分变化发现,研究组生理舒适度评分显著高于对照组(P＜0.05);评估两组预防方案应用对促进患者术后恢复变化发现,研究组术后胃肠功能恢复正常时间短、住院时间短,术后疼痛评分低(P＜0.05).结论:胃肠手术治疗后,选择多拉司琼药物进行干预,能降低术后恶心呕吐发生风险,还能提高患者生理舒适度,对于促进患者术后恢复具有积极意义,临床可进一步推广应用.
目的:分析苏合香丸联合氯吡格雷治疗急性脑梗死(ACI)患者的效果.方法:选取2020年8月—2023年7月本院收治的60例ACI患者,按随机数字表法分为两组,各30例.对照组予以氯吡格雷,观察组加以苏合香丸,持续治疗2周.比较两组的临床疗效、凝血功能、血液流变学、不良反应.结果:观察组治疗总有效率高于对照组,且观察组治疗后的凝血酶时间(TT)、部分凝血活酶时间(APTT)、凝血酶原时间(PT),长于对照组,全血低切黏度、全血高切黏度、红细胞压积(HCT),低于对照组,有统计学差异(P＜0.05);两组不良反应相当,无统计学差异(P＞0.05).结论:苏合香丸联合氯吡格雷能够有效调节ACI患者的凝血功能,改善血液流变学,且无严重不良反应.
目的:探讨带锁髓内钉内固定术与动力加压钢板在四肢骨折治疗中的应用及对患者近期康复结局的影响.方法:80例四肢骨折患者随机分为两组,对照组应用动力加压钢板治疗,观察组采用带锁髓内钉内固定术治疗.比较两组康复情况、疼痛程度及并发症风险.结果:观察组临床手术指标项目统计结果优于对照组(P＜0.05).观察组骨折愈合优良率为95.00％,高于对照组的80.00％(P＜0.05).术后7天内,观察组视觉模拟评分法(VAS)评分均低于对照组(P＜0.05).观察组并发症发生率低于对照组(P＜0.05).结论:带锁髓内钉内固定术较动力加压钢板治疗四肢骨折更具效果,可缩短患者康复时间,减轻疼痛反应,避免严重并发症发生,临床价值显著.
目的:分析普萘洛尔联合甲巯咪唑治疗甲亢的临床疗效.方法:以我院于2021年7月—2022年11月收治的70例甲亢患者为研究对象,经双盲法分为对照组(n=35)和观察组(n=35),分别实施甲巯咪唑治疗与普萘洛尔联合甲巯咪唑治疗,对比两组临床疗效.结果:观察组治疗总有效率、治疗后TSH、Ca水平高于对照组,治疗后FT3、FT4、P水平及不良反应总发生率低于对照组,差异有统计学意义(P＜0.05).结论:普萘洛尔联合甲巯咪唑用于甲亢治疗的效果显著,可有效调节患者甲状腺功能与血钙、血磷水平,安全性良好.
Objective:To analyze the relationship between meteorological factors and daily rabies exposure in Changsha from 2021-2022,and explore the lag effect of meteorological factors on daily rabies exposure.Methods:The daily meteorological data and daily rabies exposure in Changsha from 2021 to 2022 were collected,and the distributed lag nonlinear model(DLNM)was constructed with R4.2.3 software.Results:There were 216405 cases of rabies exposure be reported,with a median daily exposure of 292 cases in Changsha from 2021 to 2022.Summer and autumn were the high exposure seasons.The cumulative risk of rabies exposure increases when the daily average temperature is more than 10.0℃,reaching its maximum at 30.5℃(RR=1.63,95％CI:1.40～1.89).The risk of rabies exposure is highest on the 4th day after exposure at low temperatures(P5,4.0℃),and the risk is highest on the day of exposure at other temperature positions(P25～P95).When the daily relative humidity is 32.0％,the cumulative risk of rabies exposure is the highest,and the cumulative effect risk gradually decreases between 32.0％and 86.5％.With the highest risk being the extremely low temperature difference of-10.0℃,and the strongest effect being observed on the day of exposure.Conclusion:High temperature,low humidity,extreme cooling and warming weather will increase the risk of rabies exposure in Changsha from 2021 to 2022,which suggests that health education on rabies exposure and medical guidance on post exposure treatment should be strengthened before the arrival of key weather.
目的:探究腹泻患儿使用地衣芽孢杆菌活菌联合蒙脱石散治疗的临床疗效.方法:此次研究起始时间为2021年1月,截至2023年4月,将该时间内在本院进行治疗的90例腹泻患儿纳入研究对象,按照门诊就诊先后顺序进行编码和分组,其中1～45号为对照组,46～90号为实验组,每组45例,对照组单独使用蒙脱石散,实验组使用地衣芽孢杆菌活菌联合蒙脱石散,对比不同方案的疗效.结果:治疗前,实验组与对照组的排便次数、Bristol粪便性状评分无明显差异(P＞0.05),治疗后,两组相比,实验组排便次数减少的更多、Bristol粪便性状评分下降的更多,且和对照组有显著差异(P＜0.05).实验组患儿的治疗总有效率为97.78％,明显高于对照组的77.78％,统计结果有显著差异(P＜0.05).两组患儿的腹泻持续时间、腹痛缓解时间、粪便恢复正常时间对比,实验组患儿明显少于对照组(P＜0.05).实验组患儿的不良反应发生率为6.67％,和对照组的4.44％相比,无统计学差异(P＞0.05).结论:地衣芽孢杆菌活菌联合蒙脱石散治疗腹泻患儿的临床疗效显著,可明显快速改善临床症状,且治疗安全性较稳定.
目的:探究辨证穴位贴敷配合医养结合模式管理对老年慢阻肺患者SGRQ评分的影响.方法:选取2021年6月—2023年4月期间在我院接受诊疗的COPD患者90例,依据管理方案不同分为两个组别,参照组与观察组,每组45例.参照组施以常规管理;观察组则施行辨证穴位贴敷配合医养结合模式管理.比较两组管理前后圣乔治呼吸问卷(SGRQ)评分、中医证候积分;管理前后肺功能指标水平呼吸峰流速(PEF)与第1秒用力呼吸容积(FEV1);管理前后健康促进生活方式量表Ⅱ(HPLP-Ⅱ)评分.结果:SGRQ评分、中医证候积分治疗后均较治疗前下降,且观察组评分明显较参照组低(P＜0.05);肺功能PEF、FEV1水平与健康行为HPLP-Ⅱ评分治疗后均较治疗前升高,且观察组评分明显较参照组高(P＜0.05).结论:老年慢阻肺患者通过辨证穴位贴敷配合医养结合模式管理后,患者呼吸情况、肺功能、症状明显改善,且有助于改善患者的不良健康行为,值得推广.
目的:探究微信平台的延续性护理在支气管哮喘患者中的应用效果.方法:采取随机数字表法将我院2019年1月—2021年12月收治的68例支气管哮喘患者分为两组,各34例.对照组实施常规护理模式,观察组加用微信平台的延续性护理.对比两组患者心理状态、自我效能、生活质量及护理满意度.结果:观察组与对照组干预后焦虑自评量表(SAS)、抑郁自评量表(SDS)评分对比,观察组更低(P＜0.05);观察组与对照组干预后自我效能对比,观察组更高(P＜0.05);观察组与对照组干预后生活质量对比,观察组更高(P＜0.05);观察组与对照组护理满意度对比,观察组更高(P＜0.05).结论:基于微信平台的延续性护理应用于支气管哮喘中,利于改善患者心理状态,加强患者自我效能,提高其生活质量,提升护理满意度,值得进一步推广应用.
Objective:To explore the clinical effect of clearing heat and removing dampness combined with 5％minoxidil tincture in the treatment of damp-heat female type hair loss.Methods:Sixty female patients with damp heat type hair loss admitted to our hospital from January 2021 to March 2022 were randomly divided into two groups,with 30 cases in each group.The control group was treated with 5％minoxidil tincture,while the observation group was treated with heat clearing and dampness removing therapy for 4 consecutive months.Compare the clinical efficacy,dermatoscopy indicators,traditional Chinese medicine syndrome scores,clinical symptom scores,and adverse reactions between two groups.Results:The total effective rate of the observation group was higher than that of the control group,and the proportion of significant differences in white spot sign and hair diameter after treatment was lower than that of the control group,with statistical differences(P＜0.05);After treatment,the TCM syndrome scores,dandruff,scalp oil,itching,and hair loss scores of the observation group were lower than those of the control group,with statistical differences(P＜0.05);Comparison of adverse reactions between the two groups(P＞0.05).Conclusion:The combination of clearing heat and removing dampness with 5％minoxidil tincture can enhance the therapeutic effect of women with damp-heat type hair loss,improve dermatological indicators,reduce traditional Chinese medicine syndrome scores,accelerate the disappearance of clinical symptoms,and is safe and reliable.
Objective:To investigate the TCM constitution of the inpatients with mental disorders in Huaiji area,and to analyze the clinical effect of TCM syndrome differentiation in the treatment of mental disorders.Methods:1500 inpatients with mental disorders in Huaiji area from April 2021 to March 2022 were evaluated by TCM constitution Classification and Evaluation Table.After that,100 patients were randomly selected as research objects and divided into 2 groups,namely the treatment group and the control group,with 50 cases in each group by random table method.The treatment group was treated with traditional Chinese medicine syndrome differentiation under conventional western medicine treatment,while the control group was treated with conventional Western medicine to compare the influence of different treatment schemes on patients.Results:The highest proportion of inpatients with mental disorders in the classification of traditional Chinese medicine physique was 50.93％,followed by Qi-deficiency,Yang-deficiency,Yin deficiency,blood stasis,phlegm-dampness,blood-deficiency,damp-heat,and characteristic quality.On the day of admission,there were no significant differences in PANSS score and CGI score between the treatment group and the control group(P＞0.05).After 28 days of treatment and 60 days of treatment,PANSS score and CGI score in the treatment group were significantly lower than those in the control group(P＜0.05).Conclusion:To understand the TCM constitution of patients with mental disorders in Huaiji area is helpful to evaluate the relationship between the disease onset,constitution and treatment.The treatment of TCM syndrome differentiation is helpful to improve clinical therapeutic effect and improve clinical symptoms significantly.
目的:探究基于情景图示的早期离床活动康复方案在骨科患者术后康复中的应用.方法:选择2021年5月—2023年5月我院收治的80例骨折术后患者,并采用随机数表法将其分为对照组及观察组,各40例,对照组采用常规骨折术后护理方案,观察组采用基于情景图示的早期离床活动康复方案.探究干预期间两组的术后恢复情况及住院时间差异;比较术后1天、7天及1个月后两组的疼痛程度及日常生活能力差异;比较术后1天、干预1个月后两组的生活质量差异;探究干预期间内两组术后并发症的发生差异.结果:干预期间内,观察组的首次下床活动时间及住院时间均短于对照组,术后7天最远行走距离高于对照组(P均＜0.05);两组术后1天的疼痛程度、日常生活能力评分均无明显差异(P均＞0.05),观察组术后7天及干预1个月后的疼痛程度低于对照组,日常生活能力评分高于对照组(P均＜0.05);两组生活质量评分均高于术后1天,且观察组高于对照组(P均＜0.05);干预期间内,观察组的术后总并发症发生低于对照组(P均＜0.05).结论:基于情景图示的早期离床活动康复方案可帮助骨折术后患者恢复情况的提升,改善其疼痛程度及日常生活能力,降低并发症发生风险.
目的:分析在高血压脑出血(HICH)患者疾病护理中用护理角色定位模式对其护理效果的影响.方法:将我院近年来(2021年1月—2023年1月)收治的86例HICH患者作为本次研究对象,以随机数字表法分组,即观察组(护理角色定位模式,43例),对照组(常规护理模式,43例),对比分析两组护理后护理满意度、改良巴氏指数(Barthel指数)、各亚型美国国立卫生研究院卒中量表(NIHSS)评分、肢体运动功能(FMA)评分、救治效率.结果:护理前两组患者NIHSS评分、FMA评分、Barthel指数比较无统计学意义(P＞0.05),护理后,观察组NIHSS评分明显低于对照组,Barthel指数、FMA评分更高于对照组,对比有统计学意义(P＜0.05);观察组护理满意度高于对照组,对比有统计学意义(P＜0.05).结论:在HICH患者护理中用护理角色定位模式可提高护理质量,较常规护理措施更有助于改善神经功能与肢体功能,对提高生活质量有重要作用,值得临床推广应用.
2022年中成药出口中口服剂型占据绝对优势,注射液仅占比2％.本文以银杏叶提取物注射液为例,介绍了如何选择中药注射液出口品种、目标注册国家,并以目标国家(韩国)药事法规作为案例,介绍了韩国监管机构对中药注射液申报中的生产、质量、非临床和临床数据要求.通过了解法规要求,对中药出口企业提出了建议,选择优势品种、加强质量对标并积极专利布局,在实现出口盈利的同时保护好自身知识产权.
