BACKGROUND: Advances in diagnosis and treatment of premature ovarian insufficiency (POI) are urgently needed. Mitochondrial dysfunction and PANoptosis are associated with ovarian damage. In this study, we aimed to identify mitochondrial and PANoptosis-related biomarkers for POI. METHODS: Integrative bioinformatics analysis was performed based on RNA sequencing datasets from the Gene Expression Omnibus (GEO) database, combined with the MitoCarta3.0 database and PANoptosis-related genes. The feature differentially expressed genes (DEGs) were screened using machine learning methods. Based on the expression levels of mitochondrial characteristic genes (ACSM3, ALDH1L1, MAOB, OSBPL1A) and pan-apoptotic genes (NOS2, UCHL1) screened out by the above machine learning, the mitochondrial and PANoptosis phenotypic scores were calculated through the GSVA algorithm. Differential expression of biomarkers was validated in clinical samples, and the role of nitric oxide synthase 2 (NOS2) was explored in POI mouse models. RESULTS: Four mitochondrial-related genes (ACSM3, ALDH1L1, MAOB, and OSBPL1A) and two PANoptosis-related genes (NOS2 and UCHL1) were screened. The mitochondrial phenotype scores of the samples were positively correlated with PANoptosis scores. All biomarkers were downregulated in human granulosa cells. Notably, NOS2, identified as the most significant biomarker, was downregulated in the POI model. Moreover, the overexpression of NOS2 markedly suppressed cell death and reactive oxygen species (ROS) production in the ovarian tissues of POI mice. CONCLUSIONS: The identified biomarkers may play key roles in the pathology of POI and serve as candidate biomarkers for its diagnosis and treatment.

Recurrence or tumor metastasis and drug resistance remain the major challenge in the treatment of thyroid cancer. It is needed to identify novel drug targets for thyroid cancer. Summary data-based Mendelian randomization (SMR) and colocalization analysis were performed to evaluate the associations between gene methylation, expression, protein levels with thyroid cancer. We additionally performed protein-protein interaction (PPI) network, gene ontology (GO) and kyoto encyclopedia of genes and genomes (KEGG) analyses to further explore the potential roles of identified genes in thyroid cancer. SDCCAG8 and VCAM1 genes were associated with risk of thyroid cancer with tier 1 evidence, while TCN2 gene was with tier 3 evidence. SDCCAG8 gene was associated with risk of papillary thyroid cancer with tier 1 evidence. At the level of circulating proteins, genetically predicted higher levels of SDCCAG8 (OR = 0.46, 95

OBJECTIVES:To compare the 2-year efficacy and safety of various anti-vascular endothelial growth factor (VEGF) regimens for neovascular age-related macular degeneration (nAMD). METHODS:A comprehensive search was performed on multiple electronic databases up to April 2023 and updated in June 2024, to identify relevant randomized controlled trials (RCTs). Key outcomes included the proportion of patients achieving a vision gain of ≥15 letters and maintaining stable vision (loss of <15 letters) in best-corrected visual acuity (BCVA), changes in mean BCVA from baseline, serious ocular adverse events (SAEs), adverse events leading to treatment discontinuation and any cause of death at 2 years. RESULTS:Nineteen trials with 12,654 patients and 25 treatment regimens were analyzed in the study. All anti-VEGF regimens showed superior efficacy compared to sham therapy. Specifically, faricimab 6 mg (4+up to Q16W) and ranibizumab 0.5 mg (2-week T&E) displayed top-level effect in vision gain. Bevacizumab 1.25 mg (2-week T&E) and aflibercept 2 mg (2-week T&E) demonstrated the most stable vision outcomes. Bevacizumab 1.25 mg (2-week T&E) and ranibizumab 0.5 mg (2-week T&E) exhibited the most pronounced mean BCVA improvement. Compared to sham therapy, the risk of SAEs was significantly higher for brolucizumab 6 mg (3 + Q12W/ Q8W) (RR = 6.04, 95% CI: 1.30-28.02) and PDS 100 mg/ml (Q24W) (RR = 10.95, 95% CI: 2.14-56.02), but not for other anti-VEGF regimens. CONCLUSIONS:Ranibizumab 0.5 mg (2-week T&E) emerges as a potentially optimal regimen for nAMD over a 2-year period. Future studies need to consider the impact of baseline characteristics on treatment outcomes.

BackgroundCatastrophic disease sufferers face a heavy financial burden and are more likely to fall victim to the “illness-poverty-illness” cycle. Deeper reform of the medical insurance system is urgently required to alleviate the financial burden of individuals with catastrophic diseases.MethodsData were obtained from a cross-sectional questionnaire survey conducted in Heilongjiang in 2021, and logistic regression and restricted cubic spline model was used to predict the core factors related to medical insurance that alleviate the financial burden of people with catastrophic diseases.ResultsOverall, 997 (50.92%) medical insurance-related professionals negatively viewed financial burden relief for people with catastrophic diseases. Factors influencing its effectiveness in relieving the financial burden were: whether or not effective control of omissions from medical insurance coverage (OR = 4.04), fund supervision (OR = 2.47) and degree of participation of stakeholders (OR = 1.91). Besides, the reimbursement standards and the regional and population benefit package gap also played a role. The likelihood of financial burden relief increased by 21 percentage points for each unit increase in the level of stakeholder discourse power in reform.ConclusionChina’s current medical insurance policies have not yet fully addressed the needs of vulnerable populations, especially the need to reduce their financial burden continuously. Future reform should focus on addressing core issues by reducing the uninsured, enhancing the width and depth of medical insurance coverage, improving the level and capacity of medical insurance governance that provides more discourse power for the vulnerable population, and building a more responsive and participatory medical insurance governance system.

Objective To establish an index system with three dimensions of health capacity, right and risk and multidimensional indexes for the measurement of household health poverty. Methods An indicator system for evaluating health poverty was preliminary established through reviewing 225 relevant studies published in Chinese or English from1983 till 2023. Delphi qualitative interview and two rounds of consultation were conducted among 10 senior experts working in regions with higher prevalence of health poverty or better implementation of healthy poverty alleviation to screening the identified indicators. The weights of the selected indicators were calculated using hierarchical analysis and a set of multidimensional health poverty indexes was constructed using the key performance indicator method and the Alkire-Foster method. Results For the two rounds of expert consultation, the positive coefficient was 100% and the authority coefficients were 0.814 5 and 0.866 7; the coordination coefficients of the experts′ opinions on the second/third level indicators were0.342/0.233 and 0.487/0.353 for the first and second round of consultation, respectively（all P ＜ 0.05）, indicating a good coordination between the expert opinions. According to the results of the expert consultations and qualitative interviews, a health poverty evaluation index system was constructed; the index system includes 3 primary, 11 secondary, 39 tertiary indicators covering the three dimensions（health right, capability and risk） for health poverty measurement; in addition, 10specific indicators were screened out from all the indicators for the measurement of multidimensional health poverty using key performance indicator method and double threshold method based on Alkire-Foster model. Conclusion The study establishes the index system and multidimensional indexes for household-based measurement on health poverty and multidimensional health poverty and the index system could provide a reference to the promotion of healthy poverty alleviation in China.

随着全球人口老龄化的不断加剧,痴呆患病率不断上升.鉴于目前痴呆暂无有效治愈手段,探索和控制可改变的危险因素对减轻痴呆疾病负担具有重要意义.大气污染物暴露与多种不良健康结局有关,其对痴呆的影响已受到广泛关注.目前,国内外已有部分研究探索了大气污染物长期、短期暴露与痴呆发生、住院、死亡等多种健康结局之间的关联,但研究数量有限且研究结果不一致.本文基于国内外现有研究,对大气污染物暴露与痴呆发生、患病、住院、死亡等结局之间关联的研究结果进行综述,为深入了解大气污染对痴呆的影响提供线索.

Abstract Background The purposes of this study were to investigate the clinical features, treatments, and prognosis of embryonal rhabdomyosarcomas (ERMS) in the female genital tract with long-term follow-up. Methods The data of 14 patients who diagnosis of ERMS in the genitourinary system from January 2010 to October 2022 were retrospectively screened. The roles of prognostic risk factors, such as age, tumor size, tumor grade, depth of myometrial infiltration, lymphvascular space invasion and primary treatment were evaluated. Results We report 14 ERMS that arose in patients aged 10 to 44 (median = 19) year. The median longest tumor diameter was 5.5 cm (range, 1.0–15.0 cm). There was no myometrial infiltration in 4 patients, superficial myometrial infiltration in 3 patients, deep myometrial infiltration in 5 patients. Lymphvascular space invasion (LVSI) was present in 2 patients, and absent in 10 patients. All of the patients performed surgery and chemotherapy, and one patient also received radiotherapy. Follow-up evaluation was lost in two patients after three or six months of combination therapy. The 2-year PFS was 83.3% and the 5-year DSS was 91.7% with a median follow-up time of 57 months (range, 10–132). Patients with LVSI (+) had a significantly increased time to progression compared with patients with LVSI (-) (PFS: p = 0.004; DSS: p = 0.046). There was a trend toward improved PFS and DSS with early-stage disease (IRSG group I/FIGO stage I (uterine sarcoma or adenosarcoma)/T1) compared to advanced-stage disease. Conclusions ERMS in the female gynecologic tract with early stage has a good prognosis, a conservative surgical approach combined with chemotherapy can lead to good outcomes, preserving-fertility may be possible for younger women of these patients.

Abstract Background The purposes of this study were to investigate the clinical features, treatments, and prognosis of embryonal rhabdomyosarcomas (ERMS) in the female genital tract with long-term follow-up. Methods The data of 14 patients who diagnosis of ERMS in the genitourinary system from January 2010 to October 2022 were retrospectively screened. The roles of prognostic risk factors, such as age, tumor size, tumor grade, depth of myometrial infiltration, lymphvascular space invasion and primary treatment were evaluated. Results We report 14 ERMS that arose in patients aged 10 to 44 (median = 19) year. The median longest tumor diameter was 5.5 cm (range, 1.0–15.0 cm). There was no myometrial infiltration in 4 patients, superficial myometrial infiltration in 3 patients, deep myometrial infiltration in 5 patients. Lymphvascular space invasion (LVSI) was present in 2 patients, and absent in 10 patients. All of the patients performed surgery and chemotherapy, and one patient also received radiotherapy. Follow-up evaluation was lost in two patients after three or six months of combination therapy. The 2-year PFS was 83.3% and the 5-year DSS was 91.7% with a median follow-up time of 57 months (range, 10–132). Patients with LVSI (+) had a significantly increased time to progression compared with patients with LVSI (-) (PFS: p = 0.004; DSS: p = 0.046). There was a trend toward improved PFS and DSS with early-stage disease (IRSG group I/FIGO stage I (uterine sarcoma or adenosarcoma)/T1) compared to advanced-stage disease. Conclusions ERMS in the female gynecologic tract with early stage has a good prognosis, a conservative surgical approach combined with chemotherapy can lead to good outcomes, preserving-fertility may be possible for younger women of these patients.

BACKGROUND:Accumulating studies have reported that chronic exposure to ambient fine particulate matter (PM2.5) can lead to adverse effects on lung cancer mortality; however, such chronic effects are less clear for mortality from other site-specific cancers. OBJECTIVE:To explore the causal effect of long-term PM2.5 exposure on mortality from all-site and a variety of site-specific cancers in Jiangsu province, China during 2015-2020 using a difference-in-differences analysis. METHODS:For each of 53 county-based spatial units in Jiangsu province, we calculated annual death counts for all-site cancer and 23 site-specific cancers. Using a validated high-resolution PM2.5 grid dataset, long-term PM2.5 exposure of a spatial unit within a given year was evaluated as the average of population-weighted annual concentrations during recent 10 years. Conditional Poisson regression models were employed to evaluate exposure-response associations adjusting for spatial and temporal variables, seasonal temperatures, relative humidity, and gross domestic product (GDP). RESULTS:During the study period, we identified 947,337 adult cancer deaths in Jiangsu province. Each 1 μg/m3 increment in PM2.5 exposure was significantly associated with a 2.7% increase in the risk of all-site cancer mortality. PM2.5-mortality associations were also observed in cancer of lip, oral cavity and pharynx, stomach, colorectum, pancreas, lung, bone and joints, ovary, prostate, and lymphoma (all adjusted P < 0.05), with the relative risks ranging from 1.028 (95% confidence interval [CI]: 1.011, 1.046) for stomach cancer to 1.201 (95% CI: 1.120, 1.308) for bone and joints cancers. Exposure-response curves showed that these associations were close to linearity, though most of them had increasing slopes at high exposure levels. Overall, women and subjects in low GDP regions were more vulnerable to PM2.5 exposures. CONCLUSIONS:Long-term exposure to ambient PM2.5 contributes to a higher risk of mortality from multiple site-specific cancers.

Objectives Patient-centred communication improves patient experiences and patient care outcomes. This study aimed to assess the preference of medical professionals in China towards patient-centred communication under the context of the deteriorating doctor–patient relationship. Methods A cross-sectional survey of medical professionals was conducted in January and February 2018 in H City of Heilongjiang province, the northeast of China. The Chinese-Revised Patient-Practitioner Orientation Scale (CR-PPOS) was adopted to measure the individual preference of respondents towards patient-centredness in clinical communication. Multivariate logistic regression models were established to identify the sociodemographic (gender, age, marital status and educational attainment) and work experience (years of working, seniority, satisfaction with income, daily workload and perceived doctor–patient relationship) predictors of the preference towards patient-centredness. Patient and public involvement Not applicable. Results A total of 618 valid questionnaires were returned. The CR-PPOS demonstrated acceptable reliability and validity. Overall, a low level of preference towards patient-centredness in clinical communication was found. Relatively higher scores on ‘caring for patients’ (20.42±4.42) was found compared with those on ‘information/responsibility sharing’ (15.26±4.21). Younger age, higher educational attainment, lower daily workload and a perception of harmonious doctor–patient relationship were associated with a higher preference towards patient-centredness in clinical communication. Conclusions A low level of preference towards patient-centredness in clinical communication was found in medical professionals in the northeast of China, which may further jeopardise the efforts to improve doctor–patient relationship.

ObjectiveThe aim of this study was to investigate the prognostic value and stratification cutoff point for tumor size in stage I ovarian clear cell carcinoma (OCCC).MethodsThis was a retrospective cohort study using the Surveillance, Epidemiology, and End Results database (version: SEER 8.3.9). Patients diagnosed with stage I OCCC from 1988 to 2018 were included for further analysis. X-Tile software was used to identify the potential cutoff point for tumor size. Stratification analysis, propensity score matching, and inverse probability weighting analysis were used to balance the potential confounding factors.ResultsA total of 1,000 stage I OCCC patients were included. Of these 1,000 patients, median follow-up was 106 months (95% confidence interval [CI]: 89–112 months). Multivariate analysis showed that tumor size, age at diagnosis, and stage IC were significantly associated with stage I OCCC patients. Eight centimeters is a promising cutoff point that can divide stage I OCCC patients into a good or a poor prognosis group. After controlling potential confounding factors with propensity score matching and inverse probability weighting, we demonstrated that stage I OCCC patients with tumor size ≤ 8 cm enjoyed a significantly better 5-year overall survival (OS, 89.8% vs. 81%, p < 0.0001). Tumor size ≤ 8 cm was an independent prognostic factor of stage I OCCC patients (hazard ratio [HR] 0.5608, 95% CI: 0.4126–0.7622, p = 0.0002).ConclusionsTumor size is an independent prognostic factor for stage I OCCC, and 8 cm is a promising cutoff point for tumor size for risk stratification. However, using tumor size in the stratification management of stage I OCCC patients warrants further investigation.

目的 旨在探讨把握老人跌倒现状,探究居家养老老人跌倒的影响因素,以提升老年人的健康水平,减轻由于跌倒所造成的疾病经济负担,对实现健康老龄化具有重要意义.方法 基于中国老年健康影响因素跟踪调查(CLHLS)2018年数据,归纳居家养老老人跌倒现状,采用卡方、logistic回归分析影响居家老人跌倒的主要因素.结果 结果显示9867名老人年跌倒发生率(人)为23.5％;年跌倒发生(次)率为41.3％.多因素结果显示屋内有霉味(OR=1.209,95％ CI:1.044～1.400)、屋内存在漏雨漏水情况(OR=1.499,95％ CI:1.371～1.707)、经常锻炼身体(OR=1.224,95％ CI:1.092～1.371)、听力差(OR=1.275,95％CI:1.140～1.427)是居家老人跌倒的危险因素;低龄(OR=0.631,95％CI:0.058～0.784)、无慢性病(OR=0.650,95％CI:0.056～0.747)、维持独立站立(OR=0.659,95％ CI:0.584～0.744)、清淡饮食习惯(OR=0.871,95％CI:0.785～0.965)是居家老人跌倒的保护因素.结论 我国居家养老老人年跌倒发生率较高,应通过改善潮湿居住环境、控制饮食等措施来预防痛风、糖尿病足等脚部疾病的发生.老人应该通过适当、多维度的身体运动来改善肌肉力量,维持关节灵活性以保持身体的动态平衡能力,从而增强独立站立能力,尽可能延长站立时间,降低跌倒的风险.

Abstract Background High-grade serous ovarian carcinoma (HGSOC) is clinically dominant and accounts for ~ 80% deaths in all types of ovarian cancer. The delayed diagnosis, rapid development, and wide dissemination of HGSOC collectively contribute to its high mortality rate and poor prognosis in the patients. Suppressors of cytokine signaling 7 (SOCS7) can regulate cytokine signaling and participate in cell cycle arrest and regulation of cell proliferation, which might also be involved in carcinogenesis. Here, we designated to investigate the functions and mechanisms of SOCS7 in HGSOC. Methods The clinical correlation between SOCS7 and HGSOC was examined by both bioinformatics and analysis of tissue samples in patients. Gain/Loss-of-function examinations were carried out to assess the effectiveness of SOCS7 in cell viability, cell cycle, and tumor growth of HGSOC. Furthermore, the underlying mechanisms were explored by identifying the downstream proteins and their interactions via proteomics analysis and immunoprecipitation. Results The expression of SOCS7, which was decreased in HGSOC tissues, was correlated with the clinical pathologic characteristics and overall survival of HGSOC patients. SOCS7 acted as a HGSOC suppressor by inhibiting cancer cell viability and tumor growth in vivo. The anti-HGSOC mechanism involves SOCS7’s regulatory effect on HuR by mediating its ubiquitination, the regulation of FOXM1 mRNA by HuR, as well as the interplays among these three clinically relevant factors. Conclusions The SOCS7 correlates with HGSOC and suppresses its tumorigenesis through regulating HuR and FOXM1, which also suggests that SOCS7 is a prospective biomarker for the clinical management of ovarian cancer, especially HGSOC.

ObjectiveOver the past decade, scarlet fever has caused a relatively high economic burden in various regions of China. Non-pharmaceutical interventions (NPIs) are necessary because of the absence of vaccines and specific drugs. This study aimed to characterize the demographics of patients with scarlet fever, describe its spatiotemporal distribution, and explore the impact of NPIs on the disease in the era of coronavirus disease 2019 (COVID-19) in China.MethodsUsing monthly scarlet fever data from January 2011 to December 2019, seasonal autoregressive integrated moving average (SARIMA), advanced innovation state-space modeling framework that combines Box-Cox transformations, Fourier series with time-varying coefficients, and autoregressive moving average error correction method (TBATS) models were developed to select the best model for comparing between the expected and actual incidence of scarlet fever in 2020. Interrupted time series analysis (ITSA) was used to explore whether NPIs have an effect on scarlet fever incidence, while the intervention effects of specific NPIs were explored using correlation analysis and ridge regression methods.ResultsFrom 2011 to 2017, the total number of scarlet fever cases was 400,691, with children aged 0–9 years being the main group affected. There were two annual incidence peaks (May to June and November to December). According to the best prediction model TBATS (0.002, {0, 0}, 0.801, {<12, 5>}), the number of scarlet fever cases was 72,148 and dual seasonality was no longer prominent. ITSA showed a significant effect of NPIs of a reduction in the number of scarlet fever episodes (β2 = −61526, P < 0.005), and the effect of canceling public events (c3) was the most significant (P = 0.0447).ConclusionsThe incidence of scarlet fever during COVID-19 was lower than expected, and the total incidence decreased by 80.74% in 2020. The results of this study indicate that strict NPIs may be of potential benefit in preventing scarlet fever occurrence, especially that related to public event cancellation. However, it is still important that vaccines and drugs are available in the future.

Ovarian cancer (OC) is a malignancy with poor prognosis, stubborn resistance, and frequent recurrence. Recently, it has been widely recognized that immune-related genes (IRGs) have demonstrated their indispensable importance in the occurrence and progression of OC. Given this, this study aimed to identify IRGs with predictive value and build a prognostic model for a more accurate assessment. First, we obtained transcriptome and clinical information of ovarian samples from both TCGA and GTEx databases. After integration, we figured out 10 genes as immune-related prognostic genes (IRPGs) by performing the univariate Cox regression analysis. Subsequently, we established a TF-associated network to investigate its internal mechanism. The prognosis model consisting of 5 IRPGs was constructed later by lasso regression analysis. The comparison of the score with the clinical factors validated its independence and superiority in OC's prognosis. Moreover, the association between the signature and immune cell infiltration demonstrated its ability to image the immune situation of the tumor microenvironment. Finally, the reliability of the risk model was confirmed by the GEO cohort. Together, our study has constructed an independent prognostic model for OC, which may deepen the understanding of the immune microenvironment and help present novel biomarkers or ideas for targeted therapy.

It is urgent to improve communities′ response and resilience against various disasters frequently posing serious threats to the safety of people′s lives and property. With literature researches and based on complex system analysis, the study summarizes constituent elements of a community resilience system for coping with public health emergencies; the study also analyzes general characteristics and main loop logic of the resilience system′s four subsystems: social capital, community′s basic characteristics, disaster management, and community′s development capability. Then, a logical model of community resilience system for public health emergencies was constructed to provide a policy simulation tool for the development of community resilience. Among a community resilience system′ four subsystems, the social capital subsystem involves residents′ participation, community norms, relationship networks, and trust; the community basic characteristics includes a community′s physical environment, economic and demographic characteristics; the disaster management covers emergency organization management, disaster prevention and mitigation activities, disaster risk assessment, and residents′ awareness and skills for disaster reduction; the community development capability involves community innovation potential, information communication and public services. The constructed logical model for community resilience system to cope with public health emergencies could provide a certain reference for theoretical research and practical cultivation of community resilience.

This phase 2 study assesses the efficacy and safety of camrelizumab (an anti-PD-1 antibody) plus famitinib (anti-angiogenic agent) in women with pretreated recurrent or metastatic cervical cancer (ClinicalTrials.gov NCT03827837). Patients with histologically or cytologically confirmed cervical squamous cell carcinoma experiencing relapse or progression during or after 1-2 lines of systemic therapy for recurrent or metastatic disease are enrolled. Eligible patients receive camrelizumab 200 mg intravenously on day 1 of each 3-week cycle plus famitinib 20 mg orally once daily. The primary endpoint is the objective response rate. Secondary endpoints are duration of response, disease control rate, time to response, progression-free survival, overall survival, and safety. The trial has met pre-specified endpoint. Thirty-three patients are enrolled; median follow-up lasts for 13.6 months (interquartile range: 10.0-23.6). Objective responses are observed in 13 (39.4%, 95% confidence interval [CI]: 22.9-57.9) patients; the 12-month duration of response rate is 74.1% (95% CI: 39.1-90.9). Median progression-free survival is 10.3 months (95% CI: 3.5-not reached) and the 12-month overall survival rate is 77.7% (95% CI: 58.9-88.7). All patients experience treatment-related adverse events; grade ≥3 events occur in 26 (78.8%) patients. Treatment-related serious adverse events and deaths are observed in 9 (27.3%) and 2 (6.1%) patients, respectively. Camrelizumab plus famitinib shows promising antitumor activity with a manageable and tolerable safety profile in patients with pretreated recurrent or metastatic cervical squamous cell carcinoma. This combination may represent a treatment option for this population.

Ovarian cancer is the leading cause of death in gynecological malignancies worldwide. Our previous studies have proved that metformin inhibited the proliferation and invasion of ovarian cancer in vitro and in vivo. However, the underlying mechanisms have not been fully elucidated. Immunohistochemistry was carried out to detect the expression of tripartite motif-containing 37 (TRIM37), Ki-67, and MMP-9 in ovarian cancer and normal tissues. The influence of TRIM37 on the proliferation and invasion of ovarian cancer cells was verified by the real-time cellular analysis proliferation test, colony formation test, and Transwell assay. Western blot analysis and immunoprecipitation were used to detect the expression of the nuclear factor-κB (NF-κB) pathway and the interaction between TRIM37 and tumor necrosis factor receptor-associated factor 2 (TRAF2). Ubiquitination detection was carried out to detect the ubiquitination level of TRAF2. The present study revealed that TRIM37 expression was significantly increased in ovarian cancer tissues compared with normal control tissues, and its overexpression was closely associated with proliferation and metastasis. Metformin inhibited the NF-κB signaling pathway by downregulating TRIM37. Metformin also inhibited the ubiquitination of TRAF2 induced by TRIM37 overexpression. Metformin inhibits the proliferation and invasion of ovarian cancer cells by suppressing TRIM37-induced TRAF2 ubiquitination.