目的:分析低位直肠癌保肛术围术期应用行为分阶段改变理论护理对患者术后排便功能、生活质量的影响作用.方法:低位直肠癌保肛术患者取样80例,入院时间2020年05月至2022年05月,顺序编码分组,给予常规组常规护理(n=40),理论组基于行为分阶段改变理论实施护理干预(n=40),对比FIQL、满意度评分,观察术后排便功能、肛肠动力学指标恢复情况.结果:护理后,理论组FIQL量表窘迫尴尬(3.25±0.49)分,生活方式(3.42±0.30)分,心理应付/行为(3.61±0.30)分,抑郁/自我感受(3.5

Objective:To develop the Peristome Skin Injury Risk Assessment Scale and to verify its reliability, validity and predictive performance in patients with colorectal cancer stoma.Methods:The initial assessment scale was developed through literature review and Delphi expert consultation. From February 2020 to April 2021, convenient sampling was used to select 290 cases of colorectal cancer stoma patients who were reexamined in the Oncology Surgery of the First Affiliated Hospital of Xi'an Jiaotong University as the research object. Item analysis, validity analysis, reliability analysis, receiver operating characteristic curve (ROC) were used to test the reliability, validity and predictive performance of the scale.Results:Exploratory factor analysis extracted a total of 4 common factors, namely general condition, stoma condition, postoperative condition, education and self-care condition, a total of 17 items, and the cumulative variance contribution rate was 85.144%. The scale-level content validity index was 0.941, and the item-level content validity index was 0.857 to 1.000. The Cronbach's α coefficient of the total scale was 0.824, the split-half reliability coefficient was 0.837, and the test-retest reliability coefficient was 0.819. There was a statistically significant difference in the scores of the Peristome Skin Injury Risk Assessment Scale in patients with colorectal cancer stoma between the injury group and the non-injury group ( P<0.05) . The area under the ROC curve was 0.838 (95% confidence interval: 0.785-0.891) . When the cut-off score was 39.5, the sensitivity of the scale was 0.849, the specificity was 0.759, the Youden index was 0.608, and the predictive performance was the best. Conclusions:The Peristome Skin Injury Risk Assessment Scale has good reliability and validity, and has high predictive performance, which is suitable for the assessment of the risk of peristome skin injury in patients with colorectal cancer in China.

肠造口患者有着艰难的心理体验和较重的自我感受负担,医护人员应关注造口患者的内心真实感受,深入了解肠造口患者居家护理状况以及自我感知状态.采用质性研究方法,目的性抽样选择16名肠造口患者进行半结构式访谈,并运用Colaizzi分析法对资料进行分析、归纳主题.结果发现肠造口患者自我感知可归纳为4个主题:复杂的情绪反应;自我护理障碍;渴望支持,维护尊严;寻找自我价值.在住院期间为造口患者提供针对性指导、个性化健康教育外,还要做好患者出院后的延续性护理,并号召家庭及社会支持系统给予造口患者更多的关爱与支持,提高造口患者生活质量,助其回归正常社交和生活.

In recent years, proteomics, transcriptomics and high-throughput sequencing technologies have developed rapidly, generating a large amount of genomics data in the field of cancer research. The Oncomine database is currently the world's largest oncology chip database, and an integrated data mining platform for mining cancer gene information. Oncomine database can analyze the expression difference of a target gene in tumor tissues and normal tissues, obtain a series of important clinical information such as tumor size, metastasis, survival time and its high-performance analysis ability and large-scale storage sample guarantee analysis. The result is extremely high quality and great reference value. The Oncomine database is open to researchers. This article aims to introduce the application method of the database and the method of genetic information mining.

In recent years, with the rapid development of next-generation sequencing technology, high-throughput sequencing data has also grown exponentially. The SRA (Sequence Read Archive) database is a representative database for storing these next-generation sequencing raw data and comparison information. Since the establishment of the SRA database, the sequence data has accumulated rapidly. At present,a large-scale database involving multiple species and multiple applications has been formed,which has become a platform for efficient storage,extraction and sharing of sequencing data. The database is currently continuously updated and open to the public. This article will introduce the SRA database website architecture and sequencing raw data extraction method.

该文通过综述国内外伤口造口失禁专科护理的发展,对伤口造口失禁专科护士相关概念进行介绍,分析总结了国外伤口造口失禁专科护士的服务模式、角色职责及培养情况,并对我国目前研究现状进行分析,同时对我国伤口造口失禁专科护士的发展提出了展望.

TCGA(The project of The Cancer Genome Atlas)was launched by the National Cancer Institute (NCI) and the National Human Genome Research Institute (NHGRI) in 2006.It is the largest cancer genome database at present. The TCGA aims to catalogue and discover major cancer-causing genome alterations and gene expression profile in almost all kinds of human tumors by using large-scale genome sequencing and integrated analyses, which provides a huge data base for exploring meaningful genomic changes and discovering biological mechanisms that affect tumors. The database provides researchers with free data for relevant research. This paper aims to introduce the database and the method of extracting tumor data.

ALL of Us Research Program is one of the projects supported by the National Institutes of Health (NIH) and is an important part of the precision medicine program. The project aims to identify the differences in physical, environmental, and behavioral differences between individuals by recruiting one million or more volunteers living in the United States to find connections with different health outcomes, enabling precision medicine to reach all diseases. The project was officially opened to the United States in May 2018. The data is divided into public data and post-registrationwhich is expected to be available in the winter of 2019. This article will introduce the research background, website architecture and data acquisition methods of the ALL of Us project.

目的 了解化疗期胃癌患者家庭功能对创伤后成长的影响,并探讨领悟社会支持的中介作用.方法 以2018年1—12月在西安市某三级甲等医院肿瘤外科接受化疗的154例胃癌患者作为研究对象,采用家庭关怀度指数问卷、创伤后成长评定量表及领悟社会支持量表进行调查.结果 154例化疗期胃癌患者的家庭功能得分为(5.46±2.13)分;创伤后成长总分为(53.20±8.59)分,人生感悟维度得分为(17.41±5.93)分,个人力量维度得分为(7.97±3.04)分,与他人关系维度得分为(8.03±2.98)分,自我转变维度得分为(9.84±2.51)分,新的可能性维度得分为(9.96±2.39)分;领悟社会支持得分为(40.00±11.32)分.中介效应分析结果显示,控制文化程度及化疗次数为控制变量后,家庭功能得分可以正向预测创伤后成长得分(P<0.05),领悟社会支持得分对家庭功能及创伤后成长关系起中介作用(ΔR2=0.2591,P<0.05).结论 化疗期胃癌患者家庭功能与创伤后成长呈正相关,领悟社会支持在家庭功能与创伤后成长之间起中介作用.

The constant changing demand of the market demands textile accessories to act accordingly in rate and in capability.The background and the basic philosophy of the mass customization production is introduced.Conlusion is made that for mass customization production,manu process innovation is the key,info-construction the base and organization innovation the guarantee.

大规模定制是一种高效率、低成本、满足客户个性化需求的生产模式,是处于信息时代的纺织企业进行生产模式创新的必然选择.在实施大规模定制生产时,制造流程创新是关键;信息化建设是基础;组织创新是保证.

大规模定制是一种高效率、低成本满足用户个性化需求的生产模式,是处于信息时代纺织企业进行生产模式创新的必然选择.实施大规模定制生产,制造流程创新是关键,纺织企业应逐步开展计算机辅助设计和产品协同设计、计算机辅助制造和虚拟制造、需求集成以及供应链管理,其中信息化建设是基础.应逐步建立和完善用户关系管理系统、定制用户关系管理系统和集成MIS系统,其中组织创新是保证.组织结构设计应突出柔性和适应性.