ABSTRACT The survival benefit of neoadjuvant chemotherapy (Neo‐CT) among male breast carcinoma (MaBC) remains unclear, and the specific population that can benefit from Neo‐CT is also not yet defined. We utilized the data from the National Cancer Institute's Surveillance, Epidemiology, and End Results (SEER) database and employed Kaplan–Meier analysis; Cox proportional hazards model and binary variable Logistic regression were performed to evaluate the effect of Neo‐CT on the therapeutic response and prognosis of MaBC patients. Among the 4171 MaBC subjects included, 194 (4.7%) patients received Neo‐CT only (Neo‐CT only group), 246 (5.9%) cases received adjuvant chemotherapy and Neo‐CT (CT + Neo‐CT group); the remaining 3731 (89.5%) cases received postoperative chemotherapy only (CT‐only group). Totally, 20 (12.12%) participants achieved pathological complete response (pCR). And patients who achieved a pCR (pCR subgroup) had improved 5‐year and 10‐year overall survival (OS) (100.0% vs. 79.70% vs. 73.81%, 100.0% vs. 59.12% vs. 28.82%, respectively) and breast cancer‐specific survival (BCSS) (86.30% vs. 91.49%, 69.04% vs. 83.32%, respectively) in comparison with those in the Non‐pCR subgroup. Further binary Logistic regression analysis showed that the achievement of pCR might be related to stage I‐II (p = 0.007) and hormone receptor (HR) negative (p = 0.010) disease, and the pCR rate of stage I‐II and HR− MaBC patients was 66.67%.

Background Recent advancements in breast cancer management have focused on de-escalating axillary surgery to minimize morbidity and improve quality of life, without compromising survival outcomes. Prior clinical trials have provided evidence supporting the use of less extensive axillary procedures in patients with favorable characteristics. However, research and evidence regarding optimal axillary lymph node surgical decisions after neoadjuvant systemic therapy (NAS) remain limited. Our study aimed to identify key factors in a real-world setting that predict the feasibility of omitting axillary surgery following NAS in clinically node negative (cN0) and clinically staged N1 (cN1) breast cancer. Methods We retrospectively analyzed 1068 clinical N0-1 breast cancer patients who received NAS followed by surgery. Univariable and multivariable logistic regression analyses were used to identify clinicopathological predictors for: (1) ypN0 after NAS in newly diagnosed cN0 patients, which could guide sentinel lymph node biopsy (SLNB) omission; and (2) ypN0 after NAS in newly diagnosed cN1 patients, which could guide axillary lymph node dissection (ALND) omission. Results In newly diagnosed cN0 patients (n = 302), 274 (90.7%) achieved ypN0. Achieving radiological partial response (rPR) after NAS (odds ratio (OR), 0.27; 95% CI, 0.11–0.65; P = 0.003) was associated with a higher ypN0 rate, suggesting potential for SLNB omission. Conversely, higher clinical T stage (cT3-4) (OR, 3.06; 95% CI, 1.11–8.39; P = 0.030) and estrogen receptor (ER) positivity (OR, 3.94; 95% CI, 1.24–12.54; P = 0.020) were associated with a lower ypN0 rate, indicating a tendency towards retaining SLNB. In newly diagnosed cN1 patients (n = 766), the ypN0 rate was 50.3% (385/766). Human epidermal growth factor receptor 2 (HER2) positivity (OR, 0.34; 95% CI, 0.25–0.48; P < 0.001), achieving rPR (OR, 0.38; 95% CI, 0.24–0.59; P < 0.001), and achieving radiological complete response (rCR) (OR, 0.06; 95% CI, 0.02–0.14; P < 0.001) were associated with a higher ypN0 rate, potentially allowing for selective ALND omission. However, tumors located in the central quadrant (OR, 2.99; 95% CI, 1.05–8.50; P = 0.040), along with ER positivity (OR, 1.82; 95% CI, 1.16–2.84; P = 0.009), progesterone receptor (PR) positivity (OR, 1.67; 95% CI, 1.08–2.56; P = 0.020) and invasive breast carcinoma of special type (IBC-ST) (OR, 2.76; 95% CI, 1.05–7.22; P = 0.039) were associated with a lower ypN0 rate, suggesting caution in omitting ALND. Conclusion For newly diagnosed cN0-1 breast cancer patients undergoing NAS, the post-NAS radiological assessment was a critical factor in guiding axillary surgical management decisions. Furthermore, in newly diagnosed cN1 patients, HER2 positivity was also associated with a higher ypN0 rate, which may inform the omission of ALND.

The critical role of protein disequilibrium in driving carcinogenesis has long been recognized. Though several inhibitors of heat shock protein (HSP) family members have entered clinical trials, none of them have been approved for clinical use as a result of inevitable toxicity, leading to the identification of safer therapeutic approaches sharing a similar efficacy relevant and urgent. Through delineating the role of HSP90 inhibitors in arresting cancer hallmarks, this paper identified HSP90 inhibition as an effective therapeutic strategy capable of concomitantly targeting multiple key transformed properties of cancers via modulating cellular proteostasis. Through interrogating intrinsic connections between proteostasis and redox homeostasis, this paper proposed cold atmospheric plasma (CAP) as a possible alternative of HSP90 inhibitors with little adverse effects. This paper extended the therapeutic spectrum of HSP90 inhibitors and CAP to inflammation-driven pathologies including autoimmune diseases, as inflammation is a manifestation of failed proteostasis. These insights may conceptually advance our understandings on the driving force of cancers that can be easily extended to other disorders originated from imbalanced proteostasis and abnormal inflammation. Tools proposed here for inhibiting HSP90 including CAP and its possible synergy with HSP90 inhibitors may shift the current treatment paradigm to a new avenue in oncology and other relevant fields.

The breast cancer specific survival (BCSS) benefits of Neoadjuvant therapy (NeoAT) for triple-negative metaplastic breast cancer (TNMpBC) was uncertain. This study aimed to develop a prediction model for assessing the BCSS for TNMpBC patients with NeoAT. The primary cohort of 1163 patients with TNMpBC, from which a nomogram was established based on the results of a LASSO regression analysis, was derived from multi-centers data in China and the SEER database. This model was further validated by an independent cohort of 155 TNMpBC patients with NeoAT, with discrimination and calibration assessed. Totally 155 (13.3%) TNMpBC patients received NeoAT, with 45 (29.0%) cases demonstrating pathologic complete response (pCR), were enrolled. Subjects acquired pCR had superior BCSS. Four variables significantly associated with BCSS were incorporated in the establishment of model: age at diagnosis, T stage, N stage, and response to NeoAT. This model was well validated, with a C-index of 0.82, and area under the curves of 0.838, 0.866 in training cohort, respectively, for 3- years and 5-years BCSS. Based on the cutoff scores from the TNMpBC-NeoBCSS model and calculated by X-tile analysis, patients in high risk group had a inferior BCSS (HR = 6.77, P < 0.0001) when compared with those in low-risk group. TNMpBC-NeoBCSS model provides a favorable tool for assessing the BCSS for the TNMpBC patients with NeoAT and may help doctors and TNMpBC patients optimally make decision on the necessity of neoadjuvant therapy on the basis of individual BCSS.

Invasive breast carcinoma of no special type (IBC-NST) with medullary pattern is a rare histological subtype, accounting for 3–5

BACKGROUND:We assessed the potential role of serial circulating tumor DNA (ctDNA) as a biomarker to monitor treatment response to primary systemic therapy (PST) in breast cancer and evaluated the predictive value of ctDNA to further identify patients with residual disease. METHODS:We prospectively enrolled 208 plasma samples collected at three time points (before PST, after 2 cycles of treatment, before surgery) of 72 patients with stage Ⅱ-III breast cancer. Somatic mutations in plasma samples were identified using a customized 128-gene capture panel with next-generation sequencing. The correlation between early change in ctDNA levels and treatment response or long-term clinical outcomes was assessed. RESULTS:37 of 72 (51.4%) patients harbored detectable ctDNA alterations at baseline. Patients with complete response showed a larger decrease in ctDNA levels during PST. The median relative change of variant allele fraction (VAF) was -97.4%, -46.7%, and +21.1% for patients who subsequently had a complete response (n = 11), partial response (n = 11), and no response (n = 15) (p = 0.0012), respectively. In addition, the relative change of VAF between the pretreatment and first on-treatment blood draw exhibited the optimal predictive value to tumor response after PST (area under the curve, AUC = 0.7448, p = 0.02). More importantly, early change of ctDNA levels during treatment have significant prognostic value for patients with BC, there was a significant correlation between early decrease of VAF and longer recurrence-free survival compared to those with an VAF increase (HR = 12.54; 95% CI, 2.084 to 75.42, p = 0.0063). CONCLUSION:Early changes of ctDNA are strongly correlated with therapeutic efficacy to PST and clinical outcomes in BC patients. The integration of preoperative ctDNA evaluation could help improving the perioperative management for BC patients receiving PST.

Abstract As a crucial therapeutic regimen, the popularity of breast reconstruction surgery (BRS) has partly been driven by the rise in the utilization of neo-adjuvant therapy (Neo-AT). However, few studies have specifically examined the survival outcome for patients underwent BRS after Neo-AT. This study aimed to investigate and elucidate the survival benefit of neo-adjuvant therapy (Neo-AT) and adjuvant therapy (AT) among the women who underwent BRS. A total of 18919 patients were obtained from the Surveillance, Epidemiology, and End Results (SEER) database between 2007 and 2020. Kaplan-Meier, Cox regression model, and propensity score matching (PSM) analyses were employed to identify the predictors associated with the survival. A nomogram was developed using the variables selected by multivariable Cox analysis to predict short and long-term probabilities of BCSS. In this study, the administration of Neo-AT was founded to be associated with a worse prognosis in comparison with AT. This model is anticipated to offer precise and personalized prediction in BCSS, aiding in treatment decision-making.

Objective To explore the application value of the workshop practice teaching method based on target-oriented study modules on the internet in orthopedic rehabilitation. Methods Thirty interns (2019-2020) in the rehabilitation department of our hospital were selected as the control group, another thirty interns (2021) in the rehabilitation department of our hospital were selected as the experimental group, and their materials were retrospectively reviewed. Both groups were given the three-month practice teaching. Besides, the conventional practice teaching method was applied to the control group, and the workshop practice teaching method based on target-oriented study modules on the internet was applied to the experimental group. After the practice teaching, the united examination paper and assessment table of the rehabilitation operation process were used to evaluate the interns' scores of theoretical knowledge about orthopedic rehabilitation, scores of practical skills, and comprehensive scores of clinical practice in the two groups. The evaluation team consisting of 5 guiding experts in the scientific research office assessed the teaching quality of the two methods. Results Compared with the control group, the experimental group had a notably higher score of theoretical knowledge about orthopedic rehabilitation, higher score of practical skills, and higher comprehensive score of clinical practice (92.47 ± 4.81 vs. 86.43 ± 5.12, 91.30 ± 5.68 vs. 81.53 ± 7.21, and 91.88 ± 2.45 vs. 83.98 ± 4.42, P < 0.001). According to the evaluation team, the teaching quality of the experimental group was observably higher than that in the control group (P < 0.05), and there was no remarkable difference in the scores of teachers' performance between the two groups (P > 0.05). Conclusion The workshop practice teaching method based on target-oriented study modules on the internet, as a high-quality “Internet+” practice teaching mode, can improve the orthopedic interns' scores of theoretical knowledge and practical operation ability and enhance their comprehensive qualities of orthopedic rehabilitation in all respects.

后疫情时代,医疗机构与政府及社会组织通力合作、合力突围,才能将危机变为转机,在抗疫中推进现代化治理和高质量发展.本研究以西安交通大学第一附属医院为例,分析了疫情期间医院利用权威部门网站搭载微信、微视、微博和其他宣传媒介形成的"一网三微+N"的全媒体传播矩阵,探析其在科学化、精细化管理的同时如何打造走心、入心、有温度、有情怀的宣传品牌,实现在抗"疫"中育人、在战"疫"中担当、在研"疫"中引领的专业目标.

为了增强医学研究生的学术交流,提高其科研创新能力,营造良好的学术氛围,形成奋发向上的科研进取精神,西安交通大学第一附属医院以在校研究生为主体,采用优秀学术壁报展、青年学术讲座、优博之路讲座等形式举办"研究生学术月"活动.这项活动不仅提升了医学研究生的科研能力、创新能力、表达和协作能力,而且提高了研究生的整体素质;但是,这项活动仍存在形式单调、缺乏自我管理等问题:因此,高校研究生学术活动应创新活动的形式与内容,加强自我管理,加大奖励机制."研究生学术月"活动对培养高素质的医学人才起到了积极推动作用.

Background: The progressive, multifactorial and multistep dynamic process of metastasis is the primary cause of breast cancer (BC) lethality. PROX1 (Prospero-related homeobox 1), as a type of transcription factor that plays a key role in the formation of lymphatic vessels in animal embryonic development, has been proven to promote or suppress cancer in a variety of malignant tumors. However, molecular mechanisms behind PROX1 induced breast cancer metastases remain elusive. Methods: Changes of PROX1 expression and clinical significance of PROX1 in BC were evaluated by BC tissue, as well as public database. The functional role of PROX1 in metastases BC was analyzed by transwell assay in vitro, and by lung metastases model of nude mice in vivo via lentivirus mediated knockdown assays. Mechanism studies were performed by public database screening, western blot and PCR assay, immunoprecipitation, immunofluorescence staining and luciferase promoter assays. Results: In this study, we found that PROX1 was upregulated in breast cancer tissues; increased PROX1 expression in breast cancer was associated with tumor size, lymph node metastasis, ER and PR status. Meanwhile, PROX1 can promote breast cancer invasion and metastasis in vitro and in vivo. Furthermore, PROX1 can interact with hnRNPK to activate WNT/β-catenin signaling in breast cancer cells. Moreover, the interaction of PROX1 and hnRNPK inhibits the ubiquitination of hnRNPK, and subsequently activates WNT pathway to promote the invasion and metastasis of breast cancer. Conclusions: In conclusion, our findings indicated PROX1 contributes to breast cancer EMT and metastasis and serves as a candidate diagnostic biomarker and promising therapeutic target for breast cancer.

目的 探讨问题教学法(PBL)结合案例教学法(CBL)在基层医师乳腺癌筛查诊断技能培训中的应用效果.方法 选取参加第5届(2018—2019年)基层医师骨干进修班的50名基层医师作为对照组,参加第6届(2019—2020年)基层医师骨干进修班的50名基层医师作为试验组.对照组采用传统教师授课(LBL)教学法,试验组采用PBL结合CBL教学法.比较两组学员的考试成绩和教学满意度.结果 试验组的理论成绩及实践成绩均高于对照组(P<0.05).试验组的教学满意度各项评分及总分均高于对照组(P<0.05).结论 PBL结合CBL教学法应用于基层医师乳腺癌筛查诊断技能培训中,能够有效提高基层医师的综合能力及教学满意度,值得在临床带教中推广.

Background: The role of surgery and surgery type in de novo stage IV breast cancer (BC) is unclear. Methods: We carried out a retrospective cohort study that included the data of 4,108 individuals with de novo stage IV BC abstracted from SEER (Surveillance, Epidemiology, and End Results) data resource from 2010 to 2015. The patients were stratified into the non-surgery group, breast-conserving (BCS) surgery group, and mastectomy group. Inverse probability propensity score weighting (IPTW) was then used to balance clinicopathologic factors. Overall survival (OS), as well as the breast cancer-specific survival (BCSS), was assessed in the three groups using Kaplan–Meier analysis and COX model. Subgroups were stratified by metastatic sites for analysis. Results: Of the 4,108 patients, 48.5% received surgery and were stratified into the BCS group (574 cases) and mastectomy group (1,419 cases). After IPTW balance demographic and clinicopathologic factors, BCS and mastectomy groups had better OS (BCS group: HR, 0.61; 95% CI: 0.49–0.75; mastectomy group: HR, 0.7; 95% CI: 0.63–0.79) and BCSS (BCS group: HR, 0.6; 95% CI, 0.47–0.75; mastectomy group: HR, 0.71; 95% CI, 0.63–0.81) than the non-therapy group. Subgroup analyses revealed that BCS, rather than mastectomy, was linked to better OS (HR, 0.66; 95% CI: 0.48–0.91) and BCSS (HR, 0.63; 95% CI: 0.45–0.89) for patients with bone-only metastasis. For patients with viscera metastasis or bone+viscera metastases, BCS achieved similar OS (viscera metastasis: HR, 1.05; 95% CI: 0.74–1.48; bone+viscera metastases: HR, 1.01; 95% CI: 0.64–1.61) and BCSS (viscera metastasis: HR, 0.94; 95% CI: 0.64–1.38; bone+viscera metastases: HR, 1.06; 95% CI: 0.66–1.73) in contrast with mastectomy. Conclusions: Local surgery for patients with distant metastasis (DS) exhibited a remarkable survival advantage in contrast with non-operative management. BCS may have more survival benefits for patients with de novo stage IV BC with bone-only metastasis than other metastatic sites. Decisions on de novo stage IV BC primary surgery should be tailored to the metastatic pattern.

目的 探讨乳腺癌患者重返工作的工作心理负荷现状及其影响因素.方法 使用方便抽样,选取2018年2-12月在西安交通大学第一附属医院门诊复查和参加病友联谊会的433例乳腺癌患者作为研究对象.使用基本资料调查表、任务负荷指数量表、领悟社会支持量表和记忆症状评估量表简表收集资料.结果 乳腺癌患者重返工作的工作心理负荷得分为54.68±11.19,领悟社会支持得分为56.74±10.12,总体困扰指数为28.43±7.22.多元线性回归结果显示,总体困扰指数、病休时间、领悟社会支持、锻炼情况和年龄可影响乳腺癌患者重返工作的工作心理负荷,且可解释总变异的52.9％.结论 临床医务工作者应关注乳腺癌患者重返工作的心理负荷状况,尤其是年龄较大的患者,提高患者对乳腺癌症状群的认识,鼓励患者每天适度锻炼,调动社会支持系统,以降低其工作期间的心理负荷水平,提高生活质量.

To date, anatomic tumor length is a key criterion for cancer staging and can be used to evaluate the effectiveness of therapies. This article describes growth pattern that can be used as a new characteristic to represent disease burden and tumor features and predict lymphatic metastasis. Patients with breast cancer were included in this 10-year (1999–2008) hospital-based multicenter retrospective study. The pathologic length/height ratio was used to illustrate the correlation between tumor features, behaviors and treatments in breast malignancies. The most appropriate ratio was chosen based on the comprehensive evaluation of p value and changing trend of each characteristic. The sample consisted of 4211 women diagnosed with breast cancer. Among them, 2037 patients with complete pathologic length, width and height information were included in the final analysis. There were 2.34 ± 4.77 metastatic lymph nodes for spheroid tumors and 3.21 ± 5.82 for ellipsoid tumors when the cutoff point was 2. In addition, the proportion of ellipsoidal tumors gradually increased from 54.36 to 56.67% in the upper outer quadrant (UOQ) and from 6.7 to 9.03% in the central region with an increase in the cutoff point. The proportion of ER + PR + ellipsoid tumors significantly decreased from 50.1 to 45.35% and that of ER–PR ellipsoid tumors significantly increased from 32.73 to 36.24% with an increase in the cutoff point. Additionally, the best length/weight ratio to distinguish spheroid and ellipsoid tumors was 2. This study described for the first time how growth pattern is correlated with tumor malignancy and how it influences the selection of therapeutic strategies for patients.

Background. The homeobox gene family, encoding a specific nuclear protein, is essential for embryonic development, differentiation, and homeostasis. The role of the HOXB3 protein varies in different tumors. This study aims to explore the role of the HOXB3 gene in breast cancer. Method. Differentially expressed genes were screened by analyzing metastatic breast cancer gene chip data from TCGA and GEO databases. The function of the selected HOXB3 gene was also analyzed in different databases and through molecular biology methods, such as qRT-PCR, western blot and IF to verify bioinformatics findings. Results. Both bioinformatics analyses and western blot showed that HOXB3 was lost in breast cancer compared to normal breast tissue. Survival analysis also showed that lower expression of HOXB3 was associated with poor prognosis. Bioinformatics analyses further showed that HOXB3 was positively correlated with hormone receptors. Metas-cape for GO analysis of GEO data provided possible mechanisms that HOXB3 could positively regulate cell adhesion, inhibit cell proliferation and activate immune response in breast cancer; moreover, GSEA included several cancer-associated pathways. Conclusion. In summary, HOXB3 expression was decreased in breast cancer, and it was associated with poor prognosis. It might become a new biomarker to predict prognosis of breast cancer.

目的 探讨年轻乳腺癌患者的依恋现状,并分析其对生育忧虑的影响.方法 使用方便抽样,选取2017年1-12月间,参加西安市2所三甲医院乳腺肿瘤病友联谊会和门诊随访复查的264例年轻乳腺癌患者作为研究对象.使用基本资料调查表,癌症后生育忧虑量表和亲密关系体验问卷进行调查.结果 研究对象的生育忧虑总分为57.49±6.11,依恋回避得分为3.31±0.74,依恋焦虑得分为3.54±0.85.安全型依恋人数为105人,占39.8％.经多元线性回归分析,生育意愿、依恋焦虑、化疗疗程和宗教信仰可影响年轻乳腺癌患者的生育忧虑水平.结论 医务工作者应关注年轻乳腺癌患者的生育忧虑状况,了解患者的生育意愿、依恋类型和社会支持状况,有针对性地进行干预,降低其生育忧虑水平,提高患者生活质量.

目的 探讨自我强化管理教育对于经外周静脉穿刺置人中心静脉导管(PICC)化疗的乳腺癌病人带管期间自我管理能力的影响.方法 乳腺癌病人130例,均行PICC化疗.采用随机数字表法将130例病人分为强化组和对照组,每组各65例,强化组给予自我强化管理教育措施干预,对照组仅给予一般护理及指导,观察两组干预前后的PICC自我管理能力(CPPSM)量表评分、PICC留置时间、带管期间并发症率.结果 干预前,强化组和对照组的日常生活管理、维护依从性管理、运动管理、信息获取、日常导管观察、异常情况处理、导管管理信心及CPPSM评分比较差异均无统计学意义(P＞0.05);干预后,强化组的日常生活管理、维护依从性管理、运动管理、信息获取、日常导管观察、异常情况处理、导管管理信心及CPPSM评分均高于对照组(P＜0.05);强化组的平均带管时间长于对照组(P＜0.05);强化组的并发症率为1.59％,对照组为11.48％,两组比较差异有统计学意义(P＜0.05).结论 自我强化管理教育可提升PICC化疗的乳腺癌病人带管期间自我管理相关评分,降低并发症发生率.

ATP-binding cassette sub-family G member 2 (ABCG2) confers to the major phenotypes of side population (SP) cells, the cancer stem-like cells. In this study, the SP cells displayed a distinctly higher ABCG2 expression level, sphere formation efficiency (SFE) and growth rate even under hypoxia condition. CXCR4 overexpression by pcDNA-CXCR4 transfection robustly increased ABCG2 expression, and promoted SFE and growth of hypoxic SP cells, while CXCR4 inhibitor AMD3100 could suppress the promotion. Additionally, we found that CXCR4 promoted the expression of c-Jun, a major gene in the oncogenic JNK/c-Jun pathway. Our data on electrophoretic mobility shift assay (EMSA) and chromatin immunoprecipitation (ChIP) assays both showed that c-Jun directly bound with the ABCG2 promoter sequence. Moreover, overexpression of JNK/c-Jun promoted ABCG2 expression, SFE, and growth of hypoxic SP cells and the promotion could be rescued by c-Jun inhibitor SP600125. In conclusion, CXCR4 increases the growth and SFE of breast cancer SP cells under hypoxia through c-Jun-mediated transcriptional activation of ABCG2.

Objective To analyze the diagnostic efficiency of sentinel lymph node biopsy (SLNB) for axillary lymph node metastasis in early invasive breast cancer and its application value in breast-conserving surgery.Methods The clinical data of 217 patients with early invasive breast cancer treated in Xianyang Central Hospital from July 2012 to May 2105 was analyzed retrospectively.All the patients underwent SLNB and breast-conserving surgery.The diagnostic efficiency of SLNB for axilla~ lymph node metastasis was analyzed taking postoperative pathology as gold standard.At the same time,the SLNB-negative patients were divided into two groups according to the patients' will:the patients in control group underwent axillary lymph node dissection,while the patients in observation group didn't undergo axillary lymph node dissection.The operation situations,postoperative outcome,and quality of life were compared between the two groups.Results The sensitivity,specificity,missed diagnostic rate,misdiagnostic rate,and accurate rate of SLNB for diagnosis of axillary lymph node metastasis were 92.1％,100.0％,7.9％,0.0％,and 94.4％,respectively.Compared with control group,the operation time in observation group was shorter,the intraoperative bleeding volume and postoperative drainage volume were less,and the drainage tube extubation time was earlier,there were statistically significant differences (P＜0.05).The incidence rate of complications in observation group was statistically significantly lower than that in control group (P＜0.05).There was no statistically significant difference in recurrence rate,metastasis rate,and mortality rate between the two groups (P＞0.05).Before treatment,there was no statistically significant difference in EORTC QLQ-C30 and QLQ-BR23 scores between the two groups (P＞0.05).After treatment,function and symptom scores in observation group were statistically significantly lower than those in control group,while the total score of life quality in observation group was statistically significantly higher than that in control group,there were statistically signific ant differences (P＜0.05).Conclusion The diagnostic efficiency of SLNB for axillary lymph node metastasis in early invasive breast cancer patients is high,SLNB can reduce postoperative complications of breast-conserving surgery and improve the quality of life,which has high application value.