INTRODUCTION:Lymphadenectomy is a cornerstone in the surgical management of resectable primary lung cancer. However, its prognostic significance in early-stage metachronous second primary lung cancer (MSPLC) remains poorly understood. This retrospective study aimed to evaluate the prognostic impact of lymphadenectomy in these patients using data from the Surveillance, Epidemiology, and End Results (SEER) Database.METHODS:A retrospective cohort study was conducted using data from the SEER Database for patients surgically treated for stage I MSPLC between 2004 and 2015. Propensity score-matching was employed to create comparable cohorts, and the Cox proportional hazards model was utilized to estimate the hazard ratio (HR) for overall survival after lymphadenectomy compared to non-lymphadenectomy. Survival analysis was performed using Kaplan-Meier curves and the log-rank test.RESULTS:Among 920 identified patients with MSPLC, 574 (62.4%) underwent lymphadenectomy. Propensity score-matching yielded 255 patients in both the lymphadenectomy and non-lymphadenectomy groups. Over a median follow-up of 38 months, the 5-year overall survival probability after a diagnosis of MSPLC was 58.7% in the lymphadenectomy group and 43.9% in the non-lymphadenectomy group (HR: 0.76; 95% confidence interval 0.64-0.90; p = 0.002).CONCLUSION:In this population-based study, lymphadenectomy is associated with prolonged overall survival in patients with stage I MSPLC. These findings suggest the potential benefit of incorporating lymphadenectomy into the surgical management of MSPLC, providing valuable guidance for thoracic surgeons in clinical decision-making.

Objective To understand the current situation and cognitive attitude of medical personnel to carry out Internet diagnosis and treatment,analyze the influencing factors,and put forward suggestions.Methods A question-naire survey was conducted among 790 medical staff in a tertiary public hospital in Beijing.SPSS 27.0 software was used to analyze the data.Results Among the medical staff who had been engaged in Internet diagnosis and treatment,the use rate of Internet diagnosis and treatment was higher in the medical staff who were male,had high professional titles,had been engaged in offline medical work for a long time,and had chronic disease departments.The willingness of female medical staff to use Internet diagnosis and treatment in fragmented time was significantly lower than that of male staff(P<0.05),and the willingness of medical staff in surgery department to use Internet diagnosis and treatment at home was significantly lower than that in chronic disease department(P<0.05).Conclusion Gender,professional title,de-partment and offline medical work time have significant influence on the participation of medical staff in Internet diagno-sis and treatment.It is necessary to formulate a reasonable flexible working system,carry out appropriate Internet diag-nosis and treatment projects,and optimize the performance appraisal system of medical personnel,so as to enhance the enthusiasm of medical personnel to carry out Internet diagnosis and treatment.

Objective:To investigate patients' preference and the attitude towards physician attire in an internal medicine clinic in China.Methods:This study was conducted from 1 January 2021 to 30 June 2021 in a tertiary care hospital in China. We surveyed 126 patients in the hospital with 6 sets of pictures of commonly worn physician attires in the hospital setting with a two-part questionnaire. The first part listed respondent demographics to collect basic information. The second part of the questionnaire was administered to adult patients who received care in the internal medicine clinics (outpatients). Survey forms collected demographic data (age, gender, patient age, education, marital status, and employment status), asked questions regarding 6 specific attires (scrubs, scrubs and white coat, casual, casual and white coat, business suit, and formal and white coat), and behavioral items (professional, responsible, reliable, knowledgeable, succession rate, and medical safety), finally, to assess the preference of attire on overall perception.Results:Scrubs and white coat scored the highest through 6 domains about physicians' attire (professional, reliable, responsible, knowledgeable, medical safety, and succession rate, p < 0.05 for all comparisons). A casual suit without a white coat was the least preferred across the surveyed attributes. There was a significant preference gap between wearing a white coat and not wearing a white coat (p < 0.001). Physician attire to white coat was considered as more professional, reliable, responsible, knowledgeable, having greater medical safety, and a higher success rate than attires without white coat.Conclusion:Patients felt that the physician wearing a white coat was better than other attires. Scrubs and white coat was the most popular attire. Hospital or related authorities may promote the standardized wearing of white coats, leading in a greater patient-physician relationship.

新冠疫情防控政策优化调整后,医疗机构均可收治新冠病毒感染患者,这无疑给医疗机构带来新的挑战.北京协和医院迅速响应,秉承"保健康、防重症、防病亡"的理念,通过实行标准化管理、统筹调配全院医疗资源、完善全方位抗疫的综合救治体系等一系列措施,提高疫情期间应急救治能力,以确保患者尤其是危重症患者获得及时有效的救治.

Abstract Background At present, the characteristics of mucinous breast carcinoma (MBC) and the factors affecting its prognosis are controversial. We compared the clinical features of MBC with those of infiltrating ductal carcinoma (IDC) and summarized the relevant prognostic factors. Methods The Surveillance, Epidemiology, and End Results (SEER) database includes information on 10,593 patients diagnosed with MBC between 2004 and 2016. Chi-square tests and analyses were used to analyze differences in variables between the MBC and IDC groups. Univariate and multivariate Cox proportional hazards models were used to assess the relative impacts of risk factors on cancer-specific survival (CSS) in patients. Kaplan-Meier survival curves were constructed to assess cancer-specific mortality and were compared using the log-rank test. Results From 2004 to 2016, 10,593 people were diagnosed with MBC, and 402,797 were diagnosed with IDC. Patients with MBC had significantly higher 5−/10-year CSS rates (96.4%/93.4%) than those with IDC (89%/83.8%). Compared with IDC patients, MBC patients had less lymph node metastasis, an earlier stage, a higher rate of hormone receptor positivity and a lower expression rate of HER2. Univariate and multivariate analyses showed that age ≥ 60 years old (HR = 1.574, 95%CI: 1.238–2.001, P < 0.001), singled status (HR = 1.676, 95%CI: 1.330–2.112, P < 0.001) and advanced TNM/SEER stage were independent prognostic risk factors for MBC. In addition, positive estrogen receptor (HR = 0.577, 95%CI: 0.334–0.997, P = 0.049), positive progesterone receptor (HR = 0.740, 95%CI: 0.552–0.992, P = 0.044), surgical treatment (HR = 0.395, 95%CI: 0.288–0.542, P < 0.001) and radiotherapy (HR = 0.589, 95%CI: 0.459–0.756, P < 0.001) were identified as protective factors. Conclusion Compared with IDC, MBC has a better prognosis. For patients with MBC, we identified prognostic factors that can help clinicians better assess patient outcomes and guide individualized treatment.

目的 基于CiteSpace知识图谱对国内外非计划再手术研究主体、热点进行可视化分析.方法 以PubMed和中国知网数据库中2000—2020年非计划再手术文献为研究对象,运用CiteSpace 5.7软件对非计划再手术文献进行关键词共现分析、突现词分析、发文作者和研究机构分析.结果 共检索到有效的非计划再手术中文文献205篇,英文文献476篇.中文文献作者以三大研究团体为主,研究机构以医院为主;英文文献作者以两大研究团体为主,研究机构以高校和医院为主.中文和英文文献关键词共现分析分别得到5大聚类群,中文文献分别为原因分析、PDCA循环、产后出血、手术并发症和临床分析,英文文献分别为morbidity、fusion、administrative data、NSQIP、laparoscopy.中文和英文文献分别得到7个突现词,中文文献分别为手术并发症、腹部损伤、预防、分析、负性事件、再次手术、影响因素,英文文献分别为adverse event、management、quality、cardiac surgery、NSQIP、pediatric、surgical site infection.结论 相比于国外,国内非计划再手术研究作者和机构更为分散,合作更少,缺少跨区域研究.国内外非计划再手术研究热点主要从临床视角出发,管理学视角和经济学视角研究较少;研究前沿主要为从科室、手术原因角度对非计划再手术进行深入探讨.

肺类癌(pulmonary carcinoids,PCs)是一种分化较好的低级别肺部神经内分泌肿瘤.PCs与常见的肺癌及其他肺部神经内分泌肿瘤相比,由于临床症状的复杂性和生物学的异质性,其具有不同的病理学分类方法、临床表现和治疗方式.对于大多数局限性PCs患者,手术是可治愈的治疗方式,通常不推荐辅助治疗.对于晚期PCs患者,常需全身综合治疗.本文就PCs的流行病学、诊断标准、病理学分类及常用治疗方法进行综述,以期提高临床医生的认识,促进PCs治疗的规范化和标准化,使更多患者获益.

BACKGROUND AND OBJECTIVE:Small bowel adenocarcinoma (SBA) is a rare malignant tumor with a poor prognosis. Most patients with SBA are diagnosed with advanced-stage disease. Due to the lack of randomized controlled trials and prospective studies, it is difficult to predict the prognosis of patients with SBA. Thus, this study aimed to establish a prognostic nomogram for evaluating the prognosis of SBA patients. METHODS:The clinical features and follow-up data of all patients diagnosed with SBA during 2004-2016 were summarized from the Surveillance, Epidemiology, and End Results (SEER) database. We separated these patients into training and validation groups. Multivariate Cox regression analyses were performed to identify independent prognostic variables for predicting cancer-specific survival (CSS) and overall survival (OS). According to the independent risk factors, we established nomograms and used the calibration curves to evaluate the accuracy. RESULTS:The data of 3301 patients with SBA were collected from the SEER database. The multivariate analysis showed that age, marital status, tumor site, grade, TNM stage and surgical history were associated with CSS and OS (P < 0.05). Based on these results, we established nomograms of CSS and OS that can predict the 3- and 5-year survival rates of SBA patients (C-index > 0.7). The calibration curves showed that the predicted survival was very close to the actual survival. CONCLUSION:We analyzed the independent risk factors for prognosis of SBA patients, and established nomograms to predict the 3- and 5-year survival rates of OS and CSS. These new prognostic tools can help clinicians to predict the survival of patients with SBA, further to guide treatment strategy.

Yolk sac tumor (YST) is a rare malignant germ cell tumor, which usually affects young males. Because of the low incidence, few studies on YST have been published. In our study, we aim to investigate the clinical characteristics, survival and risk factors of male YST patients based on the Surveillance, Epidemiology, and End Results (SEER) program. We identified 569 male YST patients from the SEER-18 database with additional treatment fields. Clinical characteristics, survival and prognostic factors were described in the study. Chi-square tests were applied to analyze categorical and continuous variables between different groups. Univariate and multivariate Cox proportional hazard model were performed to assess the relative impacts of risk factors on cancer-specific survival (CSS) in YST patients. Kaplan–Meier method and the log-rank test were used to analyze differences in survival that were significant. The major primary sites of YST were testis (74.69%), mediastinum (15.47%), retroperitoneum (2.64%) and central nervous system (1.24%). The 3-year and 5-year CSS was 70.0%, 56.5% vs. 97.2%, 96.0% for the mediastinal and testicular YST patients, respectively (p < 0.001). Primary site of mediastinum, distant SEER Summary stage were independent factors of poor prognosis (hazard ratio (HR) = 2.010 (1.094–3.695), p = 0.025; HR = 6.501 (2.294–18.424), p < 0.001, respectively). Receiving surgery was a good prognosis factor for all patients (HR = 0.495 (0.260–0.940), p = 0.032) and for the mediastinal group (p = 0.0019). Being treated with chemotherapy indicated poor outcome in all patients (HR = 3.624 (1.050–12.507), p = 0.042) and in the localized testicular YST patients (p = 0.0077). For the first time, our study revealed the primary site distribution of male YST, and summarized the clinical characteristics, survival and prognostic factors based on the SEER database, which provided important epidemiological evidence for clinical practice.

Background: Digestive neuroendocrine carcinoma (NEC) as well as mixed adeno-NEC (MANEC) is rare and highly malignant neoplasm which is classified as classes 3 and 4 neuroendocrine neoplasm (NEN) respectively according to the 2010 WHO classification of digestive NEN. The digestive NENs are found more in the rectum or appendix rather than in the stomach. Most gastric NENs belong to well differentiated class 1 or 2 neuroendocrine tumors (NETs, grade 1 or 2 respectively), while gastric NEC or MANEC are even rarer. Carcinoma of proximal stomach, i.e., carcinoma of gastroesophageal junction (GEJ) is controversial in epidemiology, clinicopathology, mechanisms of tumorigenesis, histology, clinical presentations, and staging, mostly between Western populations and Chinese. This article is to investigate the clinical characteristics, pathological classification and treatment of GEJ NEC. Methods: Clinicopathological data of 13 GEJ-NEC/MANEC patients at Peking Union Medical College Hospital (PUMCH) from January 2006 to January 2017 were reviewed and analyzed retrospectively. Results: Of 13 patients with pathologically confirmed GEJ-NEC/MANEC who underwent surgical resection, there were 10 cases (76.9%) of male and 3 cases (23.1%) of female. Patient age varied from 46 to 80 (median 64) years. Only 1 case (7.7%) was pathologically diagnosed as GEJ-NEC by pre-operational gastroscopy biopsy and 5 cases (38.5) were diagnosed as poorly differentiated adenocarcinoma. Twelve patients (92.3%) received proximal subtotal gastrectomy and lower esophagectomy. Another 1 patient (7.7%) received total gastrectomy and lower esophagectomy. Post operational histopathology revealed NEC in 8 cases (61.5%) and MANEC in 5 cases (38.5%). Conclusions: GEJ-NEC/MANEC is difficult to diagnosis before operation and surgery is still the primary treatment for resectable GEJ-NEC/MANEC.

Objective To determine correlation of invasive pulmonary adenocarcinoma micropapillary subtype and lymph node metastasis.Methods 433 cases were confirmed with invasive pulmonary adenocarcinoma through postoperative pathological examination.According to the classification criteria of IASLC/ATS/ERS,the pathological subtype was determined.Recording the patients'age,sex,smoking,tumor diameter,lymph node metastasis,tumor staging and so on.Results Micropapillary subtype were identified in 92 patients(21.2%).Patients with micropapillary subtype had a significantly higher incidence of pathologic lymph node metastasis,compared with patients without micropapillary subtype(43.4% vs.11.7%,P<0.05).Conclusion Micropapillary positive adenocarcinomas resulted in negative impact on postoperative prognosis among pulmonary adenocarcinomas.Pulmonary adenocarcinoma with a micropapillary subtype should be considered as poor prognosis factor.

Background: Vertebral augmentation has been populized as an effictive treatment for fresh vertebral compression fracture;however, for old compression fracture, few study has been reported. Objective: To evaluate the efficacy of percutaneous kyphoplasty (PKP) versus conservative treatment for patients with pain-ful vertebral compression fractures of more than 6 months' duration. Methods:From October 2007 to July 2012, 61 patients from our hospital with painful vertebral compression fractures of more than 6 months' duration were enrolled in this study. There were 15 males and 46 females with an average age of (69.8± 9.6) years (range, 48-87 years). The average duration of fracture was (9.3±4.3) months (range, 6-24 months). Concerning of the clinical symptoms and economical condition, 19 patients received only conservative treatment as the conservation group, while 42 patients received conservative treatment and PKP simultaneously as the surgery group. The conservative treatment included bracing and anti-osteoporostic medication. The average follow-up was (13.2±3.6) months (range,9-40 months). Visual analogue scale (VAS), European quality of life-5 dimensions scale (EQ-5D) , timed up and go test (UGT) and Beck index were applied to evaluate clinical outcomes before treatment and 2 days, 3 months and 1 year after treatment, and X-ray evaluation as well. Results: Compared with those before treatment, in conservation group, no difference was found in VAS, EQ-5D, UGT and Beck index 3 months after treatment, and also in EQ-5D, UGT in 1 year, except VAS showed better in 1 year afterment;while in surgery group, better VAS, EQ-5D, UGT and Beck index were found in 2 days, 3 months and 1 year after surgery. There were significant differnces in VAS, EQ-5D, UGT and Beck index in 3-month follow-up, and EQ-5D and UGT in 1-year follow-up between two groups (P<0.05). No significant difference was found in VAS one year after surgery between two groups. Conclusions: For patients with painful vertebral compression fractures of more than 6 months' duration, PKP can result in better clinical outcomes than conservative treatment within one year after treatment.

Objective To summarize the clinical features of solid pseudopapilloma tumor of pancreas(SPTP) which induce growth development dysfunction and analyze its misdiagnosis reason.Methods The clinical data of 7 radiologically and surgically confirmed pediatric patients with SPTP were retrospectirely analyzed.Results The average diameter was 7.4±1.9cm(3.0 - 12.8cm).All of them have a short build before operation:The standard deviation score(SDS) of average height was - 1.9±0.2(- 2.7 to - 1.3 ),and the growth velocity(GV) of 5 cases was 1.4±0.1 cm/year. Three months after operation,the weight was increased by an average of 1.1 kg,and GV was 4.4±0.1 cm/year(n = 6).Six months later,GV reached 7.4±0.3 cm/year(n = 6,P<0.05 ) and the SDS of average height reached - 1.0±0.3(- 1.1 to -0.4).Two cases were misdiagnosed as nonfunctional islet cell tumor and four case was misdiagnosed as mucinous cystadenoma,serous tumor,pancreatic cancer,and pseudocyst,respectively.In addition,2 cases were misdiagnosed as growth hormone deficiency and 1 case was misdiagnosed as pituitary tumor.Conclusions SPTP is a rare intraperitoneal tumor mainly affects young adults and adolescents.It should be differentiated from nonfunctional islet cell tumor,mucinous cystadenoma,serous tumor,pancreatic cancer,and pseudocyst.Retarded development of patients with SPTP and FLC can be reversed after surgical operation.

Background and Aims. The onco-protein c-fos was previously linked to favorable prognosis of gastric cancer (GC) without further validations. The present study was designed to address the issue based on a cohort of Chinese patients.Methods. Expression of c-fos was determined by immunohistochemical staining in specimens from 58 patients with GC who underwent surgical resection. The relationships between c-fos expression and clinicopathological and prognostic variables were further evaluated.Results. Expression of c-fos in tumor epithelia was observed in 39 (67.2%) patients. The protein was also positively expressed in lymphocytes within tumors and para-tumor epithelia. Tumors with positive expression of c-fos in tumor epithelia had a smaller size and marginally earlier T stage in all patients and/or those who underwent curative resection. Univariate analysis showed that patients with positive c-fos expression in tumor epithelia had significantly prolonged overall and tumor-free survival. Cox regression analysis revealed that c-fos expression in tumor epithelia was an independent or potential independent indicator of improved prognosis in different subgroups of patients. Expression of c-fos in para-tumor epithelia and intra-tumor lymphocytes was not associated with clinicopathological variables and long-term outcomes in patients.Conclusions. Our data demonstrated that c-fos expression was negatively associated with tumor progression and was predictive for favorable survival in patients with GC. (C) 2010 IMSS. Published by Elsevier Inc.

胃癌是常见的恶性肿瘤,其发病机制研究一直是研究的热点。c-Fos是1983年被克隆的一种癌基因,与c-Jun蛋白结合,形成AP-1复合物,调控下游多种肿瘤相关基因的转录水平。c-Fos与肿瘤发生的相关性已经在多种恶性肿瘤中得到证实。c-Fos在胃癌发生中的作用尚不十分明确。本文就近年来c-Fos在胃癌中的相关研究作一综述。

OBJECTIVE:To investigate the prevalence of abnormity of blood lipid and associated factors in healthy population in Beijing.METHODS:Totally, 38462 individuals who received health examination were enrolled in our study. We divided them into eight groups according to their ages. The levels of serum total cholesterol, triglyceride, high density lipoprotein cholesterol, and low density lipoprotein cholesterol were tested, and the relationship of blood lipid abnormity with body mass index (BMI) and fasting blood glucose was analyzed.RESULTS:The incidences of hypercholesterolemia, hyperglyceridemia, low high-density lipoprotein cholesterolemia, and hyper low-density lipoprotein cholesterolemia presented increasing trend in this population. The incidence rate of abnormity of blood lipid in health examination population increased with BMI increase. The incidence of abnormity of blood lipid in overweight and obesity population was significantly higher than that in low weight and normal weight populations (P<0.05). Meanwhile, the trend of abnormal blood lipid incidence coincided with that of abnormal fasting blood glucose.CONCLUSIONS:The prevalence of overweight, obesity, and abnormity of blood lipid in Beijing presents increasing trend. The incidence of abnormity of blood lipid increases with BMI increase, in coincidence with that of fasting blood glucose.

ObjectiveTo investigate the prevalence of metabolic syndrome (MS) and its associations with other metabolic disorders and cardiovascular changes in health examination population in Beijing.MethodsTotally, 10 916 individuals who received health examination in Health Examination Center of Peking Union Medical College Hospital were enrolled. The height, weight, blood pressure, serum levels of triglyceride, high-density lipoprotein cholesterol (HDL-C), and fasting blood glucose were recorded. MS was diagnosed based on the working criteria of Chinese Diabetes Society 2004 (CDS2004). Meanwhile, other metabolic disorders, including fatty liver and hyperuricemia, were recorded. The cardiovascular changes were reflected by the reports of electrocardiogram (ECG) ST-T changes and atherosclerosis of retinal arteries.ResultsThe overall prevalence rate of MS was 6.1% (666/10 916) in the population. The prevalence rate of MS in male was much higher than that in female (9.0% vs. 2.7%, P=0.000). For individuals with MS, the prevalence rates of fatty liver and hyperuricemia were significantly higher than those without MS, respectively (70.4% vs. 35.4%, P=0.000; 29.9% vs. 17.7%, P=0.000). As for cardiovascular changes, the prevalence rates of ECG ST-T changes and atherosclerosis of retinal arteries were significantly higher in individuals with MS than those without MS, respectively (13.8% vs. 11.7%, P=0.012; 12.0% vs. 6.8%, P=0.000).ConclusionsThe prevalence of MS in Beijing population is high. The individuals with MS have a higher risk for other metabolic disorders and cardiovascular changes.

Objective: To study the fasting blood glucose level and associated factors relationship in physical examination population in Beijing. Methods: Totally 38 462 individuals who received physical examination from April 2006 through December 2007 in Peking Union Medical College Hospital physical examination center were enrolled in our study.We divided them into 8 groups according to the age,and the level of fasting blood glucose was tested.The relationship between BMI,age,sex and abnormity of blood glucose were analysed. Results: The incidences of overweight and obesity were 36.4% and 13.5%,respectively.The incidences of impaired fasting glucose and diabetes mellitus were 3.2% and 3.8%,respectively.The rate of abnormal glucose level increased with age and BMI.Compared to male,female persons had lower fasting blood glucose level and lower rate of abnormality(P =0.000).Compared to normal and thin population,overweight and obesity population had higher rate of fasting glucose abnormality(P < 0.05). Conclusion: The fasting blood glucose level and its abnormity rate correlates with sex,age and BMI.

Objective To study the relationship between body mass index(BMI) and incidence of blood lipid abnormity in physical examination population aged more than 18 years old in Beijing.Methods Totally 38 462 individuals who received routine physical examination from April 2006 to December 2007 in Peking Union Medical College Hospital were enrolled in our study.We divided them into eight groups according to their ages,tested the levels of serum total cholesterol,triglyceride,high-density lipoprotein cholesterol,and low-density lipoprotein cholesterol,and analyzed the relationship between BMI and incidence of blood lipid abnormity.Results The incidence of overweight and obesity in adults(≥18 years) in Beijing was 47.8%.BMI increased along with the increase of age,reached the peak in 51-60-year-old group,and then decreased gradually.The incidences of hypercholesterolemia,hyperglyceridemia,low high-density lipoprotein cholesterolemia,and hyper low-density lipoprotein cholesterolemia were 7.0%,16.5%,12.5%,and 10.7%,respectively.The incidence of abnormity of blood lipid in physical examination population increased with the increase of BMI.The incidence of abnormity of blood lipid in the overweight and obesity population was significantly higher than that in low weight and normal populations(P0.05).Conclusions The prevalences of overweight,obesity,and abnormity of blood lipid in Beijing tend to increase in recent years.The incidence of abnormity of blood lipid increases with the increase of BMI.

目的 观察前列腺素E1(PGE1)对糖尿病肾病(DN)患者尿微量白蛋白及肾功能近期疗效.方法 选择早期DN患者83例,随机分为两组.观察组42例,在原来治疗基础上给予Lipo PGE1(前列腺素E1脂微球)10 μg加入生理盐水20 ml静脉注射,每天1次,连续3周;对照组41例,进入试验后维持原治疗不变,其降糖、降压、调脂等治疗情况与观察组基本一致.两组患者入组前调整降压药和降糖药,使血压维持在110～135/70～85 mm Hg,空腹血糖维持在4.0～7.0 mmol/L,并稳定2周进入试验.所有患者在治疗前、治疗3周结束和治疗后12周时均检测尿微量白蛋白排泄率(UAE)、血糖(FBG)、血尿素氮(BUN)、血肌酐(Scr)、糖化血红蛋白(HbA1c)等.结果 应用Lipo PGE1治疗3周时就能明显降低早期DN患者的尿微量白蛋白,逆转异常的肾功能,而且此作用在停药12周后仍然很明显,对照组则无此变化.结论 Lipo PGE1是治疗早期DN起效迅速、安全且作用较持久的药物。