Objective: To investigate the clinical value of thin-section chest computed tomography (CT) in the typing of coronavirus disease 2019 (COVID-19). Methods: A retrospective analysis was performed on 134 patients diagnosed with COVID-19 in our hospital’s Department of Infectious Diseases from December 20, 2022, to December 31, 2022. All patients underwent thin-section chest CT scan with complete clinical data. According to clinical classification, patients were divided into the non-severe and severe groups. Clinical data and imaging features of the two groups were compared and analyzed, and statistical analysis was conducted. Results: There was a statistically significant difference with respect to diabetes mellitus between the two groups, and the incidence of diabetes mellitus in the severe group (45.8%) was higher than that in the non-severe group (25.5%); There were no significant differences in sex, age, average course of disease, and clinical symptoms between the two groups; There were significant differences in the number of lesions, symmetrical distribution, predominant peripheral distribution, diffuse distribution, blurred edge, morphology of large flake and band, vascular bundle thickening, paving stone sign, arcade sign, and fried egg sign between the two groups, the number of lesions >10, diffuse distribution, morphology of large flake and band, vascular bundle thickening, paving stone sign, and arcade sign were more common in the severe group than in the non-severe group, while predominant peripheral distribution, blurred edge, and fried egg sign were more common in the non-severe group than in the severe group. Conclusions: Thin-section chest CT scan can identify the abnormal imaging manifestations of the lung in patients with COVID-19 and evaluate the number, distribution range, and morphological characteristics of the lesions. Combined background diseases, number, distribution characteristics, blurred edge, large flake and band morphology, vascular bundle thickening, paving stone sign, arcade sign, and fried egg sign can effectively indicate the classification of patients with COVID-19. This can provide imaging evidence for the diagnosis and treatment of COVID-19.

Objective: To explore the imaging characteristics of patients with novel coronavirus pneumonia (COVID-19) combined with different underlying diseases. Materials and methods: COVID-19 was diagnosed in 153 patients at Beijing Shijitan Hospital, Capital Medical University, from November 16, 2022 to December 16, 2022, and data were retrospectively collected. All patients underwent chest CT scan from 1 to 14 days after onset and were divided into two groups based on the presence or absence of underlying diseases. Forty-three patients had underlying diseases, and 110 patients had none. We compared the differences between the two groups. Result: The comparison between the two groups showed statistically significant differences in age, cough, bilateral lung distribution, diffuse distribution, honeycomb-like changes in the lungs, patchy distribution, large patchy distribution, band distribution, crazy-paving sign, air bronchogram sign, traction bronchiectasis, and pleural effusion. Conclusion: Fever and cough are the most common clinical symptoms in patients with COVID-19. Chest CT showed multiple lesions in both lungs. The most common types of lesions were thickening of bronchovascular bundle and GGO. Patients with underlying diseases had more honeycomb-like changes, crazy-paving sign, air bronchogram sign, traction bronchiectasis, and pleural effusion than those without underlying diseases. Chest thin-slice CT scan provides a key reference for the early detection and diagnosis of the disease.

Objective: This study aimed to investigate the correlation between the neutrophil-to-lymphocyte ratio (NLR) and chest high-resolution computed tomography (HRCT) findings of coronavirus disease 2019 (COVID-19). Materials and Methods: NLR and chest HRCT findings of 132 patients diagnosed with COVID-19 in the department of infectious diseases of Beijing Shijitan Hospital Capital Medical University from December 1, 2022 to February 1, 2023 were retrospectively analyzed. The patients were divided into two groups with NLR cut-off value of 3.0, and their HRCT characteristics and imaging manifestation patterns were analyzed. For the measurement data of normal distribution, the t-test of continuous variables was used between the groups. The data of non-normal distribution are expressed as median and quartile and compared using Mann-Whitney U test. The counting data are expressed as frequency, and the chi-squared or Fisher's exact test was used for comparison between the groups. P<0.05 indicates that the difference is statistically significant. Results: The number of lesions ≤5 and the proportion of lesions ≤10% were higher in the low NLR group than that in the high NLR group. The number of lesions >10 and the proportion of lesions >50% were higher in the high NLR group than that in the low NLR group. The high NLR group was prone to mixed density shadow, crazy-paving pattern, mosaic sign, anti-halo sign, subpleural black belt, arcade-like sign than that in the low NLR group. The high NLR group was most likely to have nonspecific interstitial pneumonia-like, organizing pneumonia-like, and diffuse alveolar damage-like patterns than that in the low NLR group. Conclusion: Different NLRs have different manifestations of COVID-19 chest HRCT. The high NLR group is more prone to mixed density shadow, crazy-paving pattern, mosaic sign, anti-halo sign, subpleural black belt, and arcade-like sign, as well as most likely to have radiologic patterns of nonspecific interstitial pneumonia, organizing pneumonia, diffuse alveolar damage.

目的 探讨无骨质疏松的男性2型糖尿病(T2DM)患者视网膜病变与25羟维生素D(25OHD)的关系.方法 纳入256例无骨质疏松的男性T2DM患者进行分析,其中无糖尿病视网膜病变组(NDR)152例,合并非增殖期糖尿病视网膜病变组(NPDR)74例,增殖期糖尿病视网膜病变组(PDR)30例.比较3组患者的一般资料、实验室检查指标及250HD水平;分析T2DM患者的25OHD营养情况,并对DR与25OHD水平的关系进行Pearson相关分析;采用logistic回归分析探讨DR的危险因素.结果 NDR组、NPDR组、PDR组的25OHD水平依次下降[分别为(15.92±6.84)μg/L、(13.00±5.56)μg/L、(10.35±3.25)μg/L,P＜0.05].25OHD 严重缺乏患者 DR 发生率显著高于其他组患者(P＜0.05).Pearson相关分析结果显示,DR与25OHD呈负相关(r=-0.305,P＜0.001).Logstic回归分析结果显示,25OHD和空腹C肽是DR的独立保护因素(P＜0.05).结论 无骨质疏松的男性T2DM患者25OHD水平与DR相关,25OHD可能为DR的保护性因素.

目的 评价输卵管性不孕应用CT、经阴道超声造影、抗人绒膜促性腺激素(HCG)抗体联合诊断的价值.方法 选取2016年3月至2019年3月北京世纪坛医院收治的120例输卵管性不孕患者作为研究对象.术前均接受CT、经阴道超声造影检查,并测定其血清抗HCG抗体水平,以腹腔镜下通液术诊断结果为金标准,评估CT、经阴道超声造影、抗HCG抗体水平三者单项及联合检查输卵管通畅性的诊断效能,并对比CT、经阴道超声造影的图像质量.结果 腹腔镜下通液术诊断结果显示,120例患者(240条输卵管)中输卵管通畅138条(57.5％),不通畅102条(42.5％).120例患者中血清抗HCG抗体阳性率为42.50％(51/120).CT、经阴道超声造影、抗HCG抗体水平联合诊断输卵管通畅性的灵敏度(93.14％)、特异度(91.30％)及准确度(92.08％)均比三者单项诊断高,差异具有统计学意义(P<0.05);经阴道超声造影图像质量的优良率(89.17％)比CT(75.83％)高,差异具有统计学意义(P<0.05).结论 相比CT,经阴道超声造影用于输卵管性不孕诊断具有图像质量清晰、可重复性强等优势,若将CT、经阴道超声造影、抗HCG抗体水平三者联合诊断利于判断输卵管通畅程度,可为临床诊治提供科学依据.

固有免疫亦称天然免疫或非特异性免疫，是指机体与生俱有的抵抗体外病原体侵袭、清除体内抗原性异物的一系列防御能力，与适应性免疫不同，其作用广泛，非针对特定抗原，是机体抵御病原微生物的第一道防线。分泌性中耳炎（otitis media with effusion，OME）是一种常见病，尤其在儿童多发，其发病机制较为复杂，相关机制又存在冲突和交叉。近年来随着对中耳免疫学研究的深入， 固有免疫在OME发生发展中的重要作用也得到证实。本文主要对现有的固有免疫与OME的相关研究进行系统综述，以帮助进一步理解OME发病的免疫学基础，并从儿童固有免疫的特殊性角度解释OME易在儿童中发生的原因，以期为今后的预防及治疗方案提供新思路及理论依据。

目的 明确儿童复发性分泌性中耳炎(OME)的高危致病因素,为指导复发性OME的治疗提供依据.方法 检索英文PubMed、MEDLINE和EMBASE及中文中国期刊全文数据库(CNKI)、中国科技期刊全文数据库(VIP)、万方数据库,收集各个数据库建库至2020年5月1日已发表的文献.检索策略:英文检索(pediatric or children)AND(recurrent otitis media with effusion or refractory otitis media with effusion or recurrent OME or refractory OME);中文检索(儿童)AND(复发性分泌性中耳炎OR难治性分泌性中耳炎).结果 共纳入符合检索策略的文献15篇,总研究例数1867例,反复上呼吸道感染合并OR值为4.67(95％CI为2.97～7.36),性别合并OR值为1.18(95％CI为0.80～1.73),吸烟环境合并OR值为0.91(95％CI为0.67～1.22),腭裂合并OR值为3.80(95％CI为2.50～5.79).结论 儿童复发性OME的高危因素主要包括反复上呼吸道感染和腭裂2类.对于有高危因素的复发性OME患儿,建议延长鼓膜置管留置时间至12个月以上,以最大程度降低复发率.

目的 探讨不同维生素D水平社区2型糖尿病(T2DM)患者的胰岛功能.方法 收集1024例社区T2DM患者的全部临床资料,包括一般资料、生化指标、糖代谢指标、骨代谢指标及骨密度(BMD),以胰岛素敏感指数(ISI)、胰岛素抵抗指数(HOMA-IR)、胰岛素分泌指数(IS)协助评价胰岛功能.根据患者的25羟维生素D[25(OH)D]水平四分位数将其分为4组,比较最高四分位组[17.15 ng/ml≤25(OH)D水平<62.11 ng/ml)]和最低四分位组[3.00 ng/ml≤25(OH)D水平<8.53 ng/ml]患者各项临床资料的差异,并分析T2DM患者25(OH)D水平的影响因素.结果 最高四分位组患者的睾酮(TT)和高密度脂蛋白胆固醇(HDL-C)水平明显高于最低四分位组,年龄明显低于最低四分位组(P<0.05).在最高四分位组中,2h C肽(2h CP)与Ⅰ型胶原氨基末端肽(P1NP)、β-胶原降解产物(β-CTX)均呈正相关(P<0.05);在最低四分位组中,空腹C肽(FCP)与β-CTX呈正相关(P<0.05).HDL-C水平升高(β=11.214,P=0.004)、PTH水平降低(β=-0.186,P=0.004)、年龄增长(β=0.186,P=0.030)是T2DM患者25(OH)D水平升高的独立影响因素.结论 不同25(OH)D水平社区T2DM患者胰岛功能差异不显著,部分骨代谢指标与胰岛功能相关.

眼科专业学位研究生(眼科专硕)教育阶段引入内科系统相关学科共同参与有助于研究生夯实临床基本功,锻炼全面思考问题的能力及重要临床问题的预警处置能力.明确任务、注重考核、加强管理是眼科专硕内科共同培养模式的再实践.笔者结合内科团队参与眼科专硕共同培养过程的体会,对这一教学实践进行了总结分享.

单侧耳聋(single-side deafness,SSD)对儿童言语和语言发育的影响曾被严重忽视,人们往往认为好耳可以弥补差耳的缺陷,一侧听力正常就可以让言语、语言、社交和学习能力正常发展.越来越多的研究证据表明SSD与言语和语言发育、行为和教育延迟等问题间存在着直接关联.对于SSD的潜在风险,尤其是致命的风险往往是被忽视的.近年来,学界对此的认识逐渐增强,但未形成相应的规范,就其治疗干预来说仍存在很多不确定性,以及主观上的不接受等.本文就儿童SSD的认识过程以及目前的诊治现状作以综述.

目的 探讨双侧内耳畸形患儿脑脊液耳漏修补及耳蜗植入同期手术的可行性及效果.方法 回顾性分析2018年12月-2020年3月双侧内耳畸形同期行脑脊液耳漏修补及耳蜗植入患儿的临床资料.结果 共3例患儿,IP-Ⅰ3例4耳,IP-Ⅱ及耳蜗未发育伴前庭扩大各1耳.脑脊液耳漏术中诊断1例,术前诊断2例;均同期完成脑脊液耳漏修补+人工耳蜗植入术;术后随访2-16月,均无脑脊液耳漏或脑膜炎;病例1和2语言发育可,病例3因新冠疫情术后2月开机,电反应良好,继续随访.结论 双侧内耳畸形合并脑脊液耳漏的诊断,需要结合听力筛查、病史、听力学及影像学结果综合判断;同期行脑脊液耳漏修补+人工耳蜗植入术具有可行性,术后效果可.

甲状腺功能亢进症( hyperthyroidism,以下简称甲亢)伴延髓麻痹( bulbar palsy)临床相对罕见, 急性病例可表现为进行性肌无力,吞咽困难,发音障碍及复视,发病机制尚不明确,亚急性、慢性病例临床报道更少.现将1例复发甲亢合并亚急性慢性起病的延髓麻痹病例资料整理报告如下,希望借此提高内分泌科临床医生对甲亢引起延髓麻痹这一临床过程的重视,以利早期诊断,提高治疗效果、减少不良预后的发生.

目的 对1例Waardenburg综合征2型先证者及其家系成员进行基因测序分析,探讨其可能的分子生物学病因,进一步探讨Waardenburg综合征2型的分子遗传学特征.方法 对所收集家系进行临床诊断,提取家系成员的外周血DNA,目标基因进行区域捕获测序,扩增的PCR产物酶切后进行测序分析,利用软件及遗传学网站的信息分析数据.结果 先证者存在SOX10基因杂合突变c.346C>T(p.Q116X),该突变为无义突变,可能造成蛋白截短体,经家系验证分析,先证者父母该位点均无变异,此变异为新发突变,保守性分析提示具有高度保守性,多个物种氨基酸序列一致.结论 SOX10基因c.346C>T(p.Q116X)在此Waardenburg综合征2型一家系为一新发突变位点,该突变可能造成蛋白截短,进而影响SOX10基因功能,该结果为进一步深入研究Waardenburg综合征,了解SOX10基因功能提供了线索.

目的:探讨肠内营养联合肠外营养对食管癌术后患者免疫功能、营养状况的影响,并观察其对临床结局和生活质量的影响.方法:选取2015年5月-2018年3月就诊于我院确诊为食管癌行食管癌根治术的患者106例,按照随机数字表法分为试验组和对照组,每组患者53例,对照组患者术后行单纯肠外营养(TPN组)7d,观察组患者术后行肠内营养联合肠外营养(EEN+ PN组)7d,对两组患者行营养支持期间的免疫学指标[淋巴细胞计数(LYM)、免疫球蛋白A(lgA)、免疫球蛋白M(lgM)、免疫球蛋白G(lgG)]、营养指标(白蛋白、转铁蛋白、前白蛋白)、住院情况(肛门排气时间、排便时间、术后住院时间以及住院费用)以及并发症等情况进行比较.结果:(1)两组患者营养治疗后免疫学指标(LYM、lgA、lgA及lgG)较前均有所改善,且试验组改善程度显著高于对照组;(2)两组患者营养治疗后其营养学指标(白蛋白、前白蛋白、转铁蛋白)较前均有所提高,试验组患者营养学指标显著高于对照组;(3)试验组患者首次肛门排气时间、排便时间、术后住院时间较对照组明显缩短,试验组患者住院费用显著低于对照组;(4)两组患者营养支持期间并发症发生率之间差异不显著.结论:早期肠内营养联合肠外营养能够提高患者围术期的免疫功能,改善术后营养状况,促进疾病的康复,提高患者的生活质量.

Objective:To study the etiology of vertigo in children and analyze the relationship between the etiology of vertigo and the age category. Method:One hundred and forty-four cases of children with vertigo or dizziness were selected. All patients received the vertigo questionnaire, audiological, vestibular function and other related examinations. JMP 10.0 was used for statistical analysis. Result:Of 144 patients, 17 cases were preschool age (<6 years old), 101 cases were school age (6-12 years old) and 26 cases were puberty (>12 years old). All patients were mainly distributed between 6 and 10 years old. The most common diagnoses was benign paroxysmal vertigo. The second one was vestibular migraine. Incidence rate of the same disease in different ages was also different. Benign paroxysmal vertigo and vestibular migraine in preschool age, school age and puberty accounted for 58.8%, 42.6%, 0 and 0, 17.8%, 30.8%, respectively. Conclusion:Benign paroxysmal vertigo and vestibular migraine were the most common causes of vertigo in children. Prevalence rate and the etiology was various in different ages. Due to the physical and psychological development of children, analyzing the cause of vertigo in children should be fully considered these characteristics.

目的 探讨亚临床甲状腺功能减退症(subclinical hypothyroidism,SCH)与2型糖尿病下肢动脉病变(lower extremity arterial disease,LEAD)的关系.方法 选择首都医科大学附属北京同仁医院内分泌科住院的2型糖尿病患者746例,测定所有患者甲状腺功能和踝肱指数(ankle brachial index,ABI),根据ABI分为糖尿病合并LEAD组和对照组,比较两组患者基本情况、生物化学指标和SCH的患病率.采用单因素和多因素Logistic回归分析糖尿病下肢动脉病变的危险因素.结果 746例2型糖尿病患者中,117例合并SCH,女性患病率高于男性(P＜0.05).LEAD组患者促甲状腺激素(thyroid stimulating hormone,TSH)浓度及SCH患病率较对照组升高.Logistic回归分析显示,年龄(OR=1.055,95％ CI:1.031 ～1.078,P＜0.001),SCH(OR =2.162,95％ CI:1.383 ～3.379,P=0.001),吸烟(OR=2.129,95％ CI:1.352 ～3.355,P=0.001),收缩压(OR=1.014,95％ CI:1.004～1.023,P=0.005),低密度脂蛋白胆固醇(OR=1.189,95％ CI:1.026～1.378,P=0.021)与糖尿病LEAD正相关,总肾小球滤过率下降(OR=0.984,95％ CI:0.974 ～0.995,P=0.003)与LEAD负相关.男性患者中,SCH对LEAD的影响更显著(OR=3.747,95％ CI:1.940～7.239,P＜0.001),女性患者中则无相关性.结论 SCH与男性2型糖尿病患者LEAD密切相关.

目的 探讨血管紧张素转化酶2 (angiotensin converting enzyme 2,ACE 2)对肝细胞凋亡的影响及可能机制.方法 ①利用ACE2过表达DNA载体转染人肝细胞株HepG2细胞;②MTT [3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazoliumbromide]法检测过表达ACE2基因的HepG2细胞在棕榈酸(palmitate,PA)处理下的细胞活力;③原位DNA末端酶标记技术(terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick end labeling assay,TUNEL)检测同周龄雄性C57BL/6和ACE2基因敲除(ACE2-/y)小鼠肝细胞凋亡情况;④实时荧光定量PCR(real-time PCR,RT-PCR)法检测凋亡相关基因的表达;⑤蛋白质印迹法(Western blot)检测B细胞淋巴瘤/白血病-2蛋白(anti-apoptotic protein B cell lymphoma-2,Bcl-2)、促凋亡基因(Bc1-2associated X protein,Bax)、C/EBP同源蛋白(C/EBP homologous protein,CHOP)、C-Jun氨基末端激酶(C-Jun NH2-terminal kinase,JNK)和含半胱氨酸的天冬氨酸蛋白水解酶3(cysteinyl aspartate specific proteinase-3,caspase3)蛋白水平的表达情况.结果 ①以不同浓度PA处理HepG2细胞24h后表现为细胞活力的降低,而过表达ACE2基因组细胞活力明显高于绿色荧光蛋白(green fluorescent protein,GFP)组(PA浓度为0.4、0.8、1.0 mmol/L时,P＜0.05);②同周龄雄性ACE2-/y小鼠肝脏细胞TUNEL阳性细胞明显多于对照组C57BL/6小鼠;③ACE2过表达显著降低了凋亡相关蛋白Bax,caspase-3,CHOP,磷酸化JNK的表达,而抗凋亡基因Bcl-2表达升高.与此同时,ACE2过表达也明显降低了内质网应激(endoplasmic reticulum stress,ERS)相关细胞凋亡通路基因的表达.结论 ACE2减少了肝细胞的凋亡,其机制可能与ACE2对肝脏内质网应激的保护作用有关.

Objective: To investigate the clinical characteristics, prognosis and affected branches of vestibular neuritis in children. Methods: Twenty-five patients with vestibular neuritis in ENT department, Beijing Children's Hospital, from October 2015 to October 2016, were collected. All patients were 4-14 (mean 9.8) years old including 17 boys and 8 girls. The clinical manifestations history, pure tone audiometry (PTA), vestibular function tests were done for each patient. We also took the blood samples for pathogenic virus in order to analyze the premorbid risk factors. Results: Rotational vertigo were complained by all presents. There were 17 cases (68%, 17/25) with nausea and vomiting and 19 cases (76%, 19/25) with balance dysfunction. There were 12 cases (60%, 12/20) with positive results in 20 blood samples for virology, among which 6 cases of influenza B virus and 4 cases of herpes simplex virus, 1 case of cytomegalovirus and 1 case of coxsackie were identified. The results of PTA were normal. Bithermal caloric test was abnormal in 22 cases (88%, 22/25). The ocular vestibular-evoked myogenic potential (oVEMP) in 12 cases (48%, 12/25) and cervical vestibular-evoked myogenic potential (cVEMP) in 5 cases (20%, 5/25) were abnormal. The bithermal caloric test along with oVEMP and cVEMP in 4 cases (16%, 4/25) were abnormal. The bithermal caloric test and oVEMP in 7 cases (28%, 7/25) were abnormal. The bithermal caloric test in 11 cases (44%, 11/25) were abnormal. The oVEMP in 1 cases (4%, 1/25) was abnormal. The cVEMP in 1 cases (4%, 1/25) was abnormal. All patients recovered well, but the time varied. The symptoms of 21 patients were complete recovery within 1 month. 3 patients were complete recovery within 2 months (aged 8 - 14 years old). One patient was complete recovery within 6 months (aged 13 years old). Conclusion: Rotary vertigo is most commonly in children with vestibular neuritis, accompany with imbalance and vomiting. The vestibular neuritis in children might be related with upper respiratory tract infection. Audiometry test is normal. Because of the bithermal caloric test and oVEMP are obvious abnormality, therefore it is speculated that the superior vestibular nerve may most commonly be affected. The younger patients with vestibular neuritis recovered more quickly than the older children.

Objective:To summarize the clinical characteristics and clinical treatment of congenital cholesteatoma (CC) of the middle ear in children, provide early diagnosis methods and explore standardized diagnosis and treatment plan.Method:A retrospective chart review of 94 patients with a diagnosis of middle ear cholesteatoma, in Beijing Children's Hospital, between 2009 and 2015 was carried on. 14 patients with CC were identified using the criteria proposed by Levenson, and were divided into two groups according to the course of disease. The course of disease in group A was less than 3 months, and group B was more than 3 months. The main complains, diagnostic methods and Potsic's stage of temporal bone CT findings were recorded.Result:①The age of 14 cases of congenital cholesteatoma of the middle ear ranged from 3.33 to 10.17 years, with the median age of 7.20 years. ②Hearing loss (13/14, 92.86%) was the most common complain. Finding methods included hearing screening and CT scan (11/14, 78.57%), tympanotomy (2/14, 14.28%) and otoscopic examination (1/14, 7.14%). ③There were 6 people in group A and 8 in group B. According to Potsic's grading standard, the difference between the two groups was statistically significant (P=0.043). ④The preoperative Air-Bone conduction threshold Gap (ABG) in A and B two groups were (38.10±7.43) dB and (42.09±9.96) dB, respectively, and there was no significant difference in analysis (P=0.427). ⑤The difference between pre-ABG and post-ABG ［(36.26±5.56）dB and （21.70±3.80）dB, P=0.004］ was significant. Canal wall up mastoidectomy was the preferred procedure and 11/14 (78.57%) patients had this surgery done.Conclusion:The shorter the course of disease, the lower the stage of cholesteatoma of the middle ear indicates the importance of early detection. But congenital cholesteatoma is more occult, and even within 3 months, cholesteatoma can cause severe damage to the hearing and middle ear structure. Early screening programs can recommend hearing screening and CT scan to facilitate early intervention.

目的 探讨软带骨锚式助听器(bone anchored hearing aid,BAHA)对儿童使用者的效果,为软带BA-HA适用人群的选择及听觉言语康复提供参考.方法 以23例双侧外耳畸形儿童为研究对象,月龄5～135个月,平均35.52±36.60个月.对受试儿童进行裸耳听阈和助听听阈测试,并在选配软带BAHA前后分别以婴幼儿有意义听觉整合量表(infant-toddler meaningful auditory integration scale,IT-MAIS)、有意义听觉整合量表(mean-ingful auditory integration scale,MAIS)、有意义使用言语量表(meaningful use of speech scale,MUSS)、言语可懂度分级(speech intelligbility rating,SIR)、小龄儿童听觉发展问卷(lilltEARS auditory guestionnaire,LEAQ)进行听觉感知及言语表达能力评估.结果 受试儿童配戴软带BAHA后,在0.25、0.5、1、2和4 kHz处听阈值平均降低了34.13、37.36、36.39、31.52和27.22 dB;选配软带BAHA前患儿的IT-MAIS/MAIS得分明显低于选配后3、6、12个月(均为P<0.05),选配软带BAHA前LEAQ得分仅明显低于选配后12个月时(P<0.05);选配软带BA-HA后患儿MUSS得分提高,其选配前的MUSS得分与选配后12个月时差异有统计学意义,受试儿童各时期SIR得分差异均无统计学意义.结论 软带BAHA可显著改善外耳畸形儿童听力水平,可作为BAHA手术植入前的替代听觉装置;佩戴软带BAHA后患儿听觉感知能力发育迅速,言语表达能力在佩戴后12个月时发育迅速.