ChemInformVolume 21, Issue 5 Heterocyclic Compounds ChemInform Abstract: Synthesis and Radioprotective Activity of 2-Amino-4-oxo-5-aminomethylthiazoline and 2-Amino-4-oxo-5-aminoethylthiazoline. A. A. MANDRUGIN, A. A. MANDRUGIN Khim. fak. Mosk. gos. univ. im. LomonosovaSearch for more papers by this authorA. A. RODYUNIN, A. A. RODYUNIN Khim. fak. Mosk. gos. univ. im. LomonosovaSearch for more papers by this authorV. M. FEDOSEEV, V. M. FEDOSEEV Khim. fak. Mosk. gos. univ. im. LomonosovaSearch for more papers by this authorM. M. KONSTANTINOVA, M. M. KONSTANTINOVA Khim. fak. Mosk. gos. univ. im. LomonosovaSearch for more papers by this authorG. V. DONTSOVA, G. V. DONTSOVA Khim. fak. Mosk. gos. univ. im. LomonosovaSearch for more papers by this authorO. N. RAKHMANINA, O. N. RAKHMANINA Khim. fak. Mosk. gos. univ. im. LomonosovaSearch for more papers by this author A. A. MANDRUGIN, A. A. MANDRUGIN Khim. fak. Mosk. gos. univ. im. LomonosovaSearch for more papers by this authorA. A. RODYUNIN, A. A. RODYUNIN Khim. fak. Mosk. gos. univ. im. LomonosovaSearch for more papers by this authorV. M. FEDOSEEV, V. M. FEDOSEEV Khim. fak. Mosk. gos. univ. im. LomonosovaSearch for more papers by this authorM. M. KONSTANTINOVA, M. M. KONSTANTINOVA Khim. fak. Mosk. gos. univ. im. LomonosovaSearch for more papers by this authorG. V. DONTSOVA, G. V. DONTSOVA Khim. fak. Mosk. gos. univ. im. LomonosovaSearch for more papers by this authorO. N. RAKHMANINA, O. N. RAKHMANINA Khim. fak. Mosk. gos. univ. im. LomonosovaSearch for more papers by this author First published: January 30, 1990 https://doi.org/10.1002/chin.199005182Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat No abstract is available for this article. Volume21, Issue5January 30, 1990 RelatedInformation

It has been established using hemopoietic bone marrow cells or EHrlich ascites carcinoma cells that endogenous glutathione affects the realization of only those lesions which appear in response to an increase in radioresistance, for example during anoxia. The involvement of glutathione in the realization of the oxygen effect is not limited to the time of irradiation. The effect of glutathione extends to the postirradiation period i. e., it is not determined only by the competition with oxygen for target radicals.

AbstractDas 3‐Aminobutanol (I) wirUdurch Umsetzung mit Thionylbromid und anschließend Thioharnstoffin das Isothiuroniumsalz (III) umgewandelt und durch Erhitzen in Wasser zum Dihydrothiazin (IV) cyclisiert.

Sublethal irradiation of donors leads to a change in some properties of bone marrow haemopoietic stem cells (HSC) during the exponential growth (days 1-8) of the syngeneic recipients in the spleen. They are: an increase in the rate of proliferation, a slight reduction in time of the population doubling, and a tendency toward an increase in the percentage of cells settled in the spleen after transplantation. These changes in the properties of HSC provide a more rapid repopulation thereof as compared to HSC of intact mice. In all appearance, a pretreatment of donors with AET and 2ADT does not influence the HSC changes induced by radiation, and, at the same time, retains the number of HSC at a high level.

The effect of 2-amino-2-thiazoline (2-AT) on radiosensitivity of mice, their haemopoietic system status, and GFUc has been studied. 2-AT was shown to contribute to the survival of an increased number of haemopoietic stem cells, earlier recovery of bone marrow cellularity, and normalization of the spleen weight.

Mice were injected with serotonin (0.5 and 2.0 mg/mouse) 15 min before and immediately after irradiation (4.5 and 7.0 Gy). With the preparation administered prior to irradiation one could observe an increase in the quantity of CFUc survived (endo- and exo-test), acceleration of restoration of cellularity (in the bone marrow) and growth of the spleen weight. The acceleration of restoration of the bone-marrow cellularity was also noted when serotonin was administered after irradiation. The post-irradiation effect of serotonin was also detected in cells in vitro. It is concluded that the radiomodifying effect of serotonin on the haemopoietic system is due to a decrease in the number of damaged cells and increase in the rate of reproduction of intact cells.